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    Gfra4 GDNF family receptor alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfra4provided by RGD
    Official Full Name
    GDNF family receptor alpha 4provided by RGD
    Primary source
    RGD:620503
    See related
    EnsemblRapid:ENSRNOG00000021241 AllianceGenome:RGD:620503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables glial cell-derived neurotrophic factor receptor activity. Predicted to be involved in glial cell-derived neurotrophic factor receptor signaling pathway and nervous system development. Predicted to act upstream of or within negative regulation of ossification. Located in extracellular space. Orthologous to human GFRA4 (GDNF family receptor alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 12.3), Brain (RPKM 11.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gfra4 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138707970..138715279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118254937..118262252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123573394..123582431, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547276 Neighboring gene attractin Neighboring gene uncharacterized LOC134486154 Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene sialic acid binding Ig like lectin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. Masure S, et al. J Biol Chem, 2000 Dec 15. PMID 10958791
    2. Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Lindfors PH, et al. Endocrinology, 2006 May. PMID 16497798
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glial cell-derived neurotrophic factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glial cell-derived neurotrophic factor receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glial cell-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glial cell-derived neurotrophic factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GDNF family receptor alpha-4
    Names
    GDNF receptor alpha-4
    GDNFR-alpha-4
    GFR-alpha-4
    glial cell line derived neurotrophic factor family receptor alpha 4
    persephin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395069.1 → NP_001381998.1  GDNF family receptor alpha-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9EPI2, Q9EPI3
      UniProtKB/TrEMBL
      A6HQB7
      Conserved Domains (1) summary
      pfam02351
      Location:131 → 225
      GDNF; GDNF/GAS1 domain

    2. NM_023967.2 → NP_076457.1  GDNF family receptor alpha-4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_076457.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9EPI2, Q9EPI3
      Related
      ENSRNOP00000042875.3, ENSRNOT00000047947.4
      Conserved Domains (1) summary
      pfam02351
      Location:131 → 225
      GDNF; GDNF/GAS1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138707970..138715279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762197.4 → XP_008760419.1  GDNF family receptor alpha-4 isoform X4

      UniProtKB/Swiss-Prot
      Q9EPI2, Q9EPI3
      Conserved Domains (1) summary
      pfam02351
      Location:131 → 225
      GDNF; GDNF/GAS1 domain

    2. XM_006235043.5 → XP_006235105.1  GDNF family receptor alpha-4 isoform X3

      Related
      ENSRNOP00000106510.1, ENSRNOT00000132677.1
      Conserved Domains (1) summary
      pfam02351
      Location:192 → 286
      GDNF; GDNF/GAS1 domain

    3. XM_006235042.5 → XP_006235104.1  GDNF family receptor alpha-4 isoform X2

      Conserved Domains (1) summary
      pfam02351
      Location:192 → 286
      GDNF; GDNF/GAS1 domain

    4. XM_006235041.5 → XP_006235103.1  GDNF family receptor alpha-4 isoform X1

      Related
      ENSRNOP00000109889.1, ENSRNOT00000152461.1
      Conserved Domains (1) summary
      pfam02351
      Location:192 → 286
      GDNF; GDNF/GAS1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPI2.2 GenPept UniProtKB/Swiss-Prot:Q9EPI2

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