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Conserved domains on  [gi|17942646|pdb|1JG1|A]
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Chain A, protein-L-isoaspartate O-methyltransferase

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 10011370)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

EC:  2.1.1.77
Gene Ontology:  GO:0004719|GO:0030091
PubMed:  1860862
SCOP:  4000666

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
13-227 8.73e-109

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


:

Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 311.75  E-value: 8.73e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        13 DEKELYEKWMRTVEMLKAEGIiRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPG 92
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGI-LDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        93 MNILEVGTGSGWNAALISEIVKtDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIP 172
Cdd:PRK00312  80 DRVLEIGTGSGYQAAVLAHLVR-RVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIP 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
1JG1_A       173 EPLIEQLKIGGKLIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGEYGW 227
Cdd:PRK00312 159 RALLEQLKEGGILVAPVGG-EEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
13-227 8.73e-109

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 311.75  E-value: 8.73e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        13 DEKELYEKWMRTVEMLKAEGIiRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPG 92
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGI-LDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        93 MNILEVGTGSGWNAALISEIVKtDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIP 172
Cdd:PRK00312  80 DRVLEIGTGSGYQAAVLAHLVR-RVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIP 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
1JG1_A       173 EPLIEQLKIGGKLIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGEYGW 227
Cdd:PRK00312 159 RALLEQLKEGGILVAPVGG-EEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 25-224 2.80e-97

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 281.98  E-value: 2.80e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       25 VEMLKAEGIiRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:COG2518   1 VQQLRPRGV-TDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A      105 NAALISEIVKTdVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIGGK 184
Cdd:COG2518  80 QAAVLARLAGR-VYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGR 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
1JG1_A      185 LIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGE 224
Cdd:COG2518 159 LVAPVGE-GGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
25-221 1.42e-77

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 232.26  E-value: 1.42e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         25 VEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:pfam01135   7 IENLKNYGVIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEIGSGSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        105 NAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIG 182
Cdd:pfam01135  87 LTACFARMVGEVgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEG 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
1JG1_A        183 GKLIIPVG-SYHlwQELLEVRKTKDG-IKIKNHGGVAFVPL 221
Cdd:pfam01135 167 GRLVIPVGpNGN--QVLQQFDKRNDGsVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 25-227 8.15e-71

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 215.46  E-value: 8.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         25 VEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:TIGR00080  11 IDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKVLEIGTGSGY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        105 NAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIG 182
Cdd:TIGR00080  91 QAAVLAEIVGRDglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKEG 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
1JG1_A        183 GKLIIPVGSYHlwQELLEVRKTKDGIKIKNHGGVAFVPLI-GEYGW 227
Cdd:TIGR00080 171 GILVMPVGEYL--QVLKRAEKRGGEIIIKDVEPVAFVPLVgGEGFQ 214
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 94-189 5.96e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 5.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       94 NILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKG-FPPKAPYDVIIVTAGAPKIP 172
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPLHHLV 80

                        90       100
                ....*....|....*....|....
1JG1_A      173 E---PLIEQ----LKIGGKLIIPV 189
Cdd:cd02440  81 EdlaRFLEEarrlLKPGGVLVLTL 104
rADc smart00650
Ribosomal RNA adenine dimethylases;
84-163 1.30e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A          84 LEIANLKPGMNILEVGTGSGwnaALISEIVKT--DVYTIERIPELVEFAKRNLerAGVKNVHVILGDGSKGFPPKAPYDV 161
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKG---ALTEELLERakRVTAIEIDPRLAPRLREKF--AAADNLTVIHGDALKFDLPKLQPYK 80


                   ..
1JG1_A         162 II 163
Cdd:smart00650  81 VV 82
 
Name Accession Description Interval E-value
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
13-227 8.73e-109

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 311.75  E-value: 8.73e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        13 DEKELYEKWMRTVEMLKAEGIiRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPG 92
Cdd:PRK00312   1 ARLMESERFARLVLRLRAEGI-LDERVLEAIEATPRELFVPEAFKHKAYENRALPIGCGQTISQPYMVARMTELLELKPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        93 MNILEVGTGSGWNAALISEIVKtDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIP 172
Cdd:PRK00312  80 DRVLEIGTGSGYQAAVLAHLVR-RVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIP 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
1JG1_A       173 EPLIEQLKIGGKLIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGEYGW 227
Cdd:PRK00312 159 RALLEQLKEGGILVAPVGG-EEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGELA 212
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 25-224 2.80e-97

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 281.98  E-value: 2.80e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       25 VEMLKAEGIiRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:COG2518   1 VQQLRPRGV-TDPRVLDAMRAVPRELFVPEALRELAYADRALPIGHGQTISQPYIVARMLEALDLKPGDRVLEIGTGSGY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A      105 NAALISEIVKTdVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIGGK 184
Cdd:COG2518  80 QAAVLARLAGR-VYSVERDPELAERARERLAALGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGGR 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
1JG1_A      185 LIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPLIGE 224
Cdd:COG2518 159 LVAPVGE-GGVQRLVLITRTGDGFERESLFEVRFVPLRGG 197
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 16-227 1.87e-93

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 273.05  E-value: 1.87e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        16 ELYEKWMRTVEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNI 95
Cdd:PRK13942   1 MPLEEKRRVIEELIREGYIKSKKVIDALLKVPRHLFVPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLDLKEGMKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        96 LEVGTGSGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPE 173
Cdd:PRK13942  81 LEIGTGSGYHAAVVAEIVGKSgkVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
1JG1_A       174 PLIEQLKIGGKLIIPVGSYHlwQELLEVRKTKDGIKIKNHGGVAFVPLIGEYGW 227
Cdd:PRK13942 161 PLIEQLKDGGIMVIPVGSYS--QELIRVEKDNGKIIKKKLGEVAFVPLIGKNGF 212
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
25-221 1.42e-77

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 232.26  E-value: 1.42e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         25 VEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:pfam01135   7 IENLKNYGVIKSDKVAEAMLAVDREEFVPESFKSYAYEDIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEIGSGSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        105 NAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIG 182
Cdd:pfam01135  87 LTACFARMVGEVgrVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGRQGWPEFAPYDAIHVGAAAPEIPEALIDQLKEG 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
1JG1_A        183 GKLIIPVG-SYHlwQELLEVRKTKDG-IKIKNHGGVAFVPL 221
Cdd:pfam01135 167 GRLVIPVGpNGN--QVLQQFDKRNDGsVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 25-227 8.15e-71

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 215.46  E-value: 8.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         25 VEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGW 104
Cdd:TIGR00080  11 IDKLINEGYIKSKRVIDALLSVPREEFVPEHFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLELKPGMKVLEIGTGSGY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        105 NAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLKIG 182
Cdd:TIGR00080  91 QAAVLAEIVGRDglVVSIERIPELAEKAERRLRKLGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPKIPEALIDQLKEG 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
1JG1_A        183 GKLIIPVGSYHlwQELLEVRKTKDGIKIKNHGGVAFVPLI-GEYGW 227
Cdd:TIGR00080 171 GILVMPVGEYL--QVLKRAEKRGGEIIIKDVEPVAFVPLVgGEGFQ 214
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 23-221 2.37e-59

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 186.17  E-value: 2.37e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        23 RTVEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGS 102
Cdd:PRK13944   4 RLVEELVREGIIKSERVKKAMLSVPREEFVMPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPRPGMKILEVGTGS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       103 GWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKN-VHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQL 179
Cdd:PRK13944  84 GYQAAVCAEAIERRgkVYTVEIVKELAIYAAQNIERLGYWGvVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSALVRQL 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
1JG1_A       180 KIGGKLIIPVGSyHLWQELLEVRKTKDGIKIKNHGGVAFVPL 221
Cdd:PRK13944 164 KDGGVLVIPVEE-GVGQVLYKVVKRGEKVEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 25-189 1.18e-48

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 164.08  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         25 VEMLKAEGIIRSKEVERAFLKYPRYL-----SVEDKYKKYAHI-----DEPLPIpagQTVSAPHMVAIMLEIANLKPGMN 94
Cdd:TIGR04364   9 VDELREDGVIRSPRVEAAFRTVPRHLfapgaPLEKAYAANRAVvtkrdEDGRAL---SSVSAPHIQAMMLEQAGVEPGMR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         95 ILEVGTGsGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIP 172
Cdd:TIGR04364  86 VLEIGSG-GYNAALLAELVGPSgeVTTVDIDEDVTDRARACLAAAGYPQVTVVLADAEAGVPELAPYDRIIVTVGAWDIP 164

                         170
                  ....*....|....*..
1JG1_A        173 EPLIEQLKIGGKLIIPV 189
Cdd:TIGR04364 165 PAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 28-192 4.44e-32

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 119.18  E-value: 4.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        28 LKAEGIirSKEVERAFLKYPRYLSVEDKYK-KYAHIDEPLPIPAGQ----TVSAPHMVAIMLEIANLKPGMNILEVGTGS 102
Cdd:PRK13943  14 LKKYGI--SDHIAKAFLEVPREEFLTKSYPlSYVYEDIVLVSYDDGeeysTSSQPSLMALFMEWVGLDKGMRVLEIGGGT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       103 GWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVIIVTAGAPKIPEPLIEQLK 180
Cdd:PRK13943  92 GYNAAVMSRVVGEKglVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEVPETWFTQLK 171

                        170
                 ....*....|..
1JG1_A       181 IGGKLIIPVGSY 192
Cdd:PRK13943 172 EGGRVIVPINLK 183
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 81-187 2.00e-14

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 70.19  E-value: 2.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       81 AIMLEIANLKPGMNILEVGTGSGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGV-KNVHVILGDGSKGFPPKa 157
Cdd:COG2519  81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEgkVYSYERREDFAEIARKNLERFGLpDNVELKLGDIREGIDEG- 159

                        90       100       110
                ....*....|....*....|....*....|....*.
1JG1_A      158 PYDVIIVtagapKIPEP--LIEQ----LKIGGKLII 187
Cdd:COG2519 160 DVDAVFL-----DMPDPweALEAvakaLKPGGVLVA 190
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 83-200 1.55e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 65.40  E-value: 1.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       83 MLEIANLKPGMNILEVGTGSGWNAALISEIVkTDVYTIERIPELVEFAKRNLERAGVkNVHVILGDGSK-GFPPkAPYDV 161
Cdd:COG2226  14 LLAALGLRPGARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDlPFPD-GSFDL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
1JG1_A      162 IIVTAGAPKIPEP------LIEQLKIGGKLIIPVGSYHLWQELLE 200
Cdd:COG2226  91 VISSFVLHHLPDPeralaeIARVLKPGGRLVVVDFSPPDLAELEE 135
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 94-189 5.96e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 5.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       94 NILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKG-FPPKAPYDVIIVTAGAPKIP 172
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISDPPLHHLV 80

                        90       100
                ....*....|....*....|....
1JG1_A      173 E---PLIEQ----LKIGGKLIIPV 189
Cdd:cd02440  81 EdlaRFLEEarrlLKPGGVLVLTL 104
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 78-163 8.41e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 61.10  E-value: 8.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       78 HMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKN-VHVILGDGSKgFPPK 156
Cdd:COG2230  38 AKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRD-LPAD 116


                ....*..
1JG1_A      157 APYDVII 163
Cdd:COG2230 117 GQFDAIV 123
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 86-187 1.40e-11

