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Conserved domains on  [gi|146386711|pdb|2PL3|A]
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Chain A, Probable ATP-dependent RNA helicase DDX10

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 36-233 1.08e-146

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 407.06  E-value: 1.08e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17941   1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLGALIISPTRELAMQIFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAV 195
Cdd:cd17941  81 VLRKVGKYHSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160

                       170       180       190
                ....*....|....*....|....*....|....*...
2PL3_A      196 IENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 233
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
 
Name Accession Description Interval E-value
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 36-233 1.08e-146

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 407.06  E-value: 1.08e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17941   1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLGALIISPTRELAMQIFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAV 195
Cdd:cd17941  81 VLRKVGKYHSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160

                       170       180       190
                ....*....|....*....|....*....|....*...
2PL3_A      196 IENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 233
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
24-230 9.64e-77

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 237.35  E-value: 9.64e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTDGLGVLII 103
Cdd:COG0513   1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQ---RLDPSRPRAPQALIL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      104 SPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFHatDLQMLVLDEAD 181
Cdd:COG0513  78 APTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALkRGVDIVVATPGRLLDLIErGALDLS--GVETLVLDEAD 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
2PL3_A      182 RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:COG0513 156 RMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRI 204
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 49-219 1.65e-64

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 197.85  E-value: 1.65e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         49 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQwtstDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 128
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD----NGPQALVLAPTRELAEQIYEELKKLGKGLGLKV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        129 GLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHatDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLF 208
Cdd:pfam00270  77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154

                         170
                  ....*....|.
2PL3_A        209 SATQTKSVKDL 219
Cdd:pfam00270 155 SATLPRNLEDL 165
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 25-230 1.36e-51

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 172.82  E-value: 1.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIIS 104
Cdd:PRK11192   1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRILILT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       105 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERIN-NINILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRI 183
Cdd:PRK11192  81 PTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSeNQDIVVATPGRLLQYIKEE-NFDCRAVETLILDEADRM 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
2PL3_A       184 LDMGFADTMNAVIENLPKKRQTLLFSAT-QTKSVKDLARLSLKNPEYV 230
Cdd:PRK11192 160 LDMGFAQDIETIAAETRWRKQTLLFSATlEGDAVQDFAERLLNDPVEV 207
DEXDc smart00487
DEAD-like helicases superfamily;
49-230 1.72e-46

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 153.03  E-value: 1.72e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A          49 TEIQKQTIGLALQG-KDVLGAAKTGSGKTLAFLVPVLEALYRlqwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFS 127
Cdd:smart00487  10 RPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR-----GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLK 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         128 AGLIIGGKDLKHEAERINN--INILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQT 205
Cdd:smart00487  85 VVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQL 163

                          170       180
                   ....*....|....*....|....*
2PL3_A         206 LLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:smart00487 164 LLLSATPPEEIENLLELFLNDPVFI 188
 
Name Accession Description Interval E-value
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 36-233 1.08e-146

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 407.06  E-value: 1.08e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17941   1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLGALIISPTRELAMQIFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAV 195
Cdd:cd17941  81 VLRKVGKYHSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160

                       170       180       190
                ....*....|....*....|....*....|....*...
2PL3_A      196 IENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 233
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 36-230 1.03e-85

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 252.67  E-value: 1.03e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17942   1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTGVIIISPTRELALQIYG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNA 194
Cdd:cd17942  81 VAKELLKYHSQTFGIVIGGANRKAEAEKLgKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQ 160

                       170       180       190
                ....*....|....*....|....*....|....*..
2PL3_A      195 VIENLPKKRQTLLFSATQTKSVKDLARLSLKN-PEYV 230
Cdd:cd17942 161 IIKLLPKRRQTMLFSATQTRKVEDLARISLKKkPLYV 197
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 36-230 7.90e-84

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 247.74  E-value: 7.90e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd00268   1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGPQALVLAPTRELAMQIAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRILDMGFADTMNA 194
Cdd:cd00268  81 VARKLGKGTGLKVAAIYGGAPIKKQIEALkKGPDIVVGTPGRLLDLIERG-KLDLSNVKYLVLDEADRMLDMGFEEDVEK 159

                       170       180       190
                ....*....|....*....|....*....|....*.
2PL3_A      195 VIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
24-230 9.64e-77

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 237.35  E-value: 9.64e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTDGLGVLII 103
Cdd:COG0513   1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQ---RLDPSRPRAPQALIL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      104 SPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFHatDLQMLVLDEAD 181
Cdd:COG0513  78 APTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALkRGVDIVVATPGRLLDLIErGALDLS--GVETLVLDEAD 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
2PL3_A      182 RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:COG0513 156 RMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRI 204
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 37-227 4.92e-74

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 222.90  E-value: 4.92e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTDGLG--VLIISPTRELAYQTF 114
Cdd:cd17947   2 LRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILE---RLLYRPKKKAAtrVLVLVPTRELAMQCF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      115 EVLRKVGKNHDFSAGLIIGGKDLK-HEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMN 193
Cdd:cd17947  79 SVLQQLAQFTDITFALAVGGLSLKaQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELK 158

                       170       180       190
                ....*....|....*....|....*....|....
2PL3_A      194 AVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17947 159 EILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 49-230 2.44e-67

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 206.67  E-value: 2.44e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       49 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQ--WTSTDGLGVLIISPTRELAYQTFEVLRKVGKN-HD 125
Cdd:cd17949  15 TAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEprVDRSDGTLALVLVPTRELALQIYEVLEKLLKPfHW 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      126 FSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIE------- 197
Cdd:cd17949  95 IVPGYLIGGEKRKSEKARLRKgVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILEllddkrs 174

                       170       180       190
                ....*....|....*....|....*....|....*....
2PL3_A      198 ------NLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17949 175 kaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 36-230 4.23e-67

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 205.50  E-value: 4.23e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYR--LQWTSTDgLGVLIISPTRELAYQT 113
Cdd:cd17960   1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKrkANLKKGQ-VGALIISPTRELATQI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      114 FEVLRKVGKNHD--FSAGLIIGGKDLKHEAERI--NNINILVCTPGRL---LQHMDETVSFhaTDLQMLVLDEADRILDM 186
Cdd:cd17960  80 YEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFkrNGPNILVGTPGRLeelLSRKADKVKV--KSLEVLVLDEADRLLDL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
2PL3_A      187 GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 49-219 1.65e-64

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 197.85  E-value: 1.65e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         49 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQwtstDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 128
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD----NGPQALVLAPTRELAEQIYEELKKLGKGLGLKV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        129 GLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHatDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLF 208
Cdd:pfam00270  77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154

                         170
                  ....*....|.
2PL3_A        209 SATQTKSVKDL 219
Cdd:pfam00270 155 SATLPRNLEDL 165
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 27-230 2.54e-63

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 195.99  E-value: 2.54e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTD-GLGVLIISP 105
Cdd:cd17959   3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIE---KLKAHSPTvGARALILSP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      106 TRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDEtVSFHATDLQMLVLDEADRIL 184
Cdd:cd17959  80 TRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALaSNPDIIIATPGRLLHLLVE-MNLKLSSVEYVVFDEADRLF 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
2PL3_A      185 DMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17959 159 EMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 27-227 9.26e-62

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 192.15  E-value: 9.26e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrlqWTSTDGLGVLIISPT 106
Cdd:cd17954   2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL----LENPQRFFALVLAPT 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      107 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILD 185
Cdd:cd17954  78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALaKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLN 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      186 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17954 158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 32-230 4.49e-60

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 188.18  E-value: 4.49e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       32 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQ-GKDVLGAAKTGSGKTLAFLVPVLEALYR-LQWTSTDGLGVLIISPTREL 109
Cdd:cd17964   1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNtKPAGRRSGVSALIISPTREL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      110 AYQTFEVLRKV-GKNHDFSAGLIIGGKDLKHEAERI--NNINILVCTPGRLLQHMDETVSFHA-TDLQMLVLDEADRILD 185
Cdd:cd17964  81 ALQIAAEAKKLlQGLRKLRVQSAVGGTSRRAELNRLrrGRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADRLLD 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
2PL3_A      186 MGFADTMNAVIENLPKK----RQTLLFSATQTKSVKDLARLSL-KNPEYV 230
Cdd:cd17964 161 MGFRPDLEQILRHLPEKnadpRQTLLFSATVPDEVQQIARLTLkKDYKFI 210
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 27-232 8.70e-57

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 179.34  E-value: 8.70e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrlqwtSTDGLGV--LIIS 104
Cdd:cd17955   1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL------SEDPYGIfaLVLT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      105 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNI-NILVCTPGRLLQHM----DETVSFHatDLQMLVLDE 179
Cdd:cd17955  75 PTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRpHIVVATPGRLADHLrssdDTTKVLS--RVKFLVLDE 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
2PL3_A      180 ADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPeYVWV 232
Cdd:cd17955 153 ADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP-FFWE 204
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 27-232 3.68e-52

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 168.05  E-value: 3.68e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG------V 100
Cdd:cd17967   2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRrkaypsA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      101 LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFhaTDLQMLVLD 178
Cdd:cd17967  82 LILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLlRGCDILVATPGRLVDFIErGRISL--SSIKFLVLD 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
2PL3_A      179 EADRILDMGFADTMNAVIE--NLPKK--RQTLLFSATQTKSVKDLARLSLKNpeYVWV 232
Cdd:cd17967 160 EADRMLDMGFEPQIRKIVEhpDMPPKgeRQTLMFSATFPREIQRLAADFLKN--YIFL 215
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 25-230 1.36e-51

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 172.82  E-value: 1.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIIS 104
Cdd:PRK11192   1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRILILT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       105 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERIN-NINILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRI 183
Cdd:PRK11192  81 PTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSeNQDIVVATPGRLLQYIKEE-NFDCRAVETLILDEADRM 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
2PL3_A       184 LDMGFADTMNAVIENLPKKRQTLLFSAT-QTKSVKDLARLSLKNPEYV 230
Cdd:PRK11192 160 LDMGFAQDIETIAAETRWRKQTLLFSATlEGDAVQDFAERLLNDPVEV 207
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 27-227 2.04e-51

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 165.55  E-value: 2.04e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPT 106
Cdd:cd17940   1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID----PKKDVIQALILVPT 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      107 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVSfHATDLQMLVLDEADRILD 185
Cdd:cd17940  77 RELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQtVHVLVGTPGRILDLAKKGVA-DLSHCKTLVLDEADKLLS 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      186 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17940 156 QDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 25-232 1.90e-50

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 170.37  E-value: 1.90e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEAL----YRLQwtstdglgV 100
Cdd:PRK11776   4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLdvkrFRVQ--------A 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       101 LIISPTRELAYQTFEVLRKVGKnhdFSAGLII----GGK-------DLKHEAerinniNILVCTPGRLLQHMD-ETVSFh 168
Cdd:PRK11776  76 LVLCPTRELADQVAKEIRRLAR---FIPNIKVltlcGGVpmgpqidSLEHGA------HIIVGTPGRILDHLRkGTLDL- 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2PL3_A       169 aTDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 232
Cdd:PRK11776 146 -DALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKV 208
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 37-227 4.29e-50

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 161.99  E-value: 4.29e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQwtSTDGLGVLIISPTRELAYQTFEV 116
Cdd:cd17957   2 LNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPR--KKKGLRALILAPTRELASQIYRE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      117 LRKVGKNHDFSAGLIIGG--KDLKHEAERINNINILVCTPGRLLQHMDETvsfhATDL---QMLVLDEADRILDMGFADT 191
Cdd:cd17957  80 LLKLSKGTGLRIVLLSKSleAKAKDGPKSITKYDILVSTPLRLVFLLKQG----PIDLssvEYLVLDEADKLFEPGFREQ 155

                       170       180       190
                ....*....|....*....|....*....|....*..
2PL3_A      192 MNAVIENLP-KKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDP 192
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 37-230 7.98e-49

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 159.79  E-value: 7.98e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL----QWTSTDGLGVLIISPTRELAYQ 112
Cdd:cd17945   2 LRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLppldEETKDDGPYALILAPTRELAQQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      113 TFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDEtvsfHATDL---QMLVLDEADRILDMGF 188
Cdd:cd17945  82 IEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNgCEILIATPGRLLDCLER----RLLVLnqcTYVVLDEADRMIDMGF 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2PL3_A      189 ADTMNAVIENLP--------------------KKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17945 158 EPQVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 5-232 1.09e-46

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 155.51  E-value: 1.09e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        5 ERESISRLMQ------NYEKINVN--------EITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAK 70
Cdd:cd18052   9 DEDEIFATIQtginfdKYDEIPVEvtgrnpppAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       71 TGSGKTLAFLVPVLEALYRLQWTSTDGLGV-----LIISPTRELAYQTFEVLRKvgknhdFSAGLII------GGKDLKH 139
Cdd:cd18052  89 TGSGKTAAFLLPVLTGMMKEGLTASSFSEVqepqaLIVAPTRELANQIFLEARK------FSYGTCIrpvvvyGGVSVGH 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      140 EAERI-NNINILVCTPGRLLQHMD-ETVSFhaTDLQMLVLDEADRILDMGFADTMNAVIE--NLPKK--RQTLLFSATQT 213
Cdd:cd18052 163 QIRQIeKGCHILVATPGRLLDFIGrGKISL--SKLKYLILDEADRMLDMGFGPEIRKLVSepGMPSKedRQTLMFSATFP 240

                       250
                ....*....|....*....
2PL3_A      214 KSVKDLARlSLKNPEYVWV 232
Cdd:cd18052 241 EEIQRLAA-EFLKEDYLFL 258
DEXDc smart00487
DEAD-like helicases superfamily;
49-230 1.72e-46

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 153.03  E-value: 1.72e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A          49 TEIQKQTIGLALQG-KDVLGAAKTGSGKTLAFLVPVLEALYRlqwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFS 127
Cdd:smart00487  10 RPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR-----GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLK 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         128 AGLIIGGKDLKHEAERINN--INILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQT 205
Cdd:smart00487  85 VVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQL 163

                          170       180
                   ....*....|....*....|....*
2PL3_A         206 LLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:smart00487 164 LLLSATPPEEIENLLELFLNDPVFI 188
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 24-227 1.09e-44

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 149.06  E-value: 1.09e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyRLQWTSTDGLG--VL 101
Cdd:cd17953  11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHI-KDQRPVKPGEGpiGL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      102 IISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHE-AERINNINILVCTPGRLLQhMDETVSFHATDLQ---MLVL 177
Cdd:cd17953  90 IMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQiAELKRGAEIVVCTPGRMID-ILTANNGRVTNLRrvtYVVL 168

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
2PL3_A      178 DEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17953 169 DEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKP 218
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 37-227 4.81e-43

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 144.40  E-value: 4.81e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPV----LEALYRLQWTSTDGLGVLIISPTRELAYQ 112
Cdd:cd17951   2 LKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLimfaLEQEKKLPFIKGEGPYGLIVCPSRELARQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      113 TFEVLRKVGKNhdFSAG--------LIIGGKDLKHEAERINN-INILVCTPGRLlQHMDETVSFHATDLQMLVLDEADRI 183
Cdd:cd17951  82 THEVIEYYCKA--LQEGgypqlrclLCIGGMSVKEQLEVIRKgVHIVVATPGRL-MDMLNKKKINLDICRYLCLDEADRM 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
2PL3_A      184 LDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKP 202
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 32-227 9.30e-43

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 143.49  E-value: 9.30e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       32 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTS--TDGLGVLIISPTREL 109
Cdd:cd17961   1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESgeEQGTRALILVPTREL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      110 AYQTFEVLRKVGK---NHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDM 186
Cdd:cd17961  81 AQQVSKVLEQLTAycrKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSY 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
2PL3_A      187 GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNP 201
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 37-227 2.65e-42

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 142.12  E-value: 2.65e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL---EALYRLQwtSTDGLGVLIISPTRELAYQT 113
Cdd:cd17966   2 MDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhiNAQPPLE--RGDGPIVLVLAPTRELAQQI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      114 FEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMDETvsfhATDLQ---MLVLDEADRI 183
Cdd:cd17966  80 QQEANKFGGSSRLRNTCVYGGapkgpqiRDLRRGVE------ICIATPGRLIDFLDQG----KTNLRrvtYLVLDEADRM 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
2PL3_A      184 LDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17966 150 LDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDY 193
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 37-227 3.12e-42

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 142.17  E-value: 3.12e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL-EALYRLQWTSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17952   2 LNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvHIMDQRELEKGEGPIAVIVAPTRELAQQIYL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHmdetVSFHATDLQ---MLVLDEADRILD 185
Cdd:cd17952  82 EAKKFGKAYNLRVVAVYGGgskweqaKALQEGAE------IVVATPGRLIDM----VKKKATNLQrvtYLVLDEADRMFD 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      186 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17952 152 MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDP 193
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 36-230 6.17e-41

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 138.55  E-value: 6.17e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlqwtSTDGLGVLIISPTRELAYQTFE 115
Cdd:cd17943   1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDL----ERRHPQVLILAPTREIAVQIHD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      116 VLRKVGKN-HDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLqHMDETVSFHATDLQMLVLDEADRILDMGFADTMNA 194
Cdd:cd17943  77 VFKKIGKKlEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIK-QLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNW 155

                       170       180       190
                ....*....|....*....|....*....|....*.
2PL3_A      195 VIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 25-230 7.44e-41

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 145.44  E-value: 7.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG---VL 101
Cdd:PRK01297  87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGeprAL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       102 IISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG----KDLKHEAERinNINILVCTPGRLLQhMDETVSFHATDLQMLVL 177
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGmdfdKQLKQLEAR--FCDILVATPGRLLD-FNQRGEVHLDMVEVMVL 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
2PL3_A       178 DEADRILDMGFADTMNAVIENLPKK--RQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:PRK01297 244 DEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIV 298
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 37-225 1.66e-40

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 138.91  E-value: 1.66e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLAL-QGKDVLGAAKTGSGKTLAFLVPVLEALYRLQ-----WTSTDGLGVLIISPTRELA 110
Cdd:cd17946   2 LRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQKssngvGGKQKPLRALILTPTRELA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      111 YQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMDETVSFHAT--DLQMLVLDEAD 181
Cdd:cd17946  82 VQVKDHLKAIAKYTNIKIASIVGGlavqkqeRLLKKRPE------IVVATPGRLWELIQEGNEHLANlkSLRFLVLDEAD 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
2PL3_A      182 RILDMG-FA------DTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLK 225
Cdd:cd17946 156 RMLEKGhFAelekilELLNKDRAGKKRKRQTFVFSATLTLDHQLPLKLNSK 206
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 15-226 1.25e-39

