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Conserved domains on  [gi|284055570|pdb|3H3P|I]
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Chain I, Fv 4E10 heavy chain

Protein Classification

immunoglobulin heavy chain variable domain-containing protein( domain architecture ID 10141748)

immunoglobulin heavy chain variable domain-containing protein similar to immunoglobulin heavy chains

CATH:  2.60.40.10
Gene Ontology:  GO:0003823
PubMed:  9571064|9541533
SCOP:  3000071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 5-128 1.70e-59

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 179.43  E-value: 1.70e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        5 QLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNYAPRFQGRITITADRSTSTAYLE 84
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
3H3P_I       85 LNSLRPEDTAVYYCAREGTTGAGWlgkpigAFAHWGQGTLVTVS 128
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGYS------YFDYWGQGTTVTVS 118
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 5-128 1.70e-59

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 179.43  E-value: 1.70e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        5 QLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNYAPRFQGRITITADRSTSTAYLE 84
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
3H3P_I       85 LNSLRPEDTAVYYCAREGTTGAGWlgkpigAFAHWGQGTLVTVS 128
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGYS------YFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
19-100 1.36e-31

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.47  E-value: 1.36e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I          19 SVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGgVIPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPEDTAVYYC 98
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
3H3P_I          99 AR 100
Cdd:smart00406  80 AV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 17-99 6.93e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.45  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I         17 GSSVTVSCKASGGSFS-TYALSWVRQAPGRGLEWMggvipLLTITNYAP--RFQGRITITADRSTSTAYLELNSLRPEDT 93
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEaSTSVYWYRQPPGKGPTFL-----IAYYSNGSEegVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85


                  ....*.
3H3P_I         94 AVYYCA 99
Cdd:pfam07686  86 GTYTCA 91
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 5-128 1.70e-59

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 179.43  E-value: 1.70e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        5 QLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNYAPRFQGRITITADRSTSTAYLE 84
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
3H3P_I       85 LNSLRPEDTAVYYCAREGTTGAGWlgkpigAFAHWGQGTLVTVS 128
Cdd:cd04981  81 LNSLTSEDTAVYYCARGLGGYGYS------YFDYWGQGTTVTVS 118
IGv smart00406
Immunoglobulin V-Type;
19-100 1.36e-31

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 107.47  E-value: 1.36e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I          19 SVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGgVIPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPEDTAVYYC 98
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLG-YIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
3H3P_I          99 AR 100
Cdd:smart00406  80 AV 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 6-127 2.34e-22

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 85.08  E-value: 2.34e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        6 LVQSGAEV-KRPGSSVTVSCKASGgSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNyaPRFQGRITITADrSTSTAYLE 84
Cdd:cd00099   1 VTQSPRSLsVQEGESVTLSCEVSS-SFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTK--GGVPGRFSGSRD-GTSSFSLT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
3H3P_I       85 LNSLRPEDTAVYYCARegtTGAGWLGKPIgafahWGQGTLVTV 127
Cdd:cd00099  77 ISNLQPEDSGTYYCAV---SESGGTDKLT-----FGSGTRLTV 111
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 8-127 6.79e-17

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 70.76  E-value: 6.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        8 QSGAEVKRP-GSSVTVSCKASggSFSTYALSWVRQAPGRGLEWmggvipLLTITNYAPRFQ-GRITITADRSTSTAYLEL 85
Cdd:cd04983   3 QSPQSLSVQeGENVTLNCNYS--TSTFYYLFWYRQYPGQGPQF------LIYISSDSGNKKkGRFSATLDKSRKSSSLHI 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
3H3P_I       86 NSLRPEDTAVYYCAregTTGAGWLGKPIgafahWGQGTLVTV 127
Cdd:cd04983  75 SAAQLSDSAVYFCA---LSESGGTGKLT-----FGKGTRLTV 108
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 13-128 3.05e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 67.00  E-value: 3.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I       13 VKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPED 92
Cdd:cd04982   9 TREESKSVTISCKVSGIDFSTTYIHWYRQKPGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTSTLTITNLEKED 88

                        90       100       110
                ....*....|....*....|....*....|....*.
3H3P_I       93 TAVYYCaregttgAGWLGKPIGAFAHWGQGTLVTVS 128
Cdd:cd04982  89 SATYYC-------AYWESGSGYYIKVFGSGTKLIVT 117
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 13-108 1.24e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.74  E-value: 1.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I          13 VKRPGSSVTVSCKASGgsFSTYALSWVRQapgrGLEWmggviplltitnyaPRFQGRITITadRSTSTAYLELNSLRPED 92
Cdd:smart00410   5 TVKEGESVTLSCEASG--SPPPEVTWYKQ----GGKL--------------LAESGRFSVS--RSGSTSTLTISNVTPED 62

                           90
                   ....*....|....*.
3H3P_I          93 TAVYYCAREGTTGAGW 108
Cdd:smart00410  63 SGTYTCAATNSSGSAS 78
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 13-127 2.74e-11

