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Conserved domains on  [gi|114794774|pdb|2IUB|J]
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Chain J, DIVALENT CATION TRANSPORT-RELATED PROTEIN

Protein Classification

magnesium and cobalt transport protein CorA( domain architecture ID 10191293)

magnesium and cobalt transport protein CorA mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 70-363 0e+00

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 526.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       70 TPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVL 149
Cdd:cd12828   1 GVTWINVDGLHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLYYDEDTGELESEQVSLILGKNYVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      150 MFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRN 229
Cdd:cd12828  81 SFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKLKRE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      230 LVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTII 309
Cdd:cd12828 161 LLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVLTII 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
2IUB_J      310 ATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12828 241 STIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
 
Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 70-363 0e+00

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 526.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       70 TPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVL 149
Cdd:cd12828   1 GVTWINVDGLHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLYYDEDTGELESEQVSLILGKNYVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      150 MFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRN 229
Cdd:cd12828  81 SFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKLKRE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      230 LVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTII 309
Cdd:cd12828 161 LLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVLTII 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
2IUB_J      310 ATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12828 241 STIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
57-363 2.23e-136

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 390.35  E-value: 2.23e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       57 TDVESVLPFRDSSTPTWINITGIHRtDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELES 136
Cdd:COG0598   1 RELDALEELLDPEGFVWIDLDGPTD-EELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYNEEEEELET 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      137 EQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIiRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPE 216
Cdd:COG0598  80 GPLSIFLGPNFLITVRERPLDAFDDVRERLERGPGL-LPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      217 KETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVS 296
Cdd:COG0598 159 NELLRRLYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLIS 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2IUB_J      297 NKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:COG0598 239 NRQNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 73-363 5.38e-104

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 308.55  E-value: 5.38e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J         73 WINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHeLESEQVSLILTKNCVLMFQ 152
Cdd:TIGR00383  29 WIDLIEPTDEERLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDEDDT-FETEQVSFILGKNLLFTIH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        153 EKIGDVFDPVRERIRYNrGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVE 232
Cdd:TIGR00383 108 ERELPAFDSIRERIRTS-QKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGPTSTLMDEILSLRTELLA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        233 LRKTIWPLREVLSSLYRDVP-PLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIAT 311
Cdd:TIGR00383 187 LRRSLWPLRDVLNFLLRKTHlPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTVVST 266

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
2IUB_J        312 IFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:TIGR00383 267 IFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 72-359 2.47e-81

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 249.92  E-value: 2.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J         72 TWINITGIHRTDVvQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMF 151
Cdd:pfam01544   5 VWLDLDSPTEAEL-EWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADELVTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        152 QEKIGDVFDPVRERIRYNRGiiRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLV 231
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGG--GPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRRSLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        232 ELRKTIWPLREVLSSLYRDV-PPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIA 310
Cdd:pfam01544 162 YLRRSLLPQRDVLNRLLRREdDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVVT 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
2IUB_J        311 TIFMPLTFIAGIYGMNFEYMPELRWKWGYPVV--LAVMGVIAVIMVVYFKK 359
Cdd:pfam01544 242 AIFLPLTLITGIYGMNFGGLPELEWSYGYPFVliLGLMILLAILLLFYFRR 292
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
229-363 6.06e-18

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 83.23  E-value: 6.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       229 NLVELRKTIWPLREVLSSLYRDVPPLIEKETVPyfrdvydhTIQIADTVETFRDI-------------VSGLLDVYLSSV 295
Cdd:PRK11085 177 TLAELEDIGWKVRLCLMDTQRALNFLVRKARLP--------GGQLEQAREILRDIesllphneslfqkVNFLMQAAMGFI 248

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2IUB_J       296 SNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:PRK11085 249 NIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
 
Name Accession Description Interval E-value
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 70-363 0e+00

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 526.61  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       70 TPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVL 149
Cdd:cd12828   1 GVTWINVDGLHDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLYYDEDTGELESEQVSLILGKNYVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      150 MFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRN 229
Cdd:cd12828  81 SFQERPGDVFDPVRERLRNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKLKRE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      230 LVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTII 309
Cdd:cd12828 161 LLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVLTII 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
2IUB_J      310 ATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12828 241 STIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
57-363 2.23e-136

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 390.35  E-value: 2.23e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       57 TDVESVLPFRDSSTPTWINITGIHRtDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELES 136
Cdd:COG0598   1 RELDALEELLDPEGFVWIDLDGPTD-EELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYNEEEEELET 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      137 EQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIiRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPE 216
Cdd:COG0598  80 GPLSIFLGPNFLITVRERPLDAFDDVRERLERGPGL-LPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      217 KETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVS 296
Cdd:COG0598 159 NELLRRLYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLIS 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2IUB_J      297 NKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:COG0598 239 NRQNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 73-363 3.88e-136

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 389.25  E-value: 3.88e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHrTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQ 152
Cdd:cd11744   1 WIHCERLH-DDDIRRVLEDNLHVPRALEDILLAESRPSFHPLDDNFMIILRGFNMDENASPEDMLSVRILYFQGALISTR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      153 EKIGDVFDPVRERIRYNRgiIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVE 232
Cdd:cd11744  80 EIPSRAFMEIRQRLREHS--KGPKSAASLLNQLIEGLNGKIDLYLETIEETLNELDVNDEEGHYDESTYNHIALQKALIS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      233 LRKTIWPLREVLSSLYRDVPPLiEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATI 312
Cdd:cd11744 158 IRRFIRPQQYALRDLIRSESEL-VTSRPHQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFTLVATI 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
2IUB_J      313 FMPLTFIAGIYGMNFEYMPEL-RWKWGYPVVLAVMgvIAVIMVVYFKKKKWL 363
Cdd:cd11744 237 FLPTTFLAGLYGMNFEGMPGVeSSMAFTWFCIALI--VAFGLEWLLFKRKGF 286
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 73-363 1.55e-129

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 372.67  E-value: 1.55e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHRTDVvQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQ 152
Cdd:cd12822   1 WIDLEGPTEEEL-QLLAEEFGFHPLAIEDALNERQRPKIEEYDDYLFLVLRALRYDEEELELETSELSIFLGKNFLVTVH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      153 EKIGDVFDPVRERIRYNRGIIRKKrADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVE 232
Cdd:cd12822  80 EGPLRLIDEVIERLLSDPKLLPKG-PDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRRELLR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      233 LRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATI 312
Cdd:cd12822 159 LRRILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTI 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
2IUB_J      313 FMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12822 239 FLPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 73-363 5.38e-104

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 308.55  E-value: 5.38e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J         73 WINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHeLESEQVSLILTKNCVLMFQ 152
Cdd:TIGR00383  29 WIDLIEPTDEERLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDEDDT-FETEQVSFILGKNLLFTIH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        153 EKIGDVFDPVRERIRYNrGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVE 232
Cdd:TIGR00383 108 ERELPAFDSIRERIRTS-QKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGPTSTLMDEILSLRTELLA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        233 LRKTIWPLREVLSSLYRDVP-PLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIAT 311
Cdd:TIGR00383 187 LRRSLWPLRDVLNFLLRKTHlPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTVVST 266

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
2IUB_J        312 IFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:TIGR00383 267 IFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 73-363 3.12e-94

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 282.88  E-value: 3.12e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WInitGIHRTDVVQ--RVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLM 150
Cdd:cd12830   4 WV---GLHEPDAEElaAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARYVDHTEEVETGETHVFVGPDFVVT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      151 FQEKIGDVFDPVRERIRYNRGIIRKkRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNL 230
Cdd:cd12830  81 VRHGAAGPLARVRARLEADPELLAL-GPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDRRDDIERIYRLKREV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      231 VELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIA 310
Cdd:cd12830 160 LEFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKISAWA 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
2IUB_J      311 TIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12830 240 AILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 72-359 2.47e-81

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 249.92  E-value: 2.47e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J         72 TWINITGIHRTDVvQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMF 151
Cdd:pfam01544   5 VWLDLDSPTEAEL-EWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADELVTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        152 QEKIGDVFDPVRERIRYNRGiiRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLV 231
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGG--GPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRRSLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J        232 ELRKTIWPLREVLSSLYRDV-PPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIA 310
Cdd:pfam01544 162 YLRRSLLPQRDVLNRLLRREdDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVVT 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
2IUB_J        311 TIFMPLTFIAGIYGMNFEYMPELRWKWGYPVV--LAVMGVIAVIMVVYFKK 359
Cdd:pfam01544 242 AIFLPLTLITGIYGMNFGGLPELEWSYGYPFVliLGLMILLAILLLFYFRR 292
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 90-363 7.48e-81

