|
Name |
Accession |
Description |
Interval |
E-value |
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
5-287 |
0e+00 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 587.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 5 LKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVE 84
Cdd:NF040660 1 LRPHFEDVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 85 KYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVM 164
Cdd:NF040660 81 KYDVNVVGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 165 LLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ 244
Cdd:NF040660 161 LLHTITGLHRKEMHERGLPLTMELARFIKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|...
1KPH_B 245 ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK 287
Cdd:NF040660 241 AHKDEAIAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
5-283 |
5.55e-179 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 493.77 E-value: 5.55e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 5 LKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVE 84
Cdd:pfam02353 2 KTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 85 KYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVM 164
Cdd:pfam02353 82 RYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGLM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 165 LLHTITGLHPKEIHERGLPmsftfarfLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ 244
Cdd:pfam02353 162 LLHTITGLHPDETSERGLP--------LKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENLQ 233
|
250 260 270
....*....|....*....|....*....|....*....
1KPH_B 245 ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQF 283
Cdd:pfam02353 234 ANKDEAIALQSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
14-168 |
2.73e-69 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 211.71 E-value: 2.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 14 AHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGL 93
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1KPH_B 94 TLSKNQANHVQQLVANsENLRSK-RVLLAGWEQF--DEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHT 168
Cdd:COG2230 81 TLSPEQLEYARERAAE-AGLADRvEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
15-282 |
1.24e-64 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 207.54 E-value: 1.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 15 HYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLT 94
Cdd:NF040703 110 HYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDVGCGWGGLARFAAREFGVEVFGIT 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 95 LSKNQANHVQQLVAnSENLrSKRVLLAGWEQFDEP----VDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTIT 170
Cdd:NF040703 190 LSKEQLKLARERVA-AEGL-QDRVQLELLDYRDLPqdgrFDKVVSVGMFEHVGHANLPLYCQRLFGAVRPGGLVMNHGIT 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 171 GLHPKeiherGLPMSFTFArflKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQA 250
Cdd:NF040703 268 ARHTD-----GRPVGRGAG---EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYARTLEHWSARLEARLDEA 339
|
250 260 270
....*....|....*....|....*....|..
1KPH_B 251 IALQSEEVYERYMKYLTGCAEMFRIGYIDVNQ 282
Cdd:NF040703 340 ARLVPERALRIWRLYLAGCAYGFARGWINLHQ 371
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
13-274 |
2.35e-64 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 206.62 E-value: 2.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 13 QAHYDLSDDFFRLFLDPTQTYSCAYFERDDmTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVG 92
Cdd:PRK11705 117 KEHYDLGNDLFEAMLDPRMQYSCGYWKDAD-TLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVG 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 93 LTLSKNQANHVQQLVANSenlrSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTI--- 169
Cdd:PRK11705 196 VTISAEQQKLAQERCAGL----PVEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIgsn 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 170 -TGLHPKeiherglpmsftfarflKFIVTEIFPGGRLPSIPMVQEcASANGFTVTRVQSLQPHYAKTLDLWSAALQANKG 248
Cdd:PRK11705 272 kTDTNVD-----------------PWINKYIFPNGCLPSVRQIAQ-ASEGLFVMEDWHNFGADYDRTLMAWHENFEAAWP 333
|
250 260
....*....|....*....|....*...
1KPH_B 249 QAIALQSEEVYE--RYmkYLTGCAEMFR 274
Cdd:PRK11705 334 ELADNYSERFYRmwRY--YLLSCAGAFR 359
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
67-171 |
1.27e-13 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 65.53 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 67 TLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRsKRVLLAGWEQF----DEPVDRIVSIGAFEHF 142
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*....
1KPH_B 143 gHERYDAFFSLAHRLLPADGVMLLHTITG 171
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLTLVLA 107
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
5-287 |
0e+00 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 587.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 5 LKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVE 84
Cdd:NF040660 1 LRPHFEDVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 85 KYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVM 164
Cdd:NF040660 81 KYDVNVVGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 165 LLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ 244
Cdd:NF040660 161 LLHTITGLHRKEMHERGLPLTMELARFIKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|...
1KPH_B 245 ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK 287
Cdd:NF040660 241 AHKDEAIAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
5-283 |
5.55e-179 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 493.77 E-value: 5.55e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 5 LKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVE 84
Cdd:pfam02353 2 KTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 85 KYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVM 164
Cdd:pfam02353 82 RYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGLM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 165 LLHTITGLHPKEIHERGLPmsftfarfLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQ 244
Cdd:pfam02353 162 LLHTITGLHPDETSERGLP--------LKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENLQ 233
|
250 260 270
....*....|....*....|....*....|....*....
1KPH_B 245 ANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQF 283
Cdd:pfam02353 234 ANKDEAIALQSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
14-168 |
2.73e-69 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 211.71 E-value: 2.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 14 AHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGL 93
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1KPH_B 94 TLSKNQANHVQQLVANsENLRSK-RVLLAGWEQF--DEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHT 168
Cdd:COG2230 81 TLSPEQLEYARERAAE-AGLADRvEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
15-282 |
1.24e-64 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 207.54 E-value: 1.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 15 HYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLT 94
Cdd:NF040703 110 HYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDVGCGWGGLARFAAREFGVEVFGIT 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 95 LSKNQANHVQQLVAnSENLrSKRVLLAGWEQFDEP----VDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTIT 170
Cdd:NF040703 190 LSKEQLKLARERVA-AEGL-QDRVQLELLDYRDLPqdgrFDKVVSVGMFEHVGHANLPLYCQRLFGAVRPGGLVMNHGIT 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 171 GLHPKeiherGLPMSFTFArflKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQA 250
Cdd:NF040703 268 ARHTD-----GRPVGRGAG---EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYARTLEHWSARLEARLDEA 339
|
250 260 270
....*....|....*....|....*....|..
1KPH_B 251 IALQSEEVYERYMKYLTGCAEMFRIGYIDVNQ 282
Cdd:NF040703 340 ARLVPERALRIWRLYLAGCAYGFARGWINLHQ 371
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
13-274 |
2.35e-64 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 206.62 E-value: 2.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 13 QAHYDLSDDFFRLFLDPTQTYSCAYFERDDmTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVG 92
Cdd:PRK11705 117 KEHYDLGNDLFEAMLDPRMQYSCGYWKDAD-TLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVG 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 93 LTLSKNQANHVQQLVANSenlrSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTI--- 169
Cdd:PRK11705 196 VTISAEQQKLAQERCAGL----PVEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIgsn 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 170 -TGLHPKeiherglpmsftfarflKFIVTEIFPGGRLPSIPMVQEcASANGFTVTRVQSLQPHYAKTLDLWSAALQANKG 248
Cdd:PRK11705 272 kTDTNVD-----------------PWINKYIFPNGCLPSVRQIAQ-ASEGLFVMEDWHNFGADYDRTLMAWHENFEAAWP 333
|
250 260
....*....|....*....|....*...
1KPH_B 249 QAIALQSEEVYE--RYmkYLTGCAEMFR 274
Cdd:PRK11705 334 ELADNYSERFYRmwRY--YLLSCAGAFR 359
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
67-171 |
1.27e-13 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 65.53 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 67 TLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRsKRVLLAGWEQF----DEPVDRIVSIGAFEHF 142
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*....
1KPH_B 143 gHERYDAFFSLAHRLLPADGVMLLHTITG 171
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLTLVLA 107
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
69-158 |
1.56e-12 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 62.20 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 69 LDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSE-NLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERY 147
Cdd:pfam13649 2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGlNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDPDL 81
|
90
....*....|.
1KPH_B 148 DAFFSLAHRLL 158
Cdd:pfam13649 82 EAALREIARVL 92
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
54-180 |
6.66e-11 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 59.24 E-value: 6.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 54 DLALGKLGLQPGMTLLDVGCGWGATmMRAVEKYDVNVVGLTLSKNQANHVQQLVAnSENLRSkRVLLAGWEQF---DEPV 130
Cdd:COG2226 12 EALLAALGLRPGARVLDLGCGTGRL-ALALAERGARVTGVDISPEMLELARERAA-EAGLNV-EFVVGDAEDLpfpDGSF 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
1KPH_B 131 DRIVSIGAFEHFghERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHER 180
Cdd:COG2226 89 DLVISSFVLHHL--PDPERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
62-169 |
3.71e-08 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 51.17 E-value: 3.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 62 LQPGMTLLDVGCGWGAtMMRAVEKYDVNVVGLTLSKNQANHVQQLvANSENLrskRVLLAGWEQF---DEPVDRIVSIGA 138
Cdd:COG2227 22 LPAGGRVLDVGCGTGR-LALALARRGADVTGVDISPEALEIARER-AAELNV---DFVQGDLEDLpleDGSFDLVICSEV 96
|
90 100 110
....*....|....*....|....*....|.
1KPH_B 139 FEHFGHEryDAFFSLAHRLLPADGVMLLHTI 169
Cdd:COG2227 97 LEHLPDP--AALLRELARLLKPGGLLLLSTP 125
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
53-166 |
1.43e-07 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 50.69 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 53 IDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLvANSENLRSKRVLLAGWEQF----DE 128
Cdd:COG0500 15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARAR-AAKAGLGNVEFLVADLAELdplpAE 93
|
90 100 110
....*....|....*....|....*....|....*...
1KPH_B 129 PVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLL 166
Cdd:COG0500 94 SFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLL 131
|
|
| PLN02336 |
PLN02336 |
phosphoethanolamine N-methyltransferase |
20-98 |
8.77e-07 |
|
phosphoethanolamine N-methyltransferase
Pssm-ID: 177970 [Multi-domain] Cd Length: 475 Bit Score: 49.75 E-value: 8.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 20 DDFFRLFLDPTQtYSCAYFERDDMTLQEAQIAKIDLA-----LGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLT 94
Cdd:PLN02336 218 DKGFQRFLDNVQ-YKSSGILRYERVFGEGFVSTGGLEttkefVDKLDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGID 296
|
....
1KPH_B 95 LSKN 98
Cdd:PLN02336 297 LSVN 300
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
69-166 |
4.02e-06 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 44.58 E-value: 4.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 69 LDVGCGWGAtMMRAVEKYDVNVVGLTLS---------KNQANHVQQLVANSENLrskrvllagweQF-DEPVDRIVSIGA 138
Cdd:pfam08241 1 LDVGCGTGL-LTELLARLGARVTGVDISpemlelareKAPREGLTFVVGDAEDL-----------PFpDNSFDLVLSSEV 68
|
90 100
....*....|....*....|....*...
1KPH_B 139 FEHFghERYDAFFSLAHRLLPADGVMLL 166
Cdd:pfam08241 69 LHHV--EDPERALREIARVLKPGGILII 94
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
64-166 |
7.44e-06 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 43.66 E-value: 7.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 64 PGMTLLDVGCGWGATMMRAVEKY-DVNVVGLTLSknqANHVQQLVANSENLRSKRVLLAGWeQFDEPVDRIVSIGAFEHF 142
Cdd:COG4106 1 PPRRVLDLGCGTGRLTALLAERFpGARVTGVDLS---PEMLARARARLPNVRFVVADLRDL-DPPEPFDLVVSNAALHWL 76
|
90 100
....*....|....*....|....
1KPH_B 143 ghERYDAFFSLAHRLLPADGVMLL 166
Cdd:COG4106 77 --PDHAALLARLAAALAPGGVLAV 98
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
69-163 |
2.89e-05 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 41.97 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 69 LDVGCGWGATMMRAVEKY-DVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGW---EQFDEPVDRIVSIGAFEHFGH 144
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLdlgELDPGSFDVVVASNVLHHLAD 80
|
90
....*....|....*....
1KPH_B 145 ERydAFFSLAHRLLPADGV 163
Cdd:pfam08242 81 PR--AVLRNIRRLLKPGGV 97
|
|
| Methyltransf_23 |
pfam13489 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
64-170 |
1.49e-04 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 404385 [Multi-domain] Cd Length: 162 Bit Score: 41.26 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 64 PGMTLLDVGCGWGaTMMRAVEKYDVNVVGLTLSKNQANHVqqlvanSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFG 143
Cdd:pfam13489 22 SPGRVLDFGCGTG-IFLRLLRAQGFSVTGVDPSPIAIERA------LLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVP 94
|
90 100
....*....|....*....|....*..
1KPH_B 144 HerYDAFFSLAHRLLPADGVMLLHTIT 170
Cdd:pfam13489 95 D--PPALLRQIAALLKPGGLLLLSTPL 119
|
|
| PLN02244 |
PLN02244 |
tocopherol O-methyltransferase |
37-108 |
3.05e-04 |
|
tocopherol O-methyltransferase
Pssm-ID: 215135 [Multi-domain] Cd Length: 340 Bit Score: 41.65 E-value: 3.05e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
1KPH_B 37 YFERDDMT--LQEAQIAKIDLALGKLGLQPGM-----TLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVA 108
Cdd:PLN02244 84 YYDPGASRgdHRQAQIRMIEESLAWAGVPDDDekrpkRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAARANALAA 162
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
52-226 |
4.99e-04 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 40.17 E-value: 4.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 52 KIDLA----LGKLGLQPGMTLLDVGCGWG---ATMMRA-----VEKYDVNVVGLTLSK-----NQANHVQQLVANsenlr 114
Cdd:COG2813 33 RLDIGtrllLEHLPEPLGGRVLDLGCGYGvigLALAKRnpearVTLVDVNARAVELARanaaaNGLENVEVLWSD----- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 115 skrvLLAGWEqfDEPVDRIVS---IgafeHFGHERYD----AFFSLAHRLLPADGVMLLhtitglhpkeIHERGLPMsft 187
Cdd:COG2813 108 ----GLSGVP--DGSFDLILSnppF----HAGRAVDKevahALIADAARHLRPGGELWL----------VANRHLPY--- 164
|
170 180 190
....*....|....*....|....*....|....*....
1KPH_B 188 fARFLKfivtEIFPGgrlpsipmVQECASANGFTVTRVQ 226
Cdd:COG2813 165 -ERKLE----ELFGN--------VEVLARNKGFKVLRAV 190
|
|
| CobL |
COG2242 |
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ... |
38-85 |
5.07e-04 |
|
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 441843 [Multi-domain] Cd Length: 403 Bit Score: 41.31 E-value: 5.07e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
1KPH_B 38 FERDD--MTLQEAQIakidLALGKLGLQPGMTLLDVGCGWGA---TMMR--------AVEK 85
Cdd:COG2242 223 FERDKgpITKREVRA----LTLAKLALRPGDVLWDIGAGSGSvsiEAARlapggrvyAIER 279
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
52-163 |
5.33e-04 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 39.98 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 52 KIDLALGKLGLQPGMTLLDVGCGWGaTMMRAVEKYDVNVVGLTLSKN-----QANHVQQLVANSEnlrskrvlLAGWEQF 126
Cdd:COG4976 34 LAEELLARLPPGPFGRVLDLGCGTG-LLGEALRPRGYRLTGVDLSEEmlakaREKGVYDRLLVAD--------LADLAEP 104
|
90 100 110
....*....|....*....|....*....|....*..
1KPH_B 127 DEPVDRIVSIGAFEHFGheRYDAFFSLAHRLLPADGV 163
Cdd:COG4976 105 DGRFDLIVAADVLTYLG--DLAAVFAGVARALKPGGL 139
|
|
| PCMT |
pfam01135 |
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); |
55-138 |
1.96e-03 |
|
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
Pssm-ID: 395902 [Multi-domain] Cd Length: 205 Bit Score: 38.50 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KPH_B 55 LALGKLGLQPGMTLLDVGCGWG---ATMMRAVeKYDVNVVGLtlsknqaNHVQQLV----ANSENLRSKRVLLA------ 121
Cdd:pfam01135 64 MMLELLELKPGMRVLEIGSGSGyltACFARMV-GEVGRVVSI-------EHIPELVeiarRNLEKLGLENVIVVvgdgrq 135
|
90
....*....|....*...
1KPH_B 122 GWEQFdEPVDRI-VSIGA 138
Cdd:pfam01135 136 GWPEF-APYDAIhVGAAA 152
|
|
| cbiT |
PRK00377 |
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional |
38-82 |
5.67e-03 |
|
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
Pssm-ID: 234740 Cd Length: 198 Bit Score: 37.08 E-value: 5.67e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
1KPH_B 38 FERDD---MTLQEAQIakidLALGKLGLQPGMTLLDVGCGWGATMMRA 82
Cdd:PRK00377 15 FERDEeipMTKEEIRA----LALSKLRLRKGDMILDIGCGTGSVTVEA 58
|
|
| |
