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    Slc43a1 solute carrier family 43 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc43a1provided by RGD
    Official Full Name
    solute carrier family 43 member 1provided by RGD
    Primary source
    RGD:1308229
    See related
    EnsemblRapid:ENSRNOG00000008243 AllianceGenome:RGD:1308229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-isoleucine transmembrane transporter activity; L-leucine transmembrane transporter activity; and L-valine transmembrane transporter activity. Predicted to be involved in L-leucine transport; L-valine transmembrane transport; and isoleucine transport. Predicted to act upstream of or within L-amino acid transport and negative regulation of L-leucine import across plasma membrane. Predicted to be located in apical plasma membrane and podocyte foot. Orthologous to human SLC43A1 (solute carrier family 43 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 235.2), Liver (RPKM 111.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc43a1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90327250..90353438)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69920586..69946768)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72238796..72265023)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101592 Neighboring gene smoothelin-like 1 Neighboring gene translocase of inner mitochondrial membrane 10 Neighboring gene uncharacterized LOC102554396 Neighboring gene reticulon 4 receptor-like 2 Neighboring gene solute carrier family 43, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. Babu E, et al. J Biol Chem, 2003 Oct 31. PMID 12930836
    2. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy S, et al. J Biol Chem, 2005 Mar 25. PMID 15659399
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-isoleucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-valine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-valine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podocyte foot ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large neutral amino acids transporter small subunit 3
    Names
    solute carrier family 43 (amino acid system L transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107742.1 → NP_001101212.1  large neutral amino acids transporter small subunit 3

      See identical proteins and their annotated locations for NP_001101212.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6A4J7, B1WBX5, F7FL53
      Related
      ENSRNOP00000086034.1, ENSRNOT00000096799.2
      Conserved Domains (1) summary
      cd06174
      Location:117 → 261
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90327250..90353438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104880.2 → XP_038960808.1  large neutral amino acids transporter small subunit 3 isoform X1

      UniProtKB/TrEMBL
      F7FL53
      Related
      ENSRNOP00000011006.7, ENSRNOT00000011006.9
      Conserved Domains (1) summary
      cl28910
      Location:120 → 167
      MFS; Major Facilitator Superfamily

    2. XM_063283651.1 → XP_063139721.1  large neutral amino acids transporter small subunit 3 isoform X3

      UniProtKB/TrEMBL
      F7FL53

    3. XM_039104882.2 → XP_038960810.1  large neutral amino acids transporter small subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC62, F7FL53
      Conserved Domains (1) summary
      cl28910
      Location:72 → 240
      MFS; Major Facilitator Superfamily

    4. XM_039104881.2 → XP_038960809.1  large neutral amino acids transporter small subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC62, F7FL53
      Related
      ENSRNOP00000107321.1, ENSRNOT00000159750.1
      Conserved Domains (1) summary
      cl28910
      Location:72 → 240
      MFS; Major Facilitator Superfamily

    5. XM_039104883.2 → XP_038960811.1  large neutral amino acids transporter small subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC62, F7FL53
      Related
      ENSRNOP00000089545.1, ENSRNOT00000103404.2
      Conserved Domains (1) summary
      cl28910
      Location:72 → 240
      MFS; Major Facilitator Superfamily

    6. XM_039104885.2 → XP_038960813.1  large neutral amino acids transporter small subunit 3 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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