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    Ttc7a tetratricopeptide repeat domain 7A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc7aprovided by RGD
    Official Full Name
    tetratricopeptide repeat domain 7Aprovided by RGD
    Primary source
    RGD:1306211
    See related
    EnsemblRapid:ENSRNOG00000014879 AllianceGenome:RGD:1306211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ttc7
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to act upstream of or within hemopoiesis and intracellular iron ion homeostasis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 86.4), Lung (RPKM 78.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc7a in Genome Data Viewer
    Location:
    6q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12912822..13015374, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7159285..7261826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10912383..11014279)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene calmodulin 2 Neighboring gene sperm-tail PG-rich repeat containing 4 Neighboring gene microRNA 3558 Neighboring gene uncharacterized LOC120103465 Neighboring gene uncharacterized LOC134479306 Neighboring gene multiple coagulation factor deficiency 2, ER cargo receptor complex subunit Neighboring gene uncharacterized LOC134479307

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F, et al. J Cell Biol, 2012 Dec 10. PMID 23229899, Free PMC Article
    2. Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse. White RA, et al. Blood, 2004 Sep 1. PMID 15155459
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 7A
    Names
    tetratricopeptide repeat domain 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100756.1 → NP_001094226.1  tetratricopeptide repeat protein 7A

      See identical proteins and their annotated locations for NP_001094226.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168226
      UniProtKB/TrEMBL
      A0A8I5ZS78, B4F7D1
      Related
      ENSRNOP00000058460.4, ENSRNOT00000061747.5
      Conserved Domains (2) summary
      sd00006
      Location:747 → 773
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:712 → 776
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      12912822..13015374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262049.1 → XP_063118119.1  tetratricopeptide repeat protein 7A isoform X1

    2. XM_039112459.2 → XP_038968387.1  tetratricopeptide repeat protein 7A isoform X3

      Conserved Domains (2) summary
      TIGR00990
      Location:153 → 498
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:402 → 428
      TPR; TPR repeat [structural motif]

    3. XM_008764464.4 → XP_008762686.1  tetratricopeptide repeat protein 7A isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:412 → 438
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:377 → 441
      TPR_11; TPR repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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