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    Rpap3 RNA polymerase II associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300189, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rpap3provided by RGD
    Official Full Name
    RNA polymerase II associated protein 3provided by RGD
    Primary source
    RGD:1303036
    See related
    EnsemblRapid:ENSRNOG00000053405 AllianceGenome:RGD:1303036
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol. Predicted to be part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and protein folding chaperone complex. Orthologous to human RPAP3 (RNA polymerase II associated protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 150.8), Thymus (RPKM 150.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpap3 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (130689923..130719411, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (128810820..128840006, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139167302..139196468, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093894 Neighboring gene DNA methyltransferase 1-associated protein 1-like Neighboring gene endonuclease, poly(U)-specific Neighboring gene uncharacterized LOC134479568 Neighboring gene Rap guanine nucleotide exchange factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mir RA, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711270, Free PMC Article
    2. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94954

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of R2TP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of R2TP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004243.1 → NP_001004243.1  RNA polymerase II-associated protein 3

      Status: PROVISIONAL

      Source sequence(s)
      BC079414
      UniProtKB/Swiss-Prot
      Q68FQ7
      UniProtKB/TrEMBL
      A0A8L2R8N5
      Related
      ENSRNOP00000080890.1, ENSRNOT00000111323.2
      Conserved Domains (3) summary
      PLN03088
      Location:136 → 315
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:133 → 161
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:538 → 625
      RPAP3_C; Potential Monad-binding region of RPAP3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      130689923..130719411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263372.1 → XP_063119442.1  RNA polymerase II-associated protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8L2R8N5

    2. XM_017594784.3 → XP_017450273.1  RNA polymerase II-associated protein 3 isoform X3

      UniProtKB/Swiss-Prot
      Q68FQ7
      UniProtKB/TrEMBL
      A0A8L2R8N5
      Related
      ENSRNOP00000074251.3, ENSRNOT00000083926.3
      Conserved Domains (3) summary
      PLN03088
      Location:136 → 315
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:133 → 161
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:538 → 625
      RPAP3_C; Potential Monad-binding region of RPAP3

    3. XM_063263371.1 → XP_063119441.1  RNA polymerase II-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R8N5

    4. XM_017594782.3 → XP_017450271.1  RNA polymerase II-associated protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNH5, A0A8L2R8N5
      Related
      ENSRNOP00000079798.1, ENSRNOT00000106326.2

    5. XM_017594785.3 → XP_017450274.1  RNA polymerase II-associated protein 3 isoform X3

      UniProtKB/Swiss-Prot
      Q68FQ7
      UniProtKB/TrEMBL
      A0A8L2R8N5
      Conserved Domains (3) summary
      PLN03088
      Location:136 → 315
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:133 → 161
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:538 → 625
      RPAP3_C; Potential Monad-binding region of RPAP3

    6. XM_008765690.4 → XP_008763912.1  RNA polymerase II-associated protein 3 isoform X3

      UniProtKB/Swiss-Prot
      Q68FQ7
      UniProtKB/TrEMBL
      A0A8L2R8N5
      Conserved Domains (3) summary
      PLN03088
      Location:136 → 315
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:133 → 161
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:538 → 625
      RPAP3_C; Potential Monad-binding region of RPAP3

    7. XM_017594786.3 → XP_017450275.1  RNA polymerase II-associated protein 3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FQ7.1 GenPept UniProtKB/Swiss-Prot:Q68FQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials