|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
3-246 |
2.29e-169 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 466.61 E-value: 2.29e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 3 MKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVL 82
Cdd:PRK14138 1 MKEFLELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYPQNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 83 LAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFF 162
Cdd:PRK14138 81 LAKLEEKGLIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKLEKSDVPRCDDCSGLIRPNIVFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 163 GENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVMEE 242
Cdd:PRK14138 161 GEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSE 240
|
....
2H2G_A 243 GGIS 246
Cdd:PRK14138 241 GGIS 244
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
10-231 |
6.45e-136 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 381.33 E-value: 6.45e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 10 LNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEE 88
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDpEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 89 KGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDViKKLESSDVPLCDDCNSLIRPNIVFFGENLPQ 168
Cdd:cd01413 81 QGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEV-KYAKKHEVPRCPKCGGIIRPDVVLFGEPLPQ 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
2H2G_A 169 DALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMD 231
Cdd:cd01413 160 ALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQDK 222
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
2-241 |
1.38e-117 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 335.59 E-value: 1.38e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 2 KMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAH 80
Cdd:COG0846 3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDpEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 81 VLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIV 160
Cdd:COG0846 83 RALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPKCGGLLRPDVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 161 FFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVM 240
Cdd:COG0846 163 WFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALV 242
|
.
2H2G_A 241 E 241
Cdd:COG0846 243 E 243
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
4-242 |
1.30e-113 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 325.68 E-value: 1.30e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 4 KEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQ-NVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVL 82
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPeELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 83 LAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESS-DVPLCDDCNSLIRPNIVF 161
Cdd:NF040867 81 LAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGeLPPRCPECGGLLRPDVVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 162 FGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVME 241
Cdd:NF040867 161 FGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLVE 240
|
.
2H2G_A 242 E 242
Cdd:NF040867 241 E 241
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
21-195 |
3.99e-73 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 220.59 E-value: 3.99e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 21 GAGISTPSGIPDFRGPNGIYKKYS-------QNVFDIDFFYSHPEEFYRFAKEGIFPmlQAKPNLAHVLLAKLEEKGLIE 93
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLApeelaspEAFFSNPELVWDPEPFYNIARELLPG--EAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 94 AVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPqDALRE 173
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLP-DKFHR 157
|
170 180
....*....|....*....|..
2H2G_A 174 AIGLSSRASLMIVLGSSLVVYP 195
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
3-246 |
2.29e-169 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 466.61 E-value: 2.29e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 3 MKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVL 82
Cdd:PRK14138 1 MKEFLELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKYPQNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 83 LAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFF 162
Cdd:PRK14138 81 LAKLEEKGLIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKLEKSDVPRCDDCSGLIRPNIVFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 163 GENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVMEE 242
Cdd:PRK14138 161 GEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSE 240
|
....
2H2G_A 243 GGIS 246
Cdd:PRK14138 241 GGIS 244
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
10-231 |
6.45e-136 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 381.33 E-value: 6.45e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 10 LNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEE 88
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDpEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 89 KGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDViKKLESSDVPLCDDCNSLIRPNIVFFGENLPQ 168
Cdd:cd01413 81 QGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEV-KYAKKHEVPRCPKCGGIIRPDVVLFGEPLPQ 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
2H2G_A 169 DALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMD 231
Cdd:cd01413 160 ALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQDK 222
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
2-241 |
1.38e-117 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 335.59 E-value: 1.38e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 2 KMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAH 80
Cdd:COG0846 3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDpEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 81 VLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIV 160
Cdd:COG0846 83 RALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPKCGGLLRPDVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 161 FFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVM 240
Cdd:COG0846 163 WFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALV 242
|
.
2H2G_A 241 E 241
Cdd:COG0846 243 E 243
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
4-242 |
1.30e-113 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 325.68 E-value: 1.30e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 4 KEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQ-NVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVL 82
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPeELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 83 LAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESS-DVPLCDDCNSLIRPNIVF 161
Cdd:NF040867 81 LAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGeLPPRCPECGGLLRPDVVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 162 FGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVME 241
Cdd:NF040867 161 FGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLVE 240
|
.
2H2G_A 242 E 242
Cdd:NF040867 241 E 241
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
14-231 |
5.17e-109 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 312.97 E-value: 5.17e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 14 RLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQN--VFDIDFFYSHPEEFYRFAKEgIFPMLQAKPNLAHVLLAKLEEKGL 91
Cdd:cd01407 1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPEelAFSPEAFRRDPELFWGFYRE-RRYPLNAQPNPAHRALAELERKGK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 92 IEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDAL 171
Cdd:cd01407 80 LKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDREEVPRCPKCGGLLRPDVVFFGESLPEELD 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 172 REAIGLsSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMD 231
Cdd:cd01407 160 EAAEAL-AKADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
1-242 |
8.78e-108 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 310.57 E-value: 8.78e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 1 MKMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLA 79
Cdd:PRK00481 1 MRIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRpEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 80 HVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKklesSDVPLCDDCNSLIRPNI 159
Cdd:PRK00481 81 HRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLK----PEPPRCPKCGGILRPDV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 160 VFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRV 239
Cdd:PRK00481 157 VLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPEL 236
|
...
