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Conserved domains on  [gi|158429263|pdb|2OT2|A]
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Chain A, Hydrogenase isoenzymes formation protein hypC

Protein Classification

HypC/HybG/HupF family hydrogenase formation chaperone( domain architecture ID 10013512)

HypC/HybG/HupF family hydrogenase formation chaperone such as Escherichia coli hydrogenase maturation factor HybG

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10409 PRK10409
HypC/HybG/HupF family hydrogenase formation chaperone;
1-90 1.16e-56

HypC/HybG/HupF family hydrogenase formation chaperone;


:

Pssm-ID: 182435  Cd Length: 90  Bit Score: 169.21  E-value: 1.16e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A        1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80
Cdd:PRK10409  1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80

                        90
                ....*....|
2OT2_A       81 VGALLYGEEK 90
Cdd:PRK10409 81 VGALLYGEEK 90
 
Name Accession Description Interval E-value
PRK10409 PRK10409
HypC/HybG/HupF family hydrogenase formation chaperone;
1-90 1.16e-56

HypC/HybG/HupF family hydrogenase formation chaperone;


Pssm-ID: 182435  Cd Length: 90  Bit Score: 169.21  E-value: 1.16e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A        1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80
Cdd:PRK10409  1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80

                        90
                ....*....|
2OT2_A       81 VGALLYGEEK 90
Cdd:PRK10409 81 VGALLYGEEK 90
hypC_hupF TIGR00074
hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for ...
 1-82 4.71e-33

hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation. [SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. . Added metallochaperone and protein mod GO terms. [Protein fate, Protein folding and stabilization, Protein fate, Protein modification and repair]


Pssm-ID: 129184  Cd Length: 76  Bit Score: 109.00  E-value: 4.71e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A         1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80
Cdd:TIGR00074  1 MCIAIPGQVVEIDENIALVEFCGIKRDVSLDLVG------EVKVGDYVLVHVGFAISVLDEEEARETLDALQELFDAVEE 74


                 ..
2OT2_A        81 VG 82
Cdd:TIGR00074 75 GD 76
HypC COG0298
Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein ...
 1-83 3.09e-30

Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440067  Cd Length: 78  Bit Score: 101.76  E-value: 3.09e-30
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A       1 MCIGVPGQIRTI-DGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEP 79
Cdd:COG0298  1 MCLAIPGKVVEIlDGDTALVDVGGVRREVSLALVP------EVKVGDYVLVHVGFAIEKIDEEEAEETLELLEELGAALE 74


               ....
2OT2_A      80 DVGA 83
Cdd:COG0298 75 EVDA 78
HupF_HypC pfam01455
HupF/HypC family;
2-71 5.76e-27

HupF/HypC family;


Pssm-ID: 460218  Cd Length: 64  Bit Score: 93.20  E-value: 5.76e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A         2 CIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDAL 71
Cdd:pfam01455  1 CLAIPGKVVEIDDEMAVVDFGGVRREVSLALVP------EVKVGDYVLVHAGFAIEKIDEEEAEETLALL 64
 
Name Accession Description Interval E-value
PRK10409 PRK10409
HypC/HybG/HupF family hydrogenase formation chaperone;
1-90 1.16e-56

HypC/HybG/HupF family hydrogenase formation chaperone;


Pssm-ID: 182435  Cd Length: 90  Bit Score: 169.21  E-value: 1.16e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A        1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80
Cdd:PRK10409  1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80

                        90
                ....*....|
2OT2_A       81 VGALLYGEEK 90
Cdd:PRK10409 81 VGALLYGEEK 90
hypC_hupF TIGR00074
hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for ...
 1-82 4.71e-33

hydrogenase assembly chaperone HypC/HupF; This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation. [SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. . Added metallochaperone and protein mod GO terms. [Protein fate, Protein folding and stabilization, Protein fate, Protein modification and repair]


Pssm-ID: 129184  Cd Length: 76  Bit Score: 109.00  E-value: 4.71e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A         1 MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD 80
Cdd:TIGR00074  1 MCIAIPGQVVEIDENIALVEFCGIKRDVSLDLVG------EVKVGDYVLVHVGFAISVLDEEEARETLDALQELFDAVEE 74


                 ..
2OT2_A        81 VG 82
Cdd:TIGR00074 75 GD 76
HypC COG0298
Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein ...
 1-83 3.09e-30

Hydrogenase maturation factor HybG, HypC/HupF family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440067  Cd Length: 78  Bit Score: 101.76  E-value: 3.09e-30
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A       1 MCIGVPGQIRTI-DGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEP 79
Cdd:COG0298  1 MCLAIPGKVVEIlDGDTALVDVGGVRREVSLALVP------EVKVGDYVLVHVGFAIEKIDEEEAEETLELLEELGAALE 74


               ....
2OT2_A      80 DVGA 83
Cdd:COG0298 75 EVDA 78
PRK10413 PRK10413
hydrogenase maturation factor HybG;
1-74 1.13e-27

hydrogenase maturation factor HybG;


Pssm-ID: 182438  Cd Length: 82  Bit Score: 95.58  E-value: 1.13e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2OT2_A        1 MCIGVPGQIRTI--DGNQ-AKVDVCGIQRDVDLTLVgsCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNM 74
Cdd:PRK10413  1 MCIGVPGQVLAVgeDIHQlAQVEVCGIKRDVNIALI--CEGNPADLLGQWVLVHVGFAMSIIDEDEAKATLDALRQM 75
HupF_HypC pfam01455
HupF/HypC family;
2-71 5.76e-27

HupF/HypC family;


Pssm-ID: 460218  Cd Length: 64  Bit Score: 93.20  E-value: 5.76e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2OT2_A         2 CIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGscdengQPRVGQWVLVHVGFAMSVINEAEARDTLDAL 71
Cdd:pfam01455  1 CLAIPGKVVEIDDEMAVVDFGGVRREVSLALVP------EVKVGDYVLVHAGFAIEKIDEEEAEETLALL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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