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 60.97  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       86 IANLKPGMNILEVGTGSGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGV-KNVHVILGDGSKGFP--PKAPYD 160
Cdd:COG4122  11 LARLLGAKRILEIGTGTGYSTLWLARALPDDgrLTTIEIDPERAAIARENFARAGLaDRIRLILGDALEVLPrlADGPFD 90

                        90       100       110
                ....*....|....*....|....*....|
1JG1_A      161 VIIVTA---GAPKIPEPLIEQLKIGGkLII 187
Cdd:COG4122  91 LVFIDAdksNYPDYLELALPLLRPGG-LIV 119
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 81-187 1.03e-10

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 60.57  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       81 AIMLEIANLKPGMNILEVGTGSG-----WnaALISEivKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPP 155
Cdd:COG2242 237 ALTLAKLALRPGDVLWDIGAGSGsvsieA--ARLAP--GGRVYAIERDPERAALIRANARRFGVPNVEVVEGEAPEALAD 312

                        90       100       110
                ....*....|....*....|....*....|....*.
1JG1_A      156 KAPYDVIIVTAGAPKIPEpLIEQ----LKIGGKLII 187
Cdd:COG2242 313 LPDPDAVFIGGSGGNLPE-ILEAcwarLRPGGRLVA 347
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 65-164 1.11e-10

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 60.58  E-value: 1.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       65 PLPIPAG---QT--VSAPHMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIVKTdVYTIERIPELVEFAKRNLERAGV 139
Cdd:COG2265 202 TFRISPGsffQVnpEQAEALYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKK-VIGVEIVPEAVEDARENARLNGL 280

                        90       100
                ....*....|....*....|....*...
1JG1_A      140 KNVHVILGDGSKGFP---PKAPYDVIIV 164
Cdd:COG2265 281 KNVEFVAGDLEEVLPellWGGRPDVVVL 308
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 76-187 4.32e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 57.23  E-value: 4.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       76 APHMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGD--GSKGF 153
Cdd:COG0500  11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADlaELDPL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
1JG1_A      154 PPkAPYDVIIVTAGA----PKIPEPLIE----QLKIGGKLII 187
Cdd:COG0500  91 PA-ESFDLVVAFGVLhhlpPEEREALLRelarALKPGGVLLL 131
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 78-163 8.00e-10

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 57.47  E-value: 8.00e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       78 HMVAIMLEIANLKPGMNILEVGTGSGwnA---ALISEIVKTDVYTIERIPELVEFAKRNLERAGVKN-VHVILGDGSKGF 153
Cdd:COG2890  99 ELVELALALLPAGAPPRVLDLGTGSG--AialALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPL 176

                        90
                ....*....|
1JG1_A      154 PPKAPYDVII 163
Cdd:COG2890 177 PGDGRFDLIV 186
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
90-163 9.16e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 56.97  E-value: 9.16e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1JG1_A       90 KPGMNILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVK-NVHVILGDgSKGFPPKAPYDVII 163
Cdd:COG4076  34 KPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINAD-ATDLDLPEKADVII 107
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 95-183 9.84e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.11  E-value: 9.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         95 ILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVkNVHVILGDGSKgFP-PKAPYDVIIVTAGAPKIPE 173
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAED-LPfPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
1JG1_A        174 PLIEQ--------LKIGG 183
Cdd:pfam13649  79 PDLEAalreiarvLKPGG 96
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 89-200 1.50e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         89 LKPGMNILEVGTGSGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKgFP---PKAPYDVII 163
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEE-LPellEDDKFDVVI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
1JG1_A        164 VTAGAPKIPEP------LIEQLKIGGKLIIpvGSYHLWQELLE 200
Cdd:pfam13847  80 SNCVLNHIPDPdkvlqeILRVLKPGGRLII--SDPDSLAELPA 120
PRK14968 PRK14968
putative methyltransferase; Provisional
 82-163 6.99e-09

