Conserved Protein Domain Family
Actin

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pfam00022: Actin (484006 is an unknown moldel)
Actin
Statistics
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PSSM-Id: 484006
Aligned: 23 rows
Threshold Bit Score: 387.441
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KLG9         5 GDEVSALVLDFGSYTTRAGYAGEDCPR----------VVCPSFYGytndpSSSGSNGNSvgengankengedvtmaepvp 74  Cryptococcus ne...
Q4QF49        22 VLHTNAAVLDMGSHTTRLGFAGDTVPR----------MRQRTCVV-----KGKGTFSDAcd------------------- 67  Leishmania major
Q5NBI2         2 TGGSGVVVLDNGGGLLKAGFGGDMNPT----------AVVPNCMA-----KPPGSK------------------------ 42  Japanese rice
Q4W9M3        19 SLPEKTFIIDNGAYTLKAGYAPGFPPPedlgqalsacSTIPNAIA-----KTRGN------------------------- 68  Aspergillus fum...
Q7S6X6        16 APPTTTLVLDNGADTIKAGFVSDDKSDgk-------pRIIPNCLA-----RDRHR------------------------- 58  Neurospora cras...
Q54HF0         3 CEEVQAIVIDNGSSVCKAGFGGDDAPR----------TAFPSIVG-----RPRCTGFIVdmdkkdsyfc----------- 56  Dictyostelium d...
Q59QT2         4 ILYNQPVVIDNGSGNLKAGFAGEDKPK----------SYASAIIG-----RPKYQKIMAagstsll-------------- 54  Candida albicans
1_pfamImport   1 ---NQPVVIDNGSGVIKAGFAGDQIPK----------YCFPNYVG-----RPKHVRVMAgal------------------ 44 
Q4Q187         5 SASIQSVVVDVGTRNTRVGFSGEEAPR----------TMLRSCVGlpgtrRPRPTLLQH--------------------- 53  Leishmania major
Q4D5V4         5 RERVPVVILDTGSHCLRAGYADEQGPR----------LDIPALVG-----HPRNRGVAMaag------------------ 51  Trypanosoma cruzi
Q5KLG9        75 egaeeqskkkgsgrKYYVGEDg-vSVW---RPGMEVGNFM-LDGVVNDPEPASALLHHILHER-LGVN--------PEEH 140 Cryptococcus ne...
Q4QF49        68 -------------vLDHVDDPa-aATT------------VlENGVIVDWEGYEELLSRVARILdLENV--------ENST 113 Leishmania major
Q5NBI2        43 --------------KWLVADQl-qAQDv-dVTGMTLRRPI-DRGYLINQEVQREVWERVIRNL-LQVD--------PNNS 96  Japanese rice
Q4W9M3        69 --------------RIYIGAQlnsQVTd--WNEMVFRRPV-EKGYIVNWEAQKEIWDNAFFDE-KTVRskdlriesPEDT 130 Aspergillus fum...
Q7S6X6        59 --------------KIYVGSEl-eKCKd--FSELAFRRPV-EKGFIVNWEAQKEIWDREFFDD-KAAQkc-----dPSDT 114 Neurospora cras...
Q54HF0        57 ----kknscfmgqkDLYIGDE---AQSk--RGILNVKYPI-ERGIITNWNDMEEIWYHTFYNE-LHVA--------PEEH 117 Dictyostelium d...
Q59QT2        55 -------seqqshdQLFIGNS---AQDn--RGLLKLSYPI-EHGIVNNWSDMEKLWYHTYTQD-LKTQ--------SEDH 112 Candida albicans
1_pfamImport  45 ------------egDLFIGPK---AEEh--RGLLSVRYPM-EHGIVKDWNDMERIWQYVYSKEqLQTF--------SEEH 98 
Q4Q187        54 --------------PFDIATG---DAAyndGGLLSLTYPV-RAGHVCDYDALEKLLFYALVEE-ARVT--------PDTS 106 Leishmania major
Q4D5V4        52 ------------mnEYEIGEE---ALVk--RGMLTVGSPI-ENGLVVNWEHMEKLWSHVMFSE-MRVT--------PESH 104 Trypanosoma cruzi
Q5KLG9       141 PIMITEPAWNTPKARQVMTEMAFEGEKMPALYFGSSGVLSAFAAGKP------------------TALVLDVGYATSSAV 202 Cryptococcus ne...
Q4QF49       114 PLLVTEKALVPTHQRQKIAEVLFETHRVVATSFALSPVLSLYASGLG------------------TGVAVELGHDQSHVA 175 Leishmania major
Q5NBI2        97 SLLLVEPQFNPPALQHATDELVFEELGFKSLCVADAPSLVHLYEASRqpsl----------fraqCSLVVDCGFSFTHAS 166 Japanese rice
Q4W9M3       131 TLVLTEAPNALPTLQKNADEIVMEEWGFGGYVRFVGPVLNAWNEVQSlfgdpigqdssspispkqCLLVVDSGYSHTTVT 210 Aspergillus fum...