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 137.09  E-value: 1.25e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       15 NYEKINVN--------EITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEA 86
Cdd:cd18051   3 KYEDIPVEatgencppHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQ 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       87 LY-----RLQWTSTDGLG-------VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLK---HEAERinNINILV 151
Cdd:cd18051  83 IYeqgpgESLPSESGYYGrrkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGqqmRDLER--GCHLLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      152 CTPGRLLQHMD------ETVSFhatdlqmLVLDEADRILDMGFADTMNAVIE--NLPKK--RQTLLFSATQTKSVKDLAR 221
Cdd:cd18051 161 ATPGRLVDMLErgkiglDYCKY-------LVLDEADRMLDMGFEPQIRRIVEqdTMPPTgeRQTLMFSATFPKEIQMLAR 233


                ....*
2PL3_A      222 LSLKN 226
Cdd:cd18051 234 DFLDN 238
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 27-232 1.86e-39

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 135.14  E-value: 1.86e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwtstdglgVLIISPT 106
Cdd:cd17938   1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-----------ALILEPS 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      107 RELAYQTFEVLRKVGK---NHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQhMDETVSFHATDLQMLVLDEADR 182
Cdd:cd17938  70 RELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLeSGVDIVVGTPGRLED-LIKTGKLDLSSVRFFVLDEADR 148

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
2PL3_A      183 ILDMGFADTMNAVIENLPK-----KR-QTLLFSAT-QTKSVKDLARLSLKNPeyVWV 232
Cdd:cd17938 149 LLSQGNLETINRIYNRIPKitsdgKRlQVIVCSATlHSFEVKKLADKIMHFP--TWV 203
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 27-232 2.18e-39

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 141.10  E-value: 2.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGV--LIIS 104
Cdd:PRK10590   3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVraLILT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       105 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLL--QHMDetvsfhATDL---QMLVLD 178
Cdd:PRK10590  83 PTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLrGGVDVLVATPGRLLdlEHQN------AVKLdqvEILVLD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
2PL3_A       179 EADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 232
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEV 210
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 27-228 2.68e-39

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 142.78  E-value: 2.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYR---LQWTSTDGLGVLII 103
Cdd:PRK04537  11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSrpaLADRKPEDPRALIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       104 SPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLL----QHmdETVSFHATDLqmLVLD 178
Cdd:PRK04537  91 APTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQgVDVIIATPGRLIdyvkQH--KVVSLHACEI--CVLD 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
2PL3_A       179 EADRILDMGFADTMNAVIENLPKK--RQTLLFSATQTKSVKDLARLSLKNPE 228
Cdd:PRK04537 167 EADRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPE 218
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 25-232 3.96e-38

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 137.02  E-value: 3.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrLQWTSTDGLGV---- 100
Cdd:PRK04837   8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYL--LSHPAPEDRKVnqpr 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       101 -LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVsFHATDLQMLVLD 178
Cdd:PRK04837  86 aLIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESgVDILIGTTGRLIDYAKQNH-INLGAIQVVVLD 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
2PL3_A       179 EADRILDMGFADTMNAVIENLP--KKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 232
Cdd:PRK04837 165 EADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEV 220
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 16-230 3.71e-37

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 130.06  E-value: 3.71e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       16 YEKINVNEITRFsdFPLSKKTLKGLQEAQyrlvteiqkqTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSt 95
Cdd:cd17956   2 LKNLQNNGITSA--FPVQAAVIPWLLPSS----------KSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPR- 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       96 dgLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI---------NNINILVCTPGRLLQHMDETVS 166
Cdd:cd17956  69 --LRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLlvdtsgrylSRVDILVATPGRLVDHLNSTPG 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      167 FHATDLQMLVLDEADRILDMGFADTMNAVIENL--------------------PKKRQTLLFSATQTKSVKDLARLSLKN 226
Cdd:cd17956 147 FTLKHLRFLVIDEADRLLNQSFQDWLETVMKALgrptapdlgsfgdanllersVRPLQKLLFSATLTRDPEKLSSLKLHR 226


                ....
2PL3_A      227 PEYV 230
Cdd:cd17956 227 PRLF 230
PTZ00110 PTZ00110
helicase; Provisional
 23-221 8.39e-35

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 129.89  E-value: 8.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        23 EITRFSDFplskkTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPV---LEALYRLQWTstDGLG 99
Cdd:PTZ00110 133 EYTSFPDY-----ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAivhINAQPLLRYG--DGPI 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       100 VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG--KDLKHEAERiNNINILVCTPGRLLQHMDETVsfhaTDLQ---M 174
Cdd:PTZ00110 206 VLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGvpKRGQIYALR-RGVEILIACPGRLIDFLESNV----TNLRrvtY 280

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
2PL3_A       175 LVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLAR 221
Cdd:PTZ00110 281 LVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLAR 327
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 24-227 1.34e-34

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 129.14  E-value: 1.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLE--ALYRLQWTSTD-GLGV 100
Cdd:PLN00206 120 ILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcCTIRSGHPSEQrNPLA 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       101 LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLqhmdETVSFHATDLQ---MLV 176
Cdd:PLN00206 200 MVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQgVELIVGTPGRLI----DLLSKHDIELDnvsVLV 275

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
2PL3_A       177 LDEADRILDMGFADTMNAVIENLPKKrQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:PLN00206 276 LDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDI 325
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 32-227 1.69e-34

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 121.91  E-value: 1.69e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       32 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEAL-YRLQWTStdglgVLIISPTRE 108
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVdPTLKSPQ-----ALCLAPTRE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      109 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEaERINNiNILVCTPGRLLQHMDeTVSFHATDLQMLVLDEADRILDM-G 187
Cdd:cd17963  76 LARQIGEVVEKMGKFTGVKVALAVPGNDVPRG-KKITA-QIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTqG 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2PL3_A      188 FADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17963 153 HGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNA 192
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 40-227 2.29e-34

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 121.89  E-value: 2.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       40 LQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL-EALyrlqwTSTDGLGVLIISPTRELAYQTFEVLR 118
Cdd:cd17962   5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIiRCL-----TEHRNPSALILTPTRELAVQIEDQAK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      119 KVGKNH-DFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDE-TVSFHatDLQMLVLDEADRILDMGFADTMNAV 195
Cdd:cd17962  80 ELMKGLpPMKTALLVGGLPLPPQLYRLqQGVKVIIATPGRLLDILKQsSVELD--NIKIVVVDEADTMLKMGFQQQVLDI 157