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 53.75  E-value: 6.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        82 IMLEIANLKPGMNILEVGTGSGWNAALIS----EIVKTDVYtieriPELVEFAKRNLERAGVKN--VHVILGDGSKGFPP 155
Cdd:PRK14968  14 LLAENAVDKKGDRVLEVGTGSGIVAIVAAkngkKVVGVDIN-----PYAVECAKCNAKLNNIRNngVEVIRSDLFEPFRG 88


                 ....*...
1JG1_A       156 KApYDVII 163
Cdd:PRK14968  89 DK-FDVIL 95
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 89-187 1.82e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.17  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       89 LKPGMNILEVGTGSGWNAALISEIVKtDVYTIERIPELVEFAKRNLERAgvkNVHVILGDGSKGFPPKAPYDVIIVTAGA 168
Cdd:COG2227  22 LPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGSFDLVICSEVL 97

                        90       100
                ....*....|....*....|....*
1JG1_A      169 PKIPEP------LIEQLKIGGKLII 187
Cdd:COG2227  98 EHLPDPaallreLARLLKPGGLLLL 122
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 84-163 2.34e-08

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 53.24  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        84 LEIANLKPGMNILEVGTGSGwnA---ALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFpPKAPYD 160
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSG--AialALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEPL-PGGRFD 177


                 ...
1JG1_A       161 VII 163
Cdd:PRK09328 178 LIV 180
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
91-187 1.88e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.90  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       91 PGMNILEVGTGSGWNAALISEIVKTDVYT-IERIPELVEFAKRNLEragvkNVHVILGDGSkGFPPKAPYDVIIVTAGAP 169
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERFPGARVTgVDLSPEMLARARARLP-----NVRFVVADLR-DLDPPEPFDLVVSNAALH 74

                        90       100
                ....*....|....*....|....
1JG1_A      170 KIPEP------LIEQLKIGGKLII 187
Cdd:COG4106  75 WLPDHaallarLAAALAPGGVLAV 98
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 87-164 5.69e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 48.99  E-value: 5.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       87 ANLKPGMNILEVGTGSGwnaaLISEIV-----KTDVYTIERIPELVEFAKRNLERAGVKN-VHVILGDgSKGFPPKAP-- 158
Cdd:COG4123  33 APVKKGGRVLDLGTGTG----VIALMLaqrspGARITGVEIQPEAAELARRNVALNGLEDrITVIHGD-LKEFAAELPpg 107


                ....*..
1JG1_A      159 -YDVIIV 164
Cdd:COG4123 108 sFDLVVS 114
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 77-187 6.72e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.02  E-value: 6.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       77 PHMVAIMLEIANLKPGMNILE--VGTGSGWNAALISEIvktDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFP 154
Cdd:COG1041  12 PRLARALVNLAGAKEGDTVLDpfCGTGTILIEAGLLGR---RVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDLPL 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
1JG1_A      155 PKAPYDVIIV-------TAGAPKIPEPLIEQ--------LKIGGKLII 187
Cdd:COG1041  89 ADESVDAIVTdppygrsSKISGEELLELYEKaleeaarvLKPGGRVVI 136
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 96-187 1.37e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 45.35  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         96 LEVGTGSGWNAALISEIVKTdVYTIERIPELVEFAKRNLERAGVKNVHvilGDGSK-GFPPKApYDVIIVTAGAPKIPEP 174
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELAREKAPREGLTFVV---GDAEDlPFPDNS-FDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
1JG1_A        175 ---LIE---QLKIGGKLII 187
Cdd:pfam08241  76 eraLREiarVLKPGGILII 94
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 81-189 4.23e-06

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 45.94  E-value: 4.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        81 AIMLEIANLKPGMNILEVGTGSGWNAALISEIV--KTDVYTIERIPELVEFAKRNLERAGV-KNVHVILGDGSKGFPPKA 157
Cdd:PRK00377  30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVgeTGKVYAVDKDEKAINLTRRNAEKFGVlNNIVLIKGEAPEILFTIN 109