Q7S6X6       115 RLILTEQPNSLPSLQTHCDQIVFEEYGFASYYRGLGPVFNAYRDIQSifrtpqs----tidspaqVILLIDSGYSHTTVT 190 Neurospora cras...
Q54HF0       118 PVLLTEPPLNPKANREKMTQIMFETFKTPAIYVANQGVLSLYSTGLT------------------TGIVMNSGDGVSHTV 179 Dictyostelium d...
Q59QT2       113 PLLITEAPLNPRSNRNKMCQILFENFNIPCIYISIQAVLSLYASGRT------------------TGVVIDSGDGVTHVV 174 Candida albicans
1_pfamImport  99 PVLLTEAPLNPSINREKAAEIFFETFNVPALFISMQAVLSLYATGRT------------------TGVVLDSGDGVTHVV 160
Q4Q187       107 PFLFLVPADQTRLDRERLCELLFESFNIPLAGLLTNTAATLYSSGRT------------------RGLALDSGAGRTCVA 168 Leishmania major
Q4D5V4       105 CFVVPQPVNTPAAQKEKTLELMMETFHVHSLFLGTSQVLSLYGYGLT------------------TGLVLDSGKDRTMAV 166 Trypanosoma cruzi
Q5KLG9       203 PIVDGYALRAGTMHQPLASQLIVSQLQNHFTSptptrSPLSLlprqlikqrdpSSdpgiipkpilrddraphtTTSWKLW 282 Cryptococcus ne...
Q4QF49       176 PVFQGLSLFHATHCLDVGGADLTRHFTSLMSGvatthVSVLG---------------------------------SMTPT 222 Leishmania major
Q5NBI2       167 PVLQNFTLNYAVRRMDLGGKALTNYLKELISYr------------------------------------------SLNVM 204 Japanese rice
Q4W9M3       211 PVYKGQPIQRAIRRLDIGGKHLTNYLKEMVSM-----R-------------------------------------QYNMV 248 Aspergillus fum...
Q7S6X6       191 PILQGRPLHPAIRRLDVGGKLMTNYLTRLLSVr------------------------------------------HFDMR 228 Neurospora cras...
Q54HF0       180 PVYEGYILRQAILSLDLAGRDLTDYMNELLTD---------------------R-------------------GYYFTTK 219 Dictyostelium d...
Q59QT2       175 PVYEGFALPPSIKRMDIAGRDITESLAFNIRR---------------------MT------------------GVALQSS 215 Candida albicans
1_pfamImport 161 PIYEGFAIPHSIMRVDIAGRDVSRYLRLLLRK-----E-----------------------------------GYNFNTS 200
Q4Q187       169 AVEEGYTLAHSVRSSSLAGEALTDELFAALRA---------------------G-------------------GYPLSTA 208 Leishmania major
Q4D5V4       167 PVHEGYALGRHVTESEIAGETLTNYLASLLRQ---------------------E-------------------GYSFGTP 206 Trypanosoma cruzi
Q5KLG9       283 AENNVVEGYKEACTEIVNYKGf-----------------DFQTAG-----------DLPQVL------Y----EFPDG-- 322 Cryptococcus ne...
Q4QF49       223 QRESMWEYIKERHCTVAEDAQa-----------------FSEISRvgigmgspssgSPPGSPhgeedrYreecVLPDGt- 284 Leishmania major
Q5NBI2       205 DETLLIDDAKEKLCFVSLDVPgd--------------lrLARLSSn---------dNPFRCS------Y----ILPDGit 251 Japanese rice
Q4W9M3       249 DETYIMNEVKEAVCFVSNNFAgd--------------leQTWQGNrkrgl--tdaaEGITVD------Y----VLPDPnt 302 Aspergillus fum...
Q7S6X6       229 NEPYIVNEMKEAVCYTSLDFKgd--------------leKTWKGTrgekredylsgAGIAKD------Y----VLPDSht 284 Neurospora cras...
Q54HF0       220 GEKEIVRGIKEKLSYVALDFEae---------------mQIASAS-----------PALEKS------Y----ELPDG-- 261 Dictyostelium d...
Q59QT2       216 SELEIVRLIKEQNCFISKDPVrdekk--------ygshySRNNPN-----------NELMST------Y----KLPDG-- 264 Candida albicans
1_pfamImport 201 AEFEVVRTIKERACYLSLNPQk-----------------DETLET-------------EKAQ------Y----VLPDG-- 238
Q4Q187       209 ADRGVVEAAKEALCRV-----------------------SADAKDeearqvgthshPDPADG------F----ILPDQ-- 253 Leishmania major
Q4D5V4       207 VEMQVLNKAKEELCYVRLNEFgvyspvhslgtlgnaaafDYNFSSsaq-----rpgSSPVPAte--evF----FLPDG-- 273 Trypanosoma cruzi
Q5KLG9       323 ---------------------------------------------Y--HQYFGEERYRFTEMLFDPERYYNQSIPPPPtl 355 Cryptococcus ne...
