|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1371.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 15 DYHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVRPHSVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHA 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 95 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFGDIAISERYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 335 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 415 CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 495 NLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFarSGITLPTREMWLKLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 655 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
67-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 752.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 67 VREGYYDDAVLarydRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLAQGD----- 141
Cdd:COG0209 20 VEEGLYDERLL----EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 142 ETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAK 301
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 302 ENAQMALFSPYDIQRRYGKPFGDiaISERYDELIADPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--A 379
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 380 GRINMSNLCSEILQVNSASryddnldythigHDISCNLGSLNIAHVM-----DSPDIGRTVETAIRGLTAVSDMSHIrSV 454
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 455 PSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYF 534
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 535 TQYLQDDWqpktakvralfarsgiTLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKE 614
Cdd:COG0209 477 FDKYLDDL----------------LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 615 GKTGRVYYPAPFM------------------------------TNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 664
Cdd:COG0209 541 LDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKT 620
|
650 660 670 680
....*....|....*....|....*....|....*....|.
1PEM_A 665 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTE 705
Cdd:COG0209 621 LNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
126-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 618.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 126 FEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 205
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 206 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 285
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 286 LSLGVVIPDITFRLAKenaqmalfspydiqrrygkpfgdiaiserydeliadphvrktyinaRDFFQTLAEIQFESGYPY 365
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 366 IMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRyddnldyTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLT 443
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 444 AVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagf 523
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 524 aqsryasgdyftqylqddwqpktakvralfarsgitlptremwlklrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 603
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 604 PIVAKIEIRKEGKtGRVYYPAPFMTNEN--LDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 681
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
1PEM_A 682 YAWRKGIKSLYYIR 695
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 589.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPY---DIQRRYGKPFgdiaiSERYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 333 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRYddnldythig 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 411 hdISCNLGSLNIAHVMDSP------DIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 485 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASG-DYFTQYLQDDWQPKTAKvralfarsgitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 564 EMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKtgrvyypapfmtNENLDMYQDAYDIGP 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
1PEM_A 644 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
53-713 |
2.55e-108 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 346.33 E-value: 2.55e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 53 SVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTM 132
Cdd:PRK09209 109 SEKYGSFVGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLT 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 133 VALTLAQGD-ETLATQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 207
Cdd:PRK09209 188 IALYLMQNEpRERRMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 208 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 287
Cdd:PRK09209 267 GAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVF 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 288 LGVVIPDITFRLAKENAQMALFSPYDIQRR--------YGKPFGDIAISERYDELIADPHVRKTYINARDFFQTLAEIQF 359
Cdd:PRK09209 347 TGVCIPDLFMEAVERRGDWYLFDPHEVKKVmgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 360 ESGYPYIMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRY------DDNLDYTHIGHD-ISCNLGSLNIAHVMDSPD 430
Cdd:PRK09209 427 ETGNPFMFYRDEVNRMNPnkHEGMIYSSNLCTEIMQNMSPTVMiqeiisGGQIVITKQPGDfVVCNLSSINLGRAVTADV 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 431 IGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSM 510
Cdd:PRK09209 507 LERLIPIQVRMLDNVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASM 585
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 511 RLARERGkTFAGFAQSRYASGDYftqylqddwqpktakvralFARSGItlpTREMWLKLRDDVMRYGIYNQNLQAVPPTG 590
Cdd:PRK09209 586 ELAKEKG-AYPVFKGSDWQTGEY-------------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNM 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 591 SISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNENLDMYQD-AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPD 669
Cdd:PRK09209 643 STAQIAGSTASIDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPS 721
|
650 660 670 680
....*....|....*....|....*....|....*....|....
1PEM_A 670 TATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 713
Cdd:PRK09209 722 TIRASELLDLHMTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
15-714 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1371.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 15 DYHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVRPHSVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHA 94
Cdd:TIGR04170 1 DYHALNNELNLYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 95 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGE 174
Cdd:TIGR04170 81 SKFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254
Cdd:TIGR04170 161 LVSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFGDIAISERYDEL 334
Cdd:TIGR04170 241 GAVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 335 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHDIS 414
Cdd:TIGR04170 321 VANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDIS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 415 CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 494
Cdd:TIGR04170 401 CNLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 495 NLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFarSGITLPTREMWLKLRDDVM 574
Cdd:TIGR04170 481 NIYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELF--EGIHIPTREDWAELKDDVM 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 575 RYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEAT 654
Cdd:TIGR04170 559 EYGLYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATAT 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 655 RHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL 714
Cdd:TIGR04170 639 QHVDQGLSLTLFFKDTATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
67-705 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 752.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 67 VREGYYDDAVLarydRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLAQGD----- 141
Cdd:COG0209 20 VEEGLYDERLL----EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDGK-PLETPQDLFMRVAMGLAAAEkpedr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 142 ETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPI 221
Cdd:COG0209 95 EEWAKEFYDLLSSLRFLPATPTLFNAGTP-RGQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 222 KRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAK 301
Cdd:COG0209 174 KGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVE 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 302 ENAQMALFSPYDIQRRYGKPFGDiaISERYDELIADPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--A 379
Cdd:COG0209 254 EDEDWTLFSPREVPDLYGLYGEE--FEEAYEEYEADGRVYKT-IKARELWRKILESAWETGEPGILFKDTINRRNPLphL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 380 GRINMSNLCSEILQVNSASryddnldythigHDISCNLGSLNIAHVM-----DSPDIGRTVETAIRGLTAVSDMSHIrSV 454
Cdd:COG0209 331 GVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVkdgefDWEKLEETVRTAVRFLDNVIDINDY-PV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 455 PSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYF 534
Cdd:COG0209 398 PEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFPAFEGSKYAKGILP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 535 TQYLQDDWqpktakvralfarsgiTLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKE 614
Cdd:COG0209 477 FDKYLDDL----------------LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKV 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 615 GKTGRVYYPAPFM------------------------------TNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 664
Cdd:COG0209 541 LDGGEFTVVNPYLvralkelglwdeelvekikedgsvqdidelPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKT 620
|
650 660 670 680
....*....|....*....|....*....|....*....|.
1PEM_A 665 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTE 705
Cdd:COG0209 621 LNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLS 661
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
126-695 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 618.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 126 FEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGG 205
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTP-RGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 206 GVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKT 285
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 286 LSLGVVIPDITFRLAKenaqmalfspydiqrrygkpfgdiaiserydeliadphvrktyinaRDFFQTLAEIQFESGYPY 365
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 366 IMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRyddnldyTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLT 443
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPSE-------DEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 444 AVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagf 523
Cdd:cd01679 267 NVIDLNYY-PVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 524 aqsryasgdyftqylqddwqpktakvralfarsgitlptremwlklrddvmryGIYNQNLQAVPPTGSISYINHATSSIH 603
Cdd:cd01679 340 -----------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIE 366
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 604 PIVAKIEIRKEGKtGRVYYPAPFMTNEN--LDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 681
Cdd:cd01679 367 PITSNIYVRRVLS-GEFPVVNPHLEKDLweYGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPATTRDLNSLYF 445
|
570
....*....|....
1PEM_A 682 YAWRKGIKSLYYIR 695
Cdd:cd01679 446 YAWKKGLKTLYYLR 459
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
176-694 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 589.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPY---DIQRRYGKPFgdiaiSERYD 332
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEF-----EKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 333 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRYddnldythig 410
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKhlGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 411 hdISCNLGSLNIAHVMDSP------DIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 485 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASG-DYFTQYLQDDWQPKTAKvralfarsgitlpTR 563
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-------------TR 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 564 EMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKtgrvyypapfmtNENLDMYQDAYDIGP 643
Cdd:pfam02867 369 EDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
1PEM_A 644 EKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYI 694
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
102-697 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 549.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 102 FLGAWKFYTSYTLKTFDGKR---YLEHFEDRVTMVALTLAQGDETLA-TQLTDEMLSG-RFQPATPTFLNCGKQqRGELV 176
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAiyeSPQEAYMRVAMGLASLEPKDTRLAdAIRFYDLLSRlKISPATPTLFNAGTP-RGQLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 177 SCFLLRI-EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:TIGR02506 80 SCFLLDVtDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFgdIAISERYDELI 335
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYG--EEFEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 336 ADPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA---GRINMSNLCSEILQVNSASryddnldytHIG 410
Cdd:TIGR02506 238 KDVEARKKIrkVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTDDS---------HKG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 411 HDISCNLGSLNIA-HVMDS----PDIGRTVETAIRGLTAVSDMSHIRSVPSiAAGNAASHAIGLGQMNLHGYLAREGIAY 485
Cdd:TIGR02506 309 ETAVCNLASVNLAnFVMEDkfdfSELEDAVRIAVRFLDNVIDLQNYPTAPA-AKSNQRRRSIGIGVMGLHDVLAKLGLPY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 486 GSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVralfarsgitlPTREM 565
Cdd:TIGR02506 388 DSEEARDLNDRIFEAIYYYAIKASAELAKEKG-PFPGFSGSKYAKGWLHPDTWEKTIDPKTSMA-----------PTEED 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 566 WLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGK----------------------------T 617
Cdd:TIGR02506 456 WEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSgeflipnkylmkeleelglwdadrrgdiV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 618 GRVYYPAPFMT--NENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIR 695
Cdd:TIGR02506 536 ENVGSPQPIAAipETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEEVTAKDLLKLLLLAWKKGLKTMYYCR 615
|
..
1PEM_A 696 LR 697
Cdd:TIGR02506 616 SR 617
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
53-713 |
2.55e-108 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 346.33 E-value: 2.55e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 53 SVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTM 132
Cdd:PRK09209 109 SEKYGSFVGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLT 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 133 VALTLAQGD-ETLATQLTDE---MLSGRFQP-ATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGV 207
Cdd:PRK09209 188 IALYLMQNEpRERRMQLVKEaywALSNLYMTvATPTLANAGKVG-GQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 208 AFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLS 287
Cdd:PRK09209 267 GAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVF 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 288 LGVVIPDITFRLAKENAQMALFSPYDIQRR--------YGKPFGDIAISERYDELIADPHVRKTYINARDFFQTLAEIQF 359
Cdd:PRK09209 347 TGVCIPDLFMEAVERRGDWYLFDPHEVKKVmgwyledfYDEKKGDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 360 ESGYPYIMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRY------DDNLDYTHIGHD-ISCNLGSLNIAHVMDSPD 430
Cdd:PRK09209 427 ETGNPFMFYRDEVNRMNPnkHEGMIYSSNLCTEIMQNMSPTVMiqeiisGGQIVITKQPGDfVVCNLSSINLGRAVTADV 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 431 IGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSM 510
Cdd:PRK09209 507 LERLIPIQVRMLDNVIDLNQL-PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASM 585
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 511 RLARERGkTFAGFAQSRYASGDYftqylqddwqpktakvralFARSGItlpTREMWLKLRDDVMRYGIYNQNLQAVPPTG 590
Cdd:PRK09209 586 ELAKEKG-AYPVFKGSDWQTGEY-------------------FERRGY---NSPQWDELAAQVAENGVRNAYLMAVAPNM 642
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 591 SISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNENLDMYQD-AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPD 669
Cdd:PRK09209 643 STAQIAGSTASIDPIYSAFYY-EEKKDYRRPVTAPDLSLDTWPYYEKgAYKVDQFWSIRQNAARQRHVDQSISFNFYVPS 721
|
650 660 670 680
....*....|....*....|....*....|....*....|....
