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Conserved domains on  [gi|24158744|pdb|1JPE|A]
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Chain A, DsbD-alpha

Protein Classification

protein-disulfide reductase DsbD( domain architecture ID 1001408)

protein-disulfide reductase DsbD facilitates the formation of correct disulfide bonds in some periplasmic proteins and is required for the assembly of the periplasmic c-type cytochromes

EC:  1.8.1.8
SCOP:  4000237

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
dipZ super family cl35086
thiol:disulfide interchange protein precursor; Provisional
18-148 5.18e-78

thiol:disulfide interchange protein precursor; Provisional


The actual alignment was detected with superfamily member PRK00293:

Pssm-ID: 234717 [Multi-domain]  Cd Length: 571  Bit Score: 241.27  E-value: 5.18e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JPE_A        18 QSGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYR 97
Cdd:PRK00293  19 SAGLFDAPGRSDFLPVDQAFAFDFQQQGDQLNLRWQIADGYYLYRKQIKITPEPADLGEPQLPAGEPHEDEFFGEVEVYR 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
1JPE_A        98 DRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAAP 148
Cdd:PRK00293  99 DRLDLPVPLNQAAAGATLTVTYQGCADAGFCYPPETRTVPLSAVAANSAPA 149
 
Name Accession Description Interval E-value
dipZ PRK00293
thiol:disulfide interchange protein precursor; Provisional
18-148 5.18e-78

thiol:disulfide interchange protein precursor; Provisional


Pssm-ID: 234717 [Multi-domain]  Cd Length: 571  Bit Score: 241.27  E-value: 5.18e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JPE_A        18 QSGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYR 97
Cdd:PRK00293  19 SAGLFDAPGRSDFLPVDQAFAFDFQQQGDQLNLRWQIADGYYLYRKQIKITPEPADLGEPQLPAGEPHEDEFFGEVEVYR 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
1JPE_A        98 DRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAAP 148
Cdd:PRK00293  99 DRLDLPVPLNQAAAGATLTVTYQGCADAGFCYPPETRTVPLSAVAANSAPA 149
DsbC pfam11412
Disulphide bond corrector protein DsbC; This entry represents the N-terminal domain of DsbD, a ...
29-138 7.27e-43

Disulphide bond corrector protein DsbC; This entry represents the N-terminal domain of DsbD, a transmembrane electron transporter. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm. The N-terminal domain of DsbD (DsbDN) is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD.


Pssm-ID: 463273 [Multi-domain]  Cd Length: 115  Bit Score: 137.86  E-value: 7.27e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JPE_A         29 QFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRIT---PEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVT 105
Cdd:pfam11412   2 RLLPPDEAFKFSAAGDGDTLGLRWEIAPGYYLYWDKPGFEwtpPDGVTLGELQLPAPERKPDEFFGEVEVYEGEVTLPLP 81
                          90       100       110
                  ....*....|....*....|....*....|....
1JPE_A        106 INQAS-AGATLTVTYQGCADAGFCYPPETKTVPL 138
Cdd:pfam11412  82 LAAAAgATLKLEVTYQGCAEAGICYPPETKLFLL 115
 
Name Accession Description Interval E-value
dipZ PRK00293
thiol:disulfide interchange protein precursor; Provisional
18-148 5.18e-78

thiol:disulfide interchange protein precursor; Provisional


Pssm-ID: 234717 [Multi-domain]  Cd Length: 571  Bit Score: 241.27  E-value: 5.18e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JPE_A        18 QSGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYR 97
Cdd:PRK00293  19 SAGLFDAPGRSDFLPVDQAFAFDFQQQGDQLNLRWQIADGYYLYRKQIKITPEPADLGEPQLPAGEPHEDEFFGEVEVYR 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
1JPE_A        98 DRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAAP 148
Cdd:PRK00293  99 DRLDLPVPLNQAAAGATLTVTYQGCADAGFCYPPETRTVPLSAVAANSAPA 149
DsbC pfam11412
Disulphide bond corrector protein DsbC; This entry represents the N-terminal domain of DsbD, a ...
29-138 7.27e-43

Disulphide bond corrector protein DsbC; This entry represents the N-terminal domain of DsbD, a transmembrane electron transporter. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm. The N-terminal domain of DsbD (DsbDN) is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD.


Pssm-ID: 463273 [Multi-domain]  Cd Length: 115  Bit Score: 137.86  E-value: 7.27e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1JPE_A         29 QFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRIT---PEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVT 105
Cdd:pfam11412   2 RLLPPDEAFKFSAAGDGDTLGLRWEIAPGYYLYWDKPGFEwtpPDGVTLGELQLPAPERKPDEFFGEVEVYEGEVTLPLP 81
                          90       100       110
                  ....*....|....*....|....*....|....
1JPE_A        106 INQAS-AGATLTVTYQGCADAGFCYPPETKTVPL 138
Cdd:pfam11412  82 LAAAAgATLKLEVTYQGCAEAGICYPPETKLFLL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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