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Conserved domains on  [gi|78101358|pdb|2AHX|B]
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Chain B, Receptor tyrosine-protein kinase erbB-4

Protein Classification

epidermal growth factor receptor; insulin receptor( domain architecture ID 12013602)

epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, and is activated by ligand (EGF family)-induced dimerization| insulin receptor is a receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 478-610 3.69e-64

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


:

Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 207.23  E-value: 3.69e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        478 VCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLlTCHGPGPDNCTKCS 557
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTA-TCSGPGADNCTKCA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
2AHX_B        558 HFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI 610
Cdd:pfam14843  80 HFRDGPHCVSSCPSGVLGENDLIWKYADANGVCQPCHPNCTQGCTGPGLTGCP 132
Furin-like pfam00757
Furin-like cysteine rich region;
162-308 7.08e-38

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 137.18  E-value: 7.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        162 CGRCHKSCT-GRCWGPteNHCQTltrtVCAEQCDGRCYGPyvSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ 240
Cdd:pfam00757  12 MEKCHSCCNnGYCWGP--GHCQK----VCPEQCKKRCTKP--GECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQCPP 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2AHX_B        241 tfvynpttfqlehnfnAKYTYGAFCV--KKCP-------HNFVVDSSSCVRACPSSKMEVeENGIKMCKPCTDICPK 308
Cdd:pfam00757  84 ----------------GTYQFGWRCVtfKECPkshlpgyNPLVIHNGECVRECPSGYTEV-ENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 31-143 5.07e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 125.04  E-value: 5.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B         31 NCEVVMGNLEITSIEHN---RDLSFLRSVREVTGYVLVALNQFRYL-PLENLRIIRGTKLYEDRYALAIFLNYRkdgnfg 106
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANTNLVSLsFLPNLRIIRGRNLFDDNYALYILDNPN------ 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
2AHX_B        107 LQELGLKNLTEILNGGVYVDQNKFLCYADT-IHWQDIV 143
Cdd:pfam01030  75 LTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 334-454 9.92e-28

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 107.70  E-value: 9.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        334 NCTKINGNLIFLVTGIHGDPYNaieaidpekLNVFRTVREITGFLNIQSWppNMTDFSVFSNLVTIGGRVLY-SGLSLLI 412
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSEL---------LSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFdDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
2AHX_B        413 LKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHT-INWTTLF 454
Cdd:pfam01030  70 LDNPNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 478-610 3.69e-64

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 207.23  E-value: 3.69e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        478 VCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLlTCHGPGPDNCTKCS 557
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTA-TCSGPGADNCTKCA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
2AHX_B        558 HFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI 610
Cdd:pfam14843  80 HFRDGPHCVSSCPSGVLGENDLIWKYADANGVCQPCHPNCTQGCTGPGLTGCP 132
Furin-like pfam00757
Furin-like cysteine rich region;
162-308 7.08e-38

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 137.18  E-value: 7.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        162 CGRCHKSCT-GRCWGPteNHCQTltrtVCAEQCDGRCYGPyvSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ 240
Cdd:pfam00757  12 MEKCHSCCNnGYCWGP--GHCQK----VCPEQCKKRCTKP--GECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQCPP 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2AHX_B        241 tfvynpttfqlehnfnAKYTYGAFCV--KKCP-------HNFVVDSSSCVRACPSSKMEVeENGIKMCKPCTDICPK 308
Cdd:pfam00757  84 ----------------GTYQFGWRCVtfKECPkshlpgyNPLVIHNGECVRECPSGYTEV-ENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 31-143 5.07e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 125.04  E-value: 5.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B         31 NCEVVMGNLEITSIEHN---RDLSFLRSVREVTGYVLVALNQFRYL-PLENLRIIRGTKLYEDRYALAIFLNYRkdgnfg 106
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANTNLVSLsFLPNLRIIRGRNLFDDNYALYILDNPN------ 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
2AHX_B        107 LQELGLKNLTEILNGGVYVDQNKFLCYADT-IHWQDIV 143
Cdd:pfam01030  75 LTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 334-454 9.92e-28