1PEM_A 670 TATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 713
Cdd:PRK09209 722 TIRASELLDLHMTAWKEGLKTTYYVRSTDI-----DIEECEWCS 760
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
66-713 |
5.65e-96 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 313.67 E-value: 5.65e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 66 LVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFQTFLGAWKFYTSYTLKTFDGKrYLEHFEDRVTMVALTLA--QGDET 143
Cdd:PRK07088 124 LVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYEGLKLLADRYLVKGFNRE-ILELPQERFMGIAMHLAipEGKEK 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 144 ---LATQLTDEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAP 220
Cdd:PRK07088 203 rvyYAKKFYDLLSELKATVATPTLSNAGTPFY-QLSSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSE 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 221 IKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLA 300
Cdd:PRK07088 282 IRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 301 KENAQMALFSPYDIQRRYGKP----FGDIAISE---RYDELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVN 373
Cdd:PRK07088 362 EKRENWSLFDPHEIKKVKGYSledyYDEEDRKEftkKYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVN 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 374 RANP--IAGRINMSNLCSEILQVNSASRY------DDNLDYTHI-----GHDISCNLGSLNIAHVmDSPDIGRTVETAIR 440
Cdd:PRK07088 442 KANPnkHKGMIYSSNLCHEIAQNMSESELleeeiiDENGYYEVVqkikaGDMVTCNLNSIVLGNV-DDEELEEVIPTQIR 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 441 GLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKtF 520
Cdd:PRK07088 521 MLDNVISLNYY-PVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGS-Y 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 521 AGFAQSRYASGDYFTqylqddwqpktakvralfaRSGItlpTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATS 600
Cdd:PRK07088 599 PAFKGSEWETGKYFE-------------------RRGY---NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTA 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 601 SIHPIVAK--IEIRKEGKTGRVyypAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINK 678
Cdd:PRK07088 657 GIDPVFKRffMEEKKGSFTPKT---APDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYITPEYKAKQILN 733
|
650 660 670
....*....|....*....|....*....|....*
1PEM_A 679 AQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 713
Cdd:PRK07088 734 LYIEAWKQGVKTIYYVRNKSL-----EMDECTSCS 763
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
60-713 |
1.50e-89 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 298.20 E-value: 1.50e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 60 HERLGTLVREGYYDDAVLARYDRAfvlrlfEHAHASGF------RFQTFLGAWKFYTSYTLKTFDGkRYLEHFEDRVTMV 133
Cdd:PRK12364 196 YDKIKYLTEEGLYGSYILEHYSRE------EIEEAAGFidperdKLFTYSGLDLLLKRYVIRTHSH-EPLESPQEMFLGI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 134 ALTLA--QGDETL--ATQLTDeMLSG-RFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVA 208
Cdd:PRK12364 269 ALHLAmpEKQDRMgwVKRFYD-MLSKlKVTMATPTLSNARKPFH-QLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMG 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 209 FLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSL 288
Cdd:PRK12364 347 LYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFP 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 289 GVVIPDITFRLAKE--NAQMALFSPYDIQRRYGKPFGDIAISE---RYDELIADPHVRKTYINARDFFQTLAEIQFESGY 363
Cdd:PRK12364 427 AVCYPDLFWKMVRDdiNQSWYLFCPHEILTVKGYALEDYYGEEwekRYLDCVNDARISKRSIPIKDLVRLILKSAVETGT 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 364 PYIMFEDTVNRANPIA--GRINMSNLCSEILQVNSASRY------DDNLD-----YTHIGHDISCNLGSLNIAH--VMDS 428
Cdd:PRK12364 507 PFTFNRDTVNRANPNKhkGMIYCSNLCTEIAQNMSAIETvsteieTEDGDtvvvtTTRPGDFVVCNLASLSLGNidLEDE 586
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 429 PDIGRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHT 508
Cdd:PRK12364 587 EELEEVVRTVVRALDNVIDLNFY-PVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKA 665
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 509 SMRLARERGKtFAGFAQSRYASGDYFTQ--YLQDDWQpktakvralfarsgitlptremwlKLRDDVMRYGIYNQNLQAV 586
Cdd:PRK12364 666 SMEIAKEKGA-YGYFEGSDWQTGAYFRKrgYTSEEWQ------------------------RLAREVAENGMRNAYLLAV 720
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 587 PPTGSISYINHATSSIHPIVAK--IEIRKEGKTGRVyypAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLT 664
Cdd:PRK12364 721 APTSSTSIIAGTTAGVDPVMKRyfLEEKKGALMPRV---APELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVN 797
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
1PEM_A 665 LFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLalegtEIEGCVSCA 713
Cdd:PRK12364 798 LYITNEFTMRQVLDLYLLAWEEGVKTIYYVRSKSL-----EVEECESCS 841
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
115-712 |
6.41e-80 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 266.44 E-value: 6.41e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 115 KTFDGKRYL---EHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIG 191
Cdd:PRK09102 26 KATLRDRYLlegESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTD-RGLPISCFLNYVEDSLEGIV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 192 RAVNSALQLSKRGGGVAFLLSNLREAGAPIKRiENQSSGVIP---VMKMLEDAFSyanQLGARQGAGAVYLHAHHPDILR 268
Cdd:PRK09102 105 NTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPfikVMDSLTLAIS---QGSLRRGSFAVYLDIEHPEIEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 269 FLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYdiqrrygkpfgdiaiserydeliaDPHVRKTyINAR 348
Cdd:PRK09102 181 FLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPK------------------------DKSVIRT-VKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 349 DFFQTLAEIQFESGYPYIMFEDTVNRANP----IAG-RINMSNLCSEILQVnsaSRYDdnldytHIGHDIS--CNLGSLN 421
Cdd:PRK09102 236 DLWAKILETRIETGEPYLLFIDNVNRALPevykDLGlKVKASNLCSEITLP---TGID------HLGEDRTavCCLSSLN 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 422 IAHVMDSPDIGRTVETAIRGLTAVsdMSH-IRSVPSI--AAGNAASH--AIGLGQMNLHGYLAREGIAYGSPEALDFTNL 496
Cdd:PRK09102 307 LEYYDEWKDTDAFIEDLMRFLDNV--LQDfIDKAPDEmeRAKYSAMRerSVGLGVMGFHSYLQSKMIPFESVMAKQWNKK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 497 YFYTITWHAVHTSMRLARERGktfagfaqsryasgdyftqylqddwQPKTAKVRALFARsgitlptremwlklrddvmry 576
Cdd:PRK09102 385 IFKHIREQADKASKELAKEKG-------------------------ECPDAAGYGVMRR--------------------- 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 577 giyNQNLQAVPPTGSISYINHATS-SIHPIVAKIEIRKeGKTGRVYYPAP------------------------------ 625
Cdd:PRK09102 419 ---FSTKMAIAPTASISIILGNTSpGIEPIAANYYTHK-TLKGSFTVKNKyleklleekgkdtdevwssiltnegsvqhl 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 626 -FMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLYYIR--------- 695
Cdd:PRK09102 495 dFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLPANVPKRDLNKLHFEAWKKGVKSLYYQRsksvqradk 574
|
650 660
....*....|....*....|....*.
1PEM_A 696 ---------LRQLALEGTEIEGCVSC 712
Cdd:PRK09102 575 vshdvlkkrLVEKSAFNRDYDECLAC 600
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
148-691 |
4.56e-79 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 260.24 E-value: 4.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 148 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIED-NMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIEN 226
Cdd:cd02888 4 FFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDdSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 227 QSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKiRIKTLSLGVVIPDITFRLAKENAQM 306
Cdd:cd02888 84 VASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTDAFMEAVENDEPW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 307 ALfspydIQRRYGKPfgdiaiserydeliadPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINM 384
Cdd:cd02888 163 EL-----RNPREPDT----------------GKVYRT-VPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPglGRINA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 385 SNLCSEILQvnsasryddnLDYThighdiSCNLGSLNIA---------HVMDSPDIGRTVETAIRGLTAVSDMSHIrSVP 455
Cdd:cd02888 221 TNPCGEQPL----------LPYE------SCNLGSINLSkfvknpfggASFDFERLREAVRLAVRFLDNVIDVNRY-PLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 456 SIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFT 535
Cdd:cd02888 284 EIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERG-PFPLFDASRYLMLKVIV 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 536 QylqddwqpktakvralfarsgitlpTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIvakieirkeg 615
Cdd:cd02888 363 N-------------------------AKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI---------- 407
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PEM_A 616 ktgrvyypapfmtnenldmyqdaydIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSL 691
Cdd:cd02888 408 -------------------------FSPEDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKGI 458
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-712 |
7.41e-78 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 265.44 E-value: 7.41e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 101 TFLGAWKFYTSYTLKTFDGKRyLEHFEDRVTMVALTLAQGD---ETLATQLTDeMLSgRFQP--ATPTFLNcGKQQRGEL 175
Cdd:PRK08447 138 NYLGIKTLYDRYLIKDRNNNP-IELPQHMFMAIAMFLAQNEldpQKWAKKFYD-VIS-KFEVmlATPTLSN-ARTTRHQL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:PRK08447 214 SSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAI 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQ---RRYGKPFgdiaiSERYD 332
Cdd:PRK08447 294 AVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKdltELYGEEF-----EKRYL 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 333 ELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVN--------------S 396
Cdd:PRK08447 369 EYEKDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAhaGIIRSSNLCTEIFQNTapnhykikiefedgS 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 397 ASRYDDNLD------YTHIGHDIS------------------------CNLGSLNIAHVMDSPDIGRTVETAIRGLTAVS 446
Cdd:PRK08447 449 IEFFEEEELvtvdsgITKKAKKITsldslkgkkiyivekekkdgktavCNLASINLSKINTKEDIERVVPIAIRMLDNVI 528
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 447 DMSH--IRSVpsiAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKtFAGFA 524
Cdd:PRK08447 529 DLNFypNRKV---KATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGV-YPDFE 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 525 QSRYASGdyftqYLQDDWQPKTAKvrALFARSGItLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP 604
Cdd:PRK08447 605 GSNWSKG-----IFPIDKANEEAK--KLVERGGL-FDSACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 605 iVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFP-DTATTRDINKAQIYA 683
Cdd:PRK08447 677 -VYKRKWFEENLSGLIPVVVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKASGKYLNEIYTLA 755
|
650 660 670
....*....|....*....|....*....|....
1PEM_A 684 WRKGIKSLYYIR-----LRQLALEGTEIEgCVSC 712
Cdd:PRK08447 756 WKLGLKSTYYLRsespeSEEVSVADRSIE-CEGC 788
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
112-689 |
4.61e-75 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 253.01 E-value: 4.61e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 112 YTLKTFDGkRYLEHFEDRVTMVALTLAQGD--------ETLATQLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRI 183
Cdd:TIGR02504 6 YLLKDEDG-NIIESPEDLFRRVARALAAAEdkynspvwKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFVLPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 184 EDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHH 263
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 264 PDILRFLDTKRENadEKIRIKTLSLGVvipDITFRLAKENAqmalfSPYDIQRRYGKPFGDiaiserydeliadphvrkt 343
Cdd:TIGR02504 165 PDIEEFIEAKAKE--GKLQNFNISVGV---TDEFMEAVEND-----EEYELRNPRTGEYKE------------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 344 yINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQvnsasryddnLDYThighdiSCNLGSLN 421
Cdd:TIGR02504 216 -VDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPygGRINATNPCGEQPL----------LPYE------SCNLGSIN 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 422 IAHVMDSP-------DI---GRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEAL 491
Cdd:TIGR02504 279 LAKFVKNDfgdeasfDFerlREVVRLATRFLDNVIDINVF-PLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEAR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 492 DFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFTQYLQDDwqpktakvralfarsgitLPTremwlKLRD 571
Cdd:TIGR02504 358 ELAEEVMEFIADAAYRASAELAKERG-AFPLYDASKYPMGRAMGARIPSA------------------LPA-----EIRE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 572 DVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTG---------------RVYYPAPFMT-NENLDMY 635
Cdd:TIGR02504 414 AIRKYGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGellevnplvelalreLGYYSDEIVKyVDEKGTV 493
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
1PEM_A 636 QD-------------AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK 689
Cdd:TIGR02504 494 EGapgpeelpkvfvtAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVEDVKAVYLEAWKLGLK 560
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
101-707 |
1.23e-70 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 249.48 E-value: 1.23e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 101 TFLGAWKFYTSYtLKTFDGKRyLEH---FEDRVTMvALTLAQGDETLATQLT--DEMLSGRFQPATPTFLNCGkQQRGEL 175
Cdd:PRK12365 379 SYMGVQNLYDRY-FNHHEGRR-LETpqiFWMRVSM-GLALNEGQDKTSWAITfyNLLSTFRYTPATPTLFNSG-MRHSQL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 176 VSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAG 255
Cdd:PRK12365 455 SSCYLSTVQDDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAV 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 256 AVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDI---QRRYGKPFGdiAISERYD 332
Cdd:PRK12365 535 CVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVpglHEAYGEEFE--KLYEEYE 612
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 333 ELIADPHVR-KTYINARDFFQTLAEIQFESGYPYIMFEDTVN--RANPIAGRINMSNLCSEILQVNSASRyddnldyTHI 409
Cdd:PRK12365 613 RKVDTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNirSAQDHKGVVRCSNLCTEILLNCSETE-------TAV 685
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 410 ghdisCNLGSLN-IAHV----MDSPDIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIA 484
Cdd:PRK12365 686 -----CNLGSINlVEHIvndgLDEEKLSETISIAIRILDNVIDIN-FYPTKEAKEANLAHRAIGLGVMGFQDALYKLNIS 759
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 485 YGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGdyftqYLQDDWQPKTAKVRalfARSGITLPT-- 562
Cdd:PRK12365 760 YASQEAVEFADYSSELIAYYAILASSLLAKERG-TYSSYKGSKWDRG-----YLPIDTIELLKEYR---GEANLLMDTss 830
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 563 REMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPFMTNE-------NLDMY 635
Cdd:PRK12365 831 RKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFV-KSNLSGEFTIPNVYLIEKlkklgiwDADML 909
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 636 QD------------------------AYDIGPEKIIDTYAEATRHVDQGLSLTLFF--PDtatTRDINKAQIYAWRKGIK 689
Cdd:PRK12365 910 DDlkyfdgslleieripdhlkkifltAFEIEPEWIIECASRRQKWIDMGQSLNLYLaePD---GKKLSNMYLTAWKKGLK 986
|
650
....*....|....*...
