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| Status |
Public on Nov 28, 2024 |
| Title |
Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels |
| Organism |
Ictidomys tridecemlineatus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Water deprivation is a life-threatening condition that engages a protective physiological response to couple osmolyte retention with potentiation of thirst. This response, typical for most mammals, safeguards against short-term water deprivation, but fails in the long-term. Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) employ the short-term response during summer, whereas during winter they lack thirst and survive without water for months. Here, we show that long-term thirst suppression occurs despite hormonal and behavioral signs of a dramatic fluid deficit and originates from hypoactivity of neurons in the circumventricular organs, which exhibit marked functional suppression during winter that blunts their sensitivity to thirst cues. Our work reveals a remarkable capacity of the evolutionarily conserved brain regions which control fluid homeostasis in mammals to enable long-term survival without water.
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| Overall design |
Gene expression analysis and differential transcriptomics of the subfornical organ (n = 5 biological replicates) across active (non-hibernating) and interbout arousal (IBA) (hibernating) states in thirteen-lined ground squirrel.
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| Contributor(s) |
Junkins MS, Feng NY, Bagriantsev SN, Gracheva EO |
| Citation missing |
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| Submission date |
Mar 28, 2024 |
| Last update date |
Nov 28, 2024 |
| Contact name |
Madeleine Junkins |
| E-mail(s) |
[email protected]
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| Organization name |
Yale University
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| Department |
Cellular & Molecular Physiology; Neuroscience
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| Street address |
333 Cedar Street
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| City |
New Haven |
| State/province |
Connecticut |
| ZIP/Postal code |
06510 |
| Country |
USA |
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| Platforms (1) |
| GPL30340 |
Illumina NovaSeq 6000 (Ictidomys tridecemlineatus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA1093053 |
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