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Conserved domains on  [gi|14278227|pdb|1IBX|B]
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Chain B, CHIMERA OF IGG BINDING PROTEIN G AND DNA FRAGMENTATION FACTOR 45

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIDE_N super family cl02541
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 63-141 3.47e-45

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


The actual alignment was detected with superfamily member cd06536:

Pssm-ID: 470607  Cd Length: 80  Bit Score: 142.24  E-value: 3.47e-45
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAY 141
Cdd:cd06536   2 LKPCVVCNVSRQKQHGVAASSLEELRIKACESLGFDSSSAPITLVLAEDGTIVEDEDYFLCLPPNTKFVLLAENEKWAP 80
IgG_binding_B super family cl03188
B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such ...
 3-57 3.15e-10

B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.


The actual alignment was detected with superfamily member pfam01378:

Pssm-ID: 426228  Cd Length: 68  Bit Score: 52.95  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B          3 YKLILNGKTLKGETTTEAVDAAT---AEKVFKQYANDNGV-DGEWTYDDATKTFTVTES 57
Cdd:pfam01378   9 YTLVYITQNTKGKNGATTVKASSpeeAEEYFRNYANENGLgDLEWSYDEETKTFTAREK 67
 
Name Accession Description Interval E-value
CIDE_N_ICAD cd06536
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 63-141 3.47e-45

CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease.


Pssm-ID: 119369  Cd Length: 80  Bit Score: 142.24  E-value: 3.47e-45
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAY 141
Cdd:cd06536   2 LKPCVVCNVSRQKQHGVAASSLEELRIKACESLGFDSSSAPITLVLAEDGTIVEDEDYFLCLPPNTKFVLLAENEKWAP 80
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
64-139 4.08e-36

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 118.97  E-value: 4.08e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1IBX_B          64 KPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSltPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKW 139
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSKVCDKLALPDS--PVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 64-140 1.92e-32

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 109.51  E-value: 1.92e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1IBX_B         64 KPCLLRRNYSREQHGVAASCLEDLRSKACDILAIdkSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWA 140
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQKGCEKLLL--PSEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
IgG_binding_B pfam01378
B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such ...
 3-57 3.15e-10

B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.


Pssm-ID: 426228  Cd Length: 68  Bit Score: 52.95  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B          3 YKLILNGKTLKGETTTEAVDAAT---AEKVFKQYANDNGV-DGEWTYDDATKTFTVTES 57
Cdd:pfam01378   9 YTLVYITQNTKGKNGATTVKASSpeeAEEYFRNYANENGLgDLEWSYDEETKTFTAREK 67
 
Name Accession Description Interval E-value
CIDE_N_ICAD cd06536
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 63-141 3.47e-45

CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease.


Pssm-ID: 119369  Cd Length: 80  Bit Score: 142.24  E-value: 3.47e-45
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAY 141
Cdd:cd06536   2 LKPCVVCNVSRQKQHGVAASSLEELRIKACESLGFDSSSAPITLVLAEDGTIVEDEDYFLCLPPNTKFVLLAENEKWAP 80
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
64-139 4.08e-36

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 118.97  E-value: 4.08e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1IBX_B          64 KPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSltPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKW 139
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSKVCDKLALPDS--PVTLVLEEDGTIVDDEEYFQTLPDNTELMALEKGEKW 74
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 64-140 1.92e-32

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 109.51  E-value: 1.92e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1IBX_B         64 KPCLLRRNYSREQHGVAASCLEDLRSKACDILAIdkSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWA 140
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQKGCEKLLL--PSEPVTLVLEEDGTEVDDEEYFQTLPDNTELMLLEKGEKWT 75
CIDE_N cd01615
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 63-140 7.10e-30

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


Pssm-ID: 119367  Cd Length: 78  Bit Score: 103.39  E-value: 7.10e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDksLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWA 140
Cdd:cd01615   2 LRPFKVCDSDRSRKKGVAASSLEELLSKACEKLKLP--SAPVTLVLEEDGTEVDDEEYFQTLPDNTVLMLLEPGQKWT 77
CIDE_N_FSP27 cd06538
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ...
 63-140 9.57e-15

CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.


Pssm-ID: 119371  Cd Length: 79  Bit Score: 64.84  E-value: 9.57e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKsltPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWA 140
Cdd:cd06538   2 PRPFRVSNADRSLRKGIMADSLEDLLNKVLDALLLDC---ISSLVLDEDGTGVDTEEFFQALADNTVFMVLGKGQKWK 76
CIDE_N_A cd06539
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 71-139 1.03e-14

CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119372  Cd Length: 78  Bit Score: 64.58  E-value: 1.03e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IBX_B       71 NYSRE-QHGVAASCLEDLRSKACDILAIDKSLtpVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKW 139
Cdd:cd06539   9 NHDRSsRRGVMASSLQELISKTLDALVITSGL--VTLVLEEDGTVVDTEEFFQTLGDNTHFMVLEKGQKW 76
IgG_binding_B pfam01378
B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such ...
 3-57 3.15e-10

B domain; This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.


Pssm-ID: 426228  Cd Length: 68  Bit Score: 52.95  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
1IBX_B          3 YKLILNGKTLKGETTTEAVDAAT---AEKVFKQYANDNGV-DGEWTYDDATKTFTVTES 57
Cdd:pfam01378   9 YTLVYITQNTKGKNGATTVKASSpeeAEEYFRNYANENGLgDLEWSYDEETKTFTAREK 67
CIDE_N_CAD cd06535
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ...
 63-139 1.40e-08

CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and the release of active DFF40/CAD nuclease.


Pssm-ID: 119368  Cd Length: 77  Bit Score: 48.57  E-value: 1.40e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1IBX_B       63 LKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDksLTPVTLVLAEDGTIVdDDDYFLCLPSNTKFVALASNEKW 139
Cdd:cd06535   2 PKCVKIRSLNSAQKYGVAAKNLKELLRKGCRLLQLP--CAGSRLCLYEDGTEV-TEEYFPTLPDNTELVLLTPGQSW 75
CIDE_N_B cd06537
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 61-140 4.62e-08

CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119370  Cd Length: 81  Bit Score: 47.60  E-value: 4.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IBX_B       61 RTLKPCLLRRNYSReqhGVAASCLEDLRSKACDILAIDKSLTpvtLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWA 140
Cdd:cd06537   3 RPFRVCDHKRTVRK---GLTAASLQELLAKALETLLLSGVLT---LVLEEDGTAVDSEDFFELLEDDTCLMVLEQGQSWS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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