2H2G_A 240 MEE 242
Cdd:PRK00481 237 VEE 239
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
17-222 |
5.42e-87 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 257.27 E-value: 5.42e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 17 VTLTGAGISTPSGIPDFRGPN-GIYKKYSQN--VFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEEKGLIE 93
Cdd:cd00296 4 VVFTGAGISTESGIPDFRGLGtGLWTRLDPEelAFSPEAFRRDPELFWLFYKERRYTPLDAKPNPAHRALAELERKGKLK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 94 AVITQNIDRLHQRAGSK--KVIELHGNVEEYYCVRCEKKYTVEDVikkLESSDVPLCDDCNSLIRPNIVFFGENLPQDAL 171
Cdd:cd00296 84 RIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEV---LEREKPPRCPKCGGLLRPDVVDFGEALPKEWF 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
2H2G_A 172 REAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDD 222
Cdd:cd00296 161 DRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREPTPADA 211
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
14-240 |
2.31e-74 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 225.16 E-value: 2.31e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 14 RLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPE---EFYRFAKEGIfpmLQAKPNLAHVLLAKLEEK 89
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDpEELATPEAFARDPElvwEFYNWRRRKA---LRAQPNPAHLALAELERR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 90 GLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKkleSSDVPLCDDCNSLIRPNIVFFGENLPqD 169
Cdd:cd01412 78 LPNVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNEEIP---EEELPRCPKCGGLLRPGVVWFGESLP-L 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2H2G_A 170 ALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVM 240
Cdd:cd01412 154 ALLEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
9-226 |
3.60e-73 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 222.24 E-value: 3.60e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 9 LLNESRLTVTLTGAGISTPSGIPDFRGPNGIYK-KYSQN---VFDIDFFYSHPEEFYRFAKEG-IFPmlQAKPNLAHVLL 83
Cdd:cd01411 4 ILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNeIYKYSpeyLLSHDFLEREPEKFYQFVKENlYFP--DAKPNIIHQKM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 84 AKLEEKGLIeAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKklessdVPLCDDCNSLIRPNIVFFG 163
Cdd:cd01411 82 AELEKMGLK-AVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLK------SPYHAKCGGVIRPDIVLYE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
2H2G_A 164 ENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELpLITVRSGGKLVIVNLGETPFDDIATL 226
Cdd:cd01411 155 EMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGL-IDYRQAGANLIAINKEPTQLDSPATL 216
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
21-195 |
3.99e-73 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 220.59 E-value: 3.99e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 21 GAGISTPSGIPDFRGPNGIYKKYS-------QNVFDIDFFYSHPEEFYRFAKEGIFPmlQAKPNLAHVLLAKLEEKGLIE 93
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLApeelaspEAFFSNPELVWDPEPFYNIARELLPG--EAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 94 AVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPqDALRE 173
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLP-DKFHR 157
|
170 180
....*....|....*....|..
2H2G_A 174 AIGLSSRASLMIVLGSSLVVYP 195
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
16-227 |
2.69e-68 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 209.08 E-value: 2.69e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 16 TVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDidffyshPEEFYRFAKegifpmlqAKPNLAHVLLAKLEEKGLIEAV 95
Cdd:cd01410 3 LVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKGR-------RRFSWRFRR--------AEPTLTHMALVELERAGLLKFV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 96 ITQNIDRLHQRAG--SKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDV-PLCDDCNSLIRPNIVFFGENLPQDALR 172
Cdd:cd01410 68 ISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPEYVRDDVVETRGDKETgRRCHACGGILKDTIVDFGERLPPENWM 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
2H2G_A 173 EAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLK 227
Cdd:cd01410 148 GAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLV 202
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
17-221 |
1.25e-63 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 198.24 E-value: 1.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 17 VTLTGAGISTPSGIPDFRGPN-GIYKK-------YSQNVFDIDFFYSHPEEFYRFAKEgIFPMlQAKPNLAHVLLAKLEE 88
Cdd:cd01408 4 VVLVGAGISTSAGIPDFRSPGtGLYANlarynlpYPEAMFDISYFRKNPRPFYALAKE-LYPG-QFKPSVAHYFIKLLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 89 KGLIEAVITQNIDRLHQRAG--SKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENL 166
Cdd:cd01408 82 KGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYPGDWMREDIFNQEVPKCPRCGGLVKPDIVFFGESL 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
2H2G_A 167 PQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLItVRSGGKLVIVN------LGETPFD 221
Cdd:cd01408 162 PSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSR-VPSEVPRVLINrepvghLGKRPFD 221
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
8-234 |
2.72e-56 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 180.57 E-value: 2.72e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 8 DLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKE--GIFPMLQAKPNLAHVLLAK 85
Cdd:cd01409 3 DFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSRTFRPMTHQEFMRSPAARQRYWARSfvGWPRFSAAQPNAAHRALAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 86 LEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVE------------------------DVIKKLE 141
Cdd:cd01409 83 LEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAelqdrlealnpgfaeqaagqapdgDVDLEDE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 142 SSD---VPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGET 218
Cdd:cd01409 163 QVAgfrVPECERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPIAIVNIGPT 242
|
250
....*....|....*.
