Chain B, Nonstructural protein V
Protein Classification
Soyouz_module and zf-Paramyx-P domain-containing protein( domain architecture ID 10626644)
Soyouz_module and zf-Paramyx-P domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Soyouz_module | pfam14313 | N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the ... |
5-62 | 2.19e-18 | ||
N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid. : Pssm-ID: 316803 Cd Length: 58 Bit Score: 75.84 E-value: 2.19e-18
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| zf-Paramyx-P super family | cl15235 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
176-220 | 3.22e-17 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. The actual alignment was detected with superfamily member pfam13008: Pssm-ID: 372427 Cd Length: 45 Bit Score: 72.48 E-value: 3.22e-17
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| Name | Accession | Description | Interval | E-value | ||
| Soyouz_module | pfam14313 | N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the ... |
5-62 | 2.19e-18 | ||
N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid. Pssm-ID: 316803 Cd Length: 58 Bit Score: 75.84 E-value: 2.19e-18
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| zf-Paramyx-P | pfam13008 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
176-220 | 3.22e-17 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. Pssm-ID: 372427 Cd Length: 45 Bit Score: 72.48 E-value: 3.22e-17
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| Name | Accession | Description | Interval | E-value | ||
| Soyouz_module | pfam14313 | N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the ... |
5-62 | 2.19e-18 | ||
N-terminal region of Paramyxovirinae phosphoprotein (P); The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid. Pssm-ID: 316803 Cd Length: 58 Bit Score: 75.84 E-value: 2.19e-18
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| zf-Paramyx-P | pfam13008 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
176-220 | 3.22e-17 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. Pssm-ID: 372427 Cd Length: 45 Bit Score: 72.48 E-value: 3.22e-17
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