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 248.62  E-value: 7.48e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       90 EFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKmfTYDKnlHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYN 169
Cdd:cd12831  20 SFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLH--AIDQ--EDLEAEEVNLFVGENYIVTFHKEPIREINEVWEKLKEK 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      170 RGiiRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYR 249
Cdd:cd12831  96 KD--KKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVDSSNKKLMDEVFDIRSDLLKLRRTILPMRDLLYRILN 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      250 DVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEY 329
Cdd:cd12831 174 SERLEGDKEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTIISTIFMPLTFIAGIYGMNFEY 253

                       250       260       270
                ....*....|....*....|....*....|....
2IUB_J      330 MPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12831 254 MPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 73-363 2.98e-63

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 203.22  E-value: 2.98e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHRTDVVQrVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDK-----NLHELeSEQVSLILTKNC 147
Cdd:cd12832   1 WIDVVAPTEEDLED-LARRYNLHETSLKDCLDPDHLPKYEEVDGVTFIILRVYTDKKrenadTIQEL-TTKIAIFVVDKF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      148 VLMFQEKIGDVFDPVRERirYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEV-LERPEKETVQRTHQL 226
Cdd:cd12832  79 VITIHRTDLEFIANLKEK--WLSGMHKCESPTELLLRIVKDALKTYEAPLEKLSEELDKYEEEVfLKKRKGSLLKRLYHL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      227 KRNLVELRKTIWPLREVLSSLYRDVPPLieketvPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVL 306
Cdd:cd12832 157 KRKASVIKRVLNLTQDVIDKIDTPLKSD------PYTQDLRDLLIKLLSLYDELHENATNLLSLYISLSSQRTNEVMRVL 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
2IUB_J      307 TIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12832 231 TIFSVFFLPLTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGWL 287
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 73-360 1.07e-56

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 187.09  E-value: 1.07e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHRTDVVQrVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHE--LESEQVSLILTKNCVLM 150
Cdd:cd12829   1 WLDVQSPTDDDMRA-IGKLFPIHPLTLEDILSQDTREKVELFPNYYFISFRAIESDSELDEnvLEPVNVYIVVFREGILT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      151 FQEKIGDVFDPVRERIRYNRGIIrKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKE---TVQRTHQLK 227
Cdd:cd12829  80 FHFKPLDHIERVRKRIRLLSDSH-LLSSDWVLYALLDSIVDSFFPLVDSIEKEVDSIDELVLLISSSDqsdLLRRIGDLR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      228 RNLVELRKTIWPLREVLSSLYRDV----PPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSV-------S 296
Cdd:cd12829 159 RRVTSLLRLLFAKSDVLKQLLKRLmkktFVSPDSEVAIYLGDVQDHILTLLQKLNHYEDLLSRSHSNYLAQLslemsqeS 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2IUB_J      297 NKTNEVMKVLTIIATIFMPLTFIAGIYGMN----FEYMPELRWKWGYPVVLAvMGVIAVIMVVYFKKK 360
Cdd:cd12829 239 NGTDKAMLRLTVIATIFLPLQLITGLFGMNvkvpGQDIESLYWFFGIVIVAI-MVLVAIVVVFLVRRW 305
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 73-362 1.39e-48

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 165.18  E-value: 1.39e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHrtDVVQRVGEFFG--IHPLVLEDILNVHQRPKVEFFE-NYVFIVLKmftydKNLHELESEQVSLILTKNCVL 149
Cdd:cd12821   1 WYDIDEPD--DEIRRLLEELEssHLPNDLRDILLGVSFPRFEEVSgSGIYIQLR-----KPQKDADTASFHFLITRDRLI 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      150 MFQEKIGDVFDPVRERIRYNRGIIRKKRADyLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRN 229
Cdd:cd12821  74 TVRLDELPALDELRQDLRSGQMKSAKSAAE-LLFVLLGAIIKALLTGIDQFEEKLEELEWDLLEGNNAIKLDRILELRRE 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      230 LVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTII 309
Cdd:cd12821 153 LLRLTNLIEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLTVV 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
2IUB_J      310 ATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKW 362
Cdd:cd12821 233 TTVFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 86-363 1.04e-44

