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Chain A, Penicillin-binding Protein 2b
Protein Classification
penicillin-binding protein 2 ( domain architecture ID 17609223 )
penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
strep_PBP2B
NF038278 streptococcal penicillin-binding protein PBP2B;
2-677
0e+00
streptococcal penicillin-binding protein PBP2B;
Pssm-ID: 468446 [Multi-domain]
Cd Length: 678
Bit Score: 1219.05
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 2 RK FNSH SIP I RLNLLF S I VI LLF MTI I G RL LY MQ V LNKDFY E KKLA S A SQTK V T TSS A RG E IYDA S GKPLVEN TL KQVVS 81
Cdd:NF038278 1 RK KKNA SIP R RLNLLF F I IV LLF TVL I L RL AQ MQ I LNKDFY T KKLA A A TTYT V K TSS P RG Q IYDA K GKPLVEN EI KQVVS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 82 FTRSNKMTA TDL KE I A K KL LT YV SI S SPNL T E R QLA DYYLADPE I Y K K T VE A LP SE K RL DSDGNRL S ES EL Y N NAVDSV P 161
Cdd:NF038278 81 FTRSNKMTA EEI KE L A Q KL SQ YV TV S EVKV T T R AKK DYYLADPE V Y A K V VE K LP KK K KY DSDGNRL T ES KI Y A NAVDSV T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 162 T SQLNY TED E K K E IYLFSQ L NAV G NF A T GTIA TD P L NDS Q V A V IA SISKEM PGIS IS T S WDRK I L E TSL S SI V G S VSSE K 241
Cdd:NF038278 161 D SQLNY SDE E L K V IYLFSQ M NAV A NF N T VNLK TD D L TAE Q I A Y IA ANKSKL PGIS VT T D WDRK V L D TSL A SI I G T VSSE E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 242 AGLPAEEA ES YLKKGYSLNDRVGTSYLEKQYE E VLQGKR P VKEI H LDK H G DM ES VENIE EG S KGKN I KLTIDL A FQD S V D 321
Cdd:NF038278 241 AGLPAEEA DD YLKKGYSLNDRVGTSYLEKQYE S VLQGKR E VKEI K LDK N G KI ES DKITS EG Q KGKN L KLTIDL D FQD G V E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 322 AL LK S YF N SEL GN G G A K YSEGVYAVALNP Q TGA V L S M S GL K HDL K TG E LT P D S LGT V TNVF V PGSVVK A AT ISS GWENGV 401
Cdd:NF038278 321 DI LK K YF Q SEL AS G N A T YSEGVYAVALNP K TGA I L A M A GL S HDL G TG N LT E D A LGT I TNVF T PGSVVK G AT LTA GWENGV 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 402 L SGNQ T LTDQPI V F Q GSAPI Y SW YK l A YGS F PITAV E ALEYSSN A Y V VQ T AL GI MGQ T Y Q P N M FVG T SN L ES AM G KLRST 481
Cdd:NF038278 401 I SGNQ V LTDQPI Q F A GSAPI T SW FT - Q YGS R PITAV Q ALEYSSN T Y M VQ V AL KM MGQ D Y H P G M TLT T DG L KE AM E KLRST 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 482 F G EYGLG SA TGIDLP D ESTG LV PK E Y NFA N FI T N AFGQFDNYTPMQLAQY V AT I AN N G V R L APH I VEGIYDNND K GGLG E 561
Cdd:NF038278 480 F A EYGLG VS TGIDLP G ESTG YL PK D Y TVS N VL T E AFGQFDNYTPMQLAQY A AT V AN G G K R I APH L VEGIYDNND N GGLG D 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 562 L IQA I D TK EI NKVNIS ESD MAI LH QGFYQV SHGT S PLT TGR AFS d GA T V S IS G KTGT G E S YV AGGQ ---- EAN N T N A VAY 637
Cdd:NF038278 560 L VKT I E TK VL NKVNIS DEE MAI IQ QGFYQV VNSS S GYA TGR TLQ - GA A V T IS A KTGT A E T YV KDKN gqtv TTV N L N V VAY 638
650 660 670 680
....*....|....*....|....*....|....*....|
2WAE_A 638 AP TE NPQIAVAVV F PH N T N L TKN V GPA IARDIINLY NQHH 677
Cdd:NF038278 639 AP SD NPQIAVAVV Y PH A T D L LSK V SQS IARDIINLY HSMY 678
Name
Accession
Description
Interval
E-value
strep_PBP2B
NF038278 streptococcal penicillin-binding protein PBP2B;
2-677
0e+00
streptococcal penicillin-binding protein PBP2B;
Pssm-ID: 468446 [Multi-domain]
Cd Length: 678
Bit Score: 1219.05
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 2 RK FNSH SIP I RLNLLF S I VI LLF MTI I G RL LY MQ V LNKDFY E KKLA S A SQTK V T TSS A RG E IYDA S GKPLVEN TL KQVVS 81
Cdd:NF038278 1 RK KKNA SIP R RLNLLF F I IV LLF TVL I L RL AQ MQ I LNKDFY T KKLA A A TTYT V K TSS P RG Q IYDA K GKPLVEN EI KQVVS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 82 FTRSNKMTA TDL KE I A K KL LT YV SI S SPNL T E R QLA DYYLADPE I Y K K T VE A LP SE K RL DSDGNRL S ES EL Y N NAVDSV P 161
Cdd:NF038278 81 FTRSNKMTA EEI KE L A Q KL SQ YV TV S EVKV T T R AKK DYYLADPE V Y A K V VE K LP KK K KY DSDGNRL T ES KI Y A NAVDSV T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 162 T SQLNY TED E K K E IYLFSQ L NAV G NF A T GTIA TD P L NDS Q V A V IA SISKEM PGIS IS T S WDRK I L E TSL S SI V G S VSSE K 241
Cdd:NF038278 161 D SQLNY SDE E L K V IYLFSQ M NAV A NF N T VNLK TD D L TAE Q I A Y IA ANKSKL PGIS VT T D WDRK V L D TSL A SI I G T VSSE E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 242 AGLPAEEA ES YLKKGYSLNDRVGTSYLEKQYE E VLQGKR P VKEI H LDK H G DM ES VENIE EG S KGKN I KLTIDL A FQD S V D 321
Cdd:NF038278 241 AGLPAEEA DD YLKKGYSLNDRVGTSYLEKQYE S VLQGKR E VKEI K LDK N G KI ES DKITS EG Q KGKN L KLTIDL D FQD G V E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 322 AL LK S YF N SEL GN G G A K YSEGVYAVALNP Q TGA V L S M S GL K HDL K TG E LT P D S LGT V TNVF V PGSVVK A AT ISS GWENGV 401
Cdd:NF038278 321 DI LK K YF Q SEL AS G N A T YSEGVYAVALNP K TGA I L A M A GL S HDL G TG N LT E D A LGT I TNVF T PGSVVK G AT LTA GWENGV 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 402 L SGNQ T LTDQPI V F Q GSAPI Y SW YK l A YGS F PITAV E ALEYSSN A Y V VQ T AL GI MGQ T Y Q P N M FVG T SN L ES AM G KLRST 481
Cdd:NF038278 401 I SGNQ V LTDQPI Q F A GSAPI T SW FT - Q YGS R PITAV Q ALEYSSN T Y M VQ V AL KM MGQ D Y H P G M TLT T DG L KE AM E KLRST 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 482 F G EYGLG SA TGIDLP D ESTG LV PK E Y NFA N FI T N AFGQFDNYTPMQLAQY V AT I AN N G V R L APH I VEGIYDNND K GGLG E 561
Cdd:NF038278 480 F A EYGLG VS TGIDLP G ESTG YL PK D Y TVS N VL T E AFGQFDNYTPMQLAQY A AT V AN G G K R I APH L VEGIYDNND N GGLG D 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 562 L IQA I D TK EI NKVNIS ESD MAI LH QGFYQV SHGT S PLT TGR AFS d GA T V S IS G KTGT G E S YV AGGQ ---- EAN N T N A VAY 637
Cdd:NF038278 560 L VKT I E TK VL NKVNIS DEE MAI IQ QGFYQV VNSS S GYA TGR TLQ - GA A V T IS A KTGT A E T YV KDKN gqtv TTV N L N V VAY 638
650 660 670 680
....*....|....*....|....*....|....*....|
2WAE_A 638 AP TE NPQIAVAVV F PH N T N L TKN V GPA IARDIINLY NQHH 677
Cdd:NF038278 639 AP SD NPQIAVAVV Y PH A T D L LSK V SQS IARDIINLY HSMY 678
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-670
1.71e-104
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 329.48
E-value: 1.71e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 1 M RKFNSHS - IPI RL N LLF SI V I LLF MTII GRL L Y M QV LNK D F Y EKKLASASQTK V TTSSA RG E IYD AS G KP L VE N TLKQV 79
Cdd:COG0768 1 M KRKKEKR l FRR RL L LLF LL V L LLF LLLV GRL F Y L QV VEG D E Y AELAEENRIRT V PIPAP RG L IYD RN G NV L AT N VPVYS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 80 VSFTRSN kmt AT D LK E I A K KL LTYVSIS spnlterqladyyla DP E IY KK tvealpsekrldsdgnrlseselynnavds 159
Cdd:COG0768 81 LYADPEE --- VK D PE E T A E KL AKLLGLD --------------- PE E LR KK ------------------------------ 112
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 160 vptsqln YTEDEKKEI YL FSQ L N avgnfatgtiatdpln DSQV A V I ASI sk EM PG ISISTSWD R K - ILETSLSSIV G S V S 238
Cdd:COG0768 113 ------- LKKKSRFPV YL KRN L S ---------------- PEEA A R I RAL -- KL PG VYVEAEYK R Y y PYGELAAHVL G Y V G 167
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 239 SE kaglpaeeaesylkkgy SLN D RV G T S Y LEK Q YE EV L Q G KRPVKEIHL D KH G D - MESVENIEEGSK GK NIK LTID LAF Q 317
Cdd:COG0768 168 EI ----------------- NGG D GI G K S G LEK A YE DL L R G TPGKRRVEV D AR G R v IRDLGEEKPPVP GK DLV LTID SDL Q 230
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 318 DSVDAL LK SYFNSELGNG GA kysegvy A V ALN P Q TG AV L S M SGLK ---- HDLKT G ELT P DSLGT V TNVFV PGS VV K AA T I 393
Cdd:COG0768 231 KIAEEA LK KAVEEYKAKS GA ------- V V VMD P K TG EI L A M ASYP sfdp NLFVG G PDE P LRNRA V QGTYE PGS TF K PF T A 303
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 394 SSGW E N GV LSGNQ T LTDQPIVFQ G SAP I YS W YKLAY G sf PI T AV EAL EY SSN AYVVQT AL gimgqtyqpnmfvgtsnles 473
Cdd:COG0768 304 AAAL E E GV ITPDT T FDCPGYYRV G GRT I RD W DRGGH G -- TL T LT EAL AK SSN VGFYKL AL -------------------- 361
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 474 AM G -- KL RSTFGEY GLG SA TGIDLP D E ST GL V P -- K EYNFANFI T NAF GQ FDNY TP M QLAQ YV A T IAN N GV RLA PH I V EG 549
Cdd:COG0768 362 RL G id KL YDYLKKF GLG QK TGIDLP G E AS GL L P sp K RWYPGETA T MSI GQ GLSV TP L QLAQ AY A A IAN G GV LVK PH L V KE 441
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 550 I Y D NN dkggl GE LIQA i DTKEINK V n IS ESDMAILHQ G FYQ V SHG ts P LT T G R A f SDGATVSIS GKTGT GE -- SYVA GG Q 627
Cdd:COG0768 442 I V D PD ----- GE VVKE - EPEVLRR V - IS PETAETVRE G MEG V VNE -- P GG T A R R - AAIPGYRVA GKTGT AQ vv DIGN GG Y 511
650 660 670 680
....*....|....*....|....*....|....*....|....*...
2WAE_A 628 EANNTN A -- V AY AP TE NP QI AVAVV FPHNTNLT --- KNVG P a IA R D I I 670
Cdd:COG0768 512 YKGRHI A sf V GF AP AD NP RY AVAVV VENPGGGA ygg TVAA P - VF R E I M 558
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
12-673
6.09e-73
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 246.67
E-value: 6.09e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 12 R LNL L FSI V IL LF MTIIG RL L Y M QV LNKDF Y e KK L ASASQTKVTTSSA - RG E I Y D AS G KP L VE N tlkq VV SF T rsnkmta 90
Cdd:TIGR03423 2 R ALV L GGL V LA LF GVLAA RL F Y L QV IRGEE Y - AT L SEDNRIRLVPIPP p RG L I L D RN G VL L AD N ---- RP SF S ------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 91 tdlkeiakklltyvsisspnlterqladyyladpeiykkt V E AL P SE - KR LD SDGN RL SES elynnavdsvptsq L NYTE 169
Cdd:TIGR03423 70 ---------------------------------------- L E IV P EK v DD LD ATLD RL AKL -------------- L DLDP 95
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 170 DEKKEIY lf SQ L NAVGN F ATGTIAT D p L NDSQ VA VI A SISKEM PG IS I STSWD R KILETS L SS - IV G S V SS ekag LPA E E 248
Cdd:TIGR03423 96 EDIARFL -- KE L KRSRR F EPIPLKS D - L TEEE VA RF A VNQYRL PG VE I EARLK R YYPYGE L AA h VL G Y V GE ---- INE E D 168
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 249 A E SYLKKG Y SLN D RV G T S YL EK Q YE EV L Q GK RPVK E IHLDKH G DMESVENIEEGSK GK NIK LTID LAF Q DSVDAL L K syf 328
Cdd:TIGR03423 169 L E RLEPAN Y AGG D YI G K S GI EK Y YE DE L R GK PGYR E VEVNAR G RVIRTLSRVPPVP GK DLV LTID ARL Q QAAEKA L G --- 245
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 329 nsel G NG GA kysegvy A V ALN P Q TG AV L S M ------------ S G LKH - D L K tg E L TP D SLGTVT N ----- V FV PGS VV K A 390
Cdd:TIGR03423 246 ---- G RR GA ------- V V VMD P R TG EI L A M vstpsfdpnlfv D G ISS k D Y K -- A L LN D PDRPLL N raiqg V YP PGS TF K P 312
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 391 ATISSGW E N GV LSGNQTLTD q P IV FQ - G SAPIYS W YKLAY G S fp ITAVE A L E Y S SNA Y VV Q T AL G i M G qtyqpnmfvgts 469
Cdd:TIGR03423 313 VVALAAL E E GV ITPETRIYC - P GY FQ l G GRRFRC W KRGGH G R -- VDLRK A I E E S CDV Y FY Q L AL R - L G ------------ 376
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 470 nlesa MG K LRSTFGEY G L G SA TGIDLP D E ST GLVP - K E YNFAN F --------- ITNAF GQ - FDNY TP M QLA QYV A TI AN N 538
Cdd:TIGR03423 377 ----- ID K IAEYAKRF G F G QK TGIDLP G E KS GLVP s R E WKRKR F gqpwypgdt LNVSI GQ g YVLV TP L QLA VAT A AL AN G 451
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 539 G VRLA PH I V EG I Y D NN dkggl G ELIQAIDTKEINKVN IS ESDMAILHQ G FYQ V SH G ts P LT T G R AFSD G ATVSIS GKTGT 618
Cdd:TIGR03423 452 G KLYK PH L V KS I E D PD ----- G GVVRRTEPEVLRPLP IS PENLDVVRE G MRD V VN G -- P GG T A R RARL G LPYKMA GKTGT 524
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
2WAE_A 619 GE sy V AGGQEANNTN A ------------- VA Y AP TE NP Q IAVAV VFP H NTNLTKNVG P a IAR D I INL Y 673
Cdd:TIGR03423 525 AQ -- V VSLKQGEKYD A eqiperlrdhalf VA F AP YD NP K IAVAV IVE H GGGGSSAAA P - IAR K I MDA Y 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
344-670
2.61e-67
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 222.68
E-value: 2.61e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 344 Y AV A L N P Q TG A VL S M S G LKHDLKT G ELT P DSLGT VT NVFV PGS VV K AA T ISSGWE NGVL SGNQ T LT D Q P IVF QG SAP I YS 423
Cdd:pfam00905 2 S AV V L D P K TG E VL A M V G KPSYDPN G FIG P LRNRA VT SRYE PGS TF K PF T ALAALD NGVL KPDE T IF D W P GKQ QG GKS I GD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 424 W YKLAY G S fp I T AVE ALEYSSN A Y VVQT A L gimgqtyqpnmfvgtsnles AM G -- KLRS TFGEY G L G SA TGI D LP D E ST G 501
Cdd:pfam00905 82 W NQDQV G I -- G T LRQ ALEYSSN W Y MQKL A Q -------------------- KL G ad KLRS YLKKF G Y G NK TGI G LP G E NA G 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 502 LVPKEYNFANFI tn A FG QFDNY TP M Q L AQ YV A T IAN N G VRLA PH I V EG I Y D N ndkgglgeliqa I D T K EI NK VN IS E S DM 581
Cdd:pfam00905 140 YLTPYWLEGATA -- S FG IGLTI TP L Q Q AQ AY A A IAN G G KLVP PH L V KS I E D K ------------ V D P K VL NK LP IS K S TA 205
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 582 AILHQGFYQ V SHGTSPLT T GR afsd GATVSIS GKTGT GESYVAG G Q ---- E A NNTNA V A YAP TE NP QI A V AV VFPHNTNL 657
Cdd:pfam00905 206 EKVKDMLRL V VNDGTGTG T AA ---- VPGYKVA GKTGT AQVAGPK G G gyyd G A QIGWF V G YAP AD NP KY A F AV LIDDPKRY 281
330
....*....|....
2WAE_A 658 TKN - V GPA I AR DI I 670
Cdd:pfam00905 282 YGG k V AAP I FK DI L 295
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
196-671
5.55e-27
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 116.41
E-value: 5.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 196 P L NDS QVA VI A SISKEM PG ISIS t SWD R KILE -- TS L SSIV G S VS S ekag LPAEEA E SYL K K G ---- Y SLNDRV G TSYL E 269
Cdd:PRK10795 138 N L TEV QVA RF A VNQYRF PG VEVK - GYQ R RYYP yg SA L THVI G Y VS K ---- INDKDV E RLD K E G klan Y AATHDI G KLGI E 212
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 270 KQ YE E VL Q GK RPVK E IHLDKH G DM es VENIE E GS -- K G KN I K LT I DL AF Q DSVDA LL K syfnsel G NGG A kysegvy A V A 347
Cdd:PRK10795 213 RY YE D VL H GK TGYE E VEVNNR G RV -- IRQLH E QP pq A G HD I Y LT L DL KL Q QYIET LL A ------- G SRA A ------- V V V 276
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 348 LN P Q TG AV L SM ---------------- S GLKHD L KTGELT P DSLGTVTN V FV P G S V VK AATIS S GWEN GV LSG N QT L T D q 411
Cdd:PRK10795 277 TD P R TG GI L AL vstpsydpnlfvdgis S KDYSG L LNDPNR P LINRATQG V YP P A S T VK PYVAV S ALSA GV ITR N TS L F D - 355
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 412 P IVF Q -- GS API Y - S W Y K LAY G SFPI T av EA LE Y S SNAYVV Q T A LGI mgqtyqpnmfv G TSN L ESA MGK lrstfge Y G L G 488
Cdd:PRK10795 356 P GWW Q lp GS EKR Y r D W K K WGH G RLNV T -- KS LE E S ADTFFY Q V A YDM ----------- G IDR L SEW MGK ------- F G Y G 415
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 489 SA TGIDL PD E ST G LV P - K E YNFAN F --------- I TNAF GQ - FDNY TP M Q LAQYVA T IA N N G VRLA PH IVEGIYDN ndkg 557
Cdd:PRK10795 416 HY TGIDL AE E RS G NM P t R E WKQKR F kkpwyqgdt I PVGI GQ g YWTA TP I Q MSKALM T LI N D G IVKV PH LLMSTAED ---- 491
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 558 gl G ELIQAIDTK E INKVN I SESDMA I LHQ G F Y Q V SH gt S P LT T GRAFSDG A TVS I SG K T GT GESYVAGGQ E AN N TNAV -- 635
Cdd:PRK10795 492 -- G KQVPWVQPH E PPVGD I HSGYWE I AKD G M Y G V AN -- R P NG T AHKYFAS A PYK I AA K S GT AQVFGLKAN E TY N AHKI ae 567
490 500 510 520
....*....|....*....|....*....|....*....|....*...
2WAE_A 636 --------- A Y AP TE NPQ I AVA VVFPHN tnltk NV GPA --- I A R D I IN 671
Cdd:PRK10795 568 rlrdhklmt A F AP YN NPQ V AVA IILENG ----- GA GPA vgt I M R Q I LD 610
Name
Accession
Description
Interval
E-value
strep_PBP2B
NF038278 streptococcal penicillin-binding protein PBP2B;
2-677
0e+00
streptococcal penicillin-binding protein PBP2B;
Pssm-ID: 468446 [Multi-domain]
Cd Length: 678
Bit Score: 1219.05
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 2 RK FNSH SIP I RLNLLF S I VI LLF MTI I G RL LY MQ V LNKDFY E KKLA S A SQTK V T TSS A RG E IYDA S GKPLVEN TL KQVVS 81
Cdd:NF038278 1 RK KKNA SIP R RLNLLF F I IV LLF TVL I L RL AQ MQ I LNKDFY T KKLA A A TTYT V K TSS P RG Q IYDA K GKPLVEN EI KQVVS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 82 FTRSNKMTA TDL KE I A K KL LT YV SI S SPNL T E R QLA DYYLADPE I Y K K T VE A LP SE K RL DSDGNRL S ES EL Y N NAVDSV P 161
Cdd:NF038278 81 FTRSNKMTA EEI KE L A Q KL SQ YV TV S EVKV T T R AKK DYYLADPE V Y A K V VE K LP KK K KY DSDGNRL T ES KI Y A NAVDSV T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 162 T SQLNY TED E K K E IYLFSQ L NAV G NF A T GTIA TD P L NDS Q V A V IA SISKEM PGIS IS T S WDRK I L E TSL S SI V G S VSSE K 241
Cdd:NF038278 161 D SQLNY SDE E L K V IYLFSQ M NAV A NF N T VNLK TD D L TAE Q I A Y IA ANKSKL PGIS VT T D WDRK V L D TSL A SI I G T VSSE E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 242 AGLPAEEA ES YLKKGYSLNDRVGTSYLEKQYE E VLQGKR P VKEI H LDK H G DM ES VENIE EG S KGKN I KLTIDL A FQD S V D 321
Cdd:NF038278 241 AGLPAEEA DD YLKKGYSLNDRVGTSYLEKQYE S VLQGKR E VKEI K LDK N G KI ES DKITS EG Q KGKN L KLTIDL D FQD G V E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 322 AL LK S YF N SEL GN G G A K YSEGVYAVALNP Q TGA V L S M S GL K HDL K TG E LT P D S LGT V TNVF V PGSVVK A AT ISS GWENGV 401
Cdd:NF038278 321 DI LK K YF Q SEL AS G N A T YSEGVYAVALNP K TGA I L A M A GL S HDL G TG N LT E D A LGT I TNVF T PGSVVK G AT LTA GWENGV 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 402 L SGNQ T LTDQPI V F Q GSAPI Y SW YK l A YGS F PITAV E ALEYSSN A Y V VQ T AL GI MGQ T Y Q P N M FVG T SN L ES AM G KLRST 481
Cdd:NF038278 401 I SGNQ V LTDQPI Q F A GSAPI T SW FT - Q YGS R PITAV Q ALEYSSN T Y M VQ V AL KM MGQ D Y H P G M TLT T DG L KE AM E KLRST 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 482 F G EYGLG SA TGIDLP D ESTG LV PK E Y NFA N FI T N AFGQFDNYTPMQLAQY V AT I AN N G V R L APH I VEGIYDNND K GGLG E 561
Cdd:NF038278 480 F A EYGLG VS TGIDLP G ESTG YL PK D Y TVS N VL T E AFGQFDNYTPMQLAQY A AT V AN G G K R I APH L VEGIYDNND N GGLG D 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 562 L IQA I D TK EI NKVNIS ESD MAI LH QGFYQV SHGT S PLT TGR AFS d GA T V S IS G KTGT G E S YV AGGQ ---- EAN N T N A VAY 637
Cdd:NF038278 560 L VKT I E TK VL NKVNIS DEE MAI IQ QGFYQV VNSS S GYA TGR TLQ - GA A V T IS A KTGT A E T YV KDKN gqtv TTV N L N V VAY 638
650 660 670 680
....*....|....*....|....*....|....*....|
2WAE_A 638 AP TE NPQIAVAVV F PH N T N L TKN V GPA IARDIINLY NQHH 677
Cdd:NF038278 639 AP SD NPQIAVAVV Y PH A T D L LSK V SQS IARDIINLY HSMY 678
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-670
1.71e-104
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 329.48
E-value: 1.71e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 1 M RKFNSHS - IPI RL N LLF SI V I LLF MTII GRL L Y M QV LNK D F Y EKKLASASQTK V TTSSA RG E IYD AS G KP L VE N TLKQV 79
Cdd:COG0768 1 M KRKKEKR l FRR RL L LLF LL V L LLF LLLV GRL F Y L QV VEG D E Y AELAEENRIRT V PIPAP RG L IYD RN G NV L AT N VPVYS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 80 VSFTRSN kmt AT D LK E I A K KL LTYVSIS spnlterqladyyla DP E IY KK tvealpsekrldsdgnrlseselynnavds 159
Cdd:COG0768 81 LYADPEE --- VK D PE E T A E KL AKLLGLD --------------- PE E LR KK ------------------------------ 112
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 160 vptsqln YTEDEKKEI YL FSQ L N avgnfatgtiatdpln DSQV A V I ASI sk EM PG ISISTSWD R K - ILETSLSSIV G S V S 238
Cdd:COG0768 113 ------- LKKKSRFPV YL KRN L S ---------------- PEEA A R I RAL -- KL PG VYVEAEYK R Y y PYGELAAHVL G Y V G 167
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 239 SE kaglpaeeaesylkkgy SLN D RV G T S Y LEK Q YE EV L Q G KRPVKEIHL D KH G D - MESVENIEEGSK GK NIK LTID LAF Q 317
Cdd:COG0768 168 EI ----------------- NGG D GI G K S G LEK A YE DL L R G TPGKRRVEV D AR G R v IRDLGEEKPPVP GK DLV LTID SDL Q 230
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 318 DSVDAL LK SYFNSELGNG GA kysegvy A V ALN P Q TG AV L S M SGLK ---- HDLKT G ELT P DSLGT V TNVFV PGS VV K AA T I 393
Cdd:COG0768 231 KIAEEA LK KAVEEYKAKS GA ------- V V VMD P K TG EI L A M ASYP sfdp NLFVG G PDE P LRNRA V QGTYE PGS TF K PF T A 303
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 394 SSGW E N GV LSGNQ T LTDQPIVFQ G SAP I YS W YKLAY G sf PI T AV EAL EY SSN AYVVQT AL gimgqtyqpnmfvgtsnles 473
Cdd:COG0768 304 AAAL E E GV ITPDT T FDCPGYYRV G GRT I RD W DRGGH G -- TL T LT EAL AK SSN VGFYKL AL -------------------- 361
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 474 AM G -- KL RSTFGEY GLG SA TGIDLP D E ST GL V P -- K EYNFANFI T NAF GQ FDNY TP M QLAQ YV A T IAN N GV RLA PH I V EG 549
Cdd:COG0768 362 RL G id KL YDYLKKF GLG QK TGIDLP G E AS GL L P sp K RWYPGETA T MSI GQ GLSV TP L QLAQ AY A A IAN G GV LVK PH L V KE 441
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 550 I Y D NN dkggl GE LIQA i DTKEINK V n IS ESDMAILHQ G FYQ V SHG ts P LT T G R A f SDGATVSIS GKTGT GE -- SYVA GG Q 627
Cdd:COG0768 442 I V D PD ----- GE VVKE - EPEVLRR V - IS PETAETVRE G MEG V VNE -- P GG T A R R - AAIPGYRVA GKTGT AQ vv DIGN GG Y 511
650 660 670 680
....*....|....*....|....*....|....*....|....*...
2WAE_A 628 EANNTN A -- V AY AP TE NP QI AVAVV FPHNTNLT --- KNVG P a IA R D I I 670
Cdd:COG0768 512 YKGRHI A sf V GF AP AD NP RY AVAVV VENPGGGA ygg TVAA P - VF R E I M 558
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
12-673
6.09e-73
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 246.67
E-value: 6.09e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 12 R LNL L FSI V IL LF MTIIG RL L Y M QV LNKDF Y e KK L ASASQTKVTTSSA - RG E I Y D AS G KP L VE N tlkq VV SF T rsnkmta 90
Cdd:TIGR03423 2 R ALV L GGL V LA LF GVLAA RL F Y L QV IRGEE Y - AT L SEDNRIRLVPIPP p RG L I L D RN G VL L AD N ---- RP SF S ------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 91 tdlkeiakklltyvsisspnlterqladyyladpeiykkt V E AL P SE - KR LD SDGN RL SES elynnavdsvptsq L NYTE 169
Cdd:TIGR03423 70 ---------------------------------------- L E IV P EK v DD LD ATLD RL AKL -------------- L DLDP 95
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 170 DEKKEIY lf SQ L NAVGN F ATGTIAT D p L NDSQ VA VI A SISKEM PG IS I STSWD R KILETS L SS - IV G S V SS ekag LPA E E 248
Cdd:TIGR03423 96 EDIARFL -- KE L KRSRR F EPIPLKS D - L TEEE VA RF A VNQYRL PG VE I EARLK R YYPYGE L AA h VL G Y V GE ---- INE E D 168
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 249 A E SYLKKG Y SLN D RV G T S YL EK Q YE EV L Q GK RPVK E IHLDKH G DMESVENIEEGSK GK NIK LTID LAF Q DSVDAL L K syf 328
Cdd:TIGR03423 169 L E RLEPAN Y AGG D YI G K S GI EK Y YE DE L R GK PGYR E VEVNAR G RVIRTLSRVPPVP GK DLV LTID ARL Q QAAEKA L G --- 245
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 329 nsel G NG GA kysegvy A V ALN P Q TG AV L S M ------------ S G LKH - D L K tg E L TP D SLGTVT N ----- V FV PGS VV K A 390
Cdd:TIGR03423 246 ---- G RR GA ------- V V VMD P R TG EI L A M vstpsfdpnlfv D G ISS k D Y K -- A L LN D PDRPLL N raiqg V YP PGS TF K P 312
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 391 ATISSGW E N GV LSGNQTLTD q P IV FQ - G SAPIYS W YKLAY G S fp ITAVE A L E Y S SNA Y VV Q T AL G i M G qtyqpnmfvgts 469
Cdd:TIGR03423 313 VVALAAL E E GV ITPETRIYC - P GY FQ l G GRRFRC W KRGGH G R -- VDLRK A I E E S CDV Y FY Q L AL R - L G ------------ 376
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 470 nlesa MG K LRSTFGEY G L G SA TGIDLP D E ST GLVP - K E YNFAN F --------- ITNAF GQ - FDNY TP M QLA QYV A TI AN N 538
Cdd:TIGR03423 377 ----- ID K IAEYAKRF G F G QK TGIDLP G E KS GLVP s R E WKRKR F gqpwypgdt LNVSI GQ g YVLV TP L QLA VAT A AL AN G 451
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 539 G VRLA PH I V EG I Y D NN dkggl G ELIQAIDTKEINKVN IS ESDMAILHQ G FYQ V SH G ts P LT T G R AFSD G ATVSIS GKTGT 618
Cdd:TIGR03423 452 G KLYK PH L V KS I E D PD ----- G GVVRRTEPEVLRPLP IS PENLDVVRE G MRD V VN G -- P GG T A R RARL G LPYKMA GKTGT 524
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
2WAE_A 619 GE sy V AGGQEANNTN A ------------- VA Y AP TE NP Q IAVAV VFP H NTNLTKNVG P a IAR D I INL Y 673
Cdd:TIGR03423 525 AQ -- V VSLKQGEKYD A eqiperlrdhalf VA F AP YD NP K IAVAV IVE H GGGGSSAAA P - IAR K I MDA Y 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
344-670
2.61e-67
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 222.68
E-value: 2.61e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 344 Y AV A L N P Q TG A VL S M S G LKHDLKT G ELT P DSLGT VT NVFV PGS VV K AA T ISSGWE NGVL SGNQ T LT D Q P IVF QG SAP I YS 423
Cdd:pfam00905 2 S AV V L D P K TG E VL A M V G KPSYDPN G FIG P LRNRA VT SRYE PGS TF K PF T ALAALD NGVL KPDE T IF D W P GKQ QG GKS I GD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 424 W YKLAY G S fp I T AVE ALEYSSN A Y VVQT A L gimgqtyqpnmfvgtsnles AM G -- KLRS TFGEY G L G SA TGI D LP D E ST G 501
Cdd:pfam00905 82 W NQDQV G I -- G T LRQ ALEYSSN W Y MQKL A Q -------------------- KL G ad KLRS YLKKF G Y G NK TGI G LP G E NA G 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 502 LVPKEYNFANFI tn A FG QFDNY TP M Q L AQ YV A T IAN N G VRLA PH I V EG I Y D N ndkgglgeliqa I D T K EI NK VN IS E S DM 581
Cdd:pfam00905 140 YLTPYWLEGATA -- S FG IGLTI TP L Q Q AQ AY A A IAN G G KLVP PH L V KS I E D K ------------ V D P K VL NK LP IS K S TA 205
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 582 AILHQGFYQ V SHGTSPLT T GR afsd GATVSIS GKTGT GESYVAG G Q ---- E A NNTNA V A YAP TE NP QI A V AV VFPHNTNL 657
Cdd:pfam00905 206 EKVKDMLRL V VNDGTGTG T AA ---- VPGYKVA GKTGT AQVAGPK G G gyyd G A QIGWF V G YAP AD NP KY A F AV LIDDPKRY 281
330
....*....|....
2WAE_A 658 TKN - V GPA I AR DI I 670
Cdd:pfam00905 282 YGG k V AAP I FK DI L 295
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
55-296
5.86e-32
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 122.05
E-value: 5.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 55 TTSSA RGEIYD AS G KP L VE N TLKQVVSF T R S NKMT A TD LK EI a K KL LTYV S i SSPN L TERQ L ADYY L adpeiykktveal 134
Cdd:pfam03717 1 PIPAP RGEIYD RN G VV L AT N KPVYSLTI T P S KLKK A DA LK TA - L KL AKLL S - NYED L DDED L TERF L ------------- 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 135 psekrldsdgnrlseselynnavdsvptsqlnytedekkeiylfs QL N AVGNFATGT I ATD p L NDSQ VA V I ASISK E M PG 214
Cdd:pfam03717 66 --------------------------------------------- KM N SYKSYYPVV I KKN - L SEEE VA R I EENLL E L PG 99
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 215 I SI S T SWD R KILE - TSLSSIV G S V SSEKA glpa EE A E S YL K KGYS LN D R VG T S Y LEKQYE E VL Q GK RP V KEIHL D KH G DM 293
Cdd:pfam03717 100 V SI E T DPV R YYPY g ELAAHLL G Y V GEITE ---- EE L E K YL D KGYS RG D L VG K S G LEKQYE S VL R GK DG V RQVEV D AL G RV 175
...
2WAE_A 294 ESV 296
Cdd:pfam03717 176 IRE 178
spoVD_pbp
TIGR02214 stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
21-671
1.70e-29
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]
Pssm-ID: 131269 [Multi-domain]
Cd Length: 636
Bit Score: 124.15
E-value: 1.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 21 IL LF MTI I G RL L Y M QV LNKD FY EKKLASASQTKVTTSSA RG E I Y D AS G KP L V -- ENTLKQVVSFTRSN K MTATDLK EIA K 98
Cdd:TIGR02214 10 TA LF LIL I L RL F Y V QV FRGS FY KEMAEDQWTREIPIEAK RG R I L D RN G NE L A vs VSVDRVDLDPATIR K NKEPKQR EIA N 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 99 K L LTYVSI sspnlterqladyyla D P E IYK K TVEALP S EKRLDSD G NRLSESEL yn NA V DSVPTSQLNYTE D E K K e I Y LF 178
Cdd:TIGR02214 90 E L ARVLEM ---------------- D K E KVF K RITKKN S PFVSAKL G RKIEKDKA -- EK V RNLKLNGVSVSP D S K R - Y Y PN 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 179 sqlnav G N F atgtiatdplndsqvaviasiskempgisistswdrkilets LS SIV G SVS S EKA GL paeeaesylkkgys 258
Cdd:TIGR02214 151 ------ G D F ------------------------------------------ LS HVL G FTN S DGR GL -------------- 168
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 259 lndrvgt SY LE KQ Y EEV L Q G KRP V KEIHL D KHG d M E SVENIEEGS K --- G KNIK LTID lafq DSVDALLKSYFNSE L GNG 335
Cdd:TIGR02214 169 ------- EG LE LY Y DKE L R G LPG V RVAEY D ANS - L E LPYAQHAYV K pvd G HDLV LTID ---- ENIQYIIEREADKA L RER 236
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 336 GA K yse GV YAVAL NP QT G AV L S MS G l KHDLKTGEL --- T PD SLG --- T V TNVFV PGS VV K AA T I S SGW E N G VLSGNQTLT 409
Cdd:TIGR02214 237 KP K --- GV SIIVM NP KN G EI L G MS N - RPTYDPNDP rdk S PD TAR rnr A V SDAYE PGS TF K II T S S AAM E E G IVKESDKFY 312
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 410 D QPIVFQ G SAP I YS W YKLAY GS fp I T AV E ALEY S S N AYVVQ talgi M G qtyqpn M FV G TSN L ESAMGK lrstfge Y G L GS 489
Cdd:TIGR02214 313 D DGSATV G GKK I KC W KPGGH GS -- Q T FP E VVQN S C N PGFIE ----- L G ------ M RL G AEK L NNYILA ------- F G F GS 372
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 490 A TGIDLP D E ST G - LVPK E - YNFANFI T NA FGQ FDNY TP M QL AQY V ATI AN N G VRLA PHI VEG I Y D NNDK gglgeli QAID 567
Cdd:TIGR02214 373 K TGIDLP G E AA G i LVPK K k VGPVDLA T IS FGQ ANTV TP I QL MTA V NAV AN G G KLIQ PHI MKE I S D SQNN ------- AVDQ 445
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 568 T K E - IN K VNISESDMAILHQGFYQ -- VS H G TSP lttg R AF SD G at VSIS GKTGT GESY - VA GG QEANNTNA -- V AY AP TE 641
Cdd:TIGR02214 446 T F E p EV K RQVVSKETTQKLRLALE tv VS K G SGK ---- N AF IE G -- YRVG GKTGT AQKV k PN GG YMEGEYIV sf V GF AP AD 519
650 660 670
....*....|....*....|....*....|....*..
2WAE_A 642 N P QI AV A VV F -- P HNTN ----- LTKN V GPAIAR DI I N 671
Cdd:TIGR02214 520 D P AV AV L VV V dn P KGVQ qfggl VAAP V FGSVFN DI L N 556
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
196-671
5.55e-27
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 116.41
E-value: 5.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 196 P L NDS QVA VI A SISKEM PG ISIS t SWD R KILE -- TS L SSIV G S VS S ekag LPAEEA E SYL K K G ---- Y SLNDRV G TSYL E 269
Cdd:PRK10795 138 N L TEV QVA RF A VNQYRF PG VEVK - GYQ R RYYP yg SA L THVI G Y VS K ---- INDKDV E RLD K E G klan Y AATHDI G KLGI E 212
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 270 KQ YE E VL Q GK RPVK E IHLDKH G DM es VENIE E GS -- K G KN I K LT I DL AF Q DSVDA LL K syfnsel G NGG A kysegvy A V A 347
Cdd:PRK10795 213 RY YE D VL H GK TGYE E VEVNNR G RV -- IRQLH E QP pq A G HD I Y LT L DL KL Q QYIET LL A ------- G SRA A ------- V V V 276
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 348 LN P Q TG AV L SM ---------------- S GLKHD L KTGELT P DSLGTVTN V FV P G S V VK AATIS S GWEN GV LSG N QT L T D q 411
Cdd:PRK10795 277 TD P R TG GI L AL vstpsydpnlfvdgis S KDYSG L LNDPNR P LINRATQG V YP P A S T VK PYVAV S ALSA GV ITR N TS L F D - 355
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 412 P IVF Q -- GS API Y - S W Y K LAY G SFPI T av EA LE Y S SNAYVV Q T A LGI mgqtyqpnmfv G TSN L ESA MGK lrstfge Y G L G 488
Cdd:PRK10795 356 P GWW Q lp GS EKR Y r D W K K WGH G RLNV T -- KS LE E S ADTFFY Q V A YDM ----------- G IDR L SEW MGK ------- F G Y G 415
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 489 SA TGIDL PD E ST G LV P - K E YNFAN F --------- I TNAF GQ - FDNY TP M Q LAQYVA T IA N N G VRLA PH IVEGIYDN ndkg 557
Cdd:PRK10795 416 HY TGIDL AE E RS G NM P t R E WKQKR F kkpwyqgdt I PVGI GQ g YWTA TP I Q MSKALM T LI N D G IVKV PH LLMSTAED ---- 491
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 558 gl G ELIQAIDTK E INKVN I SESDMA I LHQ G F Y Q V SH gt S P LT T GRAFSDG A TVS I SG K T GT GESYVAGGQ E AN N TNAV -- 635
Cdd:PRK10795 492 -- G KQVPWVQPH E PPVGD I HSGYWE I AKD G M Y G V AN -- R P NG T AHKYFAS A PYK I AA K S GT AQVFGLKAN E TY N AHKI ae 567
490 500 510 520
....*....|....*....|....*....|....*....|....*...
2WAE_A 636 --------- A Y AP TE NPQ I AVA VVFPHN tnltk NV GPA --- I A R D I IN 671
Cdd:PRK10795 568 rlrdhklmt A F AP YN NPQ V AVA IILENG ----- GA GPA vgt I M R Q I LD 610
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
303-622
1.83e-16
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 83.05
E-value: 1.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 303 SK G KN I KL T I D LAF Q DSVDALL K SYFN selg N G GAKYSEGV y A V ALN P Q TG A VL S M S G LKHDL K TG eltpds LGTV T NV - 381
Cdd:COG0744 292 RG G LK I YT T L D PKL Q KAAEKAV K NVLP ---- E G KPGGLQAA - L V VVD P K TG E VL A M V G GRDYG K SQ ------ FNRA T QA k 360
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 382 FV PGS VV K AATISSGW E N G v LSGNQ T LT D Q P IV F Q G S apiy S W - Y K LAY G SF -- P I T AV EAL EY S S N AYV V QT A lgimgq 458
Cdd:COG0744 361 RQ PGS TF K PFVYAAAL E Q G - YTPAT T VD D E P VT F P G G ---- G W s P K NYD G RY rg P V T LR EAL AN S L N TPA V RL A ------ 429
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 459 tyqpn MF VG TSNLESAMGK L rstfgeyglgsat GI DL P DE stglvpkeynfa NFITN A F G QFDN y T P MQL A QYV AT I AN N 538
Cdd:COG0744 430 ----- QE VG LDKVVDTARR L ------------- GI TS P LD ------------ PNPSL A L G TSEV - S P LEM A SAY AT F AN G 478
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 539 GV RLA PH IVEGIY D NN dkggl G ELIQAIDT K E in KVN IS ESDMAILHQGFYQ V - SH G tsplt TGRA FS d GATVSIS GKTG 617
Cdd:COG0744 479 GV YVE PH AITKVT D AD ----- G KVLYEAKP K C -- EQV IS PEVAYLMTDMLQD V v TS G ----- TGRA AR - LPGRPVA GKTG 545
....*
2WAE_A 618 T GESY 622
Cdd:COG0744 546 T TNDN 550
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
12-540
1.61e-15
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 80.25
E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 12 R LN LL FSIVI L LFMTII GR LLYM QV L N K D FYEKKLASA S QTKVTT S SA RG E I Y D A SG K PL ventlkqvvsftrsnkmtat 91
Cdd:PRK15105 22 R FA LL CGCIL L ALVFLL GR VAWL QV I N P D MLVREGDMR S LRVQEV S TS RG M I T D R SG R PL -------------------- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 92 dlkeiakklltyv SI S S P nlterql ADYYL ADP - E IYKKTVEALPSEKRLDS D GNRLSESE L y NNAVDSV P TSQL nyted 170
Cdd:PRK15105 82 ------------- AV S V P ------- VKAIW ADP k E VHDAGGISVDDRWKALA D ALNIPLDQ L - SARINAN P KGRF ----- 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 171 ekke IYL FS Q L N - AVGNF atgtiatdplndsqvavias I S K - EM PGI SISTSWD R K iletslssivgsvssekag L P AE E 248
Cdd:PRK15105 136 ---- IYL AR Q V N p DMADY -------------------- I K K l KL PGI HLREESR R Y ------------------- Y P SG E 172
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 249 AESY L K k G YSLN D RV G TSYL EK QYEEV L Q G KRPVKEIHL D KH G DM es V E N I E -- EGSKGK N IK L T ID LAF Q DS V dallks 326
Cdd:PRK15105 173 VTAH L I - G FTNV D SQ G IEGV EK SFDKW L T G QPGERIVRK D RY G RV -- I E D I S st DSQAAH N LA L S ID ERL Q AL V ------ 243
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 327 Y fn S EL G N GG A - KYS E GVY AV ALNPQ TG A VL S M S glkhdl KTGELT P DS L - GT --------- V T N VF V PGS V VK AATISS 395
Cdd:PRK15105 244 Y -- R EL N N AV A f NKA E SGS AV LVDVN TG E VL A M A ------ NSPSYN P NN L s GT pkdamrnra I T D VF E PGS T VK PMVVMT 315
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 396 GWEN GV LSG N QT L TDQ P IVFQ G sapi YSWYKL A - Y GSFPI T A V ea L EY SSN ayvvqtalgimgqtyqpnmf VG T S N L ES A 474
Cdd:PRK15105 316 ALQR GV VKE N SV L NTV P YRIN G ---- HEIKDV A r Y SELTL T G V -- L QK SSN -------------------- VG V S K L AL A 369
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WAE_A 475 M -- GK L RS T FGEY GLG S AT GID L PD E ST GL V P KEYNFANF -- I T NA FG QFDNY TP M QLA QYV ATI ANN G V 540
Cdd:PRK15105 370 M ps SA L VD T YSRF GLG K AT NLG L VG E RS GL Y P QKQRWSDI er A T FS FG YGLMV TP L QLA RVY ATI GSY G I 439
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
