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Conserved domains on  [gi|159162417|pdb|1HN6|A]
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Chain A, APICAL MEMBRANE ANTIGEN 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMA-1 super family cl19485
Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual ...
 1-94 1.03e-38

Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites.


The actual alignment was detected with superfamily member pfam02430:

Pssm-ID: 418585  Cd Length: 432  Bit Score: 133.88  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HN6_A          1 EVEN-NFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAP-RIFISDDKDSLKCPCDPEMVSNSTCR-FFVCKCVER 77
Cdd:pfam02430 335 EVDAvNYPCSIYKDEIKKEIGYVSPRAKLKSEDKETNKYIDVPfRIFTSLDKESLKCPCYPETKSNSSCGtYFVCSCVEP 414

                          90
                  ....*....|....*..
1HN6_A         78 RAEVTSNNEVVVKEEYK 94
Cdd:pfam02430 415 RAEIRFNNMVVLKEEKR 431
 
Name Accession Description Interval E-value
AMA-1 pfam02430
Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual ...
 1-94 1.03e-38

Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites.


Pssm-ID: 396824  Cd Length: 432  Bit Score: 133.88  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HN6_A          1 EVEN-NFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAP-RIFISDDKDSLKCPCDPEMVSNSTCR-FFVCKCVER 77
Cdd:pfam02430 335 EVDAvNYPCSIYKDEIKKEIGYVSPRAKLKSEDKETNKYIDVPfRIFTSLDKESLKCPCYPETKSNSSCGtYFVCSCVEP 414

                          90
                  ....*....|....*..
1HN6_A         78 RAEVTSNNEVVVKEEYK 94
Cdd:pfam02430 415 RAEIRFNNMVVLKEEKR 431
PTZ00045 PTZ00045
apical membrane antigen 1; Provisional
 1-110 1.72e-26

apical membrane antigen 1; Provisional


Pssm-ID: 240241 [Multi-domain]  Cd Length: 595  Bit Score: 101.99  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HN6_A         1 EVENNFPCSLykdeimkeiereskriklndnddegNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAE 80
Cdd:PTZ00045 433 EVDANFPCSI-------------------------KEKIVLPRIFISTDKDSPFCPATPLKVSNSTCSFYVCERVEKSCG 487

                         90       100       110
                 ....*....|....*....|....*....|
1HN6_A        81 VTSNNEVVVKEEYKDEYADIPEHKPTYDKM 110
Cdd:PTZ00045 488 VKENNEVVVKEEFKCTYENILEDKKKRILI 517
 
Name Accession Description Interval E-value
AMA-1 pfam02430
Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual ...
 1-94 1.03e-38

Apical membrane antigen 1; Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites.


Pssm-ID: 396824  Cd Length: 432  Bit Score: 133.88  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HN6_A          1 EVEN-NFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAP-RIFISDDKDSLKCPCDPEMVSNSTCR-FFVCKCVER 77
Cdd:pfam02430 335 EVDAvNYPCSIYKDEIKKEIGYVSPRAKLKSEDKETNKYIDVPfRIFTSLDKESLKCPCYPETKSNSSCGtYFVCSCVEP 414

                          90
                  ....*....|....*..
1HN6_A         78 RAEVTSNNEVVVKEEYK 94
Cdd:pfam02430 415 RAEIRFNNMVVLKEEKR 431
PTZ00045 PTZ00045
apical membrane antigen 1; Provisional
 1-110 1.72e-26

apical membrane antigen 1; Provisional


Pssm-ID: 240241 [Multi-domain]  Cd Length: 595  Bit Score: 101.99  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1HN6_A         1 EVENNFPCSLykdeimkeiereskriklndnddegNKKIIAPRIFISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAE 80
Cdd:PTZ00045 433 EVDANFPCSI-------------------------KEKIVLPRIFISTDKDSPFCPATPLKVSNSTCSFYVCERVEKSCG 487

                         90       100       110
                 ....*....|....*....|....*....|
1HN6_A        81 VTSNNEVVVKEEYKDEYADIPEHKPTYDKM 110
Cdd:PTZ00045 488 VKENNEVVVKEEFKCTYENILEDKKKRILI 517
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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