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 155.03  E-value: 1.04e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       86 QRVGEFFGIHPLVLEDILNVHQRpKVEFFENYVFIVlkMFTYDKNLHELESEQVSLILTKNCVLMF--QEKIGDVFDPVR 163
Cdd:cd12826  10 RELKELFGLKKELLESLESIRFC-KAEVFEDCLGGT--FGIPDKLDVLGKRDRFGFYITKNRLVFIddDGFVLKLLERIQ 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      164 ERIRYNRGIIRKkradyLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREV 243
Cdd:cd12826  87 EKKSWKGPSLER-----FLYDFLEYLIKDDLEYLEKYEEKLEELEEEILDGKLKNFNERILKIRKELLRLNSYYEQLMDI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      244 LSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIY 323
Cdd:cd12826 162 GEELEENENDLFDEEELRLFRLFSDRVERLHDNVQMLREYSLQIRELYQSQIDIRQNRIMKILTVVTTIFLPLTLITGWY 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
2IUB_J      324 GMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12826 242 GMNFTNMPELHWKYGYPVVIILSILIVVIEIIYFKKKKWL 281
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 159-363 5.71e-39

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 140.36  E-value: 5.71e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      159 FDPVRERIRynRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKT-- 236
Cdd:cd12837  86 FDTFAARAA--RQPSGCASGEDVLLGLLEAIVDRLADVLERVGADLDRLSRRIFRSSAKRRRRASRDLRSVLRRIGRAgd 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      237 -IWPLREVLSSLYRdvppliekeTVPYFRDVYDHTIQiADTVETF----RDIVSglLDVYLSSVSNKT------------ 299
Cdd:cd12837 164 lLSKIRESLLSLGR---------LLSFLSANAADWLS-KELRARLktlqRDVAS--LSEHATFLSNKIqflldatlglin 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2IUB_J      300 ---NEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12837 232 ieqNNIIKIFSVASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVLPLLWFKRRGWL 298
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 93-363 6.99e-37

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 134.54  E-value: 6.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       93 GIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFtydkNLHELES--EQVSLIL--TKNCVLMFQEKIGDVFDPVRERIRY 168
Cdd:cd12833  23 GLPELVIDALLAEETRPRATRLGDGLLLNLRGV----NLNPGADpeDMVSIRLwiTPGRIISTRRRRLLAVDDIREALEA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      169 NRGIirkKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLY 248
Cdd:cd12833  99 GKGP---KSPGDFLAALAERLTDRMEDVIDELEDRLDELEERVLEEEDEELRGELAELRRQAIALRRYLAPQRDALERLA 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      249 RDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFE 328
Cdd:cd12833 176 REDLPWLSDDDRLRLREAADRLTRYIEDLDAIRERAAVLQEELTNRRAEQMNRRMYVLSIVAAIFLPLGFLTGLLGINVG 255

                       250       260       270
                ....*....|....*....|....*....|....*
2IUB_J      329 YMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12833 256 GIPGAENPWAFWIFCGLLVVLAVGLLLLFRRKKWL 290
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 115-363 7.95e-34

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 126.66  E-value: 7.95e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      115 ENYVFIVLKMFTYDKNLHELEsEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIrkKRADYLLYSLIDALVDDYF 194
Cdd:cd12825  42 DSQLFITLSFPNQTKEDTIEE-EPVTFIIKGNILFTIRYRDLPAFDIFPKRAFSQRKFF--NSGEELFLFLFEVIVDYLA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      195 VLLEKIDDEIDVLEEEVLERPE--KETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDvpPLIEKETVPYFRDVYDHTIQ 272
Cdd:cd12825 119 DILENISKKIKQLSREILEEKQfsEEDLDALTKLNENNITLRESLIEKQRIITLLLKS--PRENSDTKEKLKIELRDLSS 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      273 IADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVI 352
Cdd:cd12825 197 LLDHTTFNFDKLDDLKNNILGKIELEQNKIIKIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTIL 276

                       250
                ....*....|.
2IUB_J      353 MVVYFKKKKWL 363
Cdd:cd12825 277 PLLYFKRKGWL 287
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 73-363 5.47e-32

