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    Dsn1 DSN1 component of MIS12 kinetochore complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dsn1provided by RGD
    Official Full Name
    DSN1 component of MIS12 kinetochore complexprovided by RGD
    Primary source
    RGD:1565179
    See related
    EnsemblRapid:ENSRNOG00000006236 AllianceGenome:RGD:1565179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cell division and chromosome segregation. Predicted to act upstream of or within skeletal muscle satellite cell proliferation. Predicted to be located in cytosol; kinetochore; and nuclear lumen. Predicted to be part of MIS12/MIND type complex. Orthologous to human DSN1 (DSN1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 69.3), Spleen (RPKM 51.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dsn1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166072775..166089029, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145652741..145668025, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (153101020..153115326, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein NDRG3-like Neighboring gene NDRG family member 3 Neighboring gene microtubule crosslinking factor 2 Neighboring gene TBC/LysM-associated domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma. Sun C, et al. Hum Pathol, 2018 Nov. PMID 30136646
    2. Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Chuang TP, et al. Oncotarget, 2016 Jul 19. PMID 27329586, Free PMC Article
    3. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. Kline SL, et al. J Cell Biol, 2006 Apr 10. PMID 16585270, Free PMC Article
    4. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Cheeseman IM, et al. Genes Dev, 2004 Sep 15. PMID 15371340, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116180

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated protein DSN1 homolog
    Names
    DSN1 homolog, MIS12 kinetochore complex component
    DSN1, MIND kinetochore complex component, homolog
    DSN1, MIS12 kinetochore complex component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025768.2 → NP_001020939.1  kinetochore-associated protein DSN1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001020939.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADJ6, A6JWQ5, F7F478, Q4V7C0
      Related
      ENSRNOP00000008255.4, ENSRNOT00000008254.8
      Conserved Domains (1) summary
      pfam08202
      Location:76 → 345
      MIS13; Mis12-Mtw1 protein family

    2. NM_001428683.1 → NP_001415612.1  kinetochore-associated protein DSN1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADJ6, A6JWQ5, F7F478, Q4V7C0

    3. NM_001428684.1 → NP_001415613.1  kinetochore-associated protein DSN1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADJ6

    4. NM_001428685.1 → NP_001415614.1  kinetochore-associated protein DSN1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADJ6, A0A8I6AFX7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166072775..166089029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284393.1 → XP_063140463.1  kinetochore-associated protein DSN1 homolog isoform X3

    2. XM_039105707.2 → XP_038961635.1  kinetochore-associated protein DSN1 homolog isoform X5

      Conserved Domains (1) summary
      pfam08202
      Location:9 → 272
      MIS13; Mis12-Mtw1 protein family

    3. XM_063284394.1 → XP_063140464.1  kinetochore-associated protein DSN1 homolog isoform X5

    4. XM_006235376.5 → XP_006235438.1  kinetochore-associated protein DSN1 homolog isoform X2

      Conserved Domains (1) summary
      pfam08202
      Location:76 → 345
      MIS13; Mis12-Mtw1 protein family

    5. XM_039105706.2 → XP_038961634.1  kinetochore-associated protein DSN1 homolog isoform X4

      Conserved Domains (1) summary
      pfam08202
      Location:11 → 274
      MIS13; Mis12-Mtw1 protein family

    6. XM_006235375.4 → XP_006235437.1  kinetochore-associated protein DSN1 homolog isoform X1

      Related
      ENSRNOP00000091670.1, ENSRNOT00000100568.2
      Conserved Domains (1) summary
      pfam08202
      Location:78 → 347
      MIS13; Mis12-Mtw1 protein family

    7. XM_063284395.1 → XP_063140465.1  kinetochore-associated protein DSN1 homolog isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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