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    Zfp14 ZFP14 zinc finger protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp14provided by RGD
    Official Full Name
    ZFP14 zinc finger proteinprovided by RGD
    Primary source
    RGD:1560188
    See related
    EnsemblRapid:ENSRNOG00000030932 AllianceGenome:RGD:1560188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp968
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in nucleus. Orthologous to human ZFP14 (ZFP14 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 28.3), Kidney (RPKM 23.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp14 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94396055..94413338, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85268649..85286125, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88350361..88367370, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691076 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 568 like, pseudogene 1 Neighboring gene uncharacterized LOC134483093 Neighboring gene zinc finger protein 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel profile of expressed sequence tags for zinc finger encoding genes from the poorly differentiated exocrine pancreatic cell line AR4IP. Gebelein B, et al. Cancer Lett, 1996 Aug 2. PMID 8697448
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 14 homolog
    Names
    zinc finger protein 14-like
    zinc finger protein 2
    zinc finger protein 968

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100991.4 → NP_001094461.1  zinc finger protein 14 homolog

      See identical proteins and their annotated locations for NP_001094461.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94396055..94413338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087318.2 → XP_038943246.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    2. XM_063270895.1 → XP_063126965.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5

    3. XM_039087307.2 → XP_038943235.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    4. XM_039087316.2 → XP_038943244.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    5. XM_039087311.2 → XP_038943239.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    6. XM_063270897.1 → XP_063126967.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5

    7. XM_039087321.2 → XP_038943249.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5
      Conserved Domains (3) summary
      COG5048
      Location:222 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    8. XM_063270896.1 → XP_063126966.1  zinc finger protein 14 homolog isoform X1

      UniProtKB/TrEMBL
      A1A5R5

    9. XM_063270903.1 → XP_063126973.1  zinc finger protein 14 homolog isoform X2

      UniProtKB/TrEMBL
      F7FIE6
      Related
      ENSRNOP00000035384.6, ENSRNOT00000033661.6

    10. XM_039087330.2 → XP_038943258.1  zinc finger protein 14 homolog isoform X3

      Related
      ENSRNOP00000107037.1, ENSRNOT00000130612.1
      Conserved Domains (2) summary
      COG5048
      Location:186 → 464
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:162 → 182
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_063270899.1 → XP_063126969.1  zinc finger protein 14 homolog isoform X2

      UniProtKB/TrEMBL
      F7FIE6
    Nucleotide Protein Strain
    Heading Accession and Version

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