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 121.46  E-value: 5.47e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       73 WINITGIHRTDVvQRVGEFFGIHPLVLEDILNVHQRPKVEFFEN--YVFIVLKM-FTYDKNLHELESEQVSLILTKNCVL 149
Cdd:cd12827   1 WINVVNPTEEEI-EQLAEKYGIPEDFLTYALDEEERSRIEYDDDtdYLLIILDVpVEEEEDDDEYETIPLGIILTKDRLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      150 MFQEKIGDVFDPVRERIRYNRGIIRKKRadyLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRN 229
Cdd:cd12827  80 TICNHETDLLDDFLEGRVKNFDTSSKTR---FLLQILYRIATSYLKYLRQINKERDELEQELRKSTKNKELFQLLDLEKS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      230 LVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTII 309
Cdd:cd12827 157 LVYFSTSLKSNEIVLEKLKRSRSLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLTSI 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
2IUB_J      310 ATIFMPLTFIAGIYGMNFEyMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12827 237 TIVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKKYF 289
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 88-363 1.18e-29

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 115.43  E-value: 1.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       88 VGEFFGIhplvleDILNVHQRPKVE----FFENYVFIVLKMFTYDKNLHELESEQVSLILTKNcvLMFQEKIGDV--FDP 161
Cdd:cd12836  17 VEQYFNI------EFPTKQESEEIEsssrYWEDEDSITINSNFLVPDDDGYHNEPVSFILKDN--ILFTIRYGELrtFSE 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      162 VRERIRYNRgiiRKKRADY-----LLYSLIDALVDdyfvLLEKIDDEIDVLEEEVL--ERPEKETVQRTHQLKRNLVELR 234
Cdd:cd12836  89 TSKKLRANP---KKFQTGYdifssILEIRIDYDAD----LLENISKEISKLRKKLFadEDLDEELLEKISRLQELNMTIR 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      235 KTIWPLREVLSSLYRD--VPPLIEKETVPYFRDV---YDHTIQIADTVETFRDIVSGLLDVylssvsnKTNEVMKVLTII 309
Cdd:cd12836 162 ENLIDKQRVLSSLLKSekFPEDLKENLRIMIKDInslIEHTTFNFERLDYLQNTFLGLINI-------EQNKIIKIFTVA 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
2IUB_J      310 ATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:cd12836 235 TVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 133-363 1.73e-27

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 109.27  E-value: 1.73e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      133 ELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRkkRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVL 212
Cdd:cd12835  58 RARNVTVAFTLRDDRLITLREEELPVFRLLRLRARRGPGEVS--DPKDLLLDLFEQKVEYLADIIEDIYRDLERVSREVL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      213 ErpekETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIeketvpyfRDVYDHTIQIADTVETFRDI--------- 283
Cdd:cd12835 136 E----ENDEDLEEALGRLARQEDLNGKIRLCLMDTQRALSFLL--------RTRRLSDEQLEDAREILRDIesllphtqf 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      284 ----VSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKK 359
Cdd:cd12835 204 lfdkINFLMDAAMGFINIEQNKIIKIFSVAAVVFLPPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLYFKR 283


                ....
2IUB_J      360 KKWL 363
Cdd:cd12835 284 KGWL 287
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 108-361 6.30e-20

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 88.73  E-value: 6.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      108 RPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIirKKRADyLLYSLID 187
Cdd:cd12824  38 FPHFEPVDDGFLLSLRGIRMDEAASPSDMADLRILIGQGAAVTVRSGPSRAVDELRRALRDHSSL--KSLAD-LLAQMIS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      188 ALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVY 267
Cdd:cd12824 115 GMTKRLELVIFDLTETLDEVEDNLLDGGTAPPPYALIALQRRLFRIRRQIRPQQQALRPLITDPAELLVTSDRETLRRAS 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      268 DHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMG 347
Cdd:cd12824 195 NNVTRYLETLDFCRTRVALLQDEIKAQRDEKTTRSSLLLTVVATVFLPLTFITGLLGMNVGGIPDVESPMGFWWVTGLSI 274

                       250
                ....*....|....
2IUB_J      348 VIAVIMVVYFKKKK 361
Cdd:cd12824 275 LVALLAWLLLRRLG 288
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
229-363 6.06e-18

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 83.23  E-value: 6.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       229 NLVELRKTIWPLREVLSSLYRDVPPLIEKETVPyfrdvydhTIQIADTVETFRDI-------------VSGLLDVYLSSV 295
Cdd:PRK11085 177 TLAELEDIGWKVRLCLMDTQRALNFLVRKARLP--------GGQLEQAREILRDIesllphneslfqkVNFLMQAAMGFI 248

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2IUB_J       296 SNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:PRK11085 249 NIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 179-357 2.56e-14

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 72.62  E-value: 2.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      179 DYLLYSLIDALVDdyfvLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKE 258
Cdd:cd12834 110 EHLLREQADTLSR----IVRELTDELDRIEDRLLSGRLRRERRELGALRRRLVRLHRLLAPEPAALFRLLRRPPDWLPDA 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      259 TVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWG 338
Cdd:cd12834 186 DLETLRRLTERLDALDRDLVALQERARLLQEEIAARLAEQTNRSLYILSVVTALLLPPTLVTGLFGMNTGGLPLAEGPHG 265

                       170
                ....*....|....*....
2IUB_J      339 YPVVLAVMGVIAVimVVYF 357
Cdd:cd12834 266 FWIAVALALLAAG--LAYL 282
zntB PRK09546
zinc transporter ZntB;
182-363 6.81e-08

zinc transporter ZntB;


Pssm-ID: 181941  Cd Length: 324  Bit Score: 53.47  E-value: 6.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       182 LYSLIDALVDDYFVLLEKIDDEIDVLEEEVLER---PEKETVQrthqLKRNLVELRKTIWPLREVLSSLyrdvppliEKE 258
Cdd:PRK09546 144 LVDVCDALTDHASEFIEELHDKIIDLEDNLLDQqipPRGELAL----LRKQLIVMRRYMAPQRDVFARL--------ASE 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J       259 TVPYFRDVYDHTIQ-IADTV-ETFRDIVSG------LLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYM 330
Cdd:PRK09546 212 RLPWMSDDDRRRMQdIADRLgRGLDDLDACiartavLADEIASVMAEAMNRRTYTMSLMAMVFLPTTFLTGLFGVNLGGI 291

                        170       180       190
                 ....*....|....*....|....*....|...
2IUB_J       331 PELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL 363
Cdd:PRK09546 292 PGGGWPFGFSIFCLLLVVLIGGVAWWLKRSKWL 324
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 182-362 7.86e-06

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 47.24  E-value: 7.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      182 LYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPeketVQRTHQLKRNLVELRKTIWPLREVLS----------SLY--- 248
Cdd:cd12823 119 LEEVCSHLEAELKRLEPEALPLLDELTDKISTSN----LERLLPLKRRLVELETRVQKVRDALEelldddedmaDMYltd 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      249 -RDVPPLIEKETVP------------YFRDVyDHTIQIADT----VETFRDIVSGLLDvylssvsNKTNEVMK---VLTI 308
Cdd:cd12823 195 kAAGPERLESSRKEddheevemlleaYLQQV-DELLNKLEElreyIDDTEELINLILD-------SRRNQLMRlelKLSI 266

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
2IUB_J      309 IATIFMPLTFIAGIYGMNFE-YMPELRWKWGYPVVLAVMG--VIAVIMVVYFKKKKW 362
Cdd:cd12823 267 GTLSLAVGTLVAGLFGMNLPsGLEESPYAFWIVTGGSVVGsiLIFIVVLRYLRRKRL 323
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 240-362 1.57e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 40.20  E-value: 1.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IUB_J      240 LREVLSSLYRDV--PPLIEKETVPYFRDVYdhTIQIADTVE-TFRDIVSGLLDvylssvsnkTNEVMKVLTIIA-TIFMP 315
Cdd:cd13133 331 FPELLLSIFTPGadFALIAELAVPLLRFVA--AYILFDALAlVFAGALRGAGD---------TRFVMLAELIVAwLYLLP 399

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
2IUB_J      316 LTFIAGIYGMNfeympeLRWKWGypVVLAVMGVIAVIMVVYFKKKKW 362
Cdd:cd13133 400 PAYLLVVLGAG------LAGAWT--VETVYVIVLALIFLLRFRSGKW 438
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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