|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02970 |
PLN02970 |
serine racemase |
1-322 |
2.70e-144 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 410.61 E-value: 2.70e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 1 MDAQYDISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEgkpKAVV 80
Cdd:PLN02970 3 ASEKYAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 81 THSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVI 160
Cdd:PLN02970 80 THSSGNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 161 AGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGV 240
Cdd:PLN02970 160 SGQGTIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 241 KSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSP--EVKNICIVLSGGNVD 318
Cdd:PLN02970 239 RASLGDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVD 318
|
....
3HMK_B 319 LTSL 322
Cdd:PLN02970 319 LGVL 322
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
9-318 |
7.15e-124 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 357.57 E-value: 7.15e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 9 FADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGNHG 88
Cdd:cd01562 1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSLSE---EERAKGVVAASAGNHA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:cd01562 78 QGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLN 247
Cdd:cd01562 158 EILEQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVD-TIADGLAvKRPGEL 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3HMK_B 248 TWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQtvsPEVKNICIVLSGGNVD 318
Cdd:cd01562 237 TFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSGGNID 304
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
7-327 |
1.16e-107 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 317.36 E-value: 1.16e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGN 86
Cdd:COG1171 6 PTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASLSE---EERARGVVAASAGN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTI 166
Cdd:COG1171 83 HAQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 167 ALEVLNQVPLVDALvvpvggggmvagIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVK-SSIG 245
Cdd:COG1171 163 ALEILEQLPDLDAVfvpvggggliagVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVT-LPGVDTIADGLAvGRPG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQtvsPEVKNICIVLSGGNVDLTSLSWV 325
Cdd:COG1171 242 ELTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSGGNIDPDRLAEI 318
|
..
3HMK_B 326 KQ 327
Cdd:COG1171 319 LE 320
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
7-323 |
2.19e-97 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 291.15 E-value: 2.19e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGN 86
Cdd:PRK07048 6 PTYDDVAAAAARLAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQFSP---EQRRAGVVTFSSGN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK07048 83 HAQAIALSARLLGIPATIVMPQDAPAAKVAATRGYGGEVVTYDRYTEDREEIGRRLAEERGLTLIPPYDHPHVIAGQGTA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVKS-SIG 245
Cdd:PRK07048 163 AKELFEEVGPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPEAGNDGQQSFRSGEIV-HIDTPRTIADGAQTqHLG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3HMK_B 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSqhfQTVSPEVKNICIVLSGGNVDLTSLS 323
Cdd:PRK07048 242 NYTFPIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALR---GKVPLKGKRVGVIISGGNVDLARFA 316
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
8-323 |
1.04e-75 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 236.21 E-value: 1.04e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 8 SFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGK-PKAVVTHSSGN 86
Cdd:PRK06608 6 NPQNIAAAHNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKE---QGKlPDKIVAYSTGN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRiiQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK06608 83 HGQAVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNTRQEAEEKAKED--EEQGFYYIHPSDSDSTIAGAGTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 167 ALEVLNQVPL-VDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKS-SI 244
Cdd:PRK06608 161 CYEALQQLGFsPDAIFASCGGGGLISGTYLAKELISPTSLLIGSEPLNANDAYLSLKNNKIYRLNYSPNTIADGLKTlSV 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HMK_B 245 GLNTWPIIRDLvDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPevKNICIVLSGGNVDLTSLS 323
Cdd:PRK06608 241 SARTFEYLKKL-DDFYLVEEYEIYYWTAWLTHLLKVICEPSSAINMVAVVNWLKTQSKP--QKLLVILSGGNIDPILYN 316
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
26-314 |
2.34e-72 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 226.04 E-value: 2.34e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:pfam00291 8 TPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKE---GEGGKTVVEASSGNHGRALAAAAARLGLKVTIV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 106 VPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEG-ILVHPNQEPAVIAGQGTIALEVLNQV-PLVDALVVP 183
Cdd:pfam00291 85 VPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGaYYINQYDNPLNIEGYGTIGLEILEQLgGDPDAVVVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 184 VGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GLNTWPIIRDLVDDVFT 261
