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| Status |
Public on Feb 02, 2023 |
| Title |
Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Introduction: Post-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.
Methods: Clinical samples from patients with more brain severity demonstrated altered mRNAs.
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| Overall design |
12 TBI patients and 4 healthy controls collected with PBMC for ceRNA chipset
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| Contributor(s) |
Zheng P, Sun W |
| Citation(s) |
36846021, 37263268 |
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| Submission date |
Jan 19, 2023 |
| Last update date |
Sep 11, 2023 |
| Contact name |
Ping Zheng |
| E-mail(s) |
[email protected]
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| Phone |
13917664347
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| Organization name |
Shanghai Pudong New area People's Hospital
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| Department |
Neurosurgery
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| Street address |
490 South Chuanhuan Road
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| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
201299 |
| Country |
China |
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| Platforms (1) |
| GPL33038 |
Agilent-086188 Agilent Human ceRNA Microarray 2019 |
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| Samples (16)
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| GSM6943816 |
Mi4_Mild TBI, replicate_4 |
| GSM6943817 |
Mo1_Moderate TBI, replicate_1 |
| GSM6943818 |
Mo2_Moderate TBI, replicate_2 |
| GSM6943819 |
Mo3_Moderate TBI, replicate_3 |
| GSM6943820 |
Mo4_Moderate TBI, replicate_4 |
| GSM6943821 |
Se1_Severe TBI, replicate_1 |
| GSM6943822 |
Se2_Severe TBI, replicate_2 |
| GSM6943823 |
Se3_Severe TBI, replicate_3 |
| GSM6943824 |
Se4_Severe TBI, replicate_4 |
| GSM6943825 |
Co1_Control, replicate_1 |
| GSM6943826 |
Co2_Control, replicate_2 |
| GSM6943827 |
Co3_Control, replicate_3 |
| GSM6943828 |
Co4_Control, replicate_4 |
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| Relations |
| BioProject |
PRJNA925472 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE223245_RAW.tar |
393.1 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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