                       170       180       190
                ....*....|....*....|....*....|..
2PL3_A      196 IENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17962 158 LENISHDHQTILVSATIPRGIEQLAGQLLQNP 189
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 29-227 1.11e-33

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 120.12  E-value: 1.11e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       29 DFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPTRE 108
Cdd:cd17939   1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRID----TTVRETQALVLAPTRE 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      109 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERIN-NINILVCTPGRLLqHMDETVSFHATDLQMLVLDEADRILDMG 187
Cdd:cd17939  77 LAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQyGPHIVVGTPGRVF-DMLQRRSLRTDKIKMFVLDEADEMLSRG 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2PL3_A      188 FADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDP 195
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 25-230 3.73e-33

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 126.12  E-value: 3.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIIS 104
Cdd:PRK11634   6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLD----PELKAPQILVLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       105 PTRELAYQTFEVLRKVGKN-HDFSAGLIIGGK--DLKHEAERiNNINILVCTPGRLLQHMDETvSFHATDLQMLVLDEAD 181
Cdd:PRK11634  82 PTRELAVQVAEAMTDFSKHmRGVNVVALYGGQryDVQLRALR-QGPQIVVGTPGRLLDHLKRG-TLDLSKLSGLVLDEAD 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
2PL3_A       182 RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:PRK11634 160 EMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEV 208
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 24-226 1.43e-32

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 119.35  E-value: 1.43e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTST-DGLGVLI 102
Cdd:cd18050  61 VFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERgDGPICLV 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      103 ISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMdETVSFHATDLQML 175
Cdd:cd18050 141 LAPTRELAQQVQQVADDYGKSSRLKSTCIYGGapkgpqiRDLERGVE------ICIATPGRLIDFL-EAGKTNLRRCTYL 213

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
2PL3_A      176 VLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKN 226
Cdd:cd18050 214 VLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD 264
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 24-233 7.41e-32

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 116.26  E-value: 7.41e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTST-DGLGVLI 102
Cdd:cd18049  23 VLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERgDGPICLV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      103 ISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMdETVSFHATDLQML 175
Cdd:cd18049 103 LAPTRELAQQVQQVAAEYGRACRLKSTCIYGGapkgpqiRDLERGVE------ICIATPGRLIDFL-EAGKTNLRRCTYL 175

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
2PL3_A      176 VLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKnpEYVWVH 233
Cdd:cd18049 176 VLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLK--DYIHIN 231
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 37-230 1.02e-31

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 114.87  E-value: 1.02e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       37 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRLQWTST-----DGLGVLIISPTRELAY 111
Cdd:cd17958   2 MKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLP---GFIHLDLQPIpreqrNGPGVLVLTPTRELAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      112 QTFEVLRKVGKNhDFSAGLIIGGKDLKHEAERINN-INILVCTPGRL--LQhMDETVSFhaTDLQMLVLDEADRILDMGF 188
Cdd:cd17958  79 QIEAECSKYSYK-GLKSVCVYGGGNRNEQIEDLSKgVDIIIATPGRLndLQ-MNNVINL--KSITYLVLDEADRMLDMGF 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      189 ADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd17958 155 EPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 36-225 2.59e-31

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 114.17  E-value: 2.59e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       36 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG--VLIISPTRELAYQT 113
Cdd:cd17944   1 TIKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRApkVLVLAPTRELANQV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      114 FEVLRKVGKNhdFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMdETVSFHATDLQMLVLDEADRILDMGFADTM 192
Cdd:cd17944  81 TKDFKDITRK--LSVACFYGGTPYQQQIFAIRNgIDILVGTPGRIKDHL-QNGRLDLTKLKHVVLDEVDQMLDMGFAEQV 157

                       170       180       190
                ....*....|....*....|....*....|....*...
2PL3_A      193 NAVIENLPKKR-----QTLLFSATQTKSVKDLARLSLK 225
Cdd:cd17944 158 EEILSVSYKKDsednpQTLLFSATCPDWVYNVAKKYMK 195
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 25-232 7.12e-29

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 107.82  E-value: 7.12e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       25 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIIS 104
Cdd:cd17950   2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLE----PVDGQVSVLVIC 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      105 PTRELAYQ-TFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNI--NILVCTPGRLLQHMDETvSFHATDLQMLVLDEAD 181
Cdd:cd17950  78 HTRELAFQiSNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKcpHIVVGTPGRILALVREK-KLKLSHVKHFVLDECD 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
2PL3_A      182 RILDmgfADTMNAVIENL----PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 232
Cdd:cd17950 157 KMLE---QLDMRRDVQEIfratPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 27-227 2.24e-27

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 103.70  E-value: 2.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyRLQWTSTDglgVLIISPT 106
Cdd:cd18045   1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL-DIQVRETQ---ALILSPT 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      107 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQhMDETVSFHATDLQMLVLDEADRILD 185
Cdd:cd18045  77 RELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYgQHIVSGTPGRVFD-MIRRRSLRTRHIKMLVLDEADEMLN 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      186 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDP 197
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 27-227 6.18e-27

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 102.52  E-value: 6.18e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPT 106
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQID----TSLKATQALVLAPT 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      107 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVsFHATDLQMLVLDEADRILD 185
Cdd:cd18046  77 RELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAgPHIVVGTPGRVFDMINRRY-LRTDYIKMFVLDEADEMLS 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
2PL3_A      186 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 227
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP 197
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 40-219 5.24e-25

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 98.21  E-value: 5.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       40 LQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrLQWTSTDGLG-----VLIISPTRELAYQTF 114
Cdd:cd17948   5 LQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRL--LRYKLLAEGPfnaprGLVITPSRELAEQIG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      115 EVLRKVGKNHDFSAGLIIGGKDLKH-EAERINNINILVCTPGRLLQHMdeTVSFHATD-LQMLVLDEADRILDMGFADTM 192
Cdd:cd17948  83 SVAQSLTEGLGLKVKVITGGRTKRQiRNPHFEEVDILVATPGALSKLL--TSRIYSLEqLRHLVLDEADTLLDDSFNEKL 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2PL3_A      193 -------------NAVIENLPKKRQTLLFSATQTKSVKDL 219
Cdd:cd17948 161 shflrrfplasrrSENTDGLDPGTQLVLVSATMPSGVGEV 200
PTZ00424 PTZ00424
helicase 45; Provisional
 15-232 3.45e-23