Cdd:pfam00291 165 VGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVP-VPVADTIADGLGVGDepGALALDLLDEYVGEVVT 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
3HMK_B 262 VTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEvKNICIVLSG 314
Cdd:pfam00291 244 VSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-DRVVVVLTG 295
|
|
| ilvA_1Cterm |
TIGR01127 |
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ... |
26-325 |
2.78e-68 |
|
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130197 [Multi-domain] Cd Length: 380 Bit Score: 218.46 E-value: 2.78e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:TIGR01127 1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANL---SEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 106 VPQTAPNCKKLAIQAYGASIV-YSEPSDESREnVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184
Cdd:TIGR01127 78 MPESAPPSKVKATKSYGAEVIlHGDDYDEAYA-FATSLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 185 GGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:TIGR01127 157 GGGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVR-TIADGIAvKKPGDLTFNIIKEYVDDVVTVD 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
3HMK_B 264 EDEIKYATQLVWERMKLLIEPTAGVGLAAVLSqhfQTVSPEVKNICIVLSGGNVDLTSLSWV 325
Cdd:TIGR01127 236 EEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGKKIAVVLSGGNIDLNLLNKI 294
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
9-322 |
4.17e-67 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 213.40 E-value: 4.17e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 9 FADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRgLIPDtlEGKPKAVVTHSSGNHG 88
Cdd:PRK06815 4 FDAILEAHQRLRPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLR-LLNE--AQRQQGVITASSGNHG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:PRK06815 81 QGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGDALNAELAARRAAEQQGKVYISPYNDPQVIAGQGTIGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GL 246
Cdd:PRK06815 161 ELVEQQPDLDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSLYTSLEAGEIVE-VAEQPTLSDGTAGGVepGA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3HMK_B 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQhfqtvSPEV--KNICIVLSGGNVDLTSL 322
Cdd:PRK06815 240 ITFPLCQQLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKL-----APRYqgKKVAVVLCGKNIVLEKY 312
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
1-323 |
1.59e-62 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 202.27 E-value: 1.59e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 1 MDAQYD--ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTLEGKPKA 78
Cdd:PRK08638 1 MHITYDlpVAIDDIIEAKQRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSL---TDAEKRKG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YSEPSDESRENVAQRIiqETEG-ILVHPNQE 156
Cdd:PRK08638 78 VVACSAGNHAQGVALSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVlHGDNFNDTIAKVEEIV--EEEGrTFIPPYDD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 157 PAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTI 236
Cdd:PRK08638 156 PKVIAGQGTIGLEILEDLWDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQSENVHGMAASFYAGEITTHRTTG-TL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 237 ADGVKSSI-GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVlSGG 315
Cdd:PRK08638 235 ADGCDVSRpGNLTYEIVRELVDDIVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLSGKLDQYIQNKKVVAII-SGG 313
|
....*...
3HMK_B 316 NVDLTSLS 323
Cdd:PRK08638 314 NVDLSRVS 321
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
7-318 |
7.71e-59 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 194.73 E-value: 7.71e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGN 86
Cdd:PRK07334 5 VTLADIRAAAARLAGQVLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNKLLLLTE---EERARGVIAMSAGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YSEPSDESRENVAQriIQETEG-ILVHPNQEPAVIAGQG 164
Cdd:PRK07334 82 HAQGVAYHAQRLGIPATIVMPRFTPTVKVERTRGFGAEVVlHGETLDEARAHARE--LAEEEGlTFVHPYDDPAVIAGQG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQsKLKGELTPNLHppETIADG--VKs 242
Cdd:PRK07334 160 TVALEMLEDAPDLDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQTELYPSMYA-AIKGVALPCGG--STIAEGiaVK- 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3HMK_B 243 SIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLS--QHFQTvspevKNICIVLSGGNVD 318
Cdd:PRK07334 236 QPGQLTLEIVRRLVDDILLVSEADIEQAVSLLLEIEKTVVEGAGAAGLAALLAypERFRG-----RKVGLVLSGGNID 308
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
7-319 |
2.18e-57 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 188.64 E-value: 2.18e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtlEGKPKAVVTHSSGN 86
Cdd:PRK07476 1 VSLADIYRARRRIAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSLSA---QERARGVVTASTGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK07476 78 HGRALAYAARALGIRATICMSRLVPANKVDAIRALGAEVRIVGRSQDDAQAEVERLVREEGLTMVPPFDDPRIIAGQGTI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGeltpnlHP-----PETIADGVK 241
Cdd:PRK07476 158 GLEILEALPDVATVLVPLSGGGLASGVAAAVKAIRPAIRVIGVSMERGAAMHASLAAG------RPvqveeVPTLADSLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 242 SSIGLN---TWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSqhfQTVSPEVKNICIVLSGGNVD 318
Cdd:PRK07476 232 GGIGLDnryTFAMCRALLDDVVLLDEAEIAAGIRHAYREERLVVEGAGAVGIAALLA---GKIAARDGPIVVVVSGANID 308
|
.