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 107.70  E-value: 9.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        334 NCTKINGNLIFLVTGIHGDPYNaieaidpekLNVFRTVREITGFLNIQSWppNMTDFSVFSNLVTIGGRVLY-SGLSLLI 412
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSEL---------LSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFdDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
2AHX_B        413 LKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHT-INWTTLF 454
Cdd:pfam01030  70 LDNPNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
525-572 2.21e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 44.81  E-value: 2.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
2AHX_B         525 DSICVECDPQCekmedglLTCHGPGPDNCTKCSH--FKDGPNCVEKCPDG 572
Cdd:smart00261   1 DGECKPCHPEC-------ATCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 205-250 7.76e-06

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 43.28  E-value: 7.76e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
2AHX_B      205 CCHRECAGgCSGPKDTDCFACMNFN--DSGACVTQCPQTFVYNPTTFQ 250
Cdd:cd00064   1 PCHPSCAT-CTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEGGV 47
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 530-572 2.60e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.74  E-value: 2.60e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
2AHX_B      530 ECDPQCekmedglLTCHGPGPDNCTKCSHFK--DGPNCVEKCPDG 572
Cdd:cd00064   1 PCHPSC-------ATCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
FU smart00261
Furin-like repeats;
205-242 2.07e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 39.03  E-value: 2.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2AHX_B         205 CCHRECAGgCSGPKDTDCFACMNFN--DSGACVTQCPQTF 242
Cdd:smart00261   6 PCHPECAT-CTGPGPDDCTSCKHGFflDGGKCVSECPPGT 44
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 478-610 3.69e-64

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 207.23  E-value: 3.69e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        478 VCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLlTCHGPGPDNCTKCS 557
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTA-TCSGPGADNCTKCA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
2AHX_B        558 HFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI 610
Cdd:pfam14843  80 HFRDGPHCVSSCPSGVLGENDLIWKYADANGVCQPCHPNCTQGCTGPGLTGCP 132
Furin-like pfam00757
Furin-like cysteine rich region;
162-308 7.08e-38

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 137.18  E-value: 7.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        162 CGRCHKSCT-GRCWGPteNHCQTltrtVCAEQCDGRCYGPyvSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ 240
Cdd:pfam00757  12 MEKCHSCCNnGYCWGP--GHCQK----VCPEQCKKRCTKP--GECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQCPP 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2AHX_B        241 tfvynpttfqlehnfnAKYTYGAFCV--KKCP-------HNFVVDSSSCVRACPSSKMEVeENGIKMCKPCTDICPK 308
Cdd:pfam00757  84 ----------------GTYQFGWRCVtfKECPkshlpgyNPLVIHNGECVRECPSGYTEV-ENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 31-143 5.07e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 125.04  E-value: 5.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B         31 NCEVVMGNLEITSIEHN---RDLSFLRSVREVTGYVLVALNQFRYL-PLENLRIIRGTKLYEDRYALAIFLNYRkdgnfg 106
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANTNLVSLsFLPNLRIIRGRNLFDDNYALYILDNPN------ 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
2AHX_B        107 LQELGLKNLTEILNGGVYVDQNKFLCYADT-IHWQDIV 143
Cdd:pfam01030  75 LTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 334-454 9.92e-28

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 107.70  E-value: 9.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        334 NCTKINGNLIFLVTGIHGDPYNaieaidpekLNVFRTVREITGFLNIQSWppNMTDFSVFSNLVTIGGRVLY-SGLSLLI 412
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSEL---------LSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFdDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
2AHX_B        413 LKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHT-INWTTLF 454
Cdd:pfam01030  70 LDNPNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
525-572 2.21e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 44.81  E-value: 2.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
2AHX_B         525 DSICVECDPQCekmedglLTCHGPGPDNCTKCSH--FKDGPNCVEKCPDG 572
Cdd:smart00261   1 DGECKPCHPEC-------ATCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 205-250 7.76e-06

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 43.28  E-value: 7.76e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
2AHX_B      205 CCHRECAGgCSGPKDTDCFACMNFN--DSGACVTQCPQTFVYNPTTFQ 250
Cdd:cd00064   1 PCHPSCAT-CTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEGGV 47
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 530-572 2.60e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.74  E-value: 2.60e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
2AHX_B      530 ECDPQCekmedglLTCHGPGPDNCTKCSHFK--DGPNCVEKCPDG 572
Cdd:cd00064   1 PCHPSC-------ATCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
Furin-like pfam00757
Furin-like cysteine rich region;
472-572 5.22e-05

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 43.58  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        472 CTAEGMVCNHLCSSDGCWGPGPDQclscrrfsrgRICIESCNLYdgefreFENDSICveCDPQCekmedgLLTCHGPGPD 551
Cdd:pfam00757   8 CPGTMEKCHSCCNNGYCWGPGHCQ----------KVCPEQCKKR------CTKPGEC--CHEQC------LGGCTGPNDS 63

                          90       100
                  ....*....|....*....|.
2AHX_B        552 NCTKCSHFKDGPNCVEKCPDG 572
Cdd:pfam00757  64 DCLACRHFNDEGTCVDQCPPG 84
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 206-312 9.81e-05

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 42.36  E-value: 9.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        206 CHRECAG-GCSGPKDTDCFACMNFNDSGACVTQC------PQTFVYNPTTFQ-----LEHNFN--------------AKY 259
Cdd:pfam14843   2 CDPLCSSeGCWGPGPDQCLSCRNFSRGGTCVESCnilqgePREYVVNSTCVPchpecLPQNGTatcsgpgadnctkcAHF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
2AHX_B        260 TYGAFCVKKCPHNfVVDSSSCVRACPsskmevEENGIkmCKPCTDICPKACDG 312
Cdd:pfam14843  82 RDGPHCVSSCPSG-VLGENDLIWKYA------DANGV--CQPCHPNCTQGCTG 125
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 165-241 1.63e-04

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 41.98  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2AHX_B        165 CHKSCTGR-CWGPTENHCQT----LTRTVCAEQCDGRCYGP--YVSD--C--CHRECAGG-----CSGPKDTDCFACMNF 228
Cdd:pfam14843   2 CDPLCSSEgCWGPGPDQCLScrnfSRGGTCVESCNILQGEPreYVVNstCvpCHPECLPQngtatCSGPGADNCTKCAHF 81

                          90
                  ....*....|...
2AHX_B        229 NDSGACVTQCPQT 241
Cdd:pfam14843  82 RDGPHCVSSCPSG 94
FU smart00261
Furin-like repeats;
205-242 2.07e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 39.03  E-value: 2.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2AHX_B         205 CCHRECAGgCSGPKDTDCFACMNFN--DSGACVTQCPQTF 242
Cdd:smart00261   6 PCHPECAT-CTGPGPDDCTSCKHGFflDGGKCVSECPPGT 44
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 479-512 5.24e-03

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 35.19  E-value: 5.24e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
2AHX_B      479 CNHLCssDGCWGPGPDQCLSCRRFS--RGRICIESC 512
Cdd:cd00064   2 CHPSC--ATCTGPGPDQCTSCRHGFylDGGTCVSEC 35
FU smart00261
Furin-like repeats;
477-513 9.27e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 34.41  E-value: 9.27e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
2AHX_B         477 MVCNHLCSsdGCWGPGPDQCLSCRRFSR--GRICIESCN 513
Cdd:smart00261   5 KPCHPECA--TCTGPGPDDCTSCKHGFFldGGKCVSECP 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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