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Conserved domains on  [gi|85544419|pdb|2CVL|D]
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Chain D, protein translation initiation inhibitor

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 2-121 3.56e-58

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 175.56  E-value: 3.56e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D          2 EAVKTDRAPAAIGPYAQAVKAGGFVFVSGQIPLAPD-GSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD* 80
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPStGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2CVL_D         81 EDFPGFNEVYARYFTPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 2-121 3.56e-58

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 175.56  E-value: 3.56e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D          2 EAVKTDRAPAAIGPYAQAVKAGGFVFVSGQIPLAPD-GSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD* 80
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPStGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2CVL_D         81 EDFPGFNEVYARYFTPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 9-121 1.97e-50

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 156.11  E-value: 1.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D        9 APAAIGPYAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNE 88
Cdd:COG0251  10 APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAVNE 89

                        90       100       110
                ....*....|....*....|....*....|...
2CVL_D       89 VYARYFTPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:COG0251  90 VYAEYFGEGRPARTAVGVAALPKGALVEIEAIA 122
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 16-121 4.05e-45

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 141.93  E-value: 4.05e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNEVYARYFT 95
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
2CVL_D       96 -PPYPARATVAVKALPRGVRVEVACVA 121
Cdd:cd00448  81 eGPPPARTAVGVAALPPGALVEIEAIA 107
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 9-121 1.87e-43

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 138.20  E-value: 1.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D          9 APAAIGPYAQAVKAGGFVFVSGQIPLAPD-GSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFN 87
Cdd:pfam01042   2 APAAAGPYSQAVKAGNLVYVSGQIPLDPDtGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVN 81

                          90       100       110
                  ....*....|....*....|....*....|....*
2CVL_D         88 EVYARYF-TPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:pfam01042  82 EVYAEYFdADKAPARSAVGVAALPLGALVEIEAIA 116
PRK11401 PRK11401
enamine/imine deaminase;
4-122 4.23e-28

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 99.76  E-value: 4.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D         4 VKTDRAPAAIGPYAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDF 83
Cdd:PRK11401   5 IETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
2CVL_D        84 PGFNEVYARYF---TPPYPARATVAVKALPRGVRVEVACVAL 122
Cdd:PRK11401  85 ATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 2-121 3.56e-58

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 175.56  E-value: 3.56e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D          2 EAVKTDRAPAAIGPYAQAVKAGGFVFVSGQIPLAPD-GSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD* 80
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPStGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
2CVL_D         81 EDFPGFNEVYARYFTPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 9-121 1.97e-50

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 156.11  E-value: 1.97e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D        9 APAAIGPYAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNE 88
Cdd:COG0251  10 APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGELGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTDMADFAAVNE 89

                        90       100       110
                ....*....|....*....|....*....|...
2CVL_D       89 VYARYFTPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:COG0251  90 VYAEYFGEGRPARTAVGVAALPKGALVEIEAIA 122
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 16-121 4.05e-45

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 141.93  E-value: 4.05e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNEVYARYFT 95
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFFG 80

                        90       100
                ....*....|....*....|....*..
2CVL_D       96 -PPYPARATVAVKALPRGVRVEVACVA 121
Cdd:cd00448  81 eGPPPARTAVGVAALPPGALVEIEAIA 107
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 9-121 1.87e-43

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 138.20  E-value: 1.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D          9 APAAIGPYAQAVKAGGFVFVSGQIPLAPD-GSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFN 87
Cdd:pfam01042   2 APAAAGPYSQAVKAGNLVYVSGQIPLDPDtGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEVN 81

                          90       100       110
                  ....*....|....*....|....*....|....*
2CVL_D         88 EVYARYF-TPPYPARATVAVKALPRGVRVEVACVA 121
Cdd:pfam01042  82 EVYAEYFdADKAPARSAVGVAALPLGALVEIEAIA 116
PRK11401 PRK11401
enamine/imine deaminase;
4-122 4.23e-28

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 99.76  E-value: 4.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D         4 VKTDRAPAAIGPYAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDF 83
Cdd:PRK11401   5 IETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDLNDF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
2CVL_D        84 PGFNEVYARYF---TPPYPARATVAVKALPRGVRVEVACVAL 122
Cdd:PRK11401  85 ATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAV 126
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 16-121 7.98e-25

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 90.29  E-value: 7.98e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPlapdgSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNEVYARYFT 95
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVA-----DDTSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWVP 77

                        90       100
                ....*....|....*....|....*..
2CVL_D       96 PPY-PARATVAVKALPRGVRVEVACVA 121
Cdd:cd06150  78 PGHaPARACVEAKLADPGYLVEIVVTA 104
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 16-121 7.90e-23

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 85.78  E-value: 7.90e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAPDGSlVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD-*EDFPGFNEVYARYF 94
Cdd:cd02198   3 YSPAVRVGDTLFVSGQVGSDADGS-VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDmAAHLPAFAAVKDEYF 81

                        90       100
                ....*....|....*....|....*...
2CVL_D       95 TPPYPARATVAVKALPR-GVRVEVACVA 121
Cdd:cd02198  82 KEPYPAWTAVGVAWLARpGLLVEIKVVA 109
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 16-117 2.74e-20

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 79.52  E-value: 2.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNEVYARYFT 95
Cdd:cd06154  13 YSRAVRVGNWVFVSGTTGYDYDGMVMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVFG 92

                        90       100
                ....*....|....*....|...
2CVL_D       96 PPYPARATVAVKALPR-GVRVEV 117
Cdd:cd06154  93 DIRPAATMVVVSLLVDpEMLVEI 115
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 21-122 1.11e-14

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 64.59  E-value: 1.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       21 KAGGFVFVSGQIPLAPDGSLVEgdirvQTERV*ENLKAVLEAAGSGLSRVVQTTCFLAD*EDFPGFNEVYARYFTPPYP- 99
Cdd:cd06155   5 RTGGLLWISNVTASESDETVEE-----QMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNPp 79

                        90       100
                ....*....|....*....|...
2CVL_D      100 ARATVAVKaLPRGVRVEVACVAL 122
Cdd:cd06155  80 SRVCVECG-LPEGCDVQLSCVAA 101
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 16-116 3.52e-11

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 55.80  E-value: 3.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAP-DGSLVEGDIRVQTERV*ENLKAVLEAAGSGlsRVVQTTCFLAD*EDFPGFNEVYARYF 94
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLIPaTMTLLEGGITLQAVLSLQHLERVAKAMNVQ--WVLAAVCYVTDESSVPIARSAWSKYC 78

                        90       100       110
                ....*....|....*....|....*....|....*
2CVL_D       95 TPPYPAR-------------ATVAVKALPRGVRVE 116
Cdd:cd06156  79 SELDLEDesrnesddvnpplVIVVVPELPRGALVE 113
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 9-121 1.37e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 54.77  E-value: 1.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D        9 APAAIGPYAQAVKAGGFVFVSGQIPLAPDGSLVEGdiRVQTERV*E-----------NLKAVLEAAGSGLSRV---VQTT 74
Cdd:cd02199   9 APAPVGNYVPAVRTGNLLYVSGQLPRVDGKLVYTG--KVGADLSVEegqeaarlcalNALAALKAALGDLDRVkrvVRLT 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
2CVL_D       75 CFLAD*EDFP-------GFNEVYARYFTP-PYPARATVAVKALPRGVRVEVACVA 121
Cdd:cd02199  87 GFVNSAPDFTeqpkvanGASDLLVEVFGEaGRHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 22-100 1.79e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 53.80  E-value: 1.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       22 AGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAG-----SGLSRVVQTTCFLAD*EDFPGFNEVYARYFTP 96
Cdd:cd06153  11 GRTHLFISGTASIVGHGTVHPGDVEAQTRETLENIEALLEAAGrgggaQFLADLLRLKVYLRDREDLPAVRAILAARLGP 90


                ....
2CVL_D       97 PYPA 100
Cdd:cd06153  91 AVPA 94
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 26-121 2.81e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 53.86  E-value: 2.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       26 VFVSGQIP-----LAPDGSLV-EGDIRVQTERV*ENLKAVLEAAGSGLSRVVQTTCFL-AD*E-----DFPGFNEVYARY 93
Cdd:cd06151  14 IYLSGTVPavvnaSAPKGSPArYGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvADPAldgkmDFAGFMKAYRQF 93

                        90       100       110
                ....*....|....*....|....*....|...
2CVL_D       94 F----TPPYPARATVAVKALPR-GVRVEVACVA 121
Cdd:cd06151  94 FgtaeQPNKPARSTLQVAGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 16-121 3.23e-08

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 48.07  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CVL_D       16 YAQAVKAGGFVFVSGQIPLAPDGSLVEGDIRVQTERV*ENLKAVLEAAG-SGLSRVVQTTCF---LAD*EDFPGFNEVYA 91
Cdd:cd06152   3 YSQAVRIGDRIEISGQGGWDPDTGKIPEDLEEEIDQAFDNVELALKAAGgKGWEQVYKVNSYhvdIKNEEAFGLMVENFK 82

                        90       100       110
                ....*....|....*....|....*....|.
2CVL_D       92 RYFTPPYPARATVAVKALPR-GVRVEVACVA 121
Cdd:cd06152  83 KWMPNHQPIWTCVGVTALGLpGMRVEIEVDA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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