3HMK_B 319 L 319
Cdd:PRK07476 309 M 309
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
26-315 |
3.39e-54 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 177.71 E-value: 3.39e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEE-GKLPKGVIIESTGGNTGIALAAAAARLGLKCTIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 106 VPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEG-ILVHPNQEPAVIAGQGTIALEVLNQVP--LVDALVV 182
Cdd:cd00640 80 MPEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPGaYYVNQFDNPANIAGQGTIGLEILEQLGgqKPDAVVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 183 PVGGGGMVAGIAITIKTLKPSVKVYAAEPsnaddcyqsklkgeltpnlhppetiadgvkssiglntwpiirdlvdDVFTV 262
Cdd:cd00640 160 PVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------------------EVVTV 193
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
3HMK_B 263 TEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTvsPEVKNICIVLSGG 315
Cdd:cd00640 194 SDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
7-322 |
3.01e-51 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 172.06 E-value: 3.01e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSIlNQIAGRNLFFKCELFQKTGSFKIRGALNAIR-GLIPdtlegkPKAVVTHSSG 85
Cdd:PRK08246 5 ITRSDVRAAAQRIAPHIRRTPVLEADG-AGFGPAPVWLKLEHLQHTGSFKARGAFNRLLaAPVP------AAGVVAASGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 86 NHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGT 165
Cdd:PRK08246 78 NAGLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVVVVGAEYADALEAAQAFAAETGALLCHAYDQPEVLAGAGT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 166 IALEVLNQVPLVDALVVPVGGGGMVAGIAitiKTLKPSVKVYAAEPSNADDCYQSKLKGEltpnlhPPETIADGVKSS-- 243
Cdd:PRK08246 158 LGLEIEEQAPGVDTVLVAVGGGGLIAGIA---AWFEGRARVVAVEPEGAPTLHAALAAGE------PVDVPVSGIAADsl 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 244 ----IGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEvkNICIVLSGGNVDL 319
Cdd:PRK08246 229 garrVGEIAFALARAHVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAALLSGAYVPAPGE--RVAVVLCGANTDP 306
|
...
3HMK_B 320 TSL 322
Cdd:PRK08246 307 ATL 309
|
|
| ectoine_eutB |
TIGR02991 |
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted ... |
7-319 |
1.06e-46 |
|
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida. Members of this family resemble threonine dehydratases.
Pssm-ID: 132036 [Multi-domain] Cd Length: 317 Bit Score: 160.79 E-value: 1.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTLEGKPKAVVTHSSGN 86
Cdd:TIGR02991 1 VTLQDIERAAARISGRVEETPLVESPSLSELCGVPVHLKLEHRQTTGSFKLRGATNAVLSL---SDTQRAAGVVAASTGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASI-VYSEPSDESRENVaQRIIQETEGILVHPNQEPAVIAGQGT 165
Cdd:TIGR02991 78 HGRALAYAAAEEGVRATICMSELVPQNKVDEIRRLGAEVrIVGRSQDDAQEEV-ERLVADRGLTMLPPFDHPDIVAGQGT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 166 IALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSkLKGELTPNLHPPETIADGVKSSIG 245
Cdd:TIGR02991 157 LGLEVVEQMPDLATVLVPLSGGGLASGVAMAVKAARPDTRVIGVSMERGAAMKAS-LQAGRPVLVAELPTLADSLGGGIG 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3HMK_B 246 LN---TWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPevknICIVLSGGNVDL 319
Cdd:TIGR02991 236 LDnrvTFAMCKALLDEIVLVSEAEIAAGIRHAYAEEREIVEGAGAVGIAALLAGKIKNPGP----CAVIVSGRNIDM 308
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
39-330 |
3.41e-42 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 152.99 E-value: 3.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 39 GRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEgkpKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAI 118
Cdd:PRK09224 34 GNQVLLKREDLQPVFSFKLRGAYNKMAQLTEEQLA---RGVITASAGNHAQGVALSAARLGIKAVIVMPVTTPDIKVDAV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 119 QAYGASIV-----YSEPSDESREnvaqriIQETEG-ILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMVA 191
Cdd:PRK09224 111 RAFGGEVVlhgdsFDEAYAHAIE------LAEEEGlTFIHPFDDPDVIAGQGTIAMEILQQHPhPLDAVFVPVGGGGLIA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 192 GIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADG--VKsSIGLNTWPIIRDLVDDVFTVTEDEIKY 269
Cdd:PRK09224 185 GVAAYIKQLRPEIKVIGVEPEDSACLKAALEAGERV-DLPQVGLFADGvaVK-RIGEETFRLCQEYVDDVITVDTDEICA 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
3HMK_B 270 ATQLVWERMKLLIEPTAGVGLAAvLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVkqAER 330
Cdd:PRK09224 263 AIKDVFEDTRSIAEPAGALALAG-LKKYVAQHGIEGETLVAILSGANMNFDRLRYV--AER 320
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
26-330 |
3.09e-41 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 150.72 E-value: 3.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEgkpKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:PRK12483 38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARLPAEQLA---RGVITASAGNHAQGVALAAARLGVKAVIV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 106 VPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPV 184
Cdd:PRK12483 115 MPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEEGLTFVPPFDDPDVIAGQGTVAMEILRQHPgPLDAIFVPV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 185 GGGGMVAGIAITIKTLKPSVKVYAAEPSNAdDCYQSKLKGELTPNLHPPETIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:PRK12483 195 GGGGLIAGIAAYVKYVRPEIKVIGVEPDDS-NCLQAALAAGERVVLGQVGLFADGVAvAQIGEHTFELCRHYