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    Taf11 TATA-box binding protein associated factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf11provided by RGD
    Official Full Name
    TATA-box binding protein associated factor 11provided by RGD
    Primary source
    RGD:1305626
    See related
    EnsemblRapid:ENSRNOG00000024601 AllianceGenome:RGD:1305626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including TBP-class protein binding activity; nuclear receptor binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in positive regulation by host of viral transcription; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF11 (TATA-box binding protein associated factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 54.1), Kidney (RPKM 48.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf11 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5957540..5965354, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5955774..5963593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7476648..7484417, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483861 Neighboring gene small nuclear ribonucleoprotein polypeptide C Neighboring gene small nucleolar RNA SNORA26 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene uncharacterized LOC102552617 Neighboring gene t-complex 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human TAF(II)28 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activity. Caron C, et al. Proc Natl Acad Sci U S A, 1997 Apr 15. PMID 9108034, Free PMC Article
    2. The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors. Mengus G, et al. J Biol Chem, 2000 Apr 7. PMID 10744685
    3. Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors. May M, et al. EMBO J, 1996 Jun 17. PMID 8670810, Free PMC Article
    4. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. Mengus G, et al. EMBO J, 1995 Apr 3. PMID 7729427, Free PMC Article
    5. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105516

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear vitamin D receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 11
    Names
    TAF(II)28
    TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TAFII-28
    TAFII28
    TATA box binding protein (TBP)-associated factor 11
    TFIID subunit p30-beta
    transcription initiation factor TFIID 28 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008350.1 → NP_001008351.1  transcription initiation factor TFIID subunit 11

      See identical proteins and their annotated locations for NP_001008351.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086421
      UniProtKB/Swiss-Prot
      Q5U1X0
      UniProtKB/TrEMBL
      A6JJP1
      Related
      ENSRNOP00000033634.2, ENSRNOT00000038195.4
      Conserved Domains (1) summary
      pfam04719
      Location:108 → 192
      TAFII28; hTAFII28-like protein conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5957540..5965354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279121.1 → XP_063135191.1  transcription initiation factor TFIID subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQE7
      Related
      ENSRNOP00000096221.1, ENSRNOT00000116514.2

    2. XM_063279122.1 → XP_063135192.1  transcription initiation factor TFIID subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQE7

    3. XM_039098682.2 → XP_038954610.1  transcription initiation factor TFIID subunit 11 isoform X2

      Conserved Domains (1) summary
      cl02176
      Location:108 → 136
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    4. XM_063279120.1 → XP_063135190.1  transcription initiation factor TFIID subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQE7

    5. XM_063279123.1 → XP_063135193.1  transcription initiation factor TFIID subunit 11 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1X0.1 GenPept UniProtKB/Swiss-Prot:Q5U1X0

    Gene LinkOut

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