|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
1-398 |
0e+00 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 725.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 1 MHGSNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGG 80
Cdd:PRK07503 1 MRDSHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 81 EAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPA 160
Cdd:PRK07503 81 EAAVALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 161 NPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLK 240
Cdd:PRK07503 161 NPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 241 DMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKG 320
Cdd:PRK07503 241 DMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 321 GIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:PRK07503 321 GIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACA 398
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
9-396 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 602.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGLKDMTGAVLS 248
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAE-RLRFLQNALGAVLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 249 PHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRF 328
Cdd:COG0626 241 PFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRF 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 329 MNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:COG0626 321 LDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAA 388
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
9-394 |
0e+00 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 564.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK06234 8 GFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PRK06234 88 GMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKH--GATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAV 246
Cdd:PRK06234 168 IKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKLFGIKDMTGSV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 247 LSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGR 326
Cdd:PRK06234 248 IGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGK 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 327 RFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:PRK06234 328 VVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
26-395 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 553.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 26 GALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGD 105
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 106 EVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVV 185
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 186 DNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQ-ALVDRIRLQGLkdMTGAVLSPHDAALLMRGIKTLNL 264
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGeALIQRLRFLRL--ALGTILSPFDAWLLLRGLKTLPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 265 RMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDA 344
Cdd:cd00614 239 RMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
1PG8_D 345 ESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:cd00614 319 ESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
9-396 |
0e+00 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 527.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:TIGR01328 3 TFATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:TIGR01328 83 GMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLID 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLS 248
Cdd:TIGR01328 163 MERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQIRMVGIKDMTGSVIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 249 PHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRF 328
Cdd:TIGR01328 243 PFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKKL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 329 MNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:TIGR01328 323 LNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
4-398 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 511.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 4 SNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAG 83
Cdd:COG2873 2 TEKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPN 163
Cdd:COG2873 82 LATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 164 MHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV------------------ 225
Cdd:COG2873 162 LDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVdggnfdwaangkfpelte 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 --------------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHY 291
Cdd:COG2873 242 pdpsyhglvyteafGNAAFITKARVQLLRDL-GAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 292 PGLASFPQYTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGIS 370
Cdd:COG2873 321 PGLPSHPYHELAQKYLPKgAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVT 400
|
410 420
....*....|....*....|....*...
1PG8_D 371 EGLVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:COG2873 401 PDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
11-395 |
1.66e-179 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 504.07 E-value: 1.66e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDHGGALVPPVYQTATFTFptveygaaCFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVF--------DFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIA 170
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 171 GVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAG-IVVGSQALVDriRLQGLKDMTGAVLSP 249
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGvIVVNGEELGK--ELYFLQNATGAVLSP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 250 HDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFM 329
Cdd:pfam01053 231 FDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PG8_D 330 NALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:pfam01053 311 DNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
10-397 |
6.80e-164 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 465.08 E-value: 6.80e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 10 FATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASG 89
Cdd:PRK06767 6 METALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 90 MGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADI 169
Cdd:PRK06767 86 MAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 170 AGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMtGAVLSP 249
Cdd:PRK06767 166 KQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDI-GGIMAP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 250 HDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYpglasfPQYTLARQQMSQPGGMIAFELKGGIGAGRRFM 329
Cdd:PRK06767 245 FDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQAFI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 330 NALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKAS 397
Cdd:PRK06767 319 NDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
9-396 |
1.18e-147 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 423.67 E-value: 1.18e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVeygaacfAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK07811 12 GFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGV-------GGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PRK07811 85 GMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAG-IVVGSQALVDRIRLqgLKDMTGAVL 247
Cdd:PRK07811 165 IAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGaLVTNDEELDEAFAF--LQNGAGAVP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 248 SPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRR 327
Cdd:PRK07811 243 GPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
1PG8_D 328 FMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAhygISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK07811 323 FCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
9-395 |
2.76e-146 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 421.38 E-value: 2.76e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV----------------------- 225
Cdd:TIGR01326 161 IEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnngrfplfttpdpsyh 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 --------GSQALVDRIRLQGLKDmTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASF 297
Cdd:TIGR01326 241 glvftetlGNPAFILKARVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 298 PQYTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRL 376
Cdd:TIGR01326 320 PHHALAKKYLPKgFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*....
1PG8_D 377 SVGLEDIDDLLADVQQALK 395
Cdd:TIGR01326 400 SVGIENIDDIIADLEQALE 418
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
9-396 |
1.91e-143 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 413.24 E-value: 1.91e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGY---DPQDHGGALvppvYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLA 85
Cdd:PRK08133 6 GFDTLAVRAGQlrsPFGEHSEAL----FLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 86 LASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMH 165
Cdd:PRK08133 82 TASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 166 MADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIrlQGLKDMTGA 245
Cdd:PRK08133 162 LADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEV--FGFLRTAGP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 246 VLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAG 325
Cdd:PRK08133 240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1PG8_D 326 RRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK08133 320 WRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
10-398 |
3.63e-130 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 381.02 E-value: 3.63e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 10 FATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASG 89
Cdd:PRK07812 14 FETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 90 MGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHV-DMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PRK07812 94 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV----------------------- 225
Cdd:PRK07812 174 IPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgfttpdpsyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 -------GSQALVDRIRLQGLKDmTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFP 298
Cdd:PRK07812 254 gvvfaelGPPAYALKARVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSP 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 299 QYTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLS 377
Cdd:PRK07812 333 WYERAKRLAPKgTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLA 412
|
410 420
....*....|....*....|.
1PG8_D 378 VGLEDIDDLLADVQQALKASA 398
Cdd:PRK07812 413 VGIEGIDDILADLEAGFAAAK 433
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
4-396 |
2.77e-128 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 375.98 E-value: 2.77e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 4 SNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAG 83
Cdd:PRK05994 2 TDRSPGFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPN 163
Cdd:PRK05994 82 LAVASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 164 MHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV------------------ 225
Cdd:PRK05994 162 GTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwsksgkypmlse 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 --------------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHY 291
Cdd:PRK05994 242 prpeyhglvlhetfGNFAFAIAARVLGLRDL-GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 292 PGLASFPQYTLARQQMSQPGGMI-AFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGIS 370
Cdd:PRK05994 321 AGLPDDPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAG 400
|
410 420
....*....|....*....|....*.
1PG8_D 371 EGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK05994 401 PDVVRLSIGIEDVDDIIADLEQALAK 426
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
23-394 |
7.35e-128 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 373.03 E-value: 7.35e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 23 DHGGALvppvYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLR 102
Cdd:TIGR01325 16 ETAEAL----YLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIFAALMALLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 103 PGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGAT 182
Cdd:TIGR01325 92 AGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAVAELAHAAGAK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 183 VVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIrLQGLKDMTGAVLSPHDAALLMRGIKTL 262
Cdd:TIGR01325 172 VVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEP-VQKLLRHTGPAMSPFNAWVLLKGLETL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 263 NLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGiGAGRRFMNALQLFSRAVSLG 342
Cdd:TIGR01325 251 AIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
1PG8_D 343 DAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:TIGR01325 330 DAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
8-396 |
4.51e-127 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 371.77 E-value: 4.51e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 8 PGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVE--YGAAcfAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLA 85
Cdd:PRK08249 7 AGVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDewYDVA--LGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 86 LASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMH 165
Cdd:PRK08249 85 FSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 166 MADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRlqGLKDMTGA 245
Cdd:PRK08249 165 IVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVY--HYREINGA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 246 VLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAG 325
Cdd:PRK08249 243 TMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTV 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1PG8_D 326 RRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK08249 323 KRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAH 393
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
12-395 |
1.77e-125 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 367.13 E-value: 1.77e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 12 TRAIHHGYDPQDHGGALVPPVYQTATFTFPTveygaacfAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMG 91
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEA--------VGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLwTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAG 171
Cdd:PRK07671 77 AITAVM-MLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 172 VAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-GSQALVDRIRLqgLKDMTGAVLSPH 250
Cdd:PRK07671 156 ISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVvNSPELAEDLHF--VQNSTGGILGPQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 251 DAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFElkggIGAGRR--- 327
Cdd:PRK07671 234 DSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFD----VGSEETank 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 328 FMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:PRK07671 310 VLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-397 |
1.06e-123 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 364.44 E-value: 1.06e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 6 KLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLA 85
Cdd:PRK08134 5 SPPGFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 86 LASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMH 165
Cdd:PRK08134 85 TASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 166 MADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-------------------- 225
Cdd:PRK08134 165 VLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVdggrfdweasgkfpeltepy 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 ------------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPG 293
Cdd:PRK08134 245 agfhgmvfaeesTVAAFLLRARREGLRDF-GACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPE 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 294 LASFPQYTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEG 372
Cdd:PRK08134 324 LESHPDHALAKRLLPRgAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEG 403
|
410 420
....*....|....*....|....*
1PG8_D 373 LVRLSVGLEDIDDLLADVQQALKAS 397
Cdd:PRK08134 404 TIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
11-396 |
4.49e-119 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 350.90 E-value: 4.49e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHhGYDPQDHGGALVPPVYQTATFTFPtveyGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:PRK08574 4 GTDAVR-GYRGSDPYGSLQPPIYLTALFRQE----GEAYPSDRGFDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHgIGEFGVKLRHVdMADLQAL-EAAMTPATRVIYFESPANPNMHMADI 169
Cdd:PRK08574 79 AAISTLFFSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLA-YPSTEDIiEAIKEGRTKLVFIETMTNPTLKVIDV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 170 AGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGLKDMTGAVLSP 249
Cdd:PRK08574 157 PEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLE-ELWEWRRRLGTIMQP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 250 HDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQP--GGMIAFELKGGIGAGRR 327
Cdd:PRK08574 236 FEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlyGGVVSFRVKGGRDAVLK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
1PG8_D 328 FMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK08574 316 FLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
11-397 |
4.94e-119 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 352.44 E-value: 4.94e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACF----------AGEQAGHFYSRISNPTLNLLEARMASLEGG 80
Cdd:PRK07049 19 ETQMLNYGYDPELSEGAVKPPVFLTSTFVFRSAEDGRDFFdyvsgrkeppAGEGAGLVYSRFNHPNSEIVEDRLAVYEGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 81 EAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVklRHVDMAD-------LQALEAAMTPA-TR 152
Cdd:PRK07049 99 ESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGV--GAVGFADglseaaiGAAAEAAAAKGrVS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 153 VIYFESPANPNMHMADIAGVAKIARKHGA------TVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVG 226
Cdd:PRK07049 177 LILIETPANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 227 SQALVDRIRLqgLKDMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGL--ASFPQYTLAR 304
Cdd:PRK07049 257 RKALIRQVRA--LRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYK 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 305 QQMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDID 384
Cdd:PRK07049 335 RQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPD 414
|
410
....*....|...
1PG8_D 385 DLLADVQQALKAS 397
Cdd:PRK07049 415 DLIADLAQALDAA 427
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
23-395 |
5.72e-118 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 347.46 E-value: 5.72e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 23 DHGGALVPPVYQTATFTFPTVeygaacfaGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAItSTLWTLLR 102
Cdd:PRK08247 18 ERTGTVNPPVYFSTAYRHEGI--------GESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI-QLVMSLFR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 103 PGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGAT 182
Cdd:PRK08247 89 SGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 183 VVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGS-QALVDRIRLqgLKDMTGAVLSPHDAALLMRGIKT 261
Cdd:PRK08247 169 LIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKgQELCERLAY--YQNAAGAVLSPFDSWLLIRGMKT 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 262 LNLRMDRHCANAQVLAEFLARQPQVELIHYPGlasfpqytlarqqmsqPGGMIAFELKGGIGAgRRFMNALQLFSRAVSL 341
Cdd:PRK08247 247 LALRMRQHEENAKAIAAFLNEQPGVTDVLYPG----------------RGGMLSFRLQDEEWV-NPFLKSLKLITFAESL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
1PG8_D 342 GDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:PRK08247 310 GGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
12-398 |
8.02e-118 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 349.20 E-value: 8.02e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 12 TRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMG 91
Cdd:PRK06084 5 TLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAG 171
Cdd:PRK06084 85 AITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 172 VAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-------------------------- 225
Cdd:PRK06084 165 LADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfallntpdpsyhg 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 -------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFP 298
Cdd:PRK06084 245 vtyteafGPAAFIGRCRVVPLRNM-GAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 299 QYTLARQQMS-QPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLS 377
Cdd:PRK06084 324 EHELARRYMGgKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLS 403
|
410 420
....*....|....*....|.
1PG8_D 378 VGLEDIDDLLADVQQALKASA 398
Cdd:PRK06084 404 IGIEHIDDIIADLAQALDASK 424
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
12-397 |
1.46e-117 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 348.76 E-value: 1.46e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 12 TRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMG 91
Cdd:PRK08248 11 TLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAG 171
Cdd:PRK08248 91 AITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 172 VAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-------------------------- 225
Cdd:PRK08248 171 VAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltepdpsyhgl 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 ------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQ 299
Cdd:PRK08248 251 vytdavGEAAYITKARVQLLRDL-GAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 300 YTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSV 378
Cdd:PRK08248 330 YELAKKYLPKgQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSV 409
|
410
....*....|....*....
1PG8_D 379 GLEDIDDLLADVQQALKAS 397
Cdd:PRK08248 410 GTEAIDDILDDLRQAIRQS 428
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
10-396 |
5.64e-115 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 340.34 E-value: 5.64e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 10 FATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVeygaacfaGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASG 89
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAI--------GRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 90 MGAITSTLwTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADI 169
Cdd:PRK06176 75 LAGIHAVF-SLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 170 AGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-GSQALVDRIRLqgLKDMTGAVLS 248
Cdd:PRK06176 154 AQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTtNNEALAQEIAF--FQNAIGGVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 249 PHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGiGAGRRF 328
Cdd:PRK06176 232 PQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKND-SEAVAF 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 329 MNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK06176 311 VESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
24-396 |
6.70e-115 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 340.96 E-value: 6.70e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 24 HGGALVPP-------VYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITST 96
Cdd:PRK07504 17 HSGTLRSQfgetseaLFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 97 LWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIA 176
Cdd:PRK07504 97 ILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 177 RKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGLKDMTGAVLSPHDAALLM 256
Cdd:PRK07504 177 NQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEE-HLQDYFRHTGPSLSPFNAWTLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 257 RGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMNALQLFS 336
Cdd:PRK07504 256 KGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVR 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 337 RAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK07504 336 ISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKK 395
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
11-394 |
1.34e-113 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 336.80 E-value: 1.34e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDhgGALVPPVYQTATFTFPtveygaacfAGEQagHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:PRK06460 4 ATRTVREDIDEAT--GAITTPIYQTTAYHYP---------EGEK--YRYSREANPTVLELTKKIVELENAEMGVAFSSGM 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIA 170
Cdd:PRK06460 71 GAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDIT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 171 GVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLqgLKDMTGAVLSPH 250
Cdd:PRK06460 151 ELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQ--MRRTLGTSLDPH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 251 DAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMN 330
Cdd:PRK06460 229 AAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMK 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
1PG8_D 331 ALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:PRK06460 309 SLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
11-396 |
1.43e-113 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 336.77 E-value: 1.43e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVeygaacfaGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:TIGR02080 5 ATIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGF--------NEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIA 170
Cdd:TIGR02080 77 SAIHLVTTALLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 171 GVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGLKDMTGAVLSPH 250
Cdd:TIGR02080 157 KICHLAKAVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAE-ELAWWANNLGVTGGAF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 251 DAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMN 330
Cdd:TIGR02080 236 DSYLTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLG 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PG8_D 331 ALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:TIGR02080 316 GLSLFTLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRA 381
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
21-396 |
1.81e-113 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 336.42 E-value: 1.81e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 21 PQDHGGALVPPVYQTATFTFPTveygaacfAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAItSTLWTL 100
Cdd:TIGR01329 11 KNDPYDASSMPIYQTATFKQPL--------AIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAAL-DVITRL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 101 LRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHG 180
Cdd:TIGR01329 82 LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 181 ATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAG-IVVGSQALVDRIRLqgLKDMTGAVLSPHDAALLMRGI 259
Cdd:TIGR01329 162 ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGvLAVKGEEIAKKVYF--LQNSTGSGLAPFDCWLLLRGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 260 KTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFElKGGIGAGRRFMNALQLFSRAV 339
Cdd:TIGR01329 240 KTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRLVEATKLFSITV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
1PG8_D 340 SLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:TIGR01329 319 SFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
10-395 |
1.77e-112 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 334.43 E-value: 1.77e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 10 FATRAIHHGYDPQDHGGALVPPVYQTATF-TFPTVEYGAacfageqagHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK08064 7 IDTLLLHNQYKHDKQTGAVNVPIYHASTFhQFDFDTFGK---------YDYSRSGNPTREALEDIIAELEGGTKGFAFAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAItSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PRK08064 78 GMAAI-STAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAG-IVVGSQALVDriRLQGLKDMTGAVL 247
Cdd:PRK08064 157 IRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGlAVVKDEELAQ--KLYFLQNSFGAVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 248 SPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELkGGIGAGRR 327
Cdd:PRK08064 235 GVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQ 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 328 FMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:PRK08064 314 FVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
5-398 |
9.16e-108 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 322.42 E-value: 9.16e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 5 NKLPGFATRAIHHGYDPQDH-GGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAG 83
Cdd:PRK05968 2 NDGLDPFDLAALITAHDEGNaFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMtPATRVIYFESPANPN 163
Cdd:PRK05968 82 RGFASGMAAISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 164 MHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKdMT 243
Cdd:PRK05968 161 FELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYP-YL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 244 GAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLarqqmSQPGGMIAFELKGGIG 323
Cdd:PRK05968 240 GAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSFIFREGID 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PG8_D 324 AgRRFMNALQLFSRAVSLGDAESLAQhPASMTHSSYTPEERAH-YGISEGLVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:PRK05968 315 V-RAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNSAArFGVSPRSVRLHVGLEGTEALWADLEQALAAAS 388
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
31-395 |
1.12e-107 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 322.45 E-value: 1.12e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 31 PVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLG 110
Cdd:PRK07810 36 ALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 111 NTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYC 190
Cdd:PRK07810 116 RSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 191 TPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGLKDMTGAVLSPHDAALLMRGIKTLNLRMDRHC 270
Cdd:PRK07810 196 TPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDG-PVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSN 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 271 ANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRR----FMNALQLFSRAVSLGDAES 346
Cdd:PRK07810 275 ASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAKKrafeVLDKLRVIDISNNLGDAKS 354
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
1PG8_D 347 LAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:PRK07810 355 LITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
26-397 |
1.64e-106 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 319.33 E-value: 1.64e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 26 GALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGD 105
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 106 EVLLGNTLYGCTFAFLHhGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVV 185
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFG-TLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 186 DNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSqALVD----------------------RIRLQGLKDMt 243
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDT-GLFDwsaypnifpayrkgdpqqwgltQIRKKGLRDM- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 244 GAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIG 323
Cdd:PRK05939 245 GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGID 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1PG8_D 324 AgRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKAS 397
Cdd:PRK05939 325 C-FDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
8-396 |
7.09e-102 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 306.54 E-value: 7.09e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 8 PGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEygaacfagEQAGHFYSRISNPTLNLLEARMASLEGGEAgLALA 87
Cdd:PRK07582 2 YGDGTRSVHAGGPEAVPGEPVLPGPVFAAPYHLSPGE--------PTGPDTYGRASNPTWRALEAALGELEGAEA-LVFP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 88 SGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLqaLEAAMTPAtRVIYFESPANPNMHMA 167
Cdd:PRK07582 73 SGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGM--AEAALAGA-DLVLAETPSNPGLDVC 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 168 DIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQA-LVDRIRlqGLKDMTGAV 246
Cdd:PRK07582 150 DLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPeLMAAVE--RWRLLAGAI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 247 LSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELkGGIGAGR 326
Cdd:PRK07582 228 PGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAE 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1PG8_D 327 RFMNALQLFSRAVSLGDaeslaqhpasmTHSsyTPEERAHYG--ISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK07582 307 RFVAASRLVVAATSFGG-----------VHT--SADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDA 365
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
4-396 |
1.53e-99 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 301.05 E-value: 1.53e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 4 SNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAG 83
Cdd:PRK06434 3 KRMLNGFNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEaaMTPAT-RVIYFESPANP 162
Cdd:PRK06434 83 LSFSSGMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 163 NMHMADIAGVAKiaRKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIV-VGSQALVDRIRLQglKD 241
Cdd:PRK06434 161 TLKVPDIKNVSS--FCHENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAgTNNKSIFNNLVER--RK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 242 MTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLasfpqyTLARQQMSQPGGMIAFELKGG 321
Cdd:PRK06434 237 TLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSM 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1PG8_D 322 IGAgRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK06434 311 EDV-HKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
1-394 |
3.44e-99 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 300.75 E-value: 3.44e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 1 MHGSNKLP-GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVeygaacfaGEQAGHFYSRISNPTLNLLEARMASLEG 79
Cdd:PRK08776 3 FRDPTDAPcSAATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGF--------GNKRQYDYTRSGNPTRDLLGEALAELEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 80 GEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESP 159
Cdd:PRK08776 75 GAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 160 ANPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRiRLQGL 239
Cdd:PRK08776 155 SNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQ-QLVWW 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 240 KDMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELK 319
Cdd:PRK08776 234 ANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELE 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1PG8_D 320 GGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:PRK08776 314 GGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
11-398 |
1.97e-97 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 295.65 E-value: 1.97e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEygaacfagEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:PRK08045 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIA 170
Cdd:PRK08045 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 171 GVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVdRIRLQGLKDMTGAVLSPH 250
Cdd:PRK08045 158 KICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDV-VTELAWWANNIGVTGGAF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 251 DAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMN 330
Cdd:PRK08045 237 DSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLG 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 331 ALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:PRK08045 317 GLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
9-396 |
1.19e-94 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 290.23 E-value: 1.19e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK05613 13 GFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHV-DMADLQALEAAMTPATRVIYFESPANPNMHMA 167
Cdd:PRK05613 93 GQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 168 DIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV---------------------- 225
Cdd:PRK05613 173 DIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfvt 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 -------------GSQALVDRIRLQGLKDmTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYP 292
Cdd:PRK05613 253 pdpayhglkyadlGAPAFGLKARAGLLRD-TGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 293 GLASFPQYTLARQ-QMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISE 371
Cdd:PRK05613 332 GLKDSPWYATKEKlGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQ 411
|
410 420
....*....|....*....|....*
1PG8_D 372 GLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK05613 412 ATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
19-395 |
1.84e-93 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 288.08 E-value: 1.84e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 19 YDPQDhggALVPPVYQTATFTFPTveygaacfAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAItSTLW 98
Cdd:PLN02509 98 FDPFD---AMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVT 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 99 TLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARK 178
Cdd:PLN02509 166 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHA 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 179 HGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIV-VGSQALVDRIRLqgLKDMTGAVLSPHDAALLMR 257
Cdd:PLN02509 246 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLaVKGEKLAKEVYF--LQNSEGSGLAPFDCWLCLR 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 258 GIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFeLKGGIGAGRRFMNALQLFSR 337
Cdd:PLN02509 324 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSI 402
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 338 AVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALK 395
Cdd:PLN02509 403 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
11-398 |
2.79e-90 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 277.55 E-value: 2.79e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 11 ATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVeygaacfaGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Cdd:PRK08861 7 ATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAF--------GEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIA 170
Cdd:PRK08861 79 SALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 171 GVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVG-SQALVDRIRLQGlkDMTGAVLSP 249
Cdd:PRK08861 159 ELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITkTKEHAEELAWWG--NCIGATGTP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 250 HDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFM 329
Cdd:PRK08861 237 FDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
1PG8_D 330 NALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:PRK08861 317 KALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAA 385
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
16-396 |
3.01e-88 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 271.31 E-value: 3.01e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 16 HHGYDPQDHGGALVPPVYQTATFTFPtvEYGaacfagEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITs 95
Cdd:PRK07269 13 QAGIKSDEATGALVTPLHFSTTYQHP--EFG------QSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIV- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 96 TLWTLLRPGDEVLLGNTLYGCTFAFLHH--GIGEFGVKLRHVDmadlQALEAAMTPATRVIYFESPANPNMHMADIAGVA 173
Cdd:PRK07269 84 LAFSVFPVGSKVVAVRDLYGGSFRWFNQqeKEGRFHFTYANTE----EELIAAIEEDTDIVYIETPTNPLMVEFDIEKVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 174 KIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV-GSQALVDRIRLQglKDMTGAVLSPHDA 252
Cdd:PRK07269 160 KLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVtNDLELYEKLFYN--LNTTGAVLSPFDS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 253 ALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLasfpqytlarqqmsqpGGMIAFEL--KGGIGAgrrFMN 330
Cdd:PRK07269 238 YLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILN 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PG8_D 331 ALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKA 396
Cdd:PRK07269 299 SLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
8-379 |
1.86e-76 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 242.75 E-value: 1.86e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 8 PGFATRAIHHGYDpqDHGGALVPpVYQTATFTFPTVEYGAACFAGE----QAGHFYSRISNPTLNLLEARMASLEGGEAG 83
Cdd:PLN02242 18 PAAALASARHEFG--EHGGVNMS-IEASATFTVMEPDTMRRMFSGElgpdRDFYIYSRHFNPTVLNLGRQMAALEGTEAA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGE-FGVKLRHVDMADLQALEAAMTPA-TRVIYFESPAN 161
Cdd:PLN02242 95 YCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPGkTKVLYFESISN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 162 PNMHMADIAGVAKIARKHGATVVVDNTYcTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIR--LQGL 239
Cdd:PLN02242 175 PTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMMdlHHGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 240 KDMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEflaRQPQVEL-IHYPGLASFPQYTLARQQMSQP---GGMIA 315
Cdd:PLN02242 254 LMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAK---RMKELGLkVIYPGLEDHPQHALLKSMANKGygfGGLLC 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 316 FELkGGIGAGRRFMNALQLFSR----AVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVG 379
Cdd:PLN02242 331 LDM-DTEERANRLMRYLQNSTQfgfmAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
9-394 |
1.25e-73 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 236.10 E-value: 1.25e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDhGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK06702 6 GKGTICVQGGYTPKN-GEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFlhhgigeFGVKLRHVDM------ADLQALE--AAMTPATRVIYFESPA 160
Cdd:PRK06702 85 GQAAIMLAVLNICSSGDHLLCSSTVYGGTFNL-------FGVSLRKLGIdvtffnPNLTADEivALANDKTKLVYAESLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 161 NPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVV--------------- 225
Cdd:PRK06702 158 NPAMNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypel 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 226 ----------------GSQALVDRIRLQGLKDMtGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELI 289
Cdd:PRK06702 238 vepdpsyhgvsyvqnfGAAAYIVKARVQLLRDY-GNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 290 HYPGLASFPQYTLARQQMSQ-PGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYG 368
Cdd:PRK06702 317 NYPGLDSNENYSLAQKYLKKgASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAG 396
|
410 420
....*....|....*....|....*.
1PG8_D 369 ISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:PRK06702 397 VTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
9-398 |
2.75e-72 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 231.24 E-value: 2.75e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 9 GFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTveygAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALAS 88
Cdd:PRK05967 12 GINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPD----AETMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PRK05967 88 GLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRirlqgLKDMTGAV-- 246
Cdd:PRK05967 168 IPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQ-----LLEAHGTLgl 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 247 -LSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAG 325
Cdd:PRK05967 243 cAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPEKG 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1PG8_D 326 RR----FMNALQLFSRAVSLGDAESLAQHpasmthsSYTPEERAHYGISEG-LVRLSVGLEDIDDLLADVQQALKASA 398
Cdd:PRK05967 323 KAkahaFLDALEIFGLGYSWGGYESLALH-------VKLGDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
12-396 |
5.88e-68 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 219.75 E-value: 5.88e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 12 TRAIHHGYDPQDHGGALVPPVYQTATFTFPTveygAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGMG 91
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDS----HAAQRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAG 171
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 172 VAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRlQGLKDMtGAVLSPHD 251
Cdd:TIGR01324 157 IAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLR-EHSYLM-GQMVDADD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 252 AALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIG-AGRRFMN 330
Cdd:TIGR01324 235 AYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQkQVHAFLD 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
1PG8_D 331 ALQLFSRAVSLGDAESLAqhpasMTHSSYTPEERAHYGISEG-LVRLSVGLEDIDDLLADVQQALKA 396
Cdd:TIGR01324 315 HLQLFGLGYSWGGYESLA-----LCNQPELGHRPNIKRNLEGpLIRVHIGLENVDDLKADLKAGFEA 376
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-396 |
3.49e-63 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 207.65 E-value: 3.49e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 1 MHGSNKLPGFATRAIHhgydPQDHG----GALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMAS 76
Cdd:PRK07050 1 MTASTPKRALQTRIVQ----PDDQIppgfRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 77 LEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYF 156
Cdd:PRK07050 77 IEGGRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 157 ESPANPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAG-IVVGSQALVDRIR 235
Cdd:PRK07050 157 EAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGaTITADAELHAKLK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 236 LQGLKdmTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIA 315
Cdd:PRK07050 237 LARMR--LGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 316 FELKGGIGAGR--RFMNALQLFSRAVSLGDAESLA--QHPASMthssyTPEERAHYGiseGLVRLSVGLEDIDDLLADVQ 391
Cdd:PRK07050 315 VVFDERYSPAQvdAFVEALELFAIGWSWGGACSLAmpYDVASM-----RTAKWPHRG---TLVRLYIGLEDEADLIADLE 386
|
....*
1PG8_D 392 QALKA 396
Cdd:PRK07050 387 QALEA 391
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
8-394 |
9.95e-61 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 201.12 E-value: 9.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 8 PGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGH-FYSRISNPTLNLLEARMASLEGGeAGLAL 86
Cdd:PRK09028 3 EKKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRHAAKNRANGEmFYGRRGTPTHFAFQAAIVELEGG-AGTAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 87 -ASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMH 165
Cdd:PRK09028 82 yPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITME 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 166 MADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLkdMTGA 245
Cdd:PRK09028 162 VQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSY--LMGQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 246 VLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELK-GGIGA 324
Cdd:PRK09028 240 CTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1PG8_D 325 GRRFMNALQLFSRAVSLGDAESLAqhpasMTHSSYTP-EERAHYGISEGLVRLSVGLEDIDDLLADVQQAL 394
Cdd:PRK09028 320 VTALVEGMQHFKMGFSWGGFESLI-----LGVFGINKlRTATNWDFSKPLIRLHIGLEDVDDLIADLEAGF 385
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
10-389 |
7.66e-49 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 170.27 E-value: 7.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 10 FATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGH-FYSRISNPTLNLLEARMASLEGGeAGLAL-A 87
Cdd:PRK08114 6 LDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKKHATRNRANGElFYGRRGTLTHFSLQEAMCELEGG-AGCALyP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 88 SGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMA 167
Cdd:PRK08114 85 CGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITMEVH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 168 DIAGVAKIARKHGATVVV--DNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLkdMTGA 245
Cdd:PRK08114 165 DVPAIVAAVRSVNPDAVImiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSY--LMGQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 246 VLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQPGGMIAFELKGGIGAG 325
Cdd:PRK08114 243 MVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKKLTDE 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1PG8_D 326 R--RFMNALQLFSRAVSLGDAESLAQHpasmthssYTPEERAHY------GISEGLVRLSVGLEDIDDLLAD 389
Cdd:PRK08114 323 QlaNYLDNFSLFSMAYSWGGFESLILA--------NQPEEIAAIrpagevDFTGTLIRLHIGLEDVDDLIAD 386
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
84-235 |
3.56e-15 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 76.32 E-value: 3.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 84 LALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHgigeFGVKLRHVDMA-------DLQALEAAMTPATRVIYF 156
Cdd:COG0436 94 LVTNGAKEALALALLALLNPGDEVLVPDPGYPSYRAAVRL----AGGKPVPVPLDeengflpDPEALEAAITPRTKAIVL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 157 ESPANP---NMHMADIAGVAKIARKHGATVVVDNTYC---------TPYLQRPlelGAD---LVVHSATKYLSghgdIT- 220
Cdd:COG0436 170 NSPNNPtgaVYSREELEALAELAREHDLLVISDEIYEelvydgaehVSILSLP---GLKdrtIVINSFSKSYA----MTg 242
|
170
....*....|....*..
1PG8_D 221 --AGIVVGSQALVDRIR 235
Cdd:COG0436 243 wrIGYAVGPPELIAALL 259
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
39-293 |
3.14e-14 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 73.14 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 39 TFPTVEYGAACFAGEQAGHFYSrisnPTLNLLEAR--MASLEGGEAGLAL--------ASGMGAITSTLWTLLRPGDEVL 108
Cdd:cd00609 12 PPPEVLEALAAAALRAGLLGYY----PDPGLPELReaIAEWLGRRGGVDVppeeivvtNGAQEALSLLLRALLNPGDEVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 109 LGNTLYGCTFAFLHHgigeFGVKLRHVDM-------ADLQALEAAMTPATRVIYFESPANP---NMHMADIAGVAKIARK 178
Cdd:cd00609 88 VPDPTYPGYEAAARL----AGAEVVPVPLdeeggflLDLELLEAAKTPKTKLLYLNNPNNPtgaVLSEEELEELAELAKK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 179 HGATVVVDNTYC----TPYLQRPLELGAD----LVVHSATKYLSGHGdITAGIVVGSQALVdRIRLQGLKDMTGAVLSPH 250
Cdd:cd00609 164 HGILIISDEAYAelvyDGEPPPALALLDAyervIVLRSFSKTFGLPG-LRIGYLIAPPEEL-LERLKKLLPYTTSGPSTL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
1PG8_D 251 D----AALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPG 293
Cdd:cd00609 242 SqaaaAAALDDGEEHLEELRERYRRRRDALLEALKELGPLVVVKPSG 288
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
70-236 |
3.87e-14 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 73.21 E-value: 3.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 70 LEARMASLEGGEAGL---ALASGMGAITSTLWTLLRPGDEVLL--GN---TLY---GCTfaflHHGIG---EFGVKLRHV 135
Cdd:COG4100 62 LERVYADVFGAEDALvrpQIVSGTHAIALALFGVLRPGDELLSitGKpydTLEeviGIR----GEGQGslkEFGISYRQV 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 136 DMA-----DLQALEAAMTPATRVIYFE-SPA---NPNMHMADIAGVAKIARKH--GATVVVDNTY----CTpylQRPLEL 200
Cdd:COG4100 138 PLTedgkiDLEAIKKAINEKTKMVLIQrSRGyswRPSLTIEEIGEIIKFVKSInpDVICFVDNCYgefvET---REPTEV 214
|
170 180 190
....*....|....*....|....*....|....*...
1PG8_D 201 GADLVVHSATKYLSGHGDITAGIVVGSQALVDRI--RL 236
Cdd:COG4100 215 GADLMAGSLIKNPGGGLAPTGGYIAGRKDLVELAayRL 252
|
|
| Met_gamma_lyase |
pfam06838 |
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ... |
70-233 |
3.60e-13 |
|
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.
Pssm-ID: 429146 Cd Length: 405 Bit Score: 70.43 E-value: 3.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 70 LEARMASLEGGEAGLA---LASGMGAITSTLWTLLRPGDEVLlgnTLYGCTFAFLHHGIG----------EFGVKLRHVD 136
Cdd:pfam06838 60 LDRVYARVFGAEAALVrpqFVSGTHAIATALFGVLRPGDELL---YITGSPYDTLEEVIGirgegqgslkDFGIGYREVP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 137 MA-----DLQALEAAMTPATRVIYFESPAN----PNMHMADIAGVAKIARKHGATVV--VDNTYCT-PYLQRPLELGADL 204
Cdd:pfam06838 137 LLedgkvDWEAIKTAITPKTKLILIQRSKGyswrPSLTIAEIKEIIKFVKEINPDVIvfVDNCYGEfVETKEPTHVGADL 216
|
170 180
....*....|....*....|....*....
1PG8_D 205 VVHSATKYLSGHGDITAGIVVGSQALVDR 233
Cdd:pfam06838 217 IAGSLIKNPGGGIAPTGGYIAGKADLVEQ 245
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
70-282 |
1.86e-10 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 61.81 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 70 LEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLL--GNtlygctFAFLHHGIGEFGVKLR---HVDMADL-QAL 143
Cdd:cd06454 51 LEEELAEFHGKEAALVFSSGYAANDGVLSTLAGKGDLIISdsLN------HASIIDGIRLSGAKKRifkHNDMEDLeKLL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 144 EAAMTPATRV-IYFESPANPNMHMADIAGVAKIARKHGATVVVDN--------------TYCTPYLQRPlelgaDLVVHS 208
Cdd:cd06454 125 REARRPYGKKlIVTEGVYSMDGDIAPLPELVDLAKKYGAILFVDEahsvgvygphgrgvEEFGGLTDDV-----DIIMGT 199
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1PG8_D 209 ATKYLSGHGditaGIVVGSQALVDRIRLQGLKDMTGAVLSPHDAALLMRGIKTL---NLRMDRHCANAQVLAEFLAR 282
Cdd:cd06454 200 LGKAFGAVG----GYIAGSKELIDYLRSYARGFIFSTSLPPAVAAAALAALEVLqggPERRERLQENVRYLRRGLKE 272
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
91-189 |
1.17e-09 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 59.37 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLLGN----------TLYGCTFAFLHHGIgEFGVKLrhvdmaDLQALEAAMTPATRVIYFESPA 160
Cdd:PRK05764 102 QALYNAFMALLDPGDEVIIPApywvsypemvKLAGGVPVFVPTGE-ENGFKL------TVEQLEAAITPKTKALILNSPS 174
|
90 100 110
....*....|....*....|....*....|..
1PG8_D 161 NPNMHM---ADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK05764 175 NPTGAVyspEELEAIADVAVEHDIWVLSDEIY 206
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
67-226 |
2.32e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 56.24 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 67 LNLLEARMASL--EGGEAGLALASGMGAITSTLWTLLRPGDEVLlgnTLYGCTFAFLHHGIGEFGVKLRHVD-------- 136
Cdd:cd01494 2 LEELEEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVI---VDANGHGSRYWVAAELAGAKPVPVPvddagygg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 137 MADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYCTPY----LQRPLELGADLVVHSATKY 212
Cdd:cd01494 79 LDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKN 158
|
170
....*....|....
1PG8_D 213 LSGHGditAGIVVG 226
Cdd:cd01494 159 LGGEG---GGVVIV 169
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
98-235 |
7.92e-09 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 57.07 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 98 WTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMA-----DLQALEAAMTPATRVIYFespanpnMHM------ 166
Cdd:COG0520 97 LGRLKPGDEILITEMEHHSNIVPWQELAERTGAEVRVIPLDedgelDLEALEALLTPRTKLVAV-------THVsnvtgt 169
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1PG8_D 167 -ADIAGVAKIARKHGATVVVDNTYCTPYLqrPL---ELGADLVVhsatkyLSGH---GDITAGIVVGSQALVDRIR 235
Cdd:COG0520 170 vNPVKEIAALAHAHGALVLVDGAQSVPHL--PVdvqALGCDFYA------FSGHklyGPTGIGVLYGKRELLEALP 237
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
87-189 |
8.20e-09 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 56.88 E-value: 8.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 87 ASGMGAITSTLWTLLRPGDEVLLGNTLYgctfAFLHHGIGEFGVKLRHVDMA--------DLQALEAAMTPATRVIYFES 158
Cdd:PRK06108 91 SSGVQALMLAAQALVGPGDEVVAVTPLW----PNLVAAPKILGARVVCVPLDfggggwtlDLDRLLAAITPRTRALFINS 166
|
90 100 110
....*....|....*....|....*....|....
1PG8_D 159 PANPN---MHMADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK06108 167 PNNPTgwtASRDDLRAILAHCRRHGLWIVADEVY 200
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
165-350 |
1.02e-08 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 56.67 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 165 HMADIAGVAKIARKHGATVVVD---------NTYCTPY---LQRPLELGADLVVHSATKYLSGhgdITAGIVVGSQALVD 232
Cdd:COG1921 173 EEVSLAELAELAHEHGLPVIVDlgsgslvdlSKYGLPHeptVQEYLAAGADLVTFSGDKLLGG---PQAGIIVGKKELIE 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 233 RIRLQGLK-----D-MTgavLsphdAALlmrgIKTLNLRMDRHCANAQVLAEFLARQPQVELIHY-----PGLASFPQYT 301
Cdd:COG1921 250 RIKKNPLGralrvDkET---L----AAL----EATLRLYLDPEKAAEEIPTLRMLTRPQEELRARaerlaEALNALLGVT 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
1PG8_D 302 LARQQM-SQPGGmiafelkggiGAgrrfMNALQLFSRAVSL----GDAESLAQH 350
Cdd:COG1921 319 VEIVPDeSQVGG----------GS----LPVEELPSAAVALdpagLSAEELAKA 358
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
37-281 |
4.51e-08 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 54.14 E-value: 4.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 37 TFTFPTVEYGAACFAGEQAGHFYSRisNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGC 116
Cdd:pfam01212 6 TVTGPTPAMREAMAAAMVGDEVYGG--DPTVNRLEDRVAELFGKEAALFVPSGTAANQLALMAHCQRGDEVICGEPAHIH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 117 TFAflHHGIGEF-GVKLRHVDMA-----DLQALEAAMT-------PATRVIYFESPANPN----MHMADIAGVAKIARKH 179
Cdd:pfam01212 84 FDE--TGGHAELgGVQPRPLDGDeagnmDLEDLEAAIRevgadifPPTGLISLENTHNSAggqvVSLENLREIAALAREH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 180 GATVVVDNTY----CTPYLQRPLEL--GADLVVHSATKylSGHGDItAGIVVGSQALVDRIRLQglKDMTGAVLSPHD-- 251
Cdd:pfam01212 162 GIPVHLDGARfanaAVALGVIVKEItsYADSVTMCLSK--GLGAPV-GSVLAGSDDFIAKAIRQ--RKYLGGGLRQAGvl 236
|
250 260 270
....*....|....*....|....*....|
1PG8_D 252 AALLMRGIKTLNLRMDRHCANAQVLAEFLA 281
Cdd:pfam01212 237 AAAGLRALEEGVARLARDHATARRLAEGLE 266
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
91-300 |
6.14e-08 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 54.17 E-value: 6.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLlgnTLYGcTFAfLHHGIGE-FG--VKLRHVD-----MADLQALEAAMTPATRVIYFESPANP 162
Cdd:PRK07324 91 GANFLVLYALVEPGDHVI---SVYP-TYQ-QLYDIPEsLGaeVDYWQLKeengwLPDLDELRRLVRPNTKLICINNANNP 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 163 N---MHMADIAGVAKIARKHGATVVVDNTYctpylqRPL-ELG-----ADL-----VVHSATKYLSGHGdITAGIVVGSQ 228
Cdd:PRK07324 166 TgalMDRAYLEEIVEIARSVDAYVLSDEVY------RPLdEDGstpsiADLyekgiSTNSMSKTYSLPG-IRVGWIAANE 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 229 ALVDRIRLQ--------G-LKDMTGAVLSPHDAALLMRgiktlNLRMDRhcANAQVLAEFLARQPQVELIhYP--GLASF 297
Cdd:PRK07324 239 EVIDILRKYrdytmicaGvFDDMLASLALEHRDAILER-----NRKIVR--TNLAILDEWVAKEPRVSYV-KPkaVSTSF 310
|
...
1PG8_D 298 PQY 300
Cdd:PRK07324 311 VKL 313
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
101-211 |
8.20e-08 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 53.98 E-value: 8.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 101 LRPGDEVLLgntlygcTFAFLHHGI-------GEFGVKLRHVDMA-----DLQALEAAMTPATRVIYFESPANPNMHMAD 168
Cdd:PLN02855 119 LKPGDEVIL-------SVAEHHSNIvpwqlvaQKTGAVLKFVGLTpdevlDVEQLKELLSEKTKLVATHHVSNVLGSILP 191
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
1PG8_D 169 IAGVAKIARKHGATVVVDNTYCTPYLqrPLE---LGADLVVHSATK 211
Cdd:PLN02855 192 VEDIVHWAHAVGAKVLVDACQSVPHM--PVDvqtLGADFLVASSHK 235
|
|
| PRK06207 |
PRK06207 |
pyridoxal phosphate-dependent aminotransferase; |
69-239 |
1.35e-07 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235742 Cd Length: 405 Bit Score: 53.23 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 69 LLEARMASLEG----GEAGLALASG-MGAITSTLWTLLRPGDEVLLGNTLYgctfaFLHHGIGEF------GVKLRHVDM 137
Cdd:PRK06207 86 LLAARLAAFTGapvdAADELIITPGtQGALFLAVAATVARGDKVAIVQPDY-----FANRKLVEFfegemvPVQLDYLSA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 138 -----ADLQALEAAMTPATRVIYFESPANPN---MHMADIAGVAKIARKHGATVVVDNTYC------TPYLQ-RPLELGA 202
Cdd:PRK06207 161 dkragLDLDQLEEAFKAGVRVFLFSNPNNPAgvvYSAEEIAQIAALARRYGATVIVDQLYSrllydgTSYTHlRALPIDP 240
|
170 180 190 200
....*....|....*....|....*....|....*....|..
1PG8_D 203 DLVVH----SATKYLSGHgdiTAGIVVGSQALVDRI-RLQGL 239
Cdd:PRK06207 241 ENVITimgpSKTESLSGY---RLGVAFGSPAIIDRMeKLQAI 279
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
81-235 |
1.69e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 52.69 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 81 EAGLALASGMGAITSTLWTLLR-PGDEVLLGNTlygcTFAFLHHGIGEFGVKLRHVDM-------ADLQALEAAMTPATR 152
Cdd:pfam00155 63 EAAVVFGSGAGANIEALIFLLAnPGDAILVPAP----TYASYIRIARLAGGEVVRYPLydsndfhLDFDALEAALKEKPK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 153 VIYFESPANP---NMHMADIAGVAKIARKHGATVVVDNTY-------CTPYLQRPLELGAD--LVVHSATKYLSGHGdIT 220
Cdd:pfam00155 139 VVLHTSPHNPtgtVATLEELEKLLDLAKEHNILLLVDEAYagfvfgsPDAVATRALLAEGPnlLVVGSFSKAFGLAG-WR 217
|
170
....*....|....*
1PG8_D 221 AGIVVGSQALVDRIR 235
Cdd:pfam00155 218 VGYILGNAAVISQLR 232
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
92-189 |
1.94e-07 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 52.73 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLY----------GCTF--AFLHHGIGEFGVklrhvdmaDLQALEAAMTPATRVIYFESP 159
Cdd:PRK07777 97 AIAAAVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRvpVPLVPDGRGFAL--------DLDALRAAVTPRTRALIVNSP 168
|
90 100 110
....*....|....*....|....*....|...
1PG8_D 160 ANPN---MHMADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK07777 169 HNPTgtvLTAAELAAIAELAVEHDLLVITDEVY 201
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
92-189 |
2.92e-07 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 51.90 E-value: 2.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLHH--GIGEFgVKLRHVDMA-DLQALEAAMTPATRVIYFESPANPNMHM-- 166
Cdd:PRK08912 99 ALAAALLALVEPGDEVVLFQPLYDAYLPLIRRagGVPRL-VRLEPPHWRlPRAALAAAFSPRTKAVLLNNPLNPAGKVfp 177
|
90 100
....*....|....*....|....
1PG8_D 167 -ADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK08912 178 rEELALLAEFCQRHDAVAICDEVW 201
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
48-190 |
5.84e-07 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 51.11 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 48 ACFAGEQAGHFYSRI-SNPTL-NLLEARMASLEGG---EAGLALASGMG-AITSTLWTLLRPGDEVLLGNTLYgctfaFL 121
Cdd:PRK07550 52 AEAAADPAAHLYGPVeGLPELrEAYAAHYSRLYGAaisPEQVHITSGCNqAFWAAMVTLAGAGDEVILPLPWY-----FN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 122 HH-GIGEFGVKLRHVD-------MADLQALEAAMTPATRVIYFESPANPN--MHMAD-IAGVAKIARKHGATVVVDNTYC 190
Cdd:PRK07550 127 HKmWLDMLGIRPVYLPcdegpglLPDPAAAEALITPRTRAIALVTPNNPTgvVYPPElLHELYDLARRHGIALILDETYR 206
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
62-341 |
8.27e-07 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 50.36 E-value: 8.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 62 ISNPTLNLLEARMASLEGGEAGLALASGmgaiTSTLWTLLR-----PGDEVLLGNTlygcTFAFLHHGIGEFGVKLRHVD 136
Cdd:pfam01041 21 TTGPYVREFERAFAAYLGVKHAIAVSSG----TAALHLALRalgvgPGDEVITPSF----TFVATANAALRLGAKPVFVD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 137 MA------DLQALEAAMTPATRVIYfesPANPNMHMADIAGVAKIARKHGATVVVDNTYC--TPYLQRPLELGADLVVHS 208
Cdd:pfam01041 93 IDpdtyniDPEAIEAAITPRTKAII---PVHLYGQPADMDAIRAIAARHGLPVIEDAAHAlgATYQGKKVGTLGDAATFS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 209 --ATKylsghgDITAG----IVVGSQALVDRIRL---QGLK---------DMTG--AVLSPHDAALLMRGIKTLNLRMDR 268
Cdd:pfam01041 170 fhPTK------NLTTGeggaVVTNDPELAEKARVlrnHGMVrkadkrywhEVLGynYRMTEIQAAIGLAQLERLDEFIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 269 HCANAQVLAEFLARQPQVELIHYPGLA---SFPQYT-LARQQMSQPGGMIAFELKGGIG--------------------- 323
Cdd:pfam01041 244 RREIAALYQTLLADLPGFTPLTTPPEAdvhAWHLFPiLVPEEAINRDELVEALKEAGIGtrvhypiplhlqpyyrdlfgy 323
|
330
....*....|....*...
1PG8_D 324 AGRRFMNALQLFSRAVSL 341
Cdd:pfam01041 324 APGDLPNAEDISSRVLSL 341
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
65-350 |
1.10e-06 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 50.07 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 65 PTLNLLEARMASLEGGEAGLALASGmgaiTSTLWTLLR-----PGDEVLL-GNTLYGCTFAFLHHGIgefgvKLRHVD-- 136
Cdd:COG0399 30 PEVKEFEEEFAAYLGVKHAVAVSSG----TAALHLALRalgigPGDEVITpAFTFVATANAILYVGA-----TPVFVDid 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 137 ----MADLQALEAAMTPATRVIyfespanpnM------HMADIAGVAKIARKHGATVVVDNTYCtpylqrpleLGA---- 202
Cdd:COG0399 101 pdtyNIDPEALEAAITPRTKAI---------IpvhlygQPADMDAIMAIAKKHGLKVIEDAAQA---------LGAtykg 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 203 -------DLVVHS--ATKylsgHgdITAG----IVVGSQALVDRIRLQGLKDMTGAVLSPHD------------AALLMR 257
Cdd:COG0399 163 kkvgtfgDAGCFSfyPTK----N--LTTGeggaVVTNDEELAERARSLRNHGRDRDAKYEHVelgynyrmdelqAAIGLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 258 GIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLA--SFPQYTLARQQMSQPGGMIAFELKGGIGAGRRFMNAL--- 332
Cdd:COG0399 237 QLKRLDEFIARRRAIAARYREALADLPGLTLPKVPPGAehVYHLYVIRLDEGEDRDELIAALKARGIGTRVHYPIPLhlq 316
|
330 340
....*....|....*....|..
1PG8_D 333 ----QLFSRAVSLGDAESLAQH 350
Cdd:COG0399 317 payrDLGYRPGDLPVAERLAER 338
|
|
| BioF |
COG0156 |
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ... |
70-186 |
2.05e-06 |
|
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 439926 [Multi-domain] Cd Length: 385 Bit Score: 49.28 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 70 LEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLL----------GNTLYGCTFaflhhgigefgVKLRHVDMAD 139
Cdd:COG0156 87 LEEELAEFLGKEAALLFSSGYAANLGVISALAGRGDLIFSdelnhasiidGARLSGAKV-----------VRFRHNDMDD 155
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
1PG8_D 140 L-QALEAAMTPATRVIYFE---SpanpnMH--MADIAGVAKIARKHGATVVVD 186
Cdd:COG0156 156 LeRLLKKARAARRKLIVTDgvfS-----MDgdIAPLPEIVELAEKYGALLYVD 203
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
91-162 |
3.14e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 48.65 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 91 GAITSTLWTLLRPGDEVLlgntlygcTFA--FLHHG--IGEFGVKLRHVDMA------DLQALEAAMTPATRVIYFESPA 160
Cdd:PRK06836 107 GALNVALKAILNPGDEVI--------VFApyFVEYRfyVDNHGGKLVVVPTDtdtfqpDLDALEAAITPKTKAVIINSPN 178
|
..
1PG8_D 161 NP 162
Cdd:PRK06836 179 NP 180
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
129-236 |
3.87e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 48.62 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 129 GVKLRHVDMA-----DLQALEAAMTPATRVIYFespanpnMHMA-------DIAGVAKIARKHGATVVVDNTYCTPYLqr 196
Cdd:cd06453 113 GAKLKVVPVDddgqlDLEALEKLLTERTKLVAV-------THVSnvlgtinPVKEIGEIAHEAGVPVLVDGAQSAGHM-- 183
|
90 100 110 120
....*....|....*....|....*....|....*....|...
1PG8_D 197 PL---ELGADLVVHSATKYLSGHGditAGIVVGSQALVDRIRL 236
Cdd:cd06453 184 PVdvqDLGCDFLAFSGHKMLGPTG---IGVLYGKEELLEEMPP 223
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
77-248 |
6.43e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 47.83 E-value: 6.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 77 LEGGEAgLALASGMGAITSTLWTLLRPGDEVLLGNTLYG--CTFAflhhgiGEFGVKLRHVDMAD--------LQALEAA 146
Cdd:PRK06225 81 LDDDEA-LITAGATESLYLVMRAFLSPGDNAVTPDPGYLiiDNFA------SRFGAEVIEVPIYSeecnykltPELVKEN 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 147 MTPATRVIYFESPANP---NMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGAD----LVVHSATKYLsGHGDI 219
Cdd:PRK06225 154 MDENTRLIYLIDPLNPlgsSYTEEEIKEFAEIARDNDAFLLHDCTYRDFAREHTLAAEYApehtVTSYSFSKIF-GMAGL 232
|
170 180
....*....|....*....|....*....
1PG8_D 220 TAGIVVGSQALVDRIRLQGLKDMTGAVLS 248
Cdd:PRK06225 233 RIGAVVATPDLIEVVKSIVINDLGTNVIA 261
|
|
| PLN00175 |
PLN00175 |
aminotransferase family protein; Provisional |
92-189 |
2.91e-05 |
|
aminotransferase family protein; Provisional
Pssm-ID: 215089 [Multi-domain] Cd Length: 413 Bit Score: 46.01 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLHH-GIGEFGVKLRHVDMA-DLQALEAAMTPATRVIYFESPANPNMHM--- 166
Cdd:PLN00175 127 AIAATILGLINPGDEVILFAPFYDSYEATLSMaGAKIKTVTLRPPDFAvPEDELKAAFTSKTRAILINTPHNPTGKMftr 206
|
90 100
....*....|....*....|...
1PG8_D 167 ADIAGVAKIARKHGATVVVDNTY 189
Cdd:PLN00175 207 EELELIASLCKENDVLAFTDEVY 229
|
|
| PucG |
COG0075 |
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism ... |
87-186 |
5.52e-05 |
|
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439845 [Multi-domain] Cd Length: 376 Bit Score: 44.70 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 87 ASGMGAITSTLWTLLRPGDEVLLGNTlygctfaflhhgiGEFGvkLRHVDMA------------------DLQALEAAMT 148
Cdd:COG0075 57 GSGTGAMEAALANLVSPGDKVLVLVN-------------GAFG--ERWAEIAerygaevvvlevpwgeavDPEEVEEALA 121
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
1PG8_D 149 --PATRVIYF---ESP---ANPnmhmadIAGVAKIARKHGATVVVD 186
Cdd:COG0075 122 adPDIKAVAVvhnETStgvLNP------LEEIGALAKEHGALLIVD 161
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
136-206 |
8.93e-05 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 44.36 E-value: 8.93e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1PG8_D 136 DMADLQALEAAMTPATRVIYFEspaNPNM--HMADIAGVAKIARKHGATVVVdntYCTP----YLQRPLELGADLVV 206
Cdd:PRK00451 190 GVTDLEALEAAVDDDTAAVVVQ---YPNFfgVIEDLEEIAEIAHAGGALFIV---GVDPvslgLLKPPGEYGADIVV 260
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
92-189 |
1.21e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 43.69 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAFLhhgiGEFGVKLRHVD--------MADLQALEAAMTPATRVIYFESPANPN 163
Cdd:PRK07568 100 AILFAMMAICDPGDEILVPEPFYANYNGFA----TSAGVKIVPVTtkieegfhLPSKEEIEKLITPKTKAILISNPGNPT 175
|
90 100 110
....*....|....*....|....*....|....
1PG8_D 164 --------MHMadiagVAKIARKHGATVVVDNTY 189
Cdd:PRK07568 176 gvvytkeeLEM-----LAEIAKKHDLFLISDEVY 204
|
|
| PRK13392 |
PRK13392 |
5-aminolevulinate synthase; Provisional |
69-186 |
2.27e-04 |
|
5-aminolevulinate synthase; Provisional
Pssm-ID: 184023 [Multi-domain] Cd Length: 410 Bit Score: 42.92 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 69 LLEARMASLEGGEAGLALASGMGAITSTLWTL--LRPGDeVLLGNTLygcTFAFLHHGIGEFGVK---LRHVDMADLQAL 143
Cdd:PRK13392 95 LLERELADLHGKESALLFTSGYVSNDAALSTLgkLLPGC-VILSDAL---NHASMIEGIRRSGAEkqvFRHNDLADLEEQ 170
|
90 100 110 120
....*....|....*....|....*....|....*....|....
1PG8_D 144 EAAMTPAT-RVIYFESPANPNMHMADIAGVAKIARKHGATVVVD 186
Cdd:PRK13392 171 LASVDPDRpKLIAFESVYSMDGDIAPIEAICDLADRYNALTYVD 214
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
101-242 |
4.43e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 41.85 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 101 LRPGDEVLLGNTLygctfaflHHG-------IGEF-GVKLRHVDMA-----DLQALEAAMTPATRVIYFespanpnMHM- 166
Cdd:pfam00266 85 LKPGDEIVITEME--------HHAnlvpwqeLAKRtGARVRVLPLDedgllDLDELEKLITPKTKLVAI-------THVs 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 167 ------ADIAGVAKIARKHGATVVVDNtyCTPYLQRPL---ELGADLVVHSATKYLSGHGditAGIVVGSQALVDRIR-L 236
Cdd:pfam00266 150 nvtgtiQPVPEIGKLAHQYGALVLVDA--AQAIGHRPIdvqKLGVDFLAFSGHKLYGPTG---IGVLYGRRDLLEKMPpL 224
|
....*.
1PG8_D 237 QGLKDM 242
Cdd:pfam00266 225 LGGGGM 230
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
89-212 |
6.56e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 41.58 E-value: 6.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 89 GMGAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGE-----FGVKLRHVDMADLqaLEAAMTPATRVIYFESPANPN 163
Cdd:PRK08960 101 GSGALLLASSLLVDPGKHWLLADPGYPCNRHFLRLVEGAaqlvpVGPDSRYQLTPAL--VERHWNADTVGALVASPANPT 178
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
1PG8_D 164 ---MHMADIAGVAKIARKHGATVVVDNTY--CTPYLQRPLELGAD---LVVHSATKY 212
Cdd:PRK08960 179 gtlLSRDELAALSQALRARGGHLVVDEIYhgLTYGVDAASVLEVDddaFVLNSFSKY 235
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
82-189 |
7.37e-04 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 82 AGLALASGMGAItstlwtlLRPGDEVLLGN----------TLYGCTFAFLHHGiGEFGVKLRHVDmadlqaLEAAMTPAT 151
Cdd:PRK07682 90 ASQALDVAMRAI-------INPGDEVLIVEpsfvsyaplvTLAGGVPVPVATT-LENEFKVQPAQ------IEAAITAKT 155
|
90 100 110 120
....*....|....*....|....*....|....*....|.
1PG8_D 152 RVIYFESPANPN---MHMADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK07682 156 KAILLCSPNNPTgavLNKSELEEIAVIVEKHDLIVLSDEIY 196
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
65-235 |
8.63e-04 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 41.16 E-value: 8.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 65 PTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTF-----AFLHhgigefGVKLRHVDMAD 139
Cdd:cd06502 32 PTTAKLEARAAELFGKEAALFVPSGTAANQLALAAHTQPGGSVICHETAHIYTDeagapEFLS------GVKLLPVPGEN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 140 ----LQALEAAMT-------PATRVIYFESPAN-----PNMHMADIagvAKIARKHGATVVVDN---------------T 188
Cdd:cd06502 106 gkltPEDLEAAIRprddihfPPPSLVSLENTTEggtvyPLDELKAI---SALAKENGLPLHLDGarlanaaaalgvalkT 182
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
1PG8_D 189 YCTpylqrplelGADLVVHSATKYLSGHGDitaGIVVGSQALVDRIR 235
Cdd:cd06502 183 YKS---------GVDSVSFCLSKGGGAPVG---AVVVGNRDFIARAR 217
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
75-244 |
9.42e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 41.06 E-value: 9.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 75 ASLEGGEAGLALASGMGAITSTLwtllrPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVD-----MADLQALEAAMTP 149
Cdd:cd00613 84 ASLQDEATAAAEAAGLAAIRAYH-----KRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPsdeggTVDLEALKEEVSE 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 150 ATRVIYFEspaNPNMH---MADIAGVAKIARKHGATVVV--DNTYCTpYLQRPLELGADLVVHSATKYLSGHGDIT--AG 222
Cdd:cd00613 159 EVAALMVQ---YPNTLgvfEDLIKEIADIAHSAGALVYVdgDNLNLT-GLKPPGEYGADIVVGNLQKTGVPHGGGGpgAG 234
|
170 180
....*....|....*....|....*
1PG8_D 223 IVVGSQALVDRI--RLQG-LKDMTG 244
Cdd:cd00613 235 FFAVKKELVRFLpgRLVGvTKDAEG 259
|
|
| PLN02721 |
PLN02721 |
threonine aldolase |
64-186 |
1.55e-03 |
|
threonine aldolase
Pssm-ID: 178323 [Multi-domain] Cd Length: 353 Bit Score: 40.44 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 64 NPTLNLLEARMASLEGGEAGLALASG-MGAITSTLWTLLRPGDEVLLGNTLYGCTFAflHHGIGEFG------VKLRHVD 136
Cdd:PLN02721 39 DPTALRLEEEMAKIFGKEAALFVPSGtMGNLISVLVHCDVRGSEVILGDNSHIHLYE--NGGISTLGgvhprtVKNNEDG 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
1PG8_D 137 MADLQALEAAMT-------PATRVIYFESPAN-------PNMHMADiagVAKIARKHGATVVVD 186
Cdd:PLN02721 117 TMDLDAIEAAIRpkgddhfPTTRLICLENTHAncggrclSVEYTDK---VGELAKRHGLKLHID 177
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
92-189 |
5.89e-03 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 5.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 92 AITSTLWTLLRPGDEVLLGNTLYGCTFAflhhGIGEFGVKLRHVDMA------DLQALEAAMTPATRVIYFESPANPN-- 163
Cdd:PRK09082 103 ALFAAILALVRPGDEVIVFDPSYDSYAP----AIELAGGRAVRVALQppdfrvDWQRFAAAISPRTRLIILNTPHNPSgt 178
|
90 100
....*....|....*....|....*..
1PG8_D 164 -MHMADIAGVAKIARKHGATVVVDNTY 189
Cdd:PRK09082 179 vWSAADMRALWQLIAGTDIYVLSDEVY 205
|
|
| SelA |
pfam03841 |
L-seryl-tRNA selenium transferase; |
129-242 |
7.25e-03 |
|
L-seryl-tRNA selenium transferase;
Pssm-ID: 309101 Cd Length: 367 Bit Score: 38.09 E-value: 7.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 129 GVKLRHVDMAD---LQALEAAMTPATRVIYFESPANPNM----HMADIAGVAKIARKHGATVVVD---------NTYCTP 192
Cdd:pfam03841 112 GVKLVEVGTTNrthLKDYEQAINENTALLMKVHTSNYRIqgftKEVELAELVELGHEKGLPVYEDlgsgslvdlSQYGLP 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
1PG8_D 193 Y---LQRPLELGADLVVHSATKYLSGhgdITAGIVVGSQALVDRIRLQGLKDM 242
Cdd:pfam03841 192 KeptVQELIAQGVDLVSFSGDKLLGG---PQAGIIVGKKELIERIKKNPLKRA 241
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
128-206 |
8.28e-03 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 38.09 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 128 FGVKLRHVDMA----DLQALEAAMTPATRVIYFESPaNPNMHMADIAGVAKIARKHGATVVVdntYCTPY----LQRPLE 199
Cdd:COG0403 179 LGIEVVEVPDEdgvtDLEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIV---AADPLslglLKPPGE 254
|
....*..
1PG8_D 200 LGADLVV 206
Cdd:COG0403 255 LGADIVV 261
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
88-235 |
8.80e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 38.04 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 88 SGMGAITSTLWTLLRPGDEVLLGntLYGcTFAFLHHGIGE-FGVKLRHVD-----MADLQALEAAMTP----ATRVIYFE 157
Cdd:cd06451 58 SGTGAMEAALSNLLEPGDKVLVG--VNG-VFGDRWADMAErYGADVDVVEkpwgeAVSPEEIAEALEQhdikAVTLTHNE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PG8_D 158 SPANPNMhmaDIAGVAKIARKHGATVVVD--NTYCTPYLqRPLELGADLVVHSATKYLS---GhgditAGIVVGSQALVD 232
Cdd:cd06451 135 TSTGVLN---PLEGIGALAKKHDALLIVDavSSLGGEPF-RMDEWGVDVAYTGSQKALGappG-----LGPIAFSERALE 205
|
...
1PG8_D 233 RIR 235
Cdd:cd06451 206 RIK 208
|
|
| |
