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    Tppp2 tubulin polymerization-promoting protein family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tppp2provided by RGD
    Official Full Name
    tubulin polymerization-promoting protein family member 2provided by RGD
    Primary source
    RGD:1566185
    See related
    AllianceGenome:RGD:1566185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566185
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; positive regulation of protein polymerization; and regulation of flagellated sperm motility. Predicted to be located in cytosol and sperm flagellum. Predicted to colocalize with microtubule. Orthologous to human TPPP2 (tubulin polymerization promoting protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 383.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tppp2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27087457..27090869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24614284..24627123)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28319175..28321469)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene ribonuclease A family member 13 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. Zhu F, et al. J Cell Mol Med, 2019 Apr. PMID 30680919, Free PMC Article
    2. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Vincze O, et al. Biochemistry, 2006 Nov 21. PMID 17105200
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polymerization-promoting protein family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109100.1 → NP_001102570.1  tubulin polymerization-promoting protein family member 2

      See identical proteins and their annotated locations for NP_001102570.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474040
      UniProtKB/TrEMBL
      A0A8I5ZRB0, A6KEE8
      Conserved Domains (1) summary
      pfam05517
      Location:6 → 161
      p25-alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27087457..27090869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274548.1 → XP_063130618.1  tubulin polymerization-promoting protein family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRB0, A6KEE8

    2. XM_039093586.2 → XP_038949514.1  tubulin polymerization-promoting protein family member 2 isoform X1

      UniProtKB/TrEMBL
      D3ZCE7
      Conserved Domains (1) summary
      pfam05517
      Location:6 → 155
      p25-alpha

    3. XM_039093589.2 → XP_038949517.1  tubulin polymerization-promoting protein family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZRB0
      Conserved Domains (1) summary
      pfam05517
      Location:6 → 157
      p25-alpha

    4. XM_039093588.2 → XP_038949516.1  tubulin polymerization-promoting protein family member 2 isoform X4

      Conserved Domains (1) summary
      pfam05517
      Location:7 → 105
      p25-alpha

    5. XM_063274549.1 → XP_063130619.1  tubulin polymerization-promoting protein family member 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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