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Conserved domains on  [gi|61679678|pdb|1XXI|I]
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Chain I, DNA polymerase III subunit gamma

Protein Classification

DNA polymerase III subunit gamma/tau( domain architecture ID 11483016)

DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme; gamma and tau subunits are isoforms and either one or both may be present in the holoenzyme; gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex

EC:  2.7.7.7
Gene Ontology:  GO:0009360|GO:0030337|GO:0016887
PubMed:  12940977
SCOP:  8022167

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
1-368 0e+00

DNA polymerase III subunits gamma and tau; Validated


:

Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 838.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK07994   1 MSYQVLARKWRPQTFAEVVGQEHVLTALANALDLGRLHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGECDNCR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK07994  81 EIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK07994 161 KLPVTILSRCLQFHLKALDVEQIRQQLEHILQAEQIPFEPRALQLLARAADGSMRDALSLTDQAIASGNGQVTTDDVSAM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTI 320
Cdd:PRK07994 241 LGTLDDDQALSLLEALVEGDGERVMALINQLAERGPDWEGLLVELLELLHRIAMAQLLPAALDNDMADIELRLRELARTL 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMPLPEP 368
Cdd:PRK07994 321 PPEDVQLYYQTLLIGRKDLPLAPDRRMGVEMTLLRMLAFHPAAPLPEP 368
 
Name Accession Description Interval E-value
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
1-368 0e+00

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 838.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK07994   1 MSYQVLARKWRPQTFAEVVGQEHVLTALANALDLGRLHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGECDNCR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK07994  81 EIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK07994 161 KLPVTILSRCLQFHLKALDVEQIRQQLEHILQAEQIPFEPRALQLLARAADGSMRDALSLTDQAIASGNGQVTTDDVSAM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTI 320
Cdd:PRK07994 241 LGTLDDDQALSLLEALVEGDGERVMALINQLAERGPDWEGLLVELLELLHRIAMAQLLPAALDNDMADIELRLRELARTL 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMPLPEP 368
Cdd:PRK07994 321 PPEDVQLYYQTLLIGRKDLPLAPDRRMGVEMTLLRMLAFHPAAPLPEP 368
dnaX_nterm TIGR02397
DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ ...
3-357 0e+00

DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274111 [Multi-domain]  Cd Length: 355  Bit Score: 511.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I          3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREI 82
Cdd:TIGR02397   1 YQVLARKYRPQTFEDVIGQEHIVQTLKNAIKNGRIAHAYLFSGPRGTGKTSIARIFAKALNCQNGPDGEPCNECESCKEI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         83 EQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKL 162
Cdd:TIGR02397  81 NSGSSLDVIEIDAASNNGVDDIREILDNVKYAPSSGKYKVYIIDEVHMLSKSAFNALLKTLEEPPEHVVFILATTEPHKI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        163 PVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLG 242
Cdd:TIGR02397 161 PATILSRCQRFDFKRIPLEDIVERLKKILDKEGIKIEDEALELIARAADGSLRDALSLLDQLISFGNGKITYEDVNELLG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        243 TLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTIPP 322
Cdd:TIGR02397 241 LVDDEKLIELLEAILNKDTAEALKILDEILESGVDPEKFLEDLIEILRDLLLIKKTPSNLLAVLESEQEFLKELALKLSL 320
                         330       340       350
                  ....*....|....*....|....*....|....*
1XXI_I        323 TDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRAL 357
Cdd:TIGR02397 321 EFLLRLLDILLEALKDLRFSNDPRIWLEMTLLRLL 355
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
1-358 1.54e-169

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 476.22  E-value: 1.54e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        1 MSYQVlarkwrPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:COG2812   1 MSYQV------PQTFDDVVGQEHVVRTLKNALASGRLAHAYLFTGPRGVGKTTLARILAKALNCENGPTGEPCGECESCR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       81 EIEQGRFVDLIEIDA-ASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDP 159
Cdd:COG2812  75 AIAAGSHPDVIEIDAeASNIGVDDIRELIEKVSYAPVEGRYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      160 QKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIAsgdgqvstqavsa 239
Cdd:COG2812 155 QKLLPTILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQAIA------------- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      240 mLGTLD-DDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELAR 318
Cdd:COG2812 222 -FGLLDrRELLLDLLEALLAGDVAALLALAEELAKRGRDLKRFLDDLLSLLRDLLLLKLGPDAELLVNEDERERLQELAR 300
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
1XXI_I      319 TIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALA 358
Cdd:COG2812 301 RLSPERLLRAIQILLEARRELERNVNPRLALEMLLLRLAR 340
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
20-179 7.81e-54

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 174.71  E-value: 7.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         20 GQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRT 99
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHAYLFSGPEGVGKLELALAFAKALFCEEPGDDLPCGQCRSCRRIESGNHPDLVIIEPEGQS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        100 -KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKAL 178
Cdd:pfam13177  81 iKIDQIRELQKEFSKSPYEGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFKPL 160

                  .
1XXI_I        179 D 179
Cdd:pfam13177 161 S 161
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
178-242 2.86e-23

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 91.41  E-value: 2.86e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I      178 LDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLG 242
Cdd:cd18137   1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALSLLDQAIAFGGGRVTLDDVREMLG 65
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
38-175 6.52e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.75  E-value: 6.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I          38 HHAYLFSGTRGVGKTSIARLLAKGLNCETGITATpcgvcDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPAR 117
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIY-----IDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1XXI_I         118 GRFKVYLIDEVHMLSRHSFNALL--------KTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHL 175
Cdd:smart00382  77 LKPDVLILDEITSLLDAEQEALLllleelrlLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRI 142
 
Name Accession Description Interval E-value
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
1-368 0e+00

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 838.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK07994   1 MSYQVLARKWRPQTFAEVVGQEHVLTALANALDLGRLHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGECDNCR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK07994  81 EIEQGRFVDLIEIDAASRTKVEDTRELLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK07994 161 KLPVTILSRCLQFHLKALDVEQIRQQLEHILQAEQIPFEPRALQLLARAADGSMRDALSLTDQAIASGNGQVTTDDVSAM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTI 320
Cdd:PRK07994 241 LGTLDDDQALSLLEALVEGDGERVMALINQLAERGPDWEGLLVELLELLHRIAMAQLLPAALDNDMADIELRLRELARTL 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMPLPEP 368
Cdd:PRK07994 321 PPEDVQLYYQTLLIGRKDLPLAPDRRMGVEMTLLRMLAFHPAAPLPEP 368
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
1-364 0e+00

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 582.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14949   1 MSYQVLARKWRPATFEQMVGQSHVLHALTNALTQQRLHHAYLFTGTRGVGKTSLARLFAKGLNCEQGVTATPCGVCSSCV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14949  81 EIAQGRFVDLIEVDAASRTKVDDTRELLDNVQYRPSRGRFKVYLIDEVHMLSRSSFNALLKTLEEPPEHVKFLLATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14949 161 KLPVTVLSRCLQFNLKSLTQDEIGTQLNHILTQEQLPFEAEALTLLAKAANGSMRDALSLTDQAIAFGGGQVMLTQVQTM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAAlgndmAAIEL---RMRELA 317
Cdd:PRK14949 241 LGSIDEQHVIALLKALTDADIGVLMQTCAQVLAFGADAQEVLRSLLELLHQITLTQFAPAA-----AQQSLyseQIRAFA 315
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
1XXI_I       318 RTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMP 364
Cdd:PRK14949 316 EQLSPEQVQLYYQILLTGRKDLPHAPDPKSGLEMALLRAVAFVPEKP 362
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
1-361 0e+00

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 538.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14969   1 MSYQVLARKWRPKSFSELVGQEHVVRALTNALEQQRLHHAYLFTGTRGVGKTTLARILAKSLNCETGVTATPCGVCSACL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14969  81 EIDSGRFVDLIEVDAASNTQVDAMRELLDNAQYAPTRGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14969 161 KIPVTVLSRCLQFNLKQMPPPLIVSHLQHILEQENIPFDATALQLLARAAAGSMRDALSLLDQAIAYGGGTVNESEVRAM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIElRMRELARTI 320
Cdd:PRK14969 241 LGAIDQDYLFALLEALLAQDGAALLAIADAMEERSLSFDAALQDLAALLHRLAIAQTVPDSIADDLPERD-RLLDLAKRL 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHP 361
Cdd:PRK14969 320 SPEDIQLYYQIALHGRRDLGLAPDEYAGFTMTLLRMLAFRP 360
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
1-362 0e+00

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 527.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14961   1 MNYQILARKWRPQYFRDIIGQKHIVTAISNGLSLGRIHHAWLLSGTRGVGKTTIARLLAKSLNCQNGITSNPCRKCIICK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14961  81 EIEKGLCLDLIEIDAASRTKVEEMREILDNIYYSPSKSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14961 161 KIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESIDTDEYALKLIAYHAHGSMRDALNLLEHAINLGKGNINIKNVTDM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPaaLGND---MAAIELRMRELA 317
Cdd:PRK14961 241 LGLLNEKQSFLLTDALLKKDSKKTMLLLNKISSIGIEWENILIEMLRFLHHISMSQSFP--KIWNtifIKNYKNQIQKIA 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
1XXI_I       318 RTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPR 362
Cdd:PRK14961 319 QNNKKTNIQLCYQILLNGRKELKFAPDQKIGVEMTLLRAINAITK 363
dnaX_nterm TIGR02397
DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ ...
3-357 0e+00

DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274111 [Multi-domain]  Cd Length: 355  Bit Score: 511.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I          3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREI 82
Cdd:TIGR02397   1 YQVLARKYRPQTFEDVIGQEHIVQTLKNAIKNGRIAHAYLFSGPRGTGKTSIARIFAKALNCQNGPDGEPCNECESCKEI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         83 EQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKL 162
Cdd:TIGR02397  81 NSGSSLDVIEIDAASNNGVDDIREILDNVKYAPSSGKYKVYIIDEVHMLSKSAFNALLKTLEEPPEHVVFILATTEPHKI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        163 PVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLG 242
Cdd:TIGR02397 161 PATILSRCQRFDFKRIPLEDIVERLKKILDKEGIKIEDEALELIARAADGSLRDALSLLDQLISFGNGKITYEDVNELLG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        243 TLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTIPP 322
Cdd:TIGR02397 241 LVDDEKLIELLEAILNKDTAEALKILDEILESGVDPEKFLEDLIEILRDLLLIKKTPSNLLAVLESEQEFLKELALKLSL 320
                         330       340       350
                  ....*....|....*....|....*....|....*
1XXI_I        323 TDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRAL 357
Cdd:TIGR02397 321 EFLLRLLDILLEALKDLRFSNDPRIWLEMTLLRLL 355
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
1-361 6.98e-171

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 493.46  E-value: 6.98e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK08691   1 MAYQVLARKWRPKTFADLVGQEHVVKALQNALDEGRLHHAYLLTGTRGVGKTTIARILAKSLNCENAQHGEPCGVCQSCT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK08691  81 QIDAGRYVDLLEIDAASNTGIDNIREVLENAQYAPTAGKYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK08691 161 KVPVTVLSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALSLLDQAIALGSGKVAENDVRQM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMReLARTI 320
Cdd:PRK08691 241 IGAVDKQYLYELLTGIINQDGAALLAKAQEMAACAVGFDNALGELAILLQQLALIQAVPSALAHDDPDSDILHR-LAQTI 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHP 361
Cdd:PRK08691 320 SGEQIQLYYQIAVHGKRDLSLAPDEYAGFMMTLLRMLAFAP 360
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
1-358 1.54e-169

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 476.22  E-value: 1.54e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        1 MSYQVlarkwrPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:COG2812   1 MSYQV------PQTFDDVVGQEHVVRTLKNALASGRLAHAYLFTGPRGVGKTTLARILAKALNCENGPTGEPCGECESCR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       81 EIEQGRFVDLIEIDA-ASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDP 159
Cdd:COG2812  75 AIAAGSHPDVIEIDAeASNIGVDDIRELIEKVSYAPVEGRYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      160 QKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIAsgdgqvstqavsa 239
Cdd:COG2812 155 QKLLPTILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQAIA------------- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      240 mLGTLD-DDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELAR 318
Cdd:COG2812 222 -FGLLDrRELLLDLLEALLAGDVAALLALAEELAKRGRDLKRFLDDLLSLLRDLLLLKLGPDAELLVNEDERERLQELAR 300
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
1XXI_I      319 TIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALA 358
Cdd:COG2812 301 RLSPERLLRAIQILLEARRELERNVNPRLALEMLLLRLAR 340
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
1-362 4.90e-164

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 472.66  E-value: 4.90e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNC-----ETGITATPCGV 75
Cdd:PRK14951   1 MSYLVLARKYRPRSFSEMVGQEHVVQALTNALTQQRLHHAYLFTGTRGVGKTTVSRILAKSLNCqgpdgQGGITATPCGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        76 CDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLA 155
Cdd:PRK14951  81 CQACRDIDSGRFVDYTELDAASNRGVDEVQQLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       156 TTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQ 235
Cdd:PRK14951 161 TTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTQVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       236 AVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDM---AAIELR 312
Cdd:PRK14951 241 AVRQMLGSVDRSHVFRLIDALAQGDGRTVVETADELRLNGLSAASTLEEMAAVLQRMAVLQAVPQAAAAATdpeAAEVAR 320
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
1XXI_I       313 mreLARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPR 362
Cdd:PRK14951 321 ---LAALMPADETQLLYSICLHGRAELGLAPDEYAALTMVLLRLLAFKPA 367
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1-361 4.11e-163

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 473.21  E-value: 4.11e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNC-----ETGITATPCGV 75
Cdd:PRK12323   1 MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCtgadgEGGITAQPCGQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        76 CDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLA 155
Cdd:PRK12323  81 CRACTEIDAGRFVDYIEMDAASNRGVDEMAQLLDKAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       156 TTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQ 235
Cdd:PRK12323 161 TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAAQGSMRDALSLTDQAIAYSAGNVSEE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       236 AVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIElRMRE 315
Cdd:PRK12323 241 AVRGMLGAIDQSYLVRLLDALAAEDGAALLAIADEMAGRSLSFAGALQDLASLLQKIALAQVVPAAVQDDWPEAD-DIRR 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
1XXI_I       316 LARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHP 361
Cdd:PRK12323 320 LAGRFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRP 365
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1-361 5.98e-162

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 474.34  E-value: 5.98e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK07003   1 MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK07003  81 EIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK07003 161 KIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMA-AIELrmRELART 319
Cdd:PRK07003 241 LGALDQTYMVRLLDALAAGDGPEILAVADEMALRSLSFSTALQDLASLLHRIAWAQFAPASVLDEWPeAADL--RRFAEL 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
1XXI_I       320 IPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHP 361
Cdd:PRK07003 319 LSPEQVQLFYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEP 360
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
3-364 6.30e-155

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 452.19  E-value: 6.30e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREI 82
Cdd:PRK14960   2 YQVLARKYRPRNFNELVGQNHVSRALSSALERGRLHHAYLFTGTRGVGKTTIARILAKCLNCETGVTSTPCEVCATCKAV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        83 EQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKL 162
Cdd:PRK14960  82 NEGRFIDLIEIDAASRTKVEDTRELLDNVPYAPTQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       163 PVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLG 242
Cdd:PRK14960 162 PITVISRCLQFTLRPLAVDEITKHLGAILEKEQIAADQDAIWQIAESAQGSLRDALSLTDQAIAYGQGAVHHQDVKEMLG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       243 TLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARTIPP 322
Cdd:PRK14960 242 LIDRTIIYDLILAVHQNQREKVSQLLLQFRYQALDVSLVLDQLISTLHELALLQYLPELGLKYSEEINAKILQLSKLISA 321
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
1XXI_I       323 TDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMP 364
Cdd:PRK14960 322 QDLQLYYQIACKGRSDLQLAVTQEQGFEMCVLRLLAFRPLAP 363
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
1-355 3.96e-152

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 440.08  E-value: 3.96e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK05563   1 MMYQALYRKWRPQTFEDVVGQEHITKTLKNAIKQGKISHAYLFSGPRGTGKTSAAKIFAKAVNCLNPPDGEPCNECEICK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK05563  81 AITNGSLMDVIEIDAASNNGVDEIRDIRDKVKYAPSEAKYKVYIIDEVHMLSTGAFNALLKTLEEPPAHVIFILATTEPH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK05563 161 KIPATILSRCQRFDFKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALSILDQAISFGDGKVTYEDALEV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIEL-RMRELART 319
Cdd:PRK05563 241 TGSVSQEALDDLVDAIVEGDVAKALKILEELLDEGKDPNRFIEDLIYYLRDLLLVKTSPELEILDESTENDeLFKELSEK 320
                        330       340       350
                 ....*....|....*....|....*....|....*.
1XXI_I       320 IPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLR 355
Cdd:PRK05563 321 LDIERLYRMIDILNDAQQQIKWTNQPRIYLEVALVK 356
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
1-361 1.31e-141

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 411.82  E-value: 1.31e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14958   1 MAHQVLARKWRPRCFQEVIGQAPVVRALSNALDQQYLHHAYLFTGTRGVGKTTISRILAKCLNCEKGVSANPCNDCENCR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14958  81 EIDEGRFPDLFEVDAASRTKVEDTRELLDNIPYAPTKGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14958 161 KLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENVEFENAALDLLARAANGSVRDALSLLDQSIAYGNGKVLIADVKTM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAAL-GNDMAaielRMRELART 319
Cdd:PRK14958 241 LGTIEPLLLFDILEALAAKAGDRLLGCVTRLVEQGVDFSNALADLLSLLHQIAIIQTVPEALiENDSE----QLRQLAKL 316
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
1XXI_I       320 IPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHP 361
Cdd:PRK14958 317 LDREDVQLFYQIGLIGQRDLAYSPTPQTGFEMTLLRMLAFYP 358
PRK09111 PRK09111
DNA polymerase III subunits gamma and tau; Validated
3-367 3.70e-133

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236382 [Multi-domain]  Cd Length: 598  Bit Score: 393.11  E-value: 3.70e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCET-----GITATPCGVCD 77
Cdd:PRK09111  11 YRVLARKYRPQTFDDLIGQEAMVRTLTNAFETGRIAQAFMLTGVRGVGKTTTARILARALNYEGpdgdgGPTIDLCGVGE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        78 NCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATT 157
Cdd:PRK09111  91 HCQAIMEGRHVDVLEMDAASHTGVDDIREIIESVRYRPVSARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHVKFIFATT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       158 DPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAV 237
Cdd:PRK09111 171 EIRKVPVTVLSRCQRFDLRRIEADVLAAHLSRIAAKEGVEVEDEALALIARAAEGSVRDGLSLLDQAIAHGAGEVTAEAV 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       238 SAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGN-DMAAIE-LRMRE 315
Cdd:PRK09111 251 RDMLGLADRARVIDLFEALMRGDVAAALAEFRAQYDAGADPVVVLTDLAEFTHLVTRLKIVPDAAEDpSLSEAErTRGAE 330
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
1XXI_I       316 LARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRaLAFHPRMPLPE 367
Cdd:PRK09111 331 FAKKLSMRVLSRLWQMLLKGIEEVQGAPRPLAAAEMVLIR-LAYAADLPTPD 381
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
1-367 1.34e-129

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 383.32  E-value: 1.34e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14965   1 MSYLVLARKYRPQTFSDLTGQEHVSRTLQNAIDTGRVAHAFLFTGARGVGKTSTARILAKALNCEQGLTAEPCNVCPPCV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14965  81 EITEGRSVDVFEIDGASNTGVDDIRELRENVKYLPSRSRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14965 161 KVPITILSRCQRFDFRRIPLQKIVDRLRYIADQEGISISDAALALVARKGDGSMRDSLSTLDQVLAFCGDAVGDDDVAEL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQL--SPAALgNDMAAIEL-RMRELA 317
Cdd:PRK14965 241 LGVVDRRLLLDISAAVFGRDTRALLEIVERVDEFGYNMRQFCQELIDHLRNLVVLRAvgEPGDL-LDLSEAELaELRAQA 319
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
1XXI_I       318 RTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMPLPE 367
Cdd:PRK14965 320 AAADAADLQRHLTLLLRAEGEMAHASFPRLVLEMALLKMATLAPGAPVSE 369
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
1-362 6.12e-127

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 375.57  E-value: 6.12e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14957   1 MSYQALARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFTGTRGVGKTTLGRLLAKCLNCKTGVTAEPCNKCENCV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14957  81 AINNNSFIDLIEIDAASRTGVEETKEILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14957 161 KIPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLDQAISFCGGELKQAQIKQM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRELARtI 320
Cdd:PRK14957 241 LGIIDSEEVYSIINAIIDNDPKAILPAIKNLALTESSADAVLDRIAEIWFACCIYSFTQSLDAVNDIDVDIINNILAK-I 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
1XXI_I       321 PPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPR 362
Cdd:PRK14957 320 SIEQAHFLYQLTITAKKDIALAPNFETGVTMAILRLIAFQKK 361
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
1-294 9.32e-117

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 347.58  E-value: 9.32e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14953   1 MMYIPFARKYRPKFFKEVIGQEIVVRILKNAVKLQRVSHAYIFAGPRGTGKTTIARILAKVLNCLNPQEGEPCGKCENCV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14953  81 EIDKGSFPDLIEIDAASNRGIDDIRALRDAVSYTPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14953 161 KIPPTILSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQASEGGMRDAASLLDQASTYGEGKVTIKVVEEF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIE----WEALLVEMLGLLHRIAM 294
Cdd:PRK14953 241 LGIVSQESVRKFLNLLLESDVDEAIKFLRTLEEKGYNlnkfWKQLEEEIRNILLNKSL 298
PRK08451 PRK08451
DNA polymerase III subunits gamma and tau; Validated
4-289 1.78e-115

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236267 [Multi-domain]  Cd Length: 535  Bit Score: 345.87  E-value: 1.78e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         4 QVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIE 83
Cdd:PRK08451   2 QALALKYRPKHFDELIGQESVSKTLSLALDNNRLAHAYLFSGLRGSGKTSSARIFARALVCEQGPSSTPCDTCIQCQSAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        84 QGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLP 163
Cdd:PRK08451  82 ENRHIDIIEMDAASNRGIDDIRELIEQTKYKPSMARFKIFIIDEVHMLTKEAFNALLKTLEEPPSYVKFILATTDPLKLP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       164 VTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGT 243
Cdd:PRK08451 162 ATILSRTQHFRFKQIPQNSIISHLKTILEKEGVSYEPEALEILARSGNGSLRDTLTLLDQAIIYCKNAITESKVADMLGL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
1XXI_I       244 LDDDQALSLVEAMVEANGERVMALINEaaARGIEWEALLVEMLGLL 289
Cdd:PRK08451 242 LDPSKLEDFFQAILNQDKEKLFELLKE--LEDYEAEMVLDEMMLFL 285
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
1-311 2.06e-108

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 329.08  E-value: 2.06e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGI-TATPCGVCDNC 79
Cdd:PRK14950   1 MTVQVLYRKWRSQTFAELVGQEHVVQTLRNAIAEGRVAHAYLFTGPRGVGKTSTARILAKAVNCTTNDpKGRPCGTCEMC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        80 REIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDP 159
Cdd:PRK14950  81 RAIAEGSAVDVIEMDAASHTSVDDAREIIERVQFRPALARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       160 QKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSA 239
Cdd:PRK14950 161 HKVPATILSRCQRFDFHRHSVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAENLLQQLATTYGGEISLSQVQS 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1XXI_I       240 MLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIEL 311
Cdd:PRK14950 241 LLGISGDEEVKALAEALLAKDLKAALRTLNAVAADGADLRQFTRDLVEYLRQVMLLNSGADRSLLDLTADEK 312
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
1-357 1.87e-102

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 313.25  E-value: 1.87e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK06647   1 MSYRGTATKRRPRDFNSLEGQDFVVETLKHSIESNKIANAYIFSGPRGVGKTSSARAFARCLNCVNGPTPMPCGECSSCK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK06647  81 SIDNDNSLDVIEIDGASNTSVQDVRQIKEEIMFPPASSRYRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK06647 161 KLPATIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIKYEDEALKWIAYKSTGSVRDAYTLFDQVVSFSDSDITLEQIRSK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLV-------EMLGLLHRI---AMVQLSPAALGNDMAAIE 310
Cdd:PRK06647 241 MGLTGDEFLEKLASSILNEDAKELLCVLDSVFLSGVSVEQFLLdcieffrELLFLKHGIkneAFIGIKAERLPEKLREFD 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
1XXI_I       311 LRMRELArtipptdIQLYYQTLligrKELPYAPDRRMGVEMTLLRAL 357
Cdd:PRK06647 321 LSQIERA-------ISVLLETY----RDLQFSVNPRYELEINFSKIL 356
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
2-291 1.40e-101

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 307.47  E-value: 1.40e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         2 SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNC-ETGITATPCGVCDNCR 80
Cdd:PRK06305   3 SYQVSSRKYRPQTFSEILGQDAVVAVLKNALRFNRAAHAYLFSGIRGTGKTTLARIFAKALNCqNPTEDQEPCNQCASCK 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK06305  83 EISSGTSLDVLEIDGASHRGIEDIRQINETVLFTPSKSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK06305 163 KIPGTILSRCQKMHLKRIPEETIIDKLALIAKQEGIETSREALLPIARAAQGSLRDAESLYDYVVGLFPKSLDPDSVAKA 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEwEALLVEMLGLLHR 291
Cdd:PRK06305 243 LGLLSQDSLYTLDEAITTQNYAQALEPVTDAMNSGVA-PAHFLHDLTLFFR 292
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
1-368 2.16e-101

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 305.28  E-value: 2.16e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGI--------TATP 72
Cdd:PRK14955   1 MSYQVIARKYRPKKFADITAQEHITRTIQNSLRMGRVGHGYIFSGLRGVGKTTAARVFAKAVNCQRMIddadylqeVTEP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        73 CGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKF 152
Cdd:PRK14955  81 CGECESCRDFDAGTSLNISEFDAASNNSVDDIRLLRENVRYGPQKGRYRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       153 LLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIA-----S 227
Cdd:PRK14955 161 IFATTELHKIPATIASRCQRFNFKRIPLEEIQQQLQGICEAEGISVDADALQLIGRKAQGSMRDAQSILDQVIAfsvesE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       228 GDGQVSTQAVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQ-LSPAALGNDM 306
Cdd:PRK14955 241 GEGSIRYDKVAELLNYIDDEHFFAVTDAVADGDAVAMLDVAQFVIRNGYDEQDFLEKLIEHLRNFLVVHnLRSTRLVERP 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
1XXI_I       307 AAIELRMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRMPLPEP 368
Cdd:PRK14955 321 DAVRERYERDAAKFSPEVIMQMTDLLLQTQKELKFQFEYQFRFELALLKLIEIGHPAPTAAA 382
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
1-289 6.67e-100

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 308.43  E-value: 6.67e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNC--ETGITATPCGVCDN 78
Cdd:PRK14948   1 MAYEPLHHKYRPQRFDELVGQEAIATTLKNALISNRIAPAYLFTGPRGTGKTSSARILAKSLNClnSDKPTPEPCGKCEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        79 CREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTD 158
Cdd:PRK14948  81 CRAIAAGNALDVIEIDAASNTGVDNIRELIERAQFAPVQARWKVYVIDECHMLSTAAFNALLKTLEEPPPRVVFVLATTD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       159 PQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQaIASGDGQVSTQAVS 238
Cdd:PRK14948 161 PQRVLPTIISRCQRFDFRRIPLEAMVQHLSEIAEKESIEIEPEALTLVAQRSQGGLRDAESLLDQ-LSLLPGPITPEAVW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
1XXI_I       239 AMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLL 289
Cdd:PRK14948 240 DLLGAVPEQDLLNLLKALASNDPESLLDSCRQLLDRGREPLAILQGLAAFY 290
PRK07133 PRK07133
DNA polymerase III subunits gamma and tau; Validated
1-289 3.46e-98

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235943 [Multi-domain]  Cd Length: 725  Bit Score: 306.74  E-value: 3.46e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGIT-ATPCGVCdnc 79
Cdd:PRK07133   3 MKYKALYRKYRPKTFDDIVGQDHIVQTLKNIIKSNKISHAYLFSGPRGTGKTSVAKIFANALNCSHKTDlLEPCQEC--- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        80 reIEQ-GRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTD 158
Cdd:PRK07133  80 --IENvNNSLDIIEMDAASNNGVDEIRELIENVKNLPTQSKYKIYIIDEVHMLSKSAFNALLKTLEEPPKHVIFILATTE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       159 PQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVS 238
Cdd:PRK07133 158 VHKIPLTILSRVQRFNFRRISEDEIVSRLEFILEKENISYEKNALKLIAKLSSGSLRDALSIAEQVSIFGNNKITLKNVE 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
1XXI_I       239 AMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLL 289
Cdd:PRK07133 238 ELFGLVSNENLINLLNLLYSKDIKEVLNILNQIKEQGIDPELLLISLINLV 288
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
1-365 2.44e-96

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 299.29  E-value: 2.44e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK14959   1 MSHASLTARYRPQTFAEVAGQETVKAILSRAAQENRVAPAYLFSGTRGVGKTTIARIFAKALNCETAPTGEPCNTCEQCR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14959  81 KVTQGMHVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14959 161 KFPVTIVSRCQHFTFTRLSEAGLEAHLTKVLGREGVDYDPAAVRLIARRAAGSVRDSMSLLGQVLALGESRLTIDGARGV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMV-QLSPAALGN-DMAAIELRM-RELA 317
Cdd:PRK14959 241 LGLAGQELFLRLMEALAAQDCLGVANVVRELLDRGVDMGFFLRELVATWRNLFMLrQAGEAALASlDLPEDEARQwLGWA 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
1XXI_I       318 RTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRaLAFHPR-MPL 365
Cdd:PRK14959 321 KRFEPAHIHACWQMTLEGQRRVLTSLEPAMALELLLLN-LAMLPRlMPV 368
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
6-367 4.55e-95

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 292.07  E-value: 4.55e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         6 LARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQG 85
Cdd:PRK14964   3 LALKYRPSSFKDLVGQDVLVRILRNAFTLNKIPQSILLVGASGVGKTTCARIISLCLNCSNGPTSDPCGTCHNCISIKNS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 RFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVT 165
Cdd:PRK14964  83 NHPDVIEIDAASNTSVDDIKVILENSCYLPISSKFKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKFILATTEVKKIPVT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       166 ILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGTLD 245
Cdd:PRK14964 163 IISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLEQAAIYSNNKISEKSVRDLLGCVD 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       246 DDQALSLVEAMVEANGERVMALINEA--AARGIeweALLVEMLGLLHRIAMVQLSP---AALGNDmaaIELRMRELARTI 320
Cdd:PRK14964 243 KHILEDLVEAILLGDAQSALNVFRELcnTSNPV---IILEGMLQIIYEICYFSITKeidFLLGED---LITRIKSLKIGS 316
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
1XXI_I       321 PPTDIQLyYQTLLIGRKELPYAPDRRMGVEMTLLRaLAFHPRMPLPE 367
Cdd:PRK14964 317 TIFLSRL-WQMLLKGIQEVKSSTCVKQAAEMMIIR-LCYLSDLPSPQ 361
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
1-357 1.36e-93

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 292.23  E-value: 1.36e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGI--------TATP 72
Cdd:PRK14954   1 MSYQVIARKYRPSKFADITAQEHITHTIQNSLRMDRVGHGYIFSGLRGVGKTTAARVFAKAVNCQRMIddpvylqeVTEP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        73 CGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKF 152
Cdd:PRK14954  81 CGECESCRDFDAGTSLNISEFDAASNNSVDDIRQLRENVRYGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       153 LLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIA-----S 227
Cdd:PRK14954 161 IFATTELHKIPATIASRCQRFNFKRIPLDEIQSQLQMICRAEGIQIDADALQLIARKAQGSMRDAQSILDQVIAfsvgsE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       228 GDGQVSTQAVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMV-QLSPAALGNDM 306
Cdd:PRK14954 241 AEKVIAYQGVAELLNYIDDEQFFDVTDAIAENDAVKMLEVARFVIDNGYDEQDFLEKLIEHFRNFLVLyNLRSTRLIERP 320
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
1XXI_I       307 AAIELRMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRAL 357
Cdd:PRK14954 321 ESVKERYQQSAGGLTPAAVMQMTDFLMKTQGELKFQFEYQFRFELALLRLI 371
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
4-286 2.36e-93

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 287.05  E-value: 2.36e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         4 QVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIE 83
Cdd:PRK14962   2 EALYRKYRPKTFSEVVGQDHVKKLIINALKKNSISHAYIFAGPRGTGKTTVARILAKSLNCENRKGVEPCNECRACRSID 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        84 QGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLP 163
Cdd:PRK14962  82 EGTFMDVIELDAASNRGIDEIRKIRDAVGYRPMEGKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       164 VTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGT 243
Cdd:PRK14962 162 PTIISRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEQVWKFSEGKITLETVHEALGL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
1XXI_I       244 LDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEML 286
Cdd:PRK14962 242 IPIEVVRDYINAIFNGDVKRVFTVLDDVYYSGKDYEVLIQQAI 284
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
3-355 9.83e-91

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 284.36  E-value: 9.83e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETgITA--TPCGVCDNCR 80
Cdd:PRK14971   4 YIVSARKYRPSTFESVVGQEALTTTLKNAIATNKLAHAYLFCGPRGVGKTTCARIFAKTINCQN-LTAdgEACNECESCV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK14971  83 AFNEQRSYNIHELDAASNNSVDDIRNLIEQVRIPPQIGKYKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK14971 163 KILPTILSRCQIFDFNRIQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSIFDQVVSFTGGNITYKSVIEN 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLhRIAMVQLSPAALG--NDMAAIELRMRELAR 318
Cdd:PRK14971 243 LNILDYDYYFRLTDALLAGKVSDSLLLFDEILNKGFDGSHFITGLASHF-RDLLVCKDAATLQllEVGESIRQRYLEQAQ 321
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
1XXI_I       319 TippTDIQLYYQTL-LIGRKELPY--APDRRMGVEMTLLR 355
Cdd:PRK14971 322 K---CPMSFLYRALkLCNQCDLNYraSKNKRLLVELTLIQ 358
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
2-300 4.85e-88

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 273.75  E-value: 4.85e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         2 SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCRE 81
Cdd:PRK14956   4 THEVLSRKYRPQFFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCENPIGNEPCNECTSCLE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        82 IEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQK 161
Cdd:PRK14956  84 ITKGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       162 LPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAML 241
Cdd:PRK14956 164 IPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLTGVKIRKMI 243
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       242 GTLDDDQALSLVEAMVE-ANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPA 300
Cdd:PRK14956 244 GYHGIEFLTSFIKSLIDpDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLA 303
PRK05896 PRK05896
DNA polymerase III subunits gamma and tau; Validated
1-289 5.41e-88

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235638 [Multi-domain]  Cd Length: 605  Bit Score: 277.11  E-value: 5.41e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         1 MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR 80
Cdd:PRK05896   1 MSEITFYRKYRPHNFKQIIGQELIKKILVNAILNNKLTHAYIFSGPRGIGKTSIAKIFAKAINCLNPKDGDCCNSCSVCE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQ 160
Cdd:PRK05896  81 SINTNQSVDIVELDAASNNGVDEIRNIIDNINYLPTTFKYKVYIIDEAHMLSTSAWNALLKTLEEPPKHVVFIFATTEFQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM 240
Cdd:PRK05896 161 KIPLTIISRCQRYNFKKLNNSELQELLKSIAKKEKIKIEDNAIDKIADLADGSLRDGLSILDQLSTFKNSEIDIEDINKT 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLL 289
Cdd:PRK05896 241 FGLVDNNKKINLIELIQKNDIEELRNLINELESKGINFEAFCRDLINLL 289
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
6-259 1.39e-87

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 281.10  E-value: 1.39e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         6 LARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQG 85
Cdd:PRK07764   5 LYRRYRPATFAEVIGQEHVTEPLSTALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGECDSCVALAPG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 RF--VDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLP 163
Cdd:PRK07764  85 GPgsLDVTEIDAASHGGVDDARELRERAFFAPAESRYKIFIIDEAHMVTPQGFNALLKIVEEPPEHLKFIFATTEPDKVI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       164 VTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIA-SGDGQVSTQAVSAMLG 242
Cdd:PRK07764 165 GTIRSRTHHYPFRLVPPEVMRGYLERICAQEGVPVEPGVLPLVIRAGGGSVRDSLSVLDQLLAgAGPEGVTYERAVALLG 244
                        250
                 ....*....|....*..
1XXI_I       243 TLDDdqalSLVEAMVEA 259
Cdd:PRK07764 245 VTDS----ALIDEAVDA 257
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
3-357 6.81e-86

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 269.04  E-value: 6.81e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         3 YQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITAT----PCGVCDN 78
Cdd:PRK06645   8 YIPFARKYRPSNFAELQGQEVLVKVLSYTILNDRLAGGYLLTGIRGVGKTTSARIIAKAVNCSALITENttikTCEQCTN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        79 CREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTD 158
Cdd:PRK06645  88 CISFNNHNHPDIIEIDAASKTSVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTE 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       159 PQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAI---ASGDGQVSTQ 235
Cdd:PRK06645 168 VQKIPATIISRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKSEGSARDAVSILDQAAsmsAKSDNIISPQ 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       236 AVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPAALGNDMAAIELRMRE 315
Cdd:PRK06645 248 VINQMLGLVDSSVIIEFVEYIIHRETEKAINLINKLYGSSVNLEIFIESVSDFIAYLNKVKMLPNYSLPIYESFNDRTKS 327
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
1XXI_I       316 LARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRAL 357
Cdd:PRK06645 328 ILDKISLPHLSILWQIYNKGVGEIKISYNQLTETEMLVIKSI 369
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
6-318 1.88e-83

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 262.47  E-value: 1.88e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         6 LARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCeTGITATPCGVCDNCREIEQG 85
Cdd:PRK14963   4 LYQRARPITFDEVVGQEHVKEVLLAALRQGRLGHAYLFSGPRGVGKTTTARLIAMAVNC-SGEDPKPCGECESCLAVRRG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 RFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVT 165
Cdd:PRK14963  83 AHPDVLEIDAASNNSVEDVRDLREKVLLAPLRGGRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       166 ILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGdGQVSTQAVSAMLGTLD 245
Cdd:PRK14963 163 ILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEPEALQLVARLADGAMRDAESLLERLLALG-TPVTRKQVEEALGLPP 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       246 DDQALSLVEAMVEanGERVMALINEA-------AARGIEwEALLVEMLGLLH-RIAM-----VQLSPAALGNDMAAIELR 312
Cdd:PRK14963 242 QERLRGIAAALAQ--GDAAEALSGAAqlyrdgfAARTLV-EGLLEAFRAALYaELGLgggprLEGAEPRLLAAMTALDEQ 318

                 ....*.
1XXI_I       313 MRELAR 318
Cdd:PRK14963 319 MERFAR 324
PRK14952 PRK14952
DNA polymerase III subunits gamma/tau;
4-357 2.01e-81

DNA polymerase III subunits gamma/tau;


Pssm-ID: 237866 [Multi-domain]  Cd Length: 584  Bit Score: 259.43  E-value: 2.01e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         4 QVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIE 83
Cdd:PRK14952   1 MALYRKYRPATFAEVVGQEHVTEPLSSALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTATPCGVCESCVALA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        84 QGR--FVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQK 161
Cdd:PRK14952  81 PNGpgSIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       162 LPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIA-SGDGQVSTQAVSAM 240
Cdd:PRK14952 161 VLPTIRSRTHHYPFRLLPPRTMRALIARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAgAADTHVTYQRALGL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       241 LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSP--AALGNDMAAIEL--RMREL 316
Cdd:PRK14952 241 LGATDVALIDDAVDALAADDAAALFGAIESVIDAGHDPRRFATDLLERFRDLIVLQAVPdaAARGVVDAPEDVleRMREQ 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
1XXI_I       317 ARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRAL 357
Cdd:PRK14952 321 AARIGLATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLL 361
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
5-302 4.76e-74

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 234.00  E-value: 4.76e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         5 VLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCeTGITATpcgvcdncreiEQ 84
Cdd:PRK14970   6 VSARKYRPQTFDDVVGQSHITNTLLNAIENNHLAQALLFCGPRGVGKTTCARILARKINQ-PGYDDP-----------NE 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        85 GRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPV 164
Cdd:PRK14970  74 DFSFNIFELDAASNNSVDDIRNLIDQVRIPPQTGKYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       165 TILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGTL 244
Cdd:PRK14970 154 TILSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSIFDRVVTFCGKNITRQAVTENLNIL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
1XXI_I       245 DDDQALSLVEAMVEANGERVMALINEAAARGIEWEaLLVEMLGLLHRIAMVQLSPAAL 302
Cdd:PRK14970 234 DYDTYINVTDLILENKIPELLLAFNEILRKGFDGH-HFIAGLASHFRDLMVSKTPATI 290
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
20-179 7.81e-54

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 174.71  E-value: 7.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         20 GQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRT 99
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHAYLFSGPEGVGKLELALAFAKALFCEEPGDDLPCGQCRSCRRIESGNHPDLVIIEPEGQS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        100 -KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKAL 178
Cdd:pfam13177  81 iKIDQIRELQKEFSKSPYEGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFKPL 160

                  .
1XXI_I        179 D 179
Cdd:pfam13177 161 S 161
holB TIGR00678
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ...
25-217 3.78e-51

DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273213 [Multi-domain]  Cd Length: 188  Bit Score: 168.96  E-value: 3.78e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         25 LTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIDA-ASRTKVED 103
Cdd:TIGR00678   1 YQQLKRALEKGRLAHAYLFTGPEGVGKELLALALAKALLCEQRGGGEPCGECHSCRLIEAGNHPDLHRLEPeGQSIKVDQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        104 TRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQI 183
Cdd:TIGR00678  81 VRELVEFLSRTPQESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPPLSEEAL 160
                         170       180       190
                  ....*....|....*....|....*....|....
1XXI_I        184 RHQLEHILNEEHiaheprALQLLARAAEGSLRDA 217
Cdd:TIGR00678 161 LQWLIRQGISEE------AAELLLALAGGSPGRA 188
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
21-318 4.66e-51

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 172.08  E-value: 4.66e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       21 QEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDnCREIEQGRFVDLIEI--DAASR 98
Cdd:COG0470   1 QEEAWEQLLAAAESGRLPHALLLHGPPGIGKTTLALALARDLLCENPEGGKACGQCH-SRLMAAGNHPDLLELnpEEKSD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       99 T-KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKA 177
Cdd:COG0470  80 QiGIDQIRELGEFLSLTPLEGGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFRP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      178 LDVEQIRHQLEhilnEEHIAHEprALQLLARAAEGSLRDALSLTDQAiasgdgQVSTQAVSAMLGTLDDDQALSLVEamv 257
Cdd:COG0470 160 PSEEEALAWLR----EEGVDED--ALEAILRLAGGDPRAAINLLQAL------AGRKELLEDLAALLSRDRALELLD--- 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
1XXI_I      258 eangervmALINEAAARGIEWeallveMLGLLHRIAMVQLSPAALGNDMAAIELRMRELAR 318
Cdd:COG0470 225 --------ALLKAEALELLDW------LLKWLLDNLPLEYAGEDLARAYEALSEADRRLGR 271
PRK08058 PRK08058
DNA polymerase III subunit delta'; Validated
21-220 3.63e-33

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181214 [Multi-domain]  Cd Length: 329  Bit Score: 125.81  E-value: 3.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        21 QEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEI--DAASr 98
Cdd:PRK08058  11 QPVVVKMLQNSIAKNRLSHAYLFEGAKGTGKKATALWLAKSLFCLERNGVEPCGTCTNCKRIDSGNHPDVHLVapDGQS- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        99 TKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEP-PEHVKFLLaTTDPQKLPVTILSRCLQFHLKA 177
Cdd:PRK08058  90 IKKDQIRYLKEEFSKSGVESNKKVYIIEHADKMTASAANSLLKFLEEPsGGTTAILL-TENKHQILPTILSRCQVVEFRP 168
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
1XXI_I       178 LDVEQIRHQLEhilnEEHIahePRALQLLARAAEGSLRDALSL 220
Cdd:PRK08058 169 LPPESLIQRLQ----EEGI---SESLATLLAGLTNSVEEALAL 204
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
9-315 4.01e-30

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 117.78  E-value: 4.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         9 KWRPQTFADVVGQEHVLTALANGLSLGRIHHaYLFSGTRGVGKTSIARLLAKGL---NCETGITATPcgVCD----NCRE 81
Cdd:PRK12402   8 KYRPALLEDILGQDEVVERLSRAVDSPNLPH-LLVQGPPGSGKTAAVRALARELygdPWENNFTEFN--VADffdqGKKY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        82 IEQG-RFVDLIEIDAASRTKVedtRDLLDNV-----QYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLA 155
Cdd:PRK12402  85 LVEDpRFAHFLGTDKRIRSSK---IDNFKHVlkeyaSYRPLSADYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       156 TTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALsLTDQAIASGDGQVSTQ 235
Cdd:PRK12402 162 TRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKAI-LTLQTAALAAGEITME 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       236 AVSAMLGTLD-DDQALSLVEAMVEANGERVMALIneaaargiewEALLV-------EMLGLLHRIAMVQLSP---AALGN 304
Cdd:PRK12402 241 AAYEALGDVGtDEVIESLLDAAEAGDFTDARKTL----------DDLLIdeglsggEVLEELLRVARSRYRGdnlARLHR 310
                        330
                 ....*....|.
1XXI_I       305 DMAAIELRMRE 315
Cdd:PRK12402 311 LAADADARLTD 321
PRK08699 PRK08699
DNA polymerase III subunit delta'; Validated
36-182 1.64e-28

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181538 [Multi-domain]  Cd Length: 325  Bit Score: 113.04  E-value: 1.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        36 RIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITA-TPCGVCDNCREIEQGRFVDLIEIDAASR----------TKVEDT 104
Cdd:PRK08699  19 RRPNAWLFAGKKGIGKTAFARFAAQALLCETPAPGhKPCGECMSCHLFGQGSHPDFYEITPLSDepengrkllqIKIDAV 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1XXI_I       105 RDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQ 182
Cdd:PRK08699  99 REIIDNVYLTSVRGGLRVILIHPAESMNLQAANSLLKVLEEPPPQVVFLLVSHAADKVLPTIKSRCRKMVLPAPSHEE 176
DNA_pol3_gamma3 pfam12169
DNA polymerase III subunits gamma and tau domain III; This domain family is found in bacteria, ...
232-367 1.72e-27

DNA polymerase III subunits gamma and tau domain III; This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.


Pssm-ID: 432379 [Multi-domain]  Cd Length: 143  Bit Score: 105.43  E-value: 1.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        232 VSTQAVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSP-AALGNDMAAIE 310
Cdd:pfam12169   1 VTAAQVRDMLGLADRGRVLDLLEALLEGDAAAALAELRDQYDAGADPVVVLRDLLELIHNLTRLKVAPdAADDLLLPEEE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
1XXI_I        311 L-RMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRaLAFHPRMPLPE 367
Cdd:pfam12169  81 RaRLAELAEKLSPEVLHRLWQMLLKGIEEVPNAPDPRQAAEMVLLR-LAYAASLPPPE 137
PRK07940 PRK07940
DNA polymerase III subunit delta'; Validated
15-282 1.47e-25

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236134 [Multi-domain]  Cd Length: 394  Bit Score: 106.15  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        15 FADVVGQEHVLTAL------ANGLSLGRIH---HAYLFSGTRGVGKTSIARLLAKGLNCeTGITATPCGVCDNCREIEQG 85
Cdd:PRK07940   4 WDDLVGQEAVVAELraaaraARADVAAAGSgmtHAWLFTGPPGSGRSVAARAFAAALQC-TDPDEPGCGECRACRTVLAG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 RFVDLIEIDAASRT-KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPV 164
Cdd:PRK07940  83 THPDVRVVAPEGLSiGVDEVRELVTIAARRPSTGRWRIVVIEDADRLTERAANALLKAVEEPPPRTVWLLCAPSPEDVLP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       165 TILSRCLQFHLKALDVEQIRHQLehiLNEEHIAHEpRAlQLLARAAEGSLRDA--LSLTDQAIASGDgqvstQAVSAMLG 242
Cdd:PRK07940 163 TIRSRCRHVALRTPSVEAVAEVL---VRRDGVDPE-TA-RRAARASQGHIGRArrLATDEEARARRA-----EVLNLALR 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
1XXI_I       243 TLDDDQALSLVEAMVEANGERVMALINEAAARgiEWEALL 282
Cdd:PRK07940 233 LARVSDAVAAAEELVKAAEAEAKALTAERDEA--ETEELR 270
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
6-228 6.16e-25

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 104.78  E-value: 6.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         6 LARKWRPQTFADVVGQEHVL---TALANGLSLGRIHHAyLFSGTRGVGKTSIARLLAKGLNCEtgitatpcgvcdncrei 82
Cdd:PRK13342   2 LAERMRPKTLDEVVGQEHLLgpgKPLRRMIEAGRLSSM-ILWGPPGTGKTTLARIIAGATDAP----------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        83 eqgrfvdLIEIDAASrTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEppEHVKFLLATT-DPQ- 160
Cdd:PRK13342  64 -------FEALSAVT-SGVKDLREVIEEARQRRSAGRRTILFIDEIHRFNKAQQDALLPHVED--GTITLIGATTeNPSf 133
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1XXI_I       161 KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEE---HIAHEPRALQLLARAAEGSLRDALSLTDQAIASG 228
Cdd:PRK13342 134 EVNPALLSRAQVFELKPLSEEDIEQLLKRALEDKergLVELDDEALDALARLANGDARRALNLLELAALGV 204
PRK05707 PRK05707
DNA polymerase III subunit delta'; Validated
35-223 2.53e-23

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180215 [Multi-domain]  Cd Length: 328  Bit Score: 99.01  E-value: 2.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        35 GRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDL--IEIDAASRT-KVEDTRDLLDNV 111
Cdd:PRK05707  19 GRHPHAYLLHGPAGIGKRALAERLAAALLCEAPQGGGACGSCKGCQLLRAGSHPDNfvLEPEEADKTiKVDQVRELVSFV 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       112 QYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHIL 191
Cdd:PRK05707  99 VQTAQLGGRKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQPSRLLPTIKSRCQQQACPLPSNEESLQWLQQAL 178
                        170       180       190
                 ....*....|....*....|....*....|..
1XXI_I       192 NEEhiaHEPRALQLLARAAEGSLRdALSLTDQ 223
Cdd:PRK05707 179 PES---DERERIELLTLAGGSPLR-ALQLHEQ 206
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
178-242 2.86e-23

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 91.41  E-value: 2.86e-23
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I      178 LDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLG 242
Cdd:cd18137   1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALSLLDQAIAFGGGRVTLDDVREMLG 65
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
12-221 9.03e-21

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 92.02  E-value: 9.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        12 PQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCD------NCREIEQG 85
Cdd:PRK09112  19 PSENTRLFGHEEAEAFLAQAYREGKLHHALLFEGPEGIGKATLAFHLANHILSHPDPAEAPETLADpdpaspVWRQIAQG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 ---------RFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLAT 156
Cdd:PRK09112  99 ahpnllhitRPFDEKTGKFKTAITVDEIRRVGHFLSQTSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFILIS 178
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I       157 TDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRalQLLARAAEGSLRDALSLT 221
Cdd:PRK09112 179 HSSGRLLPTIRSRCQPISLKPLDDDELKKALSHLGSSQGSDGEIT--EALLQRSKGSVRKALLLL 241
PRK07471 PRK07471
DNA polymerase III subunit delta'; Validated
11-267 3.24e-20

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236022 [Multi-domain]  Cd Length: 365  Bit Score: 90.47  E-value: 3.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        11 RPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTS----IARLLAKGLNCETGITATPCGVCD------NCR 80
Cdd:PRK07471  14 HPRETTALFGHAAAEAALLDAYRSGRLHHAWLIGGPQGIGKATlayrMARFLLATPPPGGDGAVPPPTSLAidpdhpVAR 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        81 EIEQGRFVDLIEI-----DAASRTK----VEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVK 151
Cdd:PRK07471  94 RIAAGAHGGLLTLerswnEKGKRLRtvitVDEVRELISFFGLTAAEGGWRVVIVDTADEMNANAANALLKVLEEPPARSL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       152 FLLATTDPQKLPVTILSRCLQFHLKALDVEqirhQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLtdqaiASGDGQ 231
Cdd:PRK07471 174 FLLVSHAPARLLPTIRSRCRKLRLRPLAPE----DVIDALAAAGPDLPDDPRAALAALAEGSVGRALRL-----AGGDGL 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
1XXI_I       232 VSTQAVSAMLGTL---DDDQALSLVEAMVEANGERVMAL 267
Cdd:PRK07471 245 ALYRRLTALLDTLprlDRRALHALADAAAGRDRAARFAL 283
PRK07399 PRK07399
DNA polymerase III subunit delta'; Validated
15-214 1.54e-19

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236011 [Multi-domain]  Cd Length: 314  Bit Score: 88.03  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        15 FADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLncetgITATPCGVCDNCReIEQGRFVDLIEI- 93
Cdd:PRK07399   3 FANLIGQPLAIELLTAAIKQNRIAPAYLFAGPEGVGRKLAALCFIEGL-----LSQGSPSKNIRRR-LEEGNHPDLLWVe 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        94 -------------DAASRT---------KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEpPEHVK 151
Cdd:PRK07399  77 ptyqhqgklitasEAEEAGlkrkappqiRLEQIREIKRFLSRPPLEAPRKVVVIEDAETMNEAAANALLKTLEE-PGNGT 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
1XXI_I       152 FLLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSL 214
Cdd:PRK07399 156 LILIAPSPESLLPTIVSRCQIIPFYRLSDEQLEQVLKRLGDEEILNINFPELLALAQGSPGAA 218
PRK06964 PRK06964
DNA polymerase III subunit delta'; Validated
36-175 2.30e-19

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235898 [Multi-domain]  Cd Length: 342  Bit Score: 87.89  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        36 RIHHAYLFSGTRGVGKTSIARLLAKGLNCETGIT-ATPCGVCDNCREIEQGRFVD--------------LIEIDAA---- 96
Cdd:PRK06964  19 RLPHALLLHGQAGIGKLDFAQHLAQGLLCETPQPdGEPCGTCAACNWFAQGNHPDyrivrpealaaeapGAADEAKeada 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        97 ------SRT-----KVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVT 165
Cdd:PRK06964  99 deggkkTKApskeiKIEQVRALLDFCGVGTHRGGARVVVLYPAEALNVAAANALLKTLEEPPPGTVFLLVSARIDRLLPT 178
                        170
                 ....*....|
1XXI_I       166 ILSRCLQFHL 175
Cdd:PRK06964 179 ILSRCRQFPM 188
PRK07276 PRK07276
DNA polymerase III subunit delta'; Validated
32-188 2.36e-19

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180916 [Multi-domain]  Cd Length: 290  Bit Score: 86.99  E-value: 2.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        32 LSLGRIHHAYLFSGtrGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRT-KVEDTRDLLDN 110
Cdd:PRK07276  18 LEQDRLNHAYLFSG--DFASFEMALFLAQSLFCEQKEGVLPCGHCRSCRLIEQGEFSDVTVIEPQGQViKTDTIRELVKN 95
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
1XXI_I       111 VQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKAlDVEQIRHQLE 188
Cdd:PRK07276  96 FSQSGYEGKQQVFIIKDADKMHVNAANSLLKVIEEPQSEIYIFLLTNDENKVLPTIKSRTQIFHFPK-NEAYLIQLLE 172
HLD_clamp cd18133
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ...
178-241 5.42e-19

helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.


Pssm-ID: 350838 [Multi-domain]  Cd Length: 65  Bit Score: 79.82  E-value: 5.42e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I      178 LDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGD-GQVSTQAVSAML 241
Cdd:cd18133   1 LDQEQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQRAAALGDdGKISLDRVYQAV 65
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
15-194 7.08e-18

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 83.16  E-value: 7.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        15 FADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLA-KGLNcetgitatpcgvcdncrEIEQGRFVDLIE- 92
Cdd:PRK05564   3 FHTIIGHENIKNRIKNSIIKNRFSHAHIIVGEDGIGKSLLAKEIAlKILG-----------------KSQQREYVDIIEf 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        93 -IDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCL 171
Cdd:PRK05564  66 kPINKKSIGVDDIRNIIEEVNKKPYEGDKKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQ 145
                        170       180
                 ....*....|....*....|....*.
1XXI_I       172 QFHLKALDVEQIRHQLE---HILNEE 194
Cdd:PRK05564 146 IYKLNRLSKEEIEKFISykyNDIKEE 171
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
6-242 1.25e-17

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 83.57  E-value: 1.25e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        6 LARKWRPQTFADVVGQEHVL---TALANGLSLGRIHHAYLFsGTRGVGKTSIARLLAKGLNCEtgitatpcgvcdncrei 82
Cdd:COG2256  15 LAERMRPRTLDEVVGQEHLLgpgKPLRRAIEAGRLSSMILW-GPPGTGKTTLARLIANATDAE----------------- 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       83 eqgrFVDLieidAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHmlsRhsFN-----ALLKTLEEppEHVKFLLATT 157
Cdd:COG2256  77 ----FVAL----SAVTSGVKDIREVIEEARERRAYGRRTILFVDEIH---R--FNkaqqdALLPHVED--GTITLIGATT 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      158 D--------PqklpvtILSRCLQFHLKALDVEQIR-------HQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTD 222
Cdd:COG2256 142 EnpsfevnsA------LLSRCRVFVLKPLSEEDLEqlleralADDERGLGGYKLELDDEALEALARLADGDARRALNALE 215
                       250       260
                ....*....|....*....|....
1XXI_I      223 QAIAS----GDGQVSTQAVSAMLG 242
Cdd:COG2256 216 LAVLSappdGVIEITLELVEEALQ 239
PRK06871 PRK06871
DNA polymerase III subunit delta'; Validated
35-170 2.25e-17

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180738 [Multi-domain]  Cd Length: 325  Bit Score: 82.09  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        35 GRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIdAASRTK---VEDTRDLLDNV 111
Cdd:PRK06871  21 GLGHHALLFKADSGLGTEQLIRALAQWLMCQTPQGDQPCGQCHSCHLFQAGNHPDFHIL-EPIDNKdigVDQVREINEKV 99
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
1XXI_I       112 QYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRC 170
Cdd:PRK06871 100 SQHAQQGGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRC 158
PRK07993 PRK07993
DNA polymerase III subunit delta'; Validated
35-249 3.05e-17

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181190 [Multi-domain]  Cd Length: 334  Bit Score: 81.65  E-value: 3.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        35 GRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVD---LIEIDAASRTKVEDTRDLLDNV 111
Cdd:PRK07993  21 GRGHHALLIQALPGMGDDALIYALSRWLMCQQPQGHKSCGHCRGCQLMQAGTHPDyytLTPEKGKSSLGVDAVREVTEKL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       112 qYAPAR-GRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHi 190
Cdd:PRK07993 101 -YEHARlGGAKVVWLPDAALLTDAAANALLKTLEEPPENTWFFLACREPARLLATLRSRCRLHYLAPPPEQYALTWLSR- 178
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1XXI_I       191 lneeHIAHEPRALQLLARAAEGSLRDALSL--TDQ-AIASGDGQVSTQAVS-----AMLGTLDDDQA 249
Cdd:PRK07993 179 ----EVTMSQDALLAALRLSAGAPGAALALlqPERwQQREALCQALAYALPsgdwlSLLPALNHEQA 241
rfc PRK00440
replication factor C small subunit; Reviewed
9-243 4.67e-17

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 81.07  E-value: 4.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         9 KWRPQTFADVVGQEHVLTALANGLSLGRIHHaYLFSGTRGVGKTSIARLLAKGLNCETGItatpcgvcDNCREI----EQ 84
Cdd:PRK00440  10 KYRPRTLDEIVGQEEIVERLKSYVKEKNMPH-LLFAGPPGTGKTTAALALARELYGEDWR--------ENFLELnasdER 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        85 GrfVDLIeidaasRTKVED---TRDLLDnvqyAPargrFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQK 161
Cdd:PRK00440  81 G--IDVI------RNKIKEfarTAPVGG----AP----FKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSK 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       162 LPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTdQAIASGDGQVSTQAVSAML 241
Cdd:PRK00440 145 IIDPIQSRCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINAL-QAAAATGKEVTEEAVYKIT 223

                 ..
1XXI_I       242 GT 243
Cdd:PRK00440 224 GT 225
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
28-251 1.31e-15

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 76.77  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        28 LANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETgITATPCGVCDNCREIEQGRFVDLIEIDAASRTK---VEDT 104
Cdd:PRK06090  15 WKAGLDAGRIPGALLLQSDEGLGVESLVELFSRALLCQN-YQSEACGFCHSCELMQSGNHPDLHVIKPEKEGKsitVEQI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       105 RDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIR 184
Cdd:PRK06090  94 RQCNRLAQESSQLNGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQQWVVTPPSTAQAM 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I       185 HQlehiLNEEHIAHEPRALQL--------LARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGTLDDDQALS 251
Cdd:PRK06090 174 QW----LKGQGITVPAYALKLnmgsplktLAMMKEGGLEKYHKLERQLVDALSGPVSDQLKCASLIAADPLTHLS 244
PRK04195 PRK04195
replication factor C large subunit; Provisional
9-256 1.06e-14

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 74.96  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         9 KWRPQTFADVVGQEHVLTAL---ANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNcetgitatpcgvcdncreieqg 85
Cdd:PRK04195   7 KYRPKTLSDVVGNEKAKEQLrewIESWLKGKPKKALLLYGPPGVGKTSLAHALANDYG---------------------- 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        86 rfVDLIEIDAA-SRTKvED----------TRDLLdnvqyapARGRfKVYLIDEVHMLS----RHSFNALLKTLEEPPEHV 150
Cdd:PRK04195  65 --WEVIELNASdQRTA-DViervageaatSGSLF-------GARR-KLILLDEVDGIHgnedRGGARAILELIKKAKQPI 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       151 kfLLATTDPQKLP-VTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDAlsLTD-QAIASG 228
Cdd:PRK04195 134 --ILTANDPYDPSlRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSA--INDlQAIAEG 209
                        250       260
                 ....*....|....*....|....*...
1XXI_I       229 DGQVSTQAVSAMlgtLDDDQALSLVEAM 256
Cdd:PRK04195 210 YGKLTLEDVKTL---GRRDREESIFDAL 234
44 PHA02544
clamp loader, small subunit; Provisional
9-203 1.22e-13

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 70.79  E-value: 1.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         9 KWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLakglncetgitatpcgvcdnCREIEqgrfV 88
Cdd:PHA02544  14 KYRPSTIDECILPAADKETFKSIVKKGRIPNMLLHSPSPGTGKTTVAKAL--------------------CNEVG----A 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        89 DLIEIDAASrTKVEDTRDLLDNvqYAPA---RGRFKVYLIDEVHMLSRHSFNALLKTL-EEPPEHVKFLLATTDPQKLPV 164
Cdd:PHA02544  70 EVLFVNGSD-CRIDFVRNRLTR--FASTvslTGGGKVIIIDEFDRLGLADAQRHLRSFmEAYSKNCSFIITANNKNGIIE 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
1XXI_I       165 TILSRCLQFHL-KALDVEQIR------HQLEHILNEEHIAHEPRAL 203
Cdd:PHA02544 147 PLRSRCRVIDFgVPTKEEQIEmmkqmiVRCKGILEAEGVEVDMKVL 192
PRK05917 PRK05917
DNA polymerase III subunit delta'; Validated
101-175 2.29e-13

DNA polymerase III subunit delta'; Validated


Pssm-ID: 102059 [Multi-domain]  Cd Length: 290  Bit Score: 69.82  E-value: 2.29e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1XXI_I       101 VEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHL 175
Cdd:PRK05917  77 IETPRAIKKQIWIHPYESPYKIYIIHEADRMTLDAISAFLKVLEDPPQHGVIILTSAKPQRLPPTIRSRSLSIHI 151
PRK05818 PRK05818
DNA polymerase III subunit delta'; Validated
72-173 1.27e-11

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235618 [Multi-domain]  Cd Length: 261  Bit Score: 64.08  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        72 PCGVCDNCREIEQGRFVDLIEI-DAASRTKVEDTRDLLD--NVQYAPARGRfKVYLIDEVHMLSRHSFNALLKTLEEPPE 148
Cdd:PRK05818  39 FCKTCESCLKILNGKYNDFYLIfDQKNPIKKEDALSIINklNRPSVESNGK-KIYIIYGIEKLNKQSANSLLKLIEEPPK 117
                         90       100
                 ....*....|....*....|....*
1XXI_I       149 HVKFLLATTDPQKLPVTILSRCLQF 173
Cdd:PRK05818 118 NTYGIFTTRNENNILNTILSRCVQY 142
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
19-170 5.52e-11

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 60.24  E-value: 5.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       19 VGQEHVLTALANGLSLGRIHHaYLFSGTRGVGKTSIARLLAKGLNcetgitatpcgvcdncreieqGRFVDLIEIDAASR 98
Cdd:cd00009   1 VGQEEAIEALREALELPPPKN-LLLYGPPGTGKTTLARAIANELF---------------------RPGAPFLYLNASDL 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       99 TKVEDTRDLLDNVQYAPARGRFK-----VYLIDEVHMLSRHSFNALLKTLEE------PPEHVKFLLATTDP--QKLPVT 165
Cdd:cd00009  59 LEGLVVAELFGHFLVRLLFELAEkakpgVLFIDEIDSLSRGAQNALLRVLETlndlriDRENVRVIGATNRPllGDLDRA 138

                ....*
1XXI_I      166 ILSRC 170
Cdd:cd00009 139 LYDRL 143
PRK08769 PRK08769
DNA polymerase III subunit delta'; Validated
32-175 8.56e-11

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181551 [Multi-domain]  Cd Length: 319  Bit Score: 62.28  E-value: 8.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        32 LSLGRIHHAYLFSGTRGVGKTSIARLLAKGLnceTGITATPcGVCDNCRE-IEQGRFVDLIEID-AASRTK--------V 101
Cdd:PRK08769  20 LDAGRLGHGLLICGPEGLGKRAVALALAEHV---LASGPDP-AAAQRTRQlIAAGTHPDLQLVSfIPNRTGdklrteivI 95
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1XXI_I       102 EDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRC--LQFHL 175
Cdd:PRK08769  96 EQVREISQKLALTPQYGIAQVVIVDPADAINRAACNALLKTLEEPSPGRYLWLISAQPARLPATIRSRCqrLEFKL 171
PRK07132 PRK07132
DNA polymerase III subunit delta'; Validated
28-193 2.86e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180855 [Multi-domain]  Cd Length: 299  Bit Score: 60.51  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        28 LANGLSLGRIHHAYLFSGT-RGVGKTSIARLLAKGLNCETGitatpcGVCDNCREIEqGRFVDLIEIDaasrTKVEDTRD 106
Cdd:PRK07132   8 LDNSATQNKISHSFLLKSNyNEDIDEKILYFLNKFNNLQIT------NLNEQELPAN-IILFDIFDKD----LSKSEFLS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       107 LLDNVQYAP-ARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIrh 185
Cdd:PRK07132  77 AINKLYFSSfVQSQKKILIIKNIEKTSNSLLNALLKTIEEPPKDTYFLLTTKNINKVLPTIVSRCQVFNVKEPDQQKI-- 154

                 ....*...
1XXI_I       186 qLEHILNE 193
Cdd:PRK07132 155 -LAKLLSK 161
PRK13341 PRK13341
AAA family ATPase;
6-232 5.91e-10

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 60.84  E-value: 5.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         6 LARKWRPQTFADVVGQEHVLTA---LANGLSLGRIHHAyLFSGTRGVGKTSIARLLAKGLNCE-TGITATPCGVCDNCRE 81
Cdd:PRK13341  18 LADRLRPRTLEEFVGQDHILGEgrlLRRAIKADRVGSL-ILYGPPGVGKTTLARIIANHTRAHfSSLNAVLAGVKDLRAE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        82 IEQGRfvdlieidaaSRTKVEDTRDLLdnvqyapargrfkvyLIDEVHMLSRHSFNALLKTLEEPPehVKFLLATTDPQK 161
Cdd:PRK13341  97 VDRAK----------ERLERHGKRTIL---------------FIDEVHRFNKAQQDALLPWVENGT--ITLIGATTENPY 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       162 LPV--TILSRCLQFHLKALDVEQIRHQLEHILNEEH-------IAHEPRALQLLARAAEG---SLRDALSLTDQA-IASG 228
Cdd:PRK13341 150 FEVnkALVSRSRLFRLKSLSDEDLHQLLKRALQDKErgygdrkVDLEPEAEKHLVDVANGdarSLLNALELAVEStPPDE 229

                 ....
1XXI_I       229 DGQV 232
Cdd:PRK13341 230 DGLI 233
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
41-170 3.59e-09

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 54.52  E-value: 3.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         41 YLFSGTRGVGKTSIARLLAKglncETGItatpcgvcdNCREIEQGRFVDLIEIDAASRtkvedTRDLLDNVQyapaRGRF 120
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAK----ELGA---------PFIEISGSELVSKYVGESEKR-----LRELFEAAK----KLAP 58
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
1XXI_I        121 KVYLIDEVHMLSRHSF-----------NALLKTLEEP---PEHVKFLLATTDPQKLPVTILSRC 170
Cdd:pfam00004  59 CVIFIDEIDALAGSRGsggdsesrrvvNQLLTELDGFtssNSKVIVIAATNRPDKLDPALLGRF 122
PLN03025 PLN03025
replication factor C subunit; Provisional
9-237 3.89e-09

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 57.43  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         9 KWRPQTFADVVGQEHVLTALANGLSLGRIHHaYLFSGTRGVGKTSIARLLAKGLncetgitatpcgVCDNCREIeqgrfv 88
Cdd:PLN03025   6 KYRPTKLDDIVGNEDAVSRLQVIARDGNMPN-LILSGPPGTGKTTSILALAHEL------------LGPNYKEA------ 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        89 dLIEIDAASRTKVEDTRDLL-----DNVQYAParGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLP 163
Cdd:PLN03025  67 -VLELNASDDRGIDVVRNKIkmfaqKKVTLPP--GRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKII 143
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1XXI_I       164 VTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSlTDQAIASGDGQVSTQAV 237
Cdd:PLN03025 144 EPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALN-NLQATHSGFGFVNQENV 216
PRK04132 PRK04132
replication factor C small subunit; Provisional
120-237 1.18e-08

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 56.77  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       120 FKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHE 199
Cdd:PRK04132 631 FKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELT 710
                         90       100       110
                 ....*....|....*....|....*....|....*...
1XXI_I       200 PRALQLLARAAEGSLRDALSLTdQAIASGDGQVSTQAV 237
Cdd:PRK04132 711 EEGLQAILYIAEGDMRRAINIL-QAAAALDDKITDENV 747
PRK08485 PRK08485
DNA polymerase III subunit delta'; Validated
137-223 7.07e-07

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236274 [Multi-domain]  Cd Length: 206  Bit Score: 49.26  E-value: 7.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       137 NALLKTLEEPPEHVKFLLATTDPQKLPVTILSRC-------------LQFHLKALDVEQIRHQLEHILNEEHIAHEpRAL 203
Cdd:PRK08485  72 NALLKILEEPPKNICFIIVAKSKNLLLPTIRSRLiiekrkqkkpvkpLDLDLKKLDLKDIYEFLKELEKENKLSKE-ELK 150
                         90       100
                 ....*....|....*....|
1XXI_I       204 QLLARAAEGSLRDALSLTDQ 223
Cdd:PRK08485 151 ELIESLLKECVKYKIPLNEE 170
HolA COG1466
DNA polymerase III, delta subunit [Replication, recombination and repair];
121-313 1.26e-06

DNA polymerase III, delta subunit [Replication, recombination and repair];


Pssm-ID: 441075 [Multi-domain]  Cd Length: 305  Bit Score: 49.48  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      121 KVYLIDEVHMLSR--HSFNALLKTLEEPPEHVKFLLATTDP---QKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEH 195
Cdd:COG1466  64 RLVIVRNAEFLKKpgEGLEALEAYLANPPPDTVLVLTAGKLdkrKKLFKALEKAGVVVECYPLKERELPAWIRQRLKAAG 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      196 IAHEPRALQLLARAAEGSLRDALSLTDQ--AIASGDGQVSTQAVSAMLGTLDDDQALSLVEAMVEANGERVMALINEAAA 273
Cdd:COG1466 144 LRIDPDAAQLLAERVGGDLLALAQELEKlaLYAGDGGTITLEDVEALVGDSAEFNVFDLADALLAGDAARALRILRRLLA 223
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
1XXI_I      274 RGIEwealLVEMLGLLHR----IAMVQLSPAALGNDMAAI-ELRM 313
Cdd:COG1466 224 EGEE----PVLILAALARqfrlLLQVKALLAQGKSLAEIAkELGV 264
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
178-239 6.92e-06

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 43.29  E-value: 6.92e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
1XXI_I      178 LDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTdQAIASGDGQVSTQAVSA 239
Cdd:cd18140   1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDL-QAAAAGGGVITEEDVYE 61
PRK06581 PRK06581
DNA polymerase III subunit delta'; Validated
92-177 8.87e-06

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235833 [Multi-domain]  Cd Length: 263  Bit Score: 46.76  E-value: 8.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        92 EIDAASRTK---VEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILS 168
Cdd:PRK06581  59 ETSATSNAKnisIEQIRKLQDFLSKTSAISGYKVAIIYSAELMNLNAANSCLKILEDAPKNSYIFLITSRAASIISTIRS 138

                 ....*....
1XXI_I       169 RCLQFHLKA 177
Cdd:PRK06581 139 RCFKINVRS 147
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
6-241 4.91e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.90  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        6 LARKWRPQTFADVVGQEHVLTAL---------------ANGLSLGRihhAYLFSGTRGVGKTSIARLLAKGLNcetgita 70
Cdd:COG0464 147 ELLELREAILDDLGGLEEVKEELrelvalplkrpelreEYGLPPPR---GLLLYGPPGTGKTLLARALAGELG------- 216
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       71 tpcgvcdncreieqgrfVDLIEIDAAS-RTK-VEDT----RDLLDNV-QYAPArgrfkVYLIDEVHML--------SRHS 135
Cdd:COG0464 217 -----------------LPLIEVDLSDlVSKyVGETeknlREVFDKArGLAPC-----VLFIDEADALagkrgevgDGVG 274
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      136 ---FNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRC-LQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAE 211
Cdd:COG0464 275 rrvVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFdEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEG 354
                       250       260       270
                ....*....|....*....|....*....|....
1XXI_I      212 GSLRD----ALSLTDQAIASGDGQVSTQAVSAML 241
Cdd:COG0464 355 LSGADirnvVRRAALQALRLGREPVTTEDLLEAL 388
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
38-175 6.52e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.75  E-value: 6.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I          38 HHAYLFSGTRGVGKTSIARLLAKGLNCETGITATpcgvcDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPAR 117
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIY-----IDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1XXI_I         118 GRFKVYLIDEVHMLSRHSFNALL--------KTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHL 175
Cdd:smart00382  77 LKPDVLILDEITSLLDAEQEALLllleelrlLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRI 142
PRK04132 PRK04132
replication factor C small subunit; Provisional
9-61 7.76e-05

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 44.83  E-value: 7.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
1XXI_I         9 KWRPQTFADVVGQEHVLTALANGLSLGRIHHaYLFSGTRGVGK--TSIARLLAKG 61
Cdd:PRK04132  12 KYRPQRLDDIVGQEHIVKRLKHYVKTGSMPH-LLFAGPPGVGKclTGDTKVIANG 65
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
11-134 1.68e-04

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 41.72  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         11 RPQTFADVVGQEHVLT--------ALANGLSLGRIhhayLFSGTRGVGKTSIARLLAKGLNCETGITATPCgvcdncreI 82
Cdd:pfam05496   2 RPRTLDEYIGQEKVKEnlkifieaAKQRGEALDHV----LLYGPPGLGKTTLANIIANEMGVNIRITSGPA--------I 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
1XXI_I         83 EQGRfvDLieidAASRTKVEDtRDLLdnvqyapargrfkvyLIDEVHMLSRH 134
Cdd:pfam05496  70 ERPG--DL----AAILTNLEP-GDVL---------------FIDEIHRLNRA 99
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
11-133 6.87e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.27  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        11 RPQTFADVVGQEHVL--------TALANGLSLGRIhhayLFSGTRGVGKTSIARLLAKGLNCETGITATPcgvcdncrEI 82
Cdd:PRK00080  20 RPKSLDEFIGQEKVKenlkifieAAKKRGEALDHV----LLYGPPGLGKTTLANIIANEMGVNIRITSGP--------AL 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
1XXI_I        83 EQGRfvDLieidAASRTKVEDtRDLLdnvqyapargrFkvylIDEVHMLSR 133
Cdd:PRK00080  88 EKPG--DL----AAILTNLEE-GDVL-----------F----IDEIHRLSP 116
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
48-215 1.12e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 40.16  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       48 GVGKTSIARLLAKGL--NCETGITATPCGvcdNCREIEQGRFVDLiEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLI 125
Cdd:COG3267  53 GTGKTTLLRRLLERLpdDVKVAYIPNPQL---SPAELLRAIADEL-GLEPKGASKADLLRQLQEFLLELAAAGRRVVLII 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      126 DEVHMLSRHSFnallktleeppEHVKFLLA-TTDPQKLPVTIL-------------------SRC-LQFHLKALDVEQ-- 182
Cdd:COG3267 129 DEAQNLPPETL-----------EELRLLSNlETDSRKLLQIVLvgqpelrerlarpelrqlrQRItARYHLRPLDREEta 197
                       170       180       190
                ....*....|....*....|....*....|....*
1XXI_I      183 --IRHQLEHILNEEHIAHEPRALQLLARAAEGSLR 215
Cdd:COG3267 198 ayIEHRLKVAGGEGDPLFTPEAIEAIYRASGGIPR 232
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
11-72 2.30e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 39.68  E-value: 2.30e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I       11 RPQTFADVVGQEHVL--------TALANGLSLGRIhhayLFSGTRGVGKTSIARLLAKGLNCETGITATP 72
Cdd:COG2255  23 RPKRLDEYIGQEKVKenlkifieAAKKRGEALDHV----LLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
122-230 4.16e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 38.80  E-value: 4.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I      122 VYLIDEVHMLSRHSFNALLKTLEEppEHVKFL-LAT---------TD---PQKLPVTILSRCLQFHLKALDVEQIRHQLE 188
Cdd:COG1224 295 VLFIDDAHMLDIEAFSFLTRAMES--ELAPIIiLATnrgitkirgTDiesPHGIPLDLLDRLLIIPTRPYTEDEIREIIK 372
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
1XXI_I      189 HILNEEHIAHEPRALQLLAR-AAEGSLRDALSLTDQA--IASGDG 230
Cdd:COG1224 373 IRAEEEDIELSDDALEELTKiGVERSLRYAVQLLEPAyiIAKRRG 417
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
44-65 4.43e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 37.49  E-value: 4.43e-03
                        10        20
                ....*....|....*....|..
1XXI_I       44 SGTRGVGKTSIARLLAKGLNCE 65
Cdd:COG1936   6 TGTPGTGKTTVAKLLAERLGLE 27
DNA_pol3_delta pfam06144
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
139-219 5.97e-03

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 428788 [Multi-domain]  Cd Length: 174  Bit Score: 37.27  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I        139 LLKTLEEPPEHVKFLLATTDP----QKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLARAAEGSL 214
Cdd:pfam06144  83 LEEYLSNPPPDSLLILFAPGKlderKKLTKLLKKKATVVECFTLKEEELIQWIQSRAQELGLQIEPEAIELLCELVENNL 162

                  ....*
1XXI_I        215 RDALS 219
Cdd:pfam06144 163 SALAQ 167
AAA_18 pfam13238
AAA domain;
42-129 6.34e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 36.64  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1XXI_I         42 LFSGTRGVGKTSIARLLAKGLNCEtgitatpcgvcDNCREIEQGRFVDLIEIDAASRTKVEDTRD---LLDNVQYAPARG 118
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFG-----------DNVRDLALENGLVLGDDPETRESKRLDEDKldrLLDLLEENAALE 70
                          90
                  ....*....|.
1XXI_I        119 RFKVYLIDEVH 129
Cdd:pfam13238  71 EGGNLIIDGHL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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