Q4QF49       285 -----------------------------------------------aLPISGAARFIPGECYFQPSLSPALQQLRDQst 317 Leishmania major
Q5NBI2       252 ykkgfvkdldeacrysslpangesvrkdssdsdrskfedkkkpelSqnEFVLTNERFLVPEMLFHPIDLGMNQA------ 325 Japanese rice
Q4W9M3       303 gkkgfmrphdplsna-------------kkrksilsggnaealseD--VLILGNERFTVPEILFTPSDIGMKQA------ 361 Aspergillus fum...
Q7S6X6       285 rfhgvvrdyep----------------------gvsararkgivsTedVLTLRNERFVVPELLFNPSDIGIRQP------ 336 Neurospora cras...
Q54HF0       262 ---------------------------------------------Q--VITIGNERFRCPEALFRPYT------------ 282 Dictyostelium d...
Q59QT2       265 ---------------------------------------------H--EIQLGVERFRATEILFNPQLIGHESP------ 291 Candida albicans
1_pfamImport 239 ---------------------------------------------S--TLNIGPARFRAPELLFRPDLIGDESS------ 265
Q4Q187       254 ---------------------------------------------E--RIFLLEHAYKVPEALFDSTYLTYTTALSAErp 286 Leishmania major
Q4D5V4       274 ---------------------------------------------N--AIPLAEHRHLTTEVLFNFGIMGEE--YIPKsr 304 Trypanosoma cruzi
Q5KLG9       356 qkvlt--tehsrsLRDLVSLSQLVHDSVMACDVDVRASLLQNIVVVGNTALTRGLIERLDVELAA--------------- 418 Cryptococcus ne...
Q4QF49       318 vvde----vllrtTQTPVSIPELVVDAMKRCDHDLLPTFASHIVVSGGASLLRGLTQRVESDVQTc-------------- 379 Leishmania major
Q5NBI2       326 ------------------GLAECIVRAIQACHPHLQPVLFERIILTGGSTLFPRFTERLEKELRPl-------------- 373 Japanese rice
Q4W9M3       362 ------------------GIPDIILQSLSVLPTGLHPSFLANVLVVGGNTLIPGFLERLESELRQi-------------- 409 Aspergillus fum...
Q7S6X6       337 ------------------GIADLVKQSLLAVPIGLWPGLLANIVVVGGNSLSEGFCQRLQTEILKr-------------- 384 Neurospora cras...
Q54HF0       283 ------------------GIHETIYNSIMKCDDDIRKDLFGSVVLSGGSTMFPGIVDRMNKELTAl-------------- 330 Dictyostelium d...
Q59QT2       292 ------------------GIHELTSLAIAKTDLDLRSTLYQNIILSGGNTLLKNFGDRMLKELKDlqqplqedqkmsiwn 353 Candida albicans
1_pfamImport 266 ------------------GIHEVLAYAIQKSDMDLRRTLFSTIVLCGGSTLIKGFGERLLTEVKKl-------------- 313
Q4Q187       287 ttptgysqsnpivKKTLSGWVGMLRDAADAAPRILEQALYENVVLGGGSTLFPGTEQRVQREIAGi-------------- 352 Leishmania major
Q4D5V4       305 ymte---lgeifnPSFPMGISWLSFAAINNCQPAMRPSLFAHIVLAGGNVSFPGTRERIEAEVTRly------------- 368 Trypanosoma cruzi
Q5KLG9       419 --TMPSQ-----KIKIHSPTIPFERKYASWVGGSILASLG-TFHQLWVTKEEYEEHGMSIVHQRCK 476 Cryptococcus neoformans
Q4QF49       380 -lASTGGihsvgSARVYADV---ERRDAAFVGGSIWASLP-AAQALWVTKADYNEVGSMAVVRGGF 440 Leishmania major
Q5NBI2       374 --VPDDY-----QVKIIAQE---DPILGAWRGGSLLAHRP-DFESMCITKSEYEEMGSMRCRRRFF 428 Japanese rice
Q4W9M3       410 --ASAEC-----VVRVRRPH---DPIRSTWLGASRLAANRaELRKFAITRQEYQEYGSSWAGRKFS 465 Aspergillus fumigatus Af293
Q7S6X6       385 --FPDEC-----RVRVARPE---DPIISTWLGAANFAKHE-HASKLEVTKQEYEEHGAAWVARKFA 439 Neurospora crassa OR74A
Q54HF0       331 --APSTM-----KIKIIAPP---ERKYSVWIGGSILASLS-SFQPRWISKEEYDESGPSIVHRKCF 385 Dictyostelium discoideum
Q59QT2       354 knVQNDVyntkmKVKIYAPP---ERKYSTWIGGSILAGLS-TFKKMWVTSEEYHEN-PDIVHVKCM 414 Candida albicans
1_pfamImport 314 --APKDV-----KIKISAPQ---ERLYSTWIGGSILASLD-TFKKMWVSKREYEDDRARAIHRKTF 368
Q4Q187       353 --APKGV-----RATCVAFP---ERGAAAWMGASIWGCSS-VFPDTCLAKATYDEQGSSVVHLYTQ 407 Leishmania major
Q4D5V4       369 reTHASE-----AVTPICVHDVECRIYSAWLGGSMLARTS-MFPHLTVSRQEYEEQGYRVVHCKCQ 428 Trypanosoma cruzi
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