Oit3 oncoprotein induced transcript 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oit3provided by RGD
Official Full Name: oncoprotein induced transcript 3provided by RGD
Primary source: RGD:735082
See related: EnsemblRapid:ENSRNOG00000046365 AllianceGenome:RGD:735082
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lzp
Summary: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within renal system process. Predicted to be located in nuclear envelope. Orthologous to human OIT3 (oncoprotein induced transcript 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 115.7), Spleen (RPKM 34.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (27933106..27953683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (27390113..27410692, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29009330..29029905, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.
Sequence analysis revealed that human, rat and mouse LZP proteins are highly conserved.
Title: Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in renal system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal system process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oncoprotein-induced transcript 3 protein

Names: liver-specific zona pellucida domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001507.1 → NP_001001507.1 oncoprotein-induced transcript 3 protein precursor

See identical proteins and their annotated locations for NP_001001507.1

Status: PROVISIONAL

Source sequence(s)

AY353853

UniProtKB/Swiss-Prot

Q6V0K7

UniProtKB/TrEMBL

M0R8R4

Related

ENSRNOP00000065864.2, ENSRNOT00000075682.3

Conserved Domains (3) summary

smart00241
Location:268 → 513

ZP; Zona pellucida (ZP) domain

pfam00100
Location:394 → 513

Zona_pellucida; Zona pellucida-like domain

pfam14670
Location:227 → 262

FXa_inhibition; Coagulation Factor Xa inhibitory site