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Conserved domains on  [gi|183448196|pdb|2YUH|A]
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Chain A, Tubulin-specific chaperone C

Protein Classification

TBCC domain-containing protein( domain architecture ID 11172638)

TBCC (Tubulin binding cofactor C) domain-containing protein such as human protein XRP2 that acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane, and human TBCC-domain containing 1 (TBCCD1), a centrosomal protein required for centrosome and Golgi apparatus positioning

CATH:  2.160.20.70|3.30.70.141
Gene Ontology:  GO:0007023

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBCC pfam07986
Tubulin binding cofactor C; Members of this family are involved in the folding pathway of ...
 31-148 7.18e-53

Tubulin binding cofactor C; Members of this family are involved in the folding pathway of tubulins and form a beta helix structure.


:

Pssm-ID: 462331  Cd Length: 119  Bit Score: 164.31  E-value: 7.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YUH_A         31 RDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVED 110
Cdd:pfam07986   2 VDVKLSNLSNCTIYLLDPLSSVTIDDCKNCTIFLGPVSGSVFIRDCENCTIVVACRQLRIHDCTNCDFYLHTTSRPIIED 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
2YUH_A        111 CSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDF 148
Cdd:pfam07986  82 STGIRFAPYNTSYPGLEEHLKSAGLDPENNNWSQVDDF 119
 
Name Accession Description Interval E-value
TBCC pfam07986
Tubulin binding cofactor C; Members of this family are involved in the folding pathway of ...
 31-148 7.18e-53

Tubulin binding cofactor C; Members of this family are involved in the folding pathway of tubulins and form a beta helix structure.


Pssm-ID: 462331  Cd Length: 119  Bit Score: 164.31  E-value: 7.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YUH_A         31 RDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVED 110
Cdd:pfam07986   2 VDVKLSNLSNCTIYLLDPLSSVTIDDCKNCTIFLGPVSGSVFIRDCENCTIVVACRQLRIHDCTNCDFYLHTTSRPIIED 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
2YUH_A        111 CSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDF 148
Cdd:pfam07986  82 STGIRFAPYNTSYPGLEEHLKSAGLDPENNNWSQVDDF 119
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
38-75 9.71e-06

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 40.96  E-value: 9.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
2YUH_A          38 LSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLED 75
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Name Accession Description Interval E-value
TBCC pfam07986
Tubulin binding cofactor C; Members of this family are involved in the folding pathway of ...
 31-148 7.18e-53

Tubulin binding cofactor C; Members of this family are involved in the folding pathway of tubulins and form a beta helix structure.


Pssm-ID: 462331  Cd Length: 119  Bit Score: 164.31  E-value: 7.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YUH_A         31 RDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVED 110
Cdd:pfam07986   2 VDVKLSNLSNCTIYLLDPLSSVTIDDCKNCTIFLGPVSGSVFIRDCENCTIVVACRQLRIHDCTNCDFYLHTTSRPIIED 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
2YUH_A        111 CSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDF 148
Cdd:pfam07986  82 STGIRFAPYNTSYPGLEEHLKSAGLDPENNNWSQVDDF 119
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
38-75 9.71e-06

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 40.96  E-value: 9.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
2YUH_A          38 LSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLED 75
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
76-110 1.44e-03

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 34.80  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
2YUH_A          76 CSDCVLAVA--CQQLRIHSTKDTRIFL-QVTSRAIVED 110
Cdd:smart00673   1 CESCTIQVSgkVNTISIDKCKKCSIYLgPVSGSPEIVN 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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