4J1Q


Conserved Protein Domain Family
KR

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pfam08659: KR 
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KR domain
This enzymatic domain is part of bacterial polyketide synthases and catalyzes the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Statistics
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PSSM-Id: 430138
Aligned: 48 rows
Threshold Bit Score: 149.25
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4J1Q_A        203 GVYLITGGAGSLGLLFAKEIANRtGRSTIVLTGRSv------------LSEDkEnELEALRS-I-GAEVVYREADVSDQH 268 
Q7UJD0       1821 STVLITGGTGAIGLKLAKHLIKD-GATSIALLSRRq------------PVGDvAaKIDALKQdAdSVQVTVLQGDVGELD 1887 Pirellula sp.
CAM00062     3111 GTILVTGGTAGLGAEVARWLAGR-GAEHLALVSRRg-----------pDTEGvGdLTAELTR-L-GARVSVHACDVSSRE 3176
BAC70609     2654 GTVLVTGGTGALGRRVARWLARE-GAEHLVLTSRRg-----------pLAPGaDaLVTELTG-L-GVKVTLLSCDLADPA 2719
DU:RAM_03155 4307 GTVLVTGGAEGLGRHASVWLAQS-GAERLIVTGTD----------------GvDeLTAELAE-F-GTTVEFCA-D-TDRD 4365
BAG03685     2232 ATYLITGGIGHLGLELAEHLVNL-GAKHLILTTRRslparf-lwdsatELAQiSeKIRKLEE-K-GASIEVISADVGNFE 2307
P9WQE5       1152 aSQLVIGATGNIGPHLIRQLARM-GAKTIVAMARK-------------PGALdE-LTQCLAA-T-GTDLIAVAADATDPA 1214 Mycobacterium...
Q9L1V8       1804 GTYLVTGGAGGIGGQLALWLADQ-GARHLLLTGRSalpeqdavvsethPQATaVaVLRQLRE-R-GVNVTYKAVDVADAH 1880 Streptomyces ...
Q8XYF2       1840 GLYLVAGAYGALGRHTTDWLAAH-GATHLVLAGRRa-----------pPAGWqA-RLALLRA-Q-GVRIDPVDADLAEAA 1904 Ralstonia sol...
Q73XS9       1182 ATYLVTGGLGSIGLEIAGHLAAQ-GARHLVLTGRRa------------PGEAaQrRIDALSQ-QhGCEVRVIAADVADAH 1247 Mycobacterium...
4J1Q_A        269 AVRHL---LEEIKERY-GTLNGIIHGAGSSK-DRFIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCL 343 
Q7UJD0       1888 SLRSA---LKQLPGSL-PPIRHVYHAAGVLQ-DGLLMDMTEEQLRVPMGSKIQGGWNLHVATKDLPIETFVLFSSIAACL 1962 Pirellula sp.
CAM00062     3177 PVREL---VHGLIEQG-DVVRGVVHAAGLPQ-QVAINDMDEAAFDEVVAAKAGGAVHLDELCS--DAELFLLFSSGAGVW 3249
BAC70609     2720 QVTAM---VAEAQRDG-DPIGAVVHTAGGGG-LGPLAEAGPDDLAEAMAAKVTGIAHLEAALDPEQLDAVVYFSSISASW 2794
DU:RAM_03155 4366 AIAQL---VADSE------VTAVVHAADIAQ-TSSVDDTGVADLDEVFAAKVTTAVWLDQLFEDTPLDAFVVFSSIAGIW 4435
BAG03685     2308 AMQAI---FTQIEKTA-YPLRGIFHLAGISGrQAQLKDCTLQDLEAVFQAKVKGSWNLHQLSLGTQLDYFVLFSSAGAIW 2383
P9WQE5       1215 AMQTL---FDRFGTEL-PPLEGIYLAAFAGR-PALLSEMTDDDVTTMFRPKLDALALLHRRSLKSPVRHFVLFSSVSGLL 1289 Mycobacterium...
Q9L1V8       1881 AMQAT---LESRRRAGmPPVRGVFHAAGVID-YTLLSDMSGAEMDRVLAAKVSGAWNLHRLLREESVEAFVLFSSGSALL 1956 Streptomyces ...
Q8XYF2       1905 DVERLfdaVAALEATTgRTLAGVFHCAGTSR-FNDLAGLTTDDCAAVTGAKMTGAWLLHEQTRARRLDWFVCFTSISGVW 1983 Ralstonia sol...
Q73XS9       1248 HVARL---LGAVRAEL-PPVAGIVHAAGEIG-TTPLSDLEDAEIDRVFAGKVWGAWHLSEAAADLRLDFFVSTSSIASVW 1322 Mycobacterium...
4J1Q_A        344 GNAGQADYAAANSFMDAFAEYRRSLAAskkrfgSTISFNWPLWE 387 
Q7UJD0       1963 GSPGQANYAAANGFLDALSEYRREKGL------PATSIAWGPWA 2000 Pirellula sp.
CAM00062     3250 GSARQGAYAAGNAFLDAFARHRRGRGL------PATSVAWGLWA 3287
BAC70609     2795 GAGDHGVYAAANGVLDARAEARSAAGV------HTVSLAWAPWA 2832
DU:RAM_03155 4436 GGGGQGPAGAANAVLDALVEWRRARGL------KATSIAWGALD 4473
BAG03685     2384 GAKEQGLYDTVSHWLDALAHFRHLQQL------PATTLNWALLA 2421
P9WQE5       1290 GSRWLAHYTATSAFLDSFAGARRTMGL------PATVVDWGLWK 1327 Mycobacterium tuberculosis H37Rv
Q9L1V8       1957 SSPMLGGYAAGNAFLDALAHHRHAQGL------SGTVVNWGFWD 1994 Streptomyces coelicolor
Q8XYF2       1984 GSRLQIPYGAANAFQDALVRLRRAQGL------PALAVAWGPWG 2021 Ralstonia solanacearum
Q73XS9       1323 GGLGQTAYGAANAFLDGLAWRLREQGV------NGISVNFGPWA 1360 Mycobacterium avium subsp. paratuberculosis
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