                         90       100       110
                 ....*....|....*....|....*....|....*.
1JG1_A       158 P-YDVIIVTAGAPKIPEPL---IEQLKIGGKLIIPV 189
Cdd:PRK00377 110 EkFDRIFIGGGSEKLKEIIsasWEIIKKGGRIVIDA 145
arsM PRK11873
arsenite methyltransferase;
84-148 4.63e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 46.48  E-value: 4.63e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1JG1_A        84 LEIANLKPGMNILEVGTGSGWNAALISEIVKTD--VYTIERIPELVEFAKRNLERAGVKNVHVILGD 148
Cdd:PRK11873  70 TALAELKPGETVLDLGSGGGFDCFLAARRVGPTgkVIGVDMTPEMLAKARANARKAGYTNVEFRLGE 136
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 81-194 3.33e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 42.96  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         81 AIMLEIANLKPGMNILEVGTGSGW-NAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKaPY 159
Cdd:pfam05175  21 RLLLEHLPKDLSGKVLDLGCGAGVlGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDG-KF 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
1JG1_A        160 DVIIVT-------AGAPKIPEPLIEQ----LKIGGKLIIpVGSYHL 194
Cdd:pfam05175 100 DLIISNppfhaglATTYNVAQRFIADakrhLRPGGELWI-VANRFL 144
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-202 3.67e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.80  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         87 ANLKPGMNILEVGTGSGWNAALISEIVkTDVYTIERIPELVEFAKRNLERAGVknvhvilgDGSKGFPPKAPYDVIIVTA 166
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLRLLRAQG-FSVTGVDPSPIAIERALLNVRFDQF--------DEQEAAVPAGKFDVIVARE 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
1JG1_A        167 GAPKIPEP------LIEQLKIGGKLII--PVGSYHLWQELLEVR 202
Cdd:pfam13489  89 VLEHVPDPpallrqIAALLKPGGLLLLstPLASDEADRLLLEWP 132
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
83-202 4.76e-05

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 42.67  E-value: 4.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A        83 MLEIANLKPGMN--ILEVGTGSGW---NAALISEivKTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKA 157
Cdd:PRK07402  30 LLLISQLRLEPDsvLWDIGAGTGTipvEAGLLCP--KGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEGSAPECLAQLA 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
1JG1_A       158 PY-DVIIVTAGAP--KIPEPLIEQLKIGGKLIIPVGS----YHLWQELLEVR 202
Cdd:PRK07402 108 PApDRVCIEGGRPikEILQAVWQYLKPGGRLVATASSleglYAISEGLAQLQ 159
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 96-164 1.39e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 39.98  E-value: 1.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1JG1_A         96 LEVGTGSGWNAALISEIVK----TDVYTIERIPELVEFAkRNLERAGVK-NVHVILGDGSKGFP--PKAPYDVIIV 164
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRdnglGRLTAVDPDPGAEEAG-ALLRKAGLDdRVRLIVGDSREALPslADGPIDLLFI 75
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 77-148 1.53e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 41.65  E-value: 1.53e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1JG1_A       77 PHMVAIMLEIANLKPGMNILEVGTGSGwnaALISEIVKT--DVYTIERIPELVEFAKRNLerAGVKNVHVILGD 148
Cdd:COG0030  23 PNIIRRIVDAAGITPGDTVLEIGPGLG---ALTRALLERaaRVTAVEIDRRLAAILRETF--AAYPNLTVIEGD 91
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
79-199 2.08e-04

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 40.97  E-value: 2.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       79 MVAIMLeIANLKPgMNILEVGTGSGwnaALISEIVKTdvYTIERI------PELVEFAKRNL-ERAGV---KNVHVILGD 148
Cdd:COG0421  27 MAHVPL-LFHPNP-KRVLIIGGGDG---GLARELLKH--PPVERVdvveidPEVVELAREYFpLLAPAfddPRLRVVIGD 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1JG1_A      149 GSKGFP-PKAPYDVIIVTAGAPK-IPEPLIEQ---------LKIGGKLIIPVGSYHLWQELL 199
Cdd:COG0421 100 GRAFLReAEESYDVIIVDLTDPVgPAEGLFTRefyedcrraLKPGGVLVVNLGSPFYGLDLL 161
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 67-156 6.86e-04

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 39.78  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         67 PIPAGQTVSAPH-----------MVAIMLEianLKPGMNILEVGTGSGwnaALISEIVKT-----DVYTIERIPELVEFA 130
Cdd:pfam08704   8 PTPELWTLNLPHrtqilytpdisLITMMLE---LRPGSVVCESGTGSG---SLSHAIIRTvaptgHLFTFEFHEQRADKA 81

                          90       100
                  ....*....|....*....|....*...
1JG1_A        131 KRNLERAGV-KNVHVILGDGSK-GFPPK 156
Cdd:pfam08704  82 REEFREHGIdQLVTVTHRDVCKeGFLTE 109
rADc smart00650
Ribosomal RNA adenine dimethylases;
84-163 1.30e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A          84 LEIANLKPGMNILEVGTGSGwnaALISEIVKT--DVYTIERIPELVEFAKRNLerAGVKNVHVILGDGSKGFPPKAPYDV 161
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKG---ALTEELLERakRVTAIEIDPRLAPRLREKF--AAADNLTVIHGDALKFDLPKLQPYK 80


                   ..
1JG1_A         162 II 163
Cdd:smart00650  81 VV 82
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
84-179 2.70e-03

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 38.12  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         84 LEIANLKPGMNILEVGTGSGWNAALISEIVKtDVYTIERIPELVEFAKRNLERAgvKNVHVILGDGSK-GFPPKA--PYD 160
Cdd:pfam00398  23 VDKANLRESDTVLEIGPGKGALTVILAKRAK-QVVAIEIDPRLAKLLQKKLSLD--ENLTVIHQDFLKfEFPSLVthIHQ 99

                          90       100
                  ....*....|....*....|
1JG1_A        161 VIIVTAGAP-KIPEPLIEQL 179
Cdd:pfam00398 100 EFLVVGNLPyNISTPIVKQL 119
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 89-187 8.82e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 36.48  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A         89 LKPGMNILEVGTGSG---WNAALI--SEIVKTDvytierIPEL-VEFAKRNLERAGVK-NVHVIL-GDGskgfpPKAPYD 160
Cdd:pfam06325 159 VKPGESVLDVGCGSGilaIAALKLgaKKVVGVD------IDPVaVRAAKENAELNGVEaRLEVYLpGDL-----PKEKAD 227

                          90       100       110
                  ....*....|....*....|....*....|....
1JG1_A        161 VIIvtagAPKIPEPLIE-------QLKIGGKLII 187
Cdd:pfam06325 228 VVV----ANILADPLIElapdiyaLVKPGGYLIL 257
AdhP COG1064
D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport ...
 59-190 8.89e-03

D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism];


Pssm-ID: 440684 [Multi-domain]  Cd Length: 332  Bit Score: 36.63  E-value: 8.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JG1_A       59 YAHIDEP--LPIPAGqtVS----APHMVAIM-----LEIANLKPGMNILEVGTG-SGWNAALISEIVKTDVYTIERIPEL 126
Cdd:COG1064 121 YVVVPARflVKLPDG--LDpaeaAPLLCAGItayraLRRAGVGPGDRVAVIGAGgLGHLAVQIAKALGAEVIAVDRSPEK 198

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1JG1_A      127 VEFAKRnlerAGVknVHVIlgDGSKGFPPKA-----PYDVIIVTAGAPKIPEPLIEQLKIGGKLIIpVG 190
Cdd:COG1064 199 LELARE----LGA--DHVV--NSSDEDPVEAvreltGADVVIDTVGAPATVNAALALLRRGGRLVL-VG 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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