1XQ9,3D8H,1QHF,1YFK,1T8P,3FJY


Conserved Protein Domain Family
PGAM

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smart00855: PGAM 
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Phosphoglycerate mutase family
Phosphoglycerate mutase (PGAM) and bisphosphoglycerate mutase (BPGM) are structurally related enzymes that catalyse reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate... Both enzymes can catalyse three different reactions with different specificities, the isomerization of 2-phosphoglycerate (2-PGA) to 3-phosphoglycerate (3-PGA) with 2,3-diphosphoglycerate (2,3-DPG) as the primer of the reaction, the synthesis of 2,3-DPG from 1,3-DPG with 3-PGA as a primer and the degradation of 2,3-DPG to 3-PGA (phosphatase activity). In mammals, PGAM is a dimeric protein with two isoforms, the M (muscle) and B (brain) forms. In yeast, PGAM is a tetrameric protein.
Statistics
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PSSM-Id: 214859
Aligned: 346 rows
Threshold Bit Score: 38.2108
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XQ9_A         13 TLVLLRHGESTWNKENKFTgwTDVPLSEKGEEEAIAAGKYLkE-Kn---------------------------------- 57   malaria paras...
XP_640057     290 daSVIEHNIKETKLLSPDY--QGVDPSKAVQDFRDRINHYLkVeWcskvrad---------------------------- 339  Dictyostelium...
AAM91549      163 PILLTRHGESMDNVRGRIG--GDSVISDSGKLYAKKLASFVeKrLksek------------------------------- 209  thale cress
NP_593152     359 QIWLTRPGESLDTVAGRIG--GDASLTPIGKQYAQDLANFMdRqRvlwqlrytndla----------------------- 413  Schizosacchar...
XP_750470     460 QIWITRHGESKDNQLGRIG--GDSEISENGRRYAKALTRFIdYqRhqweqlqqqknmlrhfpp----------------- 520  Aspergillus f...
XP_956042     377 QIWITRHGQSQDNQLHKLG--GDSGLTERGHYYAQALYNFItFkRkewlieqknkiasstfpp----------------- 437  Neurospora cr...
NP_001018229  210 QIWVTRHGESVDNVRGRIG--GNAELTPLGRQFSEDLALFIdEkRdefqerlyndyskeshllqhgshsfngkqfetsfn 287  Schizosacchar...
NP_983859     377 QIWITRNGESEYNVLGRIG--GDSKLTPRGRKYARALAQFIdSkRrefneheyeqfckl--------------------- 433  Ashbya gossyp...
XP_846939     451 PIYFVRNGMSVYHCEDRIG--GDSPLSPEGEQDTIELLEFVaSlTqyveqerndtdscvcetahtagdgd---------g 519  Trypanosoma b...
XP_001463293  960 PIYFVLHGESHYNVEGRIG--GNPPLTEQGMRDAVALLEFLdSlKrhlehvdrvqrahhhnqqrlr-------------- 1023 Leishmania in...
1XQ9_A         58 -----------------------fKFDVVYTSVLKRAICTAWNVLKTADLlhvpvvktW-----RLNERHYGSLQGLNKs 109  malaria paras...
XP_640057     340 ---------------------gydgevvVWTSSLKRAIRTAQYIS----Q--------PkvvmrALDEIDAGVCDGMTYe 386  Dictyostelium...
AAM91549      210 -------------------------aasIWTSTLQRTNLTASSIV---GF--------PkvqwrALDEINAGVCDGMTYe 253  thale cress
NP_593152     414 -------------stnkrfslseasSFNVWSSVRKRAIETIEFFN-PDSY--------NvkkirLLNDLNLGSREGLTLr 471  Schizosacchar...
XP_750470     521 ------rpgdstppnpsyiprdrpRNFCVWSSMMRRSVQTVEGFN-EDEY--------DvkqmkMLDELYAGEMEGMTYs 585  Aspergillus f...
XP_956042     438 ------apgdhtppypelyqelddKNFCVWTSMLKRSIESAEYFDADDDY--------DvkqweMLNELNAGTFEGMTYe 503  Neurospora cr...
NP_001018229  288 cltpsentvndpqvldpedeerleKPYSVWTSMMQRSIQTAAYFD-EEQY--------DikamrMLNEICSGICDGLTYe 358  Schizosacchar...
NP_983859     434 ------------ndegtptdefvptsFYVWTSMLRRAEDTAADFN-EDIF--------PikqmrMLDELSAGDCEGMTYe 492  Ashbya gossyp...
XP_846939     520 rvregsgtcastdthsaygfpdspQRVVIWTSQLYRAIQTVEKCEQLLGI--------KttrchSLNELYAGVCENLTHa 591  Trypanosoma b...
XP_001463293 1024 ---sgaagndegsstaaeaspntaSTLEMWTSQLRRAIQTTELSERLLNI--------RtlrwsSLNEIHAGVCEDMTYa 1092 Leishmania in...
1XQ9_A        110 ETAKKygeeqvkIWRRSYDIPPPkldkednrwpghnvvyknvpkdALPfTECLKDTVERvLPFWFDHIAPdilankkVMV 189  malaria paras...
XP_640057     387 EIQEKmpderaaRDSDKLQYRYP----------------------R---GESYEDVIQRlEPLLLELERTks----pVLI 437  Dictyostelium...
AAM91549      254 EVKKNmpeeyesRKKDKLRYRYP----------------------R---GESYLDVIQRlEPVIIELERQra----pVVV 304  thale cress
NP_593152     472 EFSEKypdefdvIKRKDYAYRFS----------------------GQG-GESYLDVIHRlQPLIVEIERSsg----nILV 524  Schizosacchar...
XP_750470     586 EIREKypeeyaiRKKNKLFYRYP----------------------GPG-GEGYLDVINRlRAVIIEVERMtd----hVLI 638  Aspergillus f...
XP_956042     504 EIAQQypeeyqkRSKDKLHYIYP----------------------GVG-GEGYLQVISRlRDMVREIERItd----hVLI 556  Neurospora cr...
NP_001018229  359 EIKSIypkeyeaRKLDKLNYRYP----------------------GSG-GESYLDVIYRlQSVIVEIERMkh----hVLV 411  Schizosacchar...
NP_983859     493 EIHQKypeefeeRLIDKLRYRYR----------------------GIG-GESYMDVINRlRPVITELERItd----nVLI 545  Ashbya gossyp...
XP_846939     592 ELREQcplmqelRNCNKFSFRYP----------------------K---GESYKDLVQRlEPVIMELENTdr----vVVI 642  Trypanosoma b...
XP_001463293 1093 EVKERyplidyfSKLNKYSFRYP----------------------E---GESYQDLVIRlEPVIMELENAdk----vVVV 1143 Leishmania in...
1XQ9_A        190 AAHGNSLRGL 199  malaria parasite P. falciparum
XP_640057     438 VSHQATLRCL 447  Dictyostelium discoideum AX4
AAM91549      305 ISHQAVLRAL 314  thale cress
NP_593152     525 VSHRIVSNIL 534  Schizosaccharomyces pombe 972h-
XP_750470     639 VTHRSVARVL 648  Aspergillus fumigatus Af293
XP_956042     557 VGHRSVCRVL 566  Neurospora crassa OR74A
NP_001018229  412 IGHRVITRII 421  Schizosaccharomyces pombe 972h-
NP_983859     546 ITHRVVARVL 555  Ashbya gossypii ATCC 10895
XP_846939     643 VAHRAVLRAL 652  Trypanosoma brucei TREU927
XP_001463293 1144 VAHQAVLRCL 1153 Leishmania infantum JPCM5
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