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    Klra2 killer cell lectin-like receptor, subfamily A, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494194, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Klra2provided by RGD
    Official Full Name
    killer cell lectin-like receptor, subfamily A, member 2provided by RGD
    Primary source
    RGD:1359667
    See related
    EnsemblRapid:ENSRNOG00000031515 AllianceGenome:RGD:1359667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klra1; Ly49i8
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 99.6), Kidney (RPKM 20.2) and 7 other tissues See more
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    Genomic context

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    See Klra2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166604723..166717294, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164873735..164985429, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165426365..165460140, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 stimulatory receptor 7 Neighboring gene killer cell lectin-like receptor, subfamily A, member 5 Neighboring gene Ly49 inhibitory receptor 7 Neighboring gene uncharacterized LOC108350878 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mago homolog B, exon junction complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. Nylenna O, et al. Eur J Immunol, 2005 Jan. PMID 15593300
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor 2
    Names
    Ly49 inhibitory receptor 8
    killer cell lectin-like receptor, subfamily A, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009486.2 → NP_001009486.1  killer cell lectin-like receptor 2

      See identical proteins and their annotated locations for NP_001009486.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8
      Related
      ENSRNOP00000108955.1, ENSRNOT00000163444.1
      Conserved Domains (2) summary
      cd03593
      Location:154 → 268
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      166604723..166717294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108019.2 → XP_038963947.1  killer cell lectin-like receptor 2 isoform X5

      Conserved Domains (2) summary
      cd03593
      Location:154 → 229
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    2. XM_063286439.1 → XP_063142509.1  killer cell lectin-like receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8

    3. XM_063286440.1 → XP_063142510.1  killer cell lectin-like receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8

    4. XM_039108018.2 → XP_038963946.1  killer cell lectin-like receptor 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91
      Conserved Domains (2) summary
      cd03593
      Location:154 → 244
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    5. XM_039108017.2 → XP_038963945.1  killer cell lectin-like receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, F7EU37
      Related
      ENSRNOP00000081950.2, ENSRNOT00000106632.2
      Conserved Domains (2) summary
      cd03593
      Location:154 → 268
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    6. XM_039108014.2 → XP_038963942.1  killer cell lectin-like receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8
      Conserved Domains (2) summary
      cd03593
      Location:154 → 268
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    7. XM_008763404.4 → XP_008761626.1  killer cell lectin-like receptor 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYA0, A0A8I6A542, A6IM91
      Related
      ENSRNOP00000087932.2, ENSRNOT00000096273.2
      Conserved Domains (2) summary
      cd03593
      Location:124 → 238
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:46 → 137
      Ly49; Ly49-like protein, N-terminal region

    8. XM_039108015.2 → XP_038963943.1  killer cell lectin-like receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8
      Conserved Domains (2) summary
      cd03593
      Location:154 → 268
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    9. XM_039108016.2 → XP_038963944.1  killer cell lectin-like receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA0, A6IM91, Q5MPW8
      Related
      ENSRNOP00000070575.2, ENSRNOT00000082207.3
      Conserved Domains (2) summary
      cd03593
      Location:154 → 268
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:48 → 167
      Ly49; Ly49-like protein, N-terminal region

    10. XM_039108021.2 → XP_038963949.1  killer cell lectin-like receptor 2 isoform X6

      Conserved Domains (1) summary
      pfam08391
      Location:48 → 149
      Ly49; Ly49-like protein, N-terminal region

    11. XM_039108022.2 → XP_038963950.1  killer cell lectin-like receptor 2 isoform X7

      Conserved Domains (1) summary
      pfam08391
      Location:48 → 149
      Ly49; Ly49-like protein, N-terminal region

    RNA

    1. XR_010065684.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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