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 96.43  E-value: 3.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        15 NYEKInvneITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFlvpVLEALYRLQWtS 94
Cdd:PTZ00424  22 NYDEI----VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATF---VIAALQLIDY-D 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A        95 TDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETvSFHATDLQ 173
Cdd:PTZ00424  94 LNACQALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAgVHMVVGTPGRVYDMIDKR-HLRVDDLK 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
2PL3_A       174 MLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 232
Cdd:PTZ00424 173 LFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILV 231
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 62-211 1.46e-22

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 89.77  E-value: 1.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       62 GKDVLGAAKTGSGKTLAFLVPVLEALyrlqwtSTDGLGVLIISPTRELAYQTFEVLRKVGKnHDFSAGLIIGGKDLKH-E 140
Cdd:cd00046   1 GENVLITAPTGSGKTLAALLAALLLL------LKKGKKVLVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEErE 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2PL3_A      141 AERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRIL-DMGFADTMNAVIENLPKKR-QTLLFSAT 211
Cdd:cd00046  74 KNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLiDSRGALILDLAVRKAGLKNaQVILLSAT 146
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 68-215 1.29e-18

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 81.65  E-value: 1.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       68 AAKTGSGKTLAFLVPVLEALYR--LQWTSTDGLG-----------VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG 134
Cdd:cd17965  67 AAETGSGKTLAYLAPLLDYLKRqeQEPFEEAEEEyesakdtgrprSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSG 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      135 KDLKHE--AERINN-INILVCTPGrLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSAT 211
Cdd:cd17965 147 FGPSYQrlQLAFKGrIDILVTTPG-KLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225


                ....
2PL3_A      212 QTKS 215
Cdd:cd17965 226 IPKE 229
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 24-230 4.01e-16

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 74.67  E-value: 4.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       24 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTdglgVL 101
Cdd:cd18048  17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQ----CL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      102 IISPTRELAYQTFEVLRKVGKnhdFSAGLII--------GGKDLKHEAErinninILVCTPGRLLQHMDETVSFHATDLQ 173
Cdd:cd18048  93 CLSPTFELALQTGKVVEEMGK---FCVGIQViyairgnrPGKGTDIEAQ------IVIGTPGTVLDWCFKLRLIDVTNIS 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
2PL3_A      174 MLVLDEADRILDM-GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd18048 164 VFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNII 221
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 27-230 4.33e-16

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 73.99  E-value: 4.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       27 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEAL-YRLQWTStdglgVLII 103
Cdd:cd18047   3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVePANKYPQ-----CLCL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      104 SPTRELAYQTFEVLRKVGKnhdFSAGLIIGGKDLKHEAERINNI--NILVCTPGRLLQHMDETVSFHATDLQMLVLDEAD 181
Cdd:cd18047  78 SPTYELALQTGKVIEQMGK---FYPELKLAYAVRGNKLERGQKIseQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEAD 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
2PL3_A      182 -RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 230
Cdd:cd18047 155 vMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
 52-180 1.94e-11

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 60.68  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlQWTSTdglgVLIISPTRELAYQTFEVLRKVgkNHDFSAGLI 131
Cdd:cd17923   5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLR-DPGSR----ALYLYPTKALAQDQLRSLREL--LEQLGLGIR 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
2PL3_A      132 IG---GkDLKHEAER---INNINILVCTPGRL----LQHMDETVSFhATDLQMLVLDEA 180
Cdd:cd17923  78 VAtydG-DTPREERRaiiRNPPRILLTNPDMLhyalLPHHDRWARF-LRNLRYVVLDEA 134
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
42-111 4.74e-10

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 58.96  E-value: 4.74e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2PL3_A       42 EAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLA-FLvPVLEALYRLQWTST--DGLGVLIISPTRELAY 111
Cdd:COG1201  19 AARFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAaFL-PALDELARRPRPGElpDGLRVLYISPLKALAN 90
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 52-180 6.35e-10

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 58.69  E-value: 6.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlQWTSTdglgVLIISPTRELAYQTFEVLRKVGKNH--DFSAG 129
Cdd:COG1205  61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE-DPGAT----ALYLYPTKALARDQLRRLRELAEALglGVRVA 135

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
2PL3_A      130 LIIGGKDlKHEAERI-NNINILVCTP-----GrLLQHMDETVSFHATdLQMLVLDEA 180
Cdd:COG1205 136 TYDGDTP-PEERRWIrEHPDIVLTNPdmlhyG-LLPHHTRWARFFRN-LRYVVIDEA 189
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 47-221 2.17e-09

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 54.96  E-value: 2.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       47 LVTEIQKQTI-GLALQGKDVLGAAKTGSGKTLAflvpVLEALYRLqWTSTDGLgVLIISPTRELAYQTFEVLRKVGKNHD 125
Cdd:cd17921   1 LLNPIQREALrALYLSGDSVLVSAPTSSGKTLI----AELAILRA-LATSGGK-AVYIAPTRALVNQKEADLRERFGPLG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      126 FSAGLIIGgkDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLP---KK 202
Cdd:cd17921  75 KNVGLLTG--DPSVNKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKN 152

                       170
                ....*....|....*....
2PL3_A      203 RQTLLFSATqTKSVKDLAR 221
Cdd:cd17921 153 ARFVGLSAT-LPNAEDLAE 170
ResIII pfam04851
Type III restriction enzyme, res subunit;
71-211 1.80e-08

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 52.29  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A         71 TGSGKTLAFLvpvleALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLkheaERINNINIL 150
Cdd:pfam04851  32 TGSGKTLTAA-----KLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKD----ESVDDNKIV 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
2PL3_A        151 VCTPGRLLQHMDETVSFHATDLQMLVL-DEADRildmGFADTMNAVIENLPKKRQtLLFSAT 211
Cdd:pfam04851 103 VTTIQSLYKALELASLELLPDFFDVIIiDEAHR----SGASSYRNILEYFKPAFL-LGLTAT 159
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 71-211 3.71e-08