2H2G_A 219 PFDDIATLKYNMDVVE 234
Cdd:cd01409 243 RADHLATLKVDARCGE 258
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
13-227 |
2.26e-53 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 173.71 E-value: 2.26e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 13 SRLTVtLTGAGISTPSGIPDFRGPNGIYKKySQNVFDIDFFYSHPEEFYRFAKEGI-FPML-QAKPNLAHVLLAKLEEKG 90
Cdd:PRK05333 20 PRLFV-LTGAGISTDSGIPDYRDRNGQWKR-SPPITYQAFMGSDAARRRYWARSMVgWPVFgRAQPNAAHHALARLGAAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 91 LIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKY---TVEDVIKK-------------------LESSD---- 144
Cdd:PRK05333 98 RIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHpraEIQHVLEAanpewlaleaapapdgdadLEWAAfdhf 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 145 -VPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDI 223
Cdd:PRK05333 178 rVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQGKPIAALNLGRTRADPL 257
|
....
2H2G_A 224 ATLK 227
Cdd:PRK05333 258 LTLK 261
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
3-218 |
7.02e-47 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 156.62 E-value: 7.02e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 3 MKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPN-GIYKKYSQNVF-DIDFFYSHPEEFYRFAKEgIFPMLQAKPNLAH 80
Cdd:PTZ00409 18 LEDLADMIRKCKYVVALTGSGTSAESNIPSFRGPSsSIWSKYDPKIYgTIWGFWKYPEKIWEVIRD-ISSDYEIELNPGH 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 81 VLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESS---DVPLCDDCNSLIRP 157
Cdd:PTZ00409 97 VALSTLESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLNKIMLQKTSHfmhQLPPECPCGGIFKP 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
2H2G_A 158 NIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGET 218
Cdd:PTZ00409 177 NVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKT 237
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
10-217 |
6.96e-41 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 140.34 E-value: 6.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 10 LNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYsqNVFDI---DFFYSHPEEFYRFAKEGIFPML--QAKPNLAHVLLA 84
Cdd:PTZ00408 1 MKACRCITILTGAGISAESGISTFRDGNGLWENH--RVEDVatpDAFLRNPALVQRFYNERRRALLssSVKPNKAHFALA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 85 KLEE--KGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYT-VEDVIKklessDVPLCDDC--NSLIRPNI 159
Cdd:PTZ00408 79 KLEReyRGGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDwTEDVVH-----GSSRCKCCgcVGTLRPHI 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
2H2G_A 160 VFFGEN-LPQDALREAIglsSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGE 217
Cdd:PTZ00408 154 VWFGEMpLYMDEIESVM---SKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEE 209
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
11-215 |
4.67e-36 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 130.76 E-value: 4.67e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 11 NESRLTVTLTGAGISTPSGIPDFRGPN-GIYKKYSQ-------NVFDIDFFYSHPEEFYRFAKE-GIFPMlQAKPNLAHV 81
Cdd:PTZ00410 27 NNVTKILVMVGAGISVAAGIPDFRSPHtGIYAKLGKynlnsptDAFSLTLLREKPEVFYSIAREmDLWPG-HFQPTAVHH 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H2G_A 82 LLAKLEEKGLIEAVITQNIDRLHQRAGSKK--VIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNI 159
Cdd:PTZ00410 106 FIRLLADEGRLLRCCTQNIDGLERAAGVPPslLVEAHGSFSAASCIECHTPYDIEQAYLEARSGKVPHCSTCGGIVKPDV 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
2H2G_A 160 VFFGENLPqDALREAIGLSSRASLMIVLGSSLVVYPAAELPLItVRSGGKLVIVNL 215
Cdd:PTZ00410 186 VFFGENLP-DAFFNVHHDIPEAELLLIIGTSLQVHPFALLACV-VPKDVPRVLFNL 239
|
|
| |
