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    Zfp516 zinc finger protein 516 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp516provided by RGD
    Official Full Name
    zinc finger protein 516provided by RGD
    Primary source
    RGD:1306817
    See related
    EnsemblRapid:ENSRNOG00000016258 AllianceGenome:RGD:1306817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf516; RGD1306817
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of cold-induced thermogenesis. Predicted to be active in nucleus. Orthologous to human ZNF516 (zinc finger protein 516). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 50.8), Uterus (RPKM 41.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp516 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (78561069..78661263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (76286453..76386526)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (79768387..79857909)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552357 Neighboring gene uncharacterized LOC108348835 Neighboring gene uncharacterized LOC134483069 Neighboring gene uncharacterized LOC120098250

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. Dempersmier J, et al. Mol Cell, 2015 Jan 22. PMID 25578880, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 516

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191695.2 → NP_001178624.1  zinc finger protein 516 isoform 1

      See identical proteins and their annotated locations for NP_001178624.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2K242, A6K5K2, D4A239
      Related
      ENSRNOP00000021768.6, ENSRNOT00000021768.8
      Conserved Domains (4) summary
      COG5048
      Location:33 → 90
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001412457.1 → NP_001399386.1  zinc finger protein 516 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2K242
      Related
      ENSRNOP00000072097.3, ENSRNOT00000088484.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      78561069..78661263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096626.2 → XP_038952554.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    2. XM_008772099.4 → XP_008770321.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017600868.3 → XP_017456357.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    4. XM_017600870.3 → XP_017456359.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    5. XM_008772100.4 → XP_008770322.1  zinc finger protein 516 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K242
      Related
      ENSRNOP00000107085.1, ENSRNOT00000174142.1
      Conserved Domains (4) summary
      COG5048
      Location:33 → 90
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039096627.2 → XP_038952555.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    7. XM_017600871.3 → XP_017456360.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
      Conserved Domains (4) summary
      PHA03247
      Location:780 → 1040
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:36 → 56
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:34 → 56
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:48 → 73
      zf-H2C2_2; Zinc-finger double domain

    8. XM_063277156.1 → XP_063133226.1  zinc finger protein 516 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K242
    Nucleotide Protein Strain
    Heading Accession and Version

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