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 50.77  E-value: 3.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       71 TGSGKTLaFLVPVLEALYRLqwtstdglGVLIISPTRELAYQTFEVLRKVGKNHDFSaglIIGGKDLKHeaerINNINIL 150
Cdd:cd17926  27 TGSGKTL-TALALIAYLKEL--------RTLIVVPTDALLDQWKERFEDFLGDSSIG---LIGGGKKKD----FDDANVV 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
2PL3_A      151 VCTPGRLLQHMDETVSFHATDLQMLVlDEADRILdmgfADTMNAVIENLPKKRQtLLFSAT 211
Cdd:cd17926  91 VATYQSLSNLAEEEKDLFDQFGLLIV-DEAHHLP----AKTFSEILKELNAKYR-LGLTAT 145
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
 62-119 4.11e-08

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 51.04  E-value: 4.11e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
2PL3_A       62 GKDVLGAAKTGSGKTLAFLVPVLEALYRLQWtstDGLGVLIISPTRELAYQTFEVLRK 119
Cdd:cd17922   1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPE---KGVQVLYISPLKALINDQERRLEE 55
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
52-221 5.16e-08

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 52.59  E-value: 5.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTI--GLaLQGKDVLGAAKTGSGKTL-AFLvPVLEALyrlqwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 128
Cdd:COG1204  27 QAEALeaGL-LEGKNLVVSAPTASGKTLiAEL-AILKAL-------LNGGKALYIVPLRALASEKYREFKRDFEELGIKV 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      129 GLIIGGKDLkhEAERINNINILVCTPGRLLQHMDETVSFhATDLQMLVLDEADRILDMGFADTMNAVIENL---PKKRQT 205
Cdd:COG1204  98 GVSTGDYDS--DDEWLGRYDILVATPEKLDSLLRNGPSW-LRDVDLVVVDEAHLIDDESRGPTLEVLLARLrrlNPEAQI 174

                       170
                ....*....|....*.
2PL3_A      206 LLFSATqTKSVKDLAR 221
Cdd:COG1204 175 VALSAT-IGNAEEIAE 189
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
62-211 1.50e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 51.56  E-value: 1.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       62 GKDVLGAAKTGSGKTLAFLvpvlEALYRLQWTSTdglgVLIISPTRELAYQTFEVLRKVGKNHDFSAGliiggkdlKHEA 141
Cdd:COG1061 100 GGRGLVVAPTGTGKTVLAL----ALAAELLRGKR----VLVLVPRRELLEQWAEELRRFLGDPLAGGG--------KKDS 163

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      142 ERinniNILVCTPGRLLQHMDETVSFHATDLqmLVLDEADRIldmgFADTMNAVIENLPKKRqTLLFSAT 211
Cdd:COG1061 164 DA----PITVATYQSLARRAHLDELGDRFGL--VIIDEAHHA----GAPSYRRILEAFPAAY-RLGLTAT 222
DEXHc_RIG-I cd17927
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ...
 59-182 9.91e-07

DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350685 [Multi-domain]  Cd Length: 201  Bit Score: 47.81  E-value: 9.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       59 ALQGKDVLGAAKTGSGKTlafLVPVLEALYRLQWTSTDGLG-VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDL 137
Cdd:cd17927  14 ALKGKNTIICLPTGSGKT---FVAVLICEHHLKKFPAGRKGkVVFLANKVPLVEQQKEVFRKHFERPGYKVTGLSGDTSE 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
2PL3_A      138 KHEAER-INNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADR 182
Cdd:cd17927  91 NVSVEQiVESSDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
 52-216 2.13e-06

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 46.87  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLeaLYRLQwtsTDGLGvLIISPTREL-AYQTFEVLRKVgknhdfSAGL 130
Cdd:cd18018  17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL--LLRRR---GPGLT-LVVSPLIALmKDQVDALPRAI------KAAA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      131 IIGG---KDLKHEAERINN--INILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFA---DTM--NAVIENLP 200
Cdd:cd18018  85 LNSSltrEERRRILEKLRAgeVKILYVSPERLVNESFRELLRQTPPISLLVVDEAHCISEWSHNfrpDYLrlCRVLRELL 164

                       170
                ....*....|....*.
2PL3_A      201 KKRQTLLFSATQTKSV 216
Cdd:cd18018 165 GAPPVLALTATATKRV 180
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
 52-234 2.69e-06

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 46.37  E-value: 2.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRlqwtstDGLgVLIISPTreLAYQTFEVLRKvgKNHDFSAGLI 131
Cdd:cd17920  17 QLEAINAVLAGRDVLVVMPTGGGKSLCYQLP---ALLL------DGV-TLVVSPL--ISLMQDQVDRL--QQLGIRAAAL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      132 IGGKDLKHEAERINNI-----NILVCTPGRLLQ-HMDETVS--FHATDLQMLVLDEADRIL--------DMGFadtMNAV 195
Cdd:cd17920  83 NSTLSPEEKREVLLRIkngqyKLLYVTPERLLSpDFLELLQrlPERKRLALIVVDEAHCVSqwghdfrpDYLR---LGRL 159

                       170       180       190
                ....*....|....*....|....*....|....*....
2PL3_A      196 IENLPKKrQTLLFSATQTKSVKDLARLSLKNPEYVWVHE 234
Cdd:cd17920 160 RRALPGV-PILALTATATPEVREDILKRLGLRNPVIFRA 197
PRK13767 PRK13767
ATP-dependent helicase; Provisional
 44-110 3.44e-06

ATP-dependent helicase; Provisional


Pssm-ID: 237497 [Multi-domain]  Cd Length: 876  Bit Score: 47.57  E-value: 3.44e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2PL3_A        44 QYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL--QWTSTDGLGVLIISPTRELA 110
Cdd:PRK13767  29 KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLgrEGELEDKVYCLYVSPLRALN 97
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
 64-182 8.30e-06

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 44.71  E-value: 8.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       64 DVLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELAYQTFEVLRKVGKnhDFSAGLIIGGKDLKHEAEr 143
Cdd:cd17918  38 DRLLSGDVGSGKTLVALGAALLAYKN-------GKQVAILVPTEILAHQHYEEARKFLP--FINVELVTGGTKAQILSG- 107

                        90       100       110
                ....*....|....*....|....*....|....*....
2PL3_A      144 innINILVCTPGrLLQhmdETVSFHATDLqmLVLDEADR 182
Cdd:cd17918 108 ---ISLLVGTHA-LLH---LDVKFKNLDL--VIVDEQHR 137
DDXDc_reverse_gyrase cd17924
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ...
 49-184 1.09e-05

DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350682 [Multi-domain]  Cd Length: 189  Bit Score: 44.63  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       49 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLealyrlqWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 128
Cdd:cd17924  19 WGAQRTWAKRLLRGKSFAIIAPTGVGKTTFGLATSL-------YLASKGKRSYLIFPTKSLVKQAYERLSKYAEKAGVEV 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
2PL3_A      129 GLIIGGKDLKHEA-----ERINN--INILVCTPGRLLQHMDETVSFhatDLQMLVLDEADRIL 184
Cdd:cd17924  92 KILVYHSRLKKKEkeellEKIEKgdFDILVTTNQFLSKNFDLLSNK---KFDFVFVDDVDAVL 151
DEXHc_dicer cd18034
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ...
 71-180 1.53e-05

DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350792 [Multi-domain]  Cd Length: 200  Bit Score: 44.18  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       71 TGSGKTL-AFLvpVLEALYRLQ-WTSTDGLGVLIISPTRELAYQTFEVLR-----KVGKnhdFSAGLIIGGKDLKHEAER 143
Cdd:cd18034  25 TGSGKTLiAVM--LIKEMGELNrKEKNPKKRAVFLVPTVPLVAQQAEAIRshtdlKVGE---YSGEMGVDKWTKERWKEE 99

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
2PL3_A      144 INNINILVCTPGRL---LQHMDETVSfhatDLQMLVLDEA 180
Cdd:cd18034 100 LEKYDVLVMTAQILldaLRHGFLSLS----DINLLIFDEC 135
DEXHc_Hef cd18035
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ...
 51-182 2.14e-05

DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350793 [Multi-domain]  Cd Length: 181  Bit Score: 43.66  E-value: 2.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       51 IQKQTIGLALQGKDVLGAAKTGSGKTLaflVPVLEALYRLQwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGL 130
Cdd:cd18035   5 LYQVLIAAVALNGNTLIVLPTGLGKTI---IAILVAADRLT---KKGGKVLILAPSRPLVEQHAENLKRVLNIPDKITSL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
2PL3_A      131 iIGGKDLKHEAERINNINILVCTPgrllQHMDETV---SFHATDLQMLVLDEADR 182
Cdd:cd18035  79 -TGEVKPEERAERWDASKIIVATP----QVIENDLlagRITLDDVSLLIFDEAHH 128
VirD4 COG3505
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ...
 65-122 1.06e-04

Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442728 [Multi-domain]  Cd Length: 402  Bit Score: 42.66  E-value: 1.06e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
2PL3_A       65 VLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELAYQTFEVLRKVGK 122
Cdd:COG3505   2 VLVIGPTGSGKTVGLVIPNLTQLAR-------GESVVVTDPKGDLAELTAGFRRRAGY 52
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 60-211 4.61e-04

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 39.62  E-value: 4.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       60 LQGKDVLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELA---YQTFEVLRKVGKNHDFSAGliiggkD 136
Cdd:cd18028  15 LKGENLLISIPTASGKTLIAEMAMVNTLLE-------GGKALYLVPLRALAsekYEEFKKLEEIGLKVGISTG------D 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      137 LKHEAERINNINILVCTPGRLlqhmDETVSFHAT---DLQMLVLDEADRILDMGFADTMNAVI---ENLPKKRQTLLFSA 210
Cdd:cd18028  82 YDEDDEWLGDYDIIVATYEKF----DSLLRHSPSwlrDVGVVVVDEIHLISDEERGPTLESIVarlRRLNPNTQIIGLSA 157


                .
2PL3_A      211 T 211
Cdd:cd18028 158 T 158
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
52-228 4.98e-04

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 40.51  E-value: 4.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRlqwtstDGLGVlIISPtreL---------AyqtfevLRKVGk 122
Cdd:COG0514  22 QEEIIEAVLAGRDALVVMPTGGGKSLCYQLP---ALLL------PGLTL-VVSP---LialmkdqvdA------LRAAG- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      123 nhdFSAGLIIGGKDLKHEAERINNIN-----ILVCTPGRLLQhmDETVSF-HATDLQMLVLDEA--------D------R 182
Cdd:COG0514  82 ---IRAAFLNSSLSAEERREVLRALRagelkLLYVAPERLLN--PRFLELlRRLKISLFAIDEAhcisqwghDfrpdyrR 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
2PL3_A      183 IldmgfadtmNAVIENLPkKRQTLLFSATQTKSVKD--LARLSLKNPE 228
Cdd:COG0514 157 L---------GELRERLP-NVPVLALTATATPRVRAdiAEQLGLEDPR 194
DEXHc_HFM1 cd18023
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ...
 49-179 3.09e-03

DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350781 [Multi-domain]  Cd Length: 206  Bit Score: 37.72  E-value: 3.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       49 TEIQKQTIGLALQG-KDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFS 127
Cdd:cd18023   3 NRIQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWGNRKVVYIAPIKALCSEKYDDWKEKFGPLGLS 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
2PL3_A      128 AGLIIGGKDLKhEAERINNINILVCTPGR--LLQHMDETVSFHATDLQMLVLDE 179
Cdd:cd18023  83 CAELTGDTEMD-DTFEIQDADIILTTPEKwdSMTRRWRDNGNLVQLVALVLIDE 135
DEXHc_SKIV2L cd18027
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ...
 52-217 3.20e-03

DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350785 [Multi-domain]  Cd Length: 179  Bit Score: 37.24  E-value: 3.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       52 QKQTIGLALQGKDVLGAAKTGSGKTLAflvpvleALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNhdfsAGLI 131
Cdd:cd18027  13 QKQAILHLEAGDSVFVAAHTSAGKTVV-------AEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGD----VGLI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A      132 IGGKDLKHEAerinniNILVCTPgRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSAT 211
Cdd:cd18027  82 TGDVQLNPEA------SCLIMTT-EILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSAT 154


                ....*.
2PL3_A      212 QTKSVK 217
Cdd:cd18027 155 VPNTVE 160
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
 31-121 6.20e-03

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 36.57  E-value: 6.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PL3_A       31 PLSKKTLKGLQE----AQYRlvtEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEAlyrlqwtstDGLgVLIISPT 106
Cdd:cd18015   1 PWSGKVKDTLKNvfklEKFR---PLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCS---------DGF-TLVVSPL 67

                        90
                ....*....|....*
2PL3_A      107 RELAYQTFEVLRKVG 121
Cdd:cd18015  68 ISLMEDQLMALKKLG 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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