1PEM_A 690 SLYYIRlrqlALEGTEIE 707
Cdd:PRK12365 987 TTYYLR----SSAATSVE 1000
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
67-714 |
8.70e-61 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 217.66 E-value: 8.70e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 67 VREGYYDDAVLARYDRAFVLRLFEHA-HASGFRFqTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQgDETLA 145
Cdd:PHA02572 108 VNEGKYDPEILSKYSAEEITYLESFIdHDRDFEF-TYAGAMQLKEKYLVQDRSTGEIYETPQFAYMLIAMALHQ-DEPKE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 146 TQLT------DEMLSGRFQPATPTFLNCGKQQRgELVSCFLLRIEDNMESIGRAVNSALQ-LSKRGGgVAFLLSNLREAG 218
Cdd:PHA02572 186 DRLEhvirfyNAVSTRKISLPTPIMAGVRTPTR-QFSSCVVIESGDSLDSINKTAMAIVKyISKRAG-IGINAGMIRAEG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 219 APIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFR 298
Cdd:PHA02572 264 SKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYE 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 299 LAKENAQMALFSPYDIQRR-YGKPFGDI-AISERYDELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRAN 376
Cdd:PHA02572 344 RFIKNDYITLFSPHDVGGElYDAYFADQdRFRELYEALEKDPSVRKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHS 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 377 PIAGRINMSNLCSEI-LQVNSASRYDDNldythiGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMshiRSVP 455
Cdd:PHA02572 424 PFKDPIRQSNLCCEIaLPTKPLNHIDGE------GEIALCTLSAIVLGNFEDQDEIEELAEVAVRALDNLLDY---QDYP 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 456 SIAAGNA-ASHAIGLGQMNLHGYLAREGIAYGSPEAlDFTNLYFYTITWHAVHTSMRLARERGKTfAGFAQSRYASGDyf 534
Cdd:PHA02572 495 VPAALKAkKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEKGAC-EYFSDTKYSRGE-- 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 535 tqyLQDDWQPKTAKVralfarsgITLPTREM-WLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIrK 613
Cdd:PHA02572 571 ---LPIDWYKKKVDE--------LVAPKYNCdWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSI-K 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 614 EGKTGRVYYPAPfMTNENLDMYQDAYDI---GPEKIIDTYAEATRHVDQGLSL-TLFFPDTATTRDINKAQI-----YAW 684
Cdd:PHA02572 639 KSKEGPFNQVVP-NVETLKDLYDLLWDLakkGNKGYLTQVAIMQKFVDQAISAnTSYDPENYPNGKVPMSVMlddllYFY 717
|
650 660 670
....*....|....*....|....*....|....*.
1PEM_A 685 RKGIKSLYYIRLR------QLALEGTEIEGCVSCAL 714
Cdd:PHA02572 718 YYGGKTLYYHNTRdgkgteDYEIETPKAEDCDSCKL 753
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
49-697 |
1.28e-55 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 204.00 E-value: 1.28e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 49 VRPHSVTFASQHERLgtlVREGYYDDAVLARYDRAFVLRLFEHAHASGFRFqtfLGAWKFYTSYTLKTFDGKRyLE---H 125
Cdd:PRK06539 103 QDLHANHFRRTIEKG---VAEGLLDSRLGGLFDLERLAAALDPTRDELLKY---IGVVTLNNRYGIRARNGDA-LEvpqY 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 126 FEDRVTMvALTLAQGDET-LATQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRG 204
Cdd:PRK06539 176 FWMRIAM-GLSLNEDDPTsSALAFYEKMSKLEYLAAGSTLVNAGTPY-PQLSNCFVMEMQDDIEHIAKTTRDVMWLTKGT 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 205 GGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIK 284
Cdd:PRK06539 254 GGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTR 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 285 TLSLGVVIPDITFRLAKENAQMALFSPY---DIQRRYGKPFgdiaiSERYDELIADPHVRK----TYINARDFFQT-LAE 356
Cdd:PRK06539 334 TANTAVWISDEFMKRVQNDEDWYLFDPLetpDLNELYGKAF-----SKRYAQYVEQAEAGRirmfKRITAREQFRAiLMS 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 357 IQFESgYPYIMFEDTVN-RA-NPIAGRINMSNLCSEIlqvnSASRYDDNLDYthighdisCNLGSLNIA-HV----MDSP 429
Cdd:PRK06539 409 LQTTS-HPWLTWKDTINnRAlNNNTGTIHLSNLCTEI----CLPQDRDNVSV--------CNLASINLSrHLadgeLDWA 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 430 DIGRTVETAIRGLTAVSDMShIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTS 509
Cdd:PRK06539 476 QLEESTRLAVRQLDNLIDIT-ASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDES 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 510 MRLARERGkTFAGFAQSRYASG----DYFTQYLQDDWQPKTakvralfarsgITLPTREMWLKLRDDVmRYGIYNQNLQA 585
Cdd:PRK06539 555 ADLAAERG-AYPNFEGSRWSRGmvpvDSIALLEADRGVPVD-----------VNRTTRLDWDALRAKV-RGGMRNATLMA 621
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 586 VPPTGSISYINHATSSIHP---------------------IVAKIE------------IRKEGKTGRV-YYPAPFMTNen 631
Cdd:PRK06539 622 IAPTASIGLVAGTTPGLDPqfsqifsrstssgkflevnrnLVADLKelglwetvreeiLRSQGDIQEIaAIPDEIKAL-- 699
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
1PEM_A 632 ldmYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFpdtaTTRDI-NKAQIY--AWRKGIKSLYYIRLR 697
Cdd:PRK06539 700 ---YRTSFQLSPYAFLEVAARAQKWVDQAISRNMYL----ESRDIgDMMDIYtaAWEMGVKTTYYLHMK 761
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
120-689 |
2.23e-50 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 188.22 E-value: 2.23e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 120 KRYL------EHFEDRVTM---VALTLAQGD---------ETLATQLTDEMLSGRFQPATPTFLNCGKQQrGELVSCFLL 181
Cdd:PRK08665 22 KRYLkkdedgKPIETPEDMfrrVARTIAAAEliydskadvEALADRFYDLMTSLEFLPNSPTLMNAGREL-GQLSACFVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 182 RIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHA 261
Cdd:PRK08665 101 PVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 262 HHPDILRFLDTKRENADekirIKTLSLGVVIPDITFRLAKENAQMALFSPydiqrRYGKPFGDiaiserydeliadphvr 341
Cdd:PRK08665 181 DHPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINP-----RTGEVVGR----------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 342 ktyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSE--ILQvnsasrYDdnldythighdiSCNL 417
Cdd:PRK08665 235 ---LNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPhlGEIESTNPCGEqpLLP------YE------------SCNL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 418 GSLNIAHVMDSPDI-----GRTVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALD 492
Cdd:PRK08665 294 GSINLSKMVKNGDVdweklREVVHLAVRFLDNVIDANKY-PLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVE 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 493 FTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYAsgdyftqylqddwQPKTAKVRalfarsgitlptremwlklrdd 572
Cdd:PRK08665 373 LAEKVMKFIQDEAHAASRELAEERG-PFPNYEGSIYD-------------KDGLGPMR---------------------- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 573 vmrygiyNQNLQAVPPTGSISYINHATSSIHPIVA------------KIEI--------RKEG-----------KTGRV- 620
Cdd:PRK08665 417 -------NATVTTIAPTGTISIIAGCSSGIEPLFAlsftrnvmdgerLVEVnpvfeaaaKEEGfyseelmekiaEKGSIq 489
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PEM_A 621 ---YYPAP----FMTnenldmyqdAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIK 689
Cdd:PRK08665 490 didEVPEDvrrvFVT---------AHDISPEWHVRMQAAFQKHTDNAVSKTVNFPNEATIEDVREVYRLAYELGCK 556
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
74-705 |
8.61e-48 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 182.08 E-value: 8.61e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 74 DAVLARYDRAfvlRLFEHAHAS-GFRFqTFLGAWKFYTSYTLKTfDGKRYL--EHFEDRVTMvALTLAQGD-ETLATQLT 149
Cdd:PRK07207 273 DPKLAQFDLE---RLGAALDPErDLQF-TYLGLQTLYDRYFLHV-DGTRIElpQAFFMRVAM-GLALNEIDrEARAIEFY 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 150 DEMLSGRFQPATPTFLNCGKQqRGELVSCFLLRIEDNMESIGRAV-NSALqLSKRGGGVAFLLSNLREAGAPIKRIENQS 228
Cdd:PRK07207 347 NLLSSFDFMSSTPTLFNSGTL-RPQLSSCYLTTVPDDLDGIYEAIkDNAL-LSKFAGGLGNDWTPVRALGSHIKGTNGKS 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 229 SGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMAL 308
Cdd:PRK07207 425 QGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTL 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 309 FSPY---DIQRRYGKPFGdiAISERYDELIADPHVR--KTyINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI--AGR 381
Cdd:PRK07207 505 FSPSevpDLHDLFGKAFE--EAYTAYEAKAARGEIKlfKK-IPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQqhVGV 581
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 382 INMSNLCSEI-LQVNsasryDDnldythighDIS-CNLGSLNI-AHVMDSPDI-----GRTVETAIRGLTAVSDMSHIrS 453
Cdd:PRK07207 582 VHSSNLCTEItLNTS-----DD---------EIAvCNLGSVNLvAHIKDGAKLdheklKRTVSTAMRMLDNVIDINYY-A 646
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 454 VPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGktfagfaqsRYAS--G 531
Cdd:PRK07207 647 VPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERG---------RYSSyeG 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 532 DYFTQ-YLQDDWQPKTAKVRALFARsgITLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP------ 604
Cdd:PRK07207 718 SLWSRgILPIDSLKLLAEARGGYLE--VDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPtyqnly 795
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 605 ----------IVAKIEIR--KE-------------------GKTGRVyyPApfmtnENLDMYQDAYDIGPEKIIDTYAEA 653
Cdd:PRK07207 796 vksnlsgeftVVNPYLVRdlKArglwdevmvndlkyfdgslQRIDRI--PA-----DLKALYATAFEVDPRWLVEAASRR 868
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
1PEM_A 654 TRHVDQGLSLTLFFpDTATTRDINkaQIY--AWRKGIKSLYYirLRQLALEGTE 705
Cdd:PRK07207 869 QKWIDQAQSLNLYM-AGASGKKLD--ETYklAWLRGLKTTYY--LRTLGATHVE 917
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
111-700 |
1.13e-44 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 171.85 E-value: 1.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 111 SYTLKTfDGKrYLEHFEDRVTMVALTLAQGDETLATQlTDEMLSGR-FQPATPTFLNCGKQqRGELVSCFLLRI-EDNME 188
Cdd:PLN02437 154 SYLLKV-NGK-VVERPQHMLMRVSVGIHKDDIESAIK-TYHLMSQRwFTHASPTLFNAGTP-RPQLSSCFLICMkDDSIE 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 189 SIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGA-RQGAGAVYLHAHHPDIL 267
Cdd:PLN02437 230 GIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGkRKGAFAIYLEPWHADIF 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 268 RFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYD---IQRRYGKPFGdiAISERYDEliaDPHVRKTy 344
Cdd:PLN02437 310 EFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEapgLADCWGEEFE--RLYTKYER---EGKAKKV- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 345 INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMSNLCSEILQVNS-------------------------- 396
Cdd:PLN02437 384 VQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQnlGTIKSSNLCTEIIEYTSptetavcnlasialprfvrekgvple 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 397 ------------ASRYDDNLDYTHIGHDISCNLGslNIAHVMDSPdigrtVETAIRgltavSDMSHirsvpsiaagnaas 464
Cdd:PLN02437 464 shpsklvgslgsKNRYFDFEKLAEVTAVVTRNLN--KIIDVNYYP-----VETARR-----SNMRH-------------- 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 465 HAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERG--KTFAGFAQSRYAsgdyftqyLQDD- 541
Cdd:PLN02437 518 RPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGpyETYAGSPVSKGI--------LQPDm 589
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 542 WqpktakvralfarsGITLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKeGKTGRVY 621
Cdd:PLN02437 590 W--------------GVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRR-VLSGEFV 654
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 622 YPAPFMTNENLDM-------------------------------YQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDt 670
Cdd:PLN02437 655 VVNKHLLHDLTEMglwtptlknkiiaengsvqkipeipddlkaiYKTVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQ- 733
|
650 660 670
....*....|....*....|....*....|.
1PEM_A 671 ATTRDINKAQIYAWRKGIKS-LYYIRLRQLA 700
Cdd:PLN02437 734 PNFGKLTSLHFYAWSKGLKTgMYYLRSRAAA 764
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
150-688 |
4.95e-42 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 163.87 E-value: 4.95e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 150 DEMLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSS 229
Cdd:PRK06406 225 EVMSNLKFVPNSPTLMNAGTKL-GQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVAS 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 230 GVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKreNADEKIrIKTLSLGVVIPDitfrlakenaqmalf 309
Cdd:PRK06406 304 GPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK--DSENKV-LSNFNISVAVTD--------------- 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 310 spydiqrrygkPFGDIAISERYDELIaDPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIA--GRINMS 385
Cdd:PRK06406 366 -----------EFFDKLDNDDYYPLR-NPRNGKEVkrIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKnlGEIEST 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 386 NLCSEilqvnsasryDDNLDYThighdiSCNLGSLNIAHV-----MDSPDIGRTVETAIRGLTAVSDMSHIrSVPSIAAG 460
Cdd:PRK06406 434 NPCGE----------QPLLPYE------SCNLGSINLSKFvengkIDWDRLRETVHIATRFLDNVIDANKF-PVPQIKEM 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 461 NAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSryasgdyftqylqd 540
Cdd:PRK06406 497 TRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERG-VFPAWYGS-------------- 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 541 DWQPKTAKVRalfarsgitlptremwlklrddvmrygiyNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRK------- 613
Cdd:PRK06406 562 EWEKKGIKMR-----------------------------NSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHvlngqel 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 614 -------EGKTGRV-YYPAPFMTN-------ENLDMYQD-------AYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTA 671
Cdd:PRK06406 613 levnplfEEITRKRgLYSEELMRKvaetgnlQNIDVPEDikrifvtAHEIDPQWHVLMQATFQRYCDSGVSKTINLRYDA 692
|
570 580
....*....|....*....|
1PEM_A 672 TTRDINKAQIYAWR---KGI 688
Cdd:PRK06406 693 TPEDIAKAYRLAKDlhcKGI 712
|
|
| RNR_N |
pfam08343 |
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ... |
16-97 |
3.21e-33 |
|
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyze the formation of deoxyribonucleotides. It occurs together with the RNR all-alpha domain (pfam00317) and the RNR barrel domain (pfam02867).
Pssm-ID: 429933 Cd Length: 82 Bit Score: 122.18 E-value: 3.21e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 16 YHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVRPHSVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHAS 95
Cdd:pfam08343 1 YIALNNELNLYDENGKIQFDKDKEALEAYFKEHVNPNTVFFHSLKEKLDYLVENDYYEEEFLNKYSFEFIEELYKYAYSY 80
|
..
1PEM_A 96 GF 97
Cdd:pfam08343 81 KF 82
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
177-693 |
1.50e-29 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 125.10 E-value: 1.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 177 SCFLLRIEDNMESIGrAVNSAL--QLSKRGG-GVAFllSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQG 253
Cdd:PRK09103 221 SCVLIECGDSLDSIN-ATSSAIvkYVSQRAGiGINA--GRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 254 AGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITF-RLAKeNAQMALFSPYDIQRRYGKPFGDIAISER-Y 331
Cdd:PRK09103 298 AATLFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYqRLIK-GGDITLFSPSDVPGLYDAFFADQDEFERlY 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 332 DELIADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRA---NPIAGRINMSNLCSEI-LQVNSASRYDDnldyt 407
Cdd:PRK09103 377 TKYEQDDSIRKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHspfDPKVAPVRQSNLCLEIaLPTKPLNDVND----- 451
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 408 HIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHirsVPSIAAGNAA--SHAIGLGQMNLHGYLAREGIAY 485
Cdd:PRK09103 452 ENGEIALCTLSAFNLGAINSLDELEELADLAVRALDALLDYQD---YPIPAAKRGAmgRRTLGIGVINFAYYLAKNGVRY 528
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 486 GSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAgFAQSRYASG----DYFTQYLQDDwqpktakvralfarsgITLP 561
Cdd:PRK09103 529 SDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW-FNETTYAQGilpiDTYKKDLDAI----------------CNEP 591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 562 TREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIrKEGKTGRVYYPAPfmTNENL-DMYQDAYD 640
Cdd:PRK09103 592 LHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI-KASKDGILKQVVP--DYERLkDAYELLWE 668
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
1PEM_A 641 IGPEkiiDTYAEAT----RHVDQGLSL------TLFFPDTATTRDINKAQIYAWRKGIKSLYY 693
Cdd:PRK09103 669 MPNN---DGYLQLVgimqKFVDQSISAntnydpSRFPSGKVPMKQLLKDLLTAYKFGVKTLYY 728
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
148-613 |
9.48e-25 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 110.45 E-value: 9.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 148 LTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLRIEDNMESIGR-AVNSALqLSKRGGGVAFLLSNLREAGapikriEN 226
Cdd:PRK06556 122 LTWLLLHQKFSFNSPVWFNVGTESPQQVSACFILSVDDSMESILNwYKEEGM-LFKGGSGTGTNLSRIRSSK------EL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 227 QSSGVI---PV--MKMLeDAFSYANQLGA--RQGAGAVYLHAHHPDILRFLDTKrenADEKIRIKTL-------SLG--- 289
Cdd:PRK06556 195 LSGGGTasgPVsfMRGA-DASAGTIKSGGatRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALrdagydmDLGgea 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 290 ------------VVIPDiTFRLAKENaqmalfspydiqrryGKPFGDIAISerydeliaDPHVRKTYiNARDFFQTLAEI 357
Cdd:PRK06556 271 yssvqyqnannsVRVSD-EFMRAVEN---------------DGEFGLRART--------DGEVIETV-DAKELFRKIAEA 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 358 QFESGYPYIMFEDTVNR--ANPIAGRINMSNLCSEilqvnsasryddnldYTHIgHDISCNLGSLNIAHVM------DSP 429
Cdd:PRK06556 326 AWECADPGIQYDDTINDwhTCPESGRINASNPCSE---------------YMFL-DNSSCNLASLNLMKFLrddgtfDVE 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 430 DIGRTVETAIrglTAVSDMSHIRSVPS--IAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDF----TNLyfytITW 503
Cdd:PRK06556 390 SFRHAVELVI---TAMEISICFADFPTekIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALaaaiTSL----MTG 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 504 HAVHTSMRLARERGkTFAGFAQSRyasgDYFTQYLQ------DDWQPKTAKVRALFARSgitlptREMWlklrDDVMRYG 577
Cdd:PRK06556 463 EAYRRSAELAGVVG-PFEGYARNA----EPHLRVMRkhaaanDAIRPLGEVDAALLEAA------KEAW----DDALELG 527
|
490 500 510 520
....*....|....*....|....*....|....*....|.
1PEM_A 578 IYN--QNLQA--VPPTGSISY-INHATSSIHPIVAKIEIRK 613
Cdd:PRK06556 528 EKNgyRNAQAsvLAPTGTIGFmMDCDTTGIEPDFALVKYKK 568
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
166-695 |
2.07e-24 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 108.34 E-value: 2.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 166 NCGKQQRGELVSCFL--LRIEDNMESIGRAVNSALQLSKR----GGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLE 239
Cdd:PRK06948 76 NAGAAPDQTMVNCFVhpIRAPAALTAVHPNLDRALDDARLtllmGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 240 DAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENAdekiRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYG 319
Cdd:PRK06948 156 RICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWALRHRAPPRRAAG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 320 KPfgdiaiserydelIADPHVRKTY--INARDFFQTLAEIQFESGYPYIMFEDTVNRANPIAG--RINMSNLCSEilqvN 395
Cdd:PRK06948 232 GA-------------LRGADGAWTYatVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREheRIDATNPCGE----Q 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 396 SASRYDdnldythighdiSCNLGSLNIAHVM------------DSPDIGRTVETAIRGLTAVSDMSHIrsvpSIAAGNAA 463
Cdd:PRK06948 295 PLPPYG------------SCVLGPIDLSRFVrhpfgvggeprfDFAALATAVRIQVRMLDNALDLTRW----PLAAHARE 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 464 SHA---IGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYFtqylqd 540
Cdd:PRK06948 359 ARQkrrIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERG-AYPLCDPAAHLDALRA------ 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 541 dwqpktakvralfarsGITLPtremwLKLRDDVMRYGIYNQNLQAVPPTGSIS--YINHATSSIHPIVAKIEIRK-EGKT 617
Cdd:PRK06948 432 ----------------GPPLP-----HAVCHAIARHGLRNSHLLSFAPVGSVSlaFGDNCSPGIEPARAWIEHRPvRAGA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 618 GRVyypaPFMTNENL----------------DMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRDINKAQI 681
Cdd:PRK06948 491 GGA----RGMRAENHayrlfrslrgeraalpDYFVTAADVAPADHLAMRAALQPYVDAGISKTVTLPNHYSLAEVDALLF 566
|
570
....*....|....
1PEM_A 682 YAWRKGIKSLYYIR 695
Cdd:PRK06948 567 QAWRAGLKGITIFR 580
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
147-689 |
3.42e-20 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 95.68 E-value: 3.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 147 QLTDEMLSGRFQPATPTFLNCGKQQRGELVSCFLLR-IEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIE 225
Cdd:PRK08115 158 KFYQELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPfVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVN 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 226 NQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKREN-------------------ADEKIRIKTL 286
Cdd:PRK08115 238 GKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKMQNprilryllentedeqikrlVKEKLKFTPL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 287 SL-------GVV----IPDI-------------------TFR------LAKENAQMALFSPY----DIQRRYGKPFGDIa 326
Cdd:PRK08115 318 SEveeamyqAIVnyknIEGQggfdtkvikeaenklrtggTYTvnnpefLTGANISVCLTKEFmeavENDEEYELRFPDV- 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 327 isERYDEL-----------IADphVR---------KTY--INARDFFQTLAEIQFESGYPYIMFEDTVN---RANPIAGR 381
Cdd:PRK08115 397 --ENYTEEemeiyneewheVGD--VRewekmgypvRTYrkIKAKELWNLINICATYSAEPGIFFIDNANemtNAKAYGQK 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 382 INMSNLCSEilqvNSASRYDdnldythighdiSCNLGSLNIAH-------VMDSPDIGRTVETAIRGLTAVSDmshirSV 454
Cdd:PRK08115 473 VVATNPCGE----QPLAPYS------------VCNLAAINLANmadketkTVDYEKLKRTVEVGVRMQDNVID-----AT 531
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 455 PSIAAGNA----ASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAgfaqsryas 530
Cdd:PRK08115 532 PYFLEENKkqalGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKG-SFP--------- 601
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 531 gdyftqYLQDDWQPKTAKVRALFARSGItlpTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHP------ 604
Cdd:PRK08115 602 ------FLVGQTEEETAKLREAFINTGY---MKKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPyfsfsy 672
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 605 ---------IVAKIEIRKEGKTGrvyYPAPfMTNENLDMYQDAYDIGPEKIIDTYAEATRHVDQGLSLTLFFPDTATTRD 675
Cdd:PRK08115 673 yrsgrlgkfIEVKADIVQEYLDK---HPEA-DENHLPEWFISAMELKPEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQ 748
|
650
....*....|....
1PEM_A 676 INKAQIYAWRKGIK 689
Cdd:PRK08115 749 VQKVYERLYRGGAK 762
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
414-708 |
2.22e-17 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 87.13 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 414 SCNLGSLNIAHVMDSPDIGR----------TVETAIRGLTAVSDMSHIrSVPSIAAGNAASHAIGLGQMNLHGYLAREGI 483
Cdd:PRK08332 1307 SCNLASINLAKFVKYDENGKpyfdwdeyayVIQKVAKYLDNAIDVNKF-PLPEIDYNTKLTRRIGVGMMGLADALFKLGI 1385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 484 AYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSRYASGDYftqylqddwqpktaKVRALFARSGITLPtr 563
Cdd:PRK08332 1386 PYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRG-TFPLYEKTEYPKGEL--------------PVEGFYHPEIWNLP-- 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 564 emWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIeIRKEGKTGRVYYPAP----------FMTNENLD 633
Cdd:PRK08332 1449 --WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPvfeaelkkrgLYSEELLK 1525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 634 MYQDAYDI--GPEKI-----------IDTY------AEATRH--VDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKSLY 692
Cdd:PRK08332 1526 KISDNYGSvqGLEEIpedmqrvfvtaLDIHwldhilAQANIQmwLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVT 1605
|
330
....*....|....*.
1PEM_A 693 YIRLRQLALEGTEIEG 708
Cdd:PRK08332 1606 VYRDGSLSVQVYSVEG 1621
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
101-169 |
2.44e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 68.42 E-value: 2.44e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1PEM_A 101 TFLGAWKFYTSYTLKTFDGKRYlEHFEDRVTMVALTLAQ-----GDETLATQLTDEMLSGRFQPATPTFLNCGK 169
Cdd:pfam00317 2 TYLGAKVLEDRYLLKDEDGELL-ETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
333-527 |
5.71e-11 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 66.14 E-value: 5.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 333 ELIA--DPHVRKTyINARDFFQTLAEIQFESGYPYIMFEDTVN--RANPIAGRINMSNLCSEILqvnsasryddNLDyth 408
Cdd:PRK07562 418 NLTArtDGKVAKT-LKARDLWEKIGYAAWASADPGLQFNTTINdwHTCPASGPIRASNPCSEYM----------FLD--- 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 409 ighDISCNLGSLNIAHVMDsPDIGR----TVETAIRGLTAVSD----MSHIrsvPS--IAAGNAASHAIGLGQMNLHGYL 478
Cdd:PRK07562 484 ---DTACNLASLNLLTFRD-EDTKRfdveAYEHACRLWTVVLEisvlMAQF---PSkeIAELSYEFRTLGLGYANIGGLL 556
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
1PEM_A 479 AREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGkTFAGFAQSR 527
Cdd:PRK07562 557 MTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELG-PFPGYEKNA 604
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
211-388 |
6.13e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.76 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 211 LSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIrIKTLSLGV 290
Cdd:PRK08332 760 FSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-LSNFNISV 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PEM_A 291 VIPDITFRLAKENAQMALFSPydiqrrygkpfgdiaiseRYDELIADphvrktyINARDFFQTLAEIQFESGYPYIMFED 370
Cdd:PRK08332 839 GIWEDFWEALKEGKKYPLINP------------------RTGEVVKE-------IDPKSLFEELAYMAWAKADPGVIFFD 893
|
170 180
....*....|....*....|..
1PEM_A 371 TVNRANPI----AGRINMSNLC 388
Cdd:PRK08332 894 VINRRNVLkeakGGPIRATNPC 915
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
152-206 |
7.84e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 7.84e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
1PEM_A 152 MLSGRFQPATPTFLNCGKQQrGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGG 206
Cdd:PRK08332 248 MTNQIFMPNTPALINSGRPL-GMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGG 301
|
|
| |