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 56.52  E-value: 2.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I       13 VKRPGSSVTVSCKASGGSfstYALSWVRQAPGRGLEWMG---GVIPLLTITNYAPRFQGRITitadrSTSTAYLELNSLR 89
Cdd:cd05899   9 IKRRGQSVTLRCSQKSGH---DNMYWYRQDPGKGLQLLFysyGGGLNEEGDLPGDRFSASRP-----SLTRSSLTIKSAE 80

                        90       100       110
                ....*....|....*....|....*....|....*...
3H3P_I       90 PEDTAVYYCAregtTGAGWLGKPigafAHWGQGTLVTV 127
Cdd:cd05899  81 PEDSAVYLCA----SSLGGGADE----AYFGPGTRLTV 110
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 6-99 3.07e-09

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 50.92  E-value: 3.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        6 LVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGlewmggviPLLTI--TNYAP-----RFQGRItitadrST 78
Cdd:cd04984   2 LTQPSSLSVSPGETVTITCTGSSGNISGNYVNWYQQKPGSA--------PRYLIyeDKHRPsgipdRFSGSK------SG 67

                        90       100
                ....*....|....*....|.
3H3P_I       79 STAYLELNSLRPEDTAVYYCA 99
Cdd:cd04984  68 NTASLTISGAQTEDEADYYCQ 88
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 3-100 3.24e-09

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 51.02  E-value: 3.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        3 QVQLVQSGAEVKRPGSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWMGGVIPLLTITNyaprfQGRITITADRSTSTAY 82
Cdd:cd16095   1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLTSLDHISTKVS-----EDRITSSREDTNSQIF 75

                        90
                ....*....|....*...
3H3P_I       83 LELNSLRPEDTAVYYCAR 100
Cdd:cd16095  76 LQIKGLGLRDSGQYHCAR 93
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 17-127 1.33e-08

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 49.48  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I       17 GSSVTVSCKASGGSFSTYALSWVRQAPGRGLEWM---GGViplltitnYAPRFQGRITITADRSTSTAYLELNSLRPEDT 93
Cdd:cd20988  13 GKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFIyreGGI--------YGPGFKDNFRGDIDSSNNLAVLKILEASERDE 84

                        90       100       110
                ....*....|....*....|....*....|....
3H3P_I       94 AVYYCAREGTTGAGWLGKPIgafahWGQGTLVTV 127
Cdd:cd20988  85 GSYYCASDTPGGGREYDPLI-----FGKGTYLTV 113
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 4-104 2.57e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 48.54  E-value: 2.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        4 VQLVQSGAEVK-RPGSSVTVSCKASGGSFSTYaLSWVRQAPGRglewmggvIPLLTITNYAPRFQGritiTADRSTSTAY 82
Cdd:cd04980   1 IVMTQSPASLSvSPGERVTISCKASQSISSNY-LAWYQQKPGQ--------APKLLIYYASTLHSG----VPSRFSGSGS 67

                        90       100
                ....*....|....*....|....*..
3H3P_I       83 -----LELNSLRPEDTAVYYCAREGTT 104
Cdd:cd04980  68 gtdftLTISSVEPEDAAVYYCQQGYTF 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 17-99 6.93e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.45  E-value: 6.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I         17 GSSVTVSCKASGGSFS-TYALSWVRQAPGRGLEWMggvipLLTITNYAP--RFQGRITITADRSTSTAYLELNSLRPEDT 93
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEaSTSVYWYRQPPGKGPTFL-----IAYYSNGSEegVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85


                  ....*.
3H3P_I         94 AVYYCA 99
Cdd:pfam07686  86 GTYTCA 91
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 19-103 1.62e-06

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 43.98  E-value: 1.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I       19 SVTVSCKASGGSFST--YALSWvRQAPG--RGLEWMGGVIPLLTITNYAPRFQGRITITADRSTSTAYLELNSLRPEDTA 94
Cdd:cd07700  15 TVKMSCEAKTSPKNTriYWLRQ-RQAPSkdSHFEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRYILSLMSVKPEDSG 93


                ....*....
3H3P_I       95 VYYCAREGT 103
Cdd:cd07700  94 TYFCMTVGS 102
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 2-127 1.32e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 39.04  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3H3P_I        2 SQVQLVQSGAEvkrpGSSVTVSCKASGgSFSTYALSWVRQAPGRGLEWMggvipLLTITNYAPRFQGRITITADRSTSTA 81
Cdd:cd07706   3 TQAQPDVSVQV----GEEVTLNCRYET-SWTNYYLFWYKQLPSGEMTFL-----IRQDSSEQNAKSGRYSVNFQKAQKSI 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
3H3P_I       82 YLELNSLRPEDTAVYYCAregTTGAGWLGKPIgafahWGQGTLVTV 127
Cdd:cd07706  73 SLTISALQLEDSAKYFCA---LSLPYDTDKLI-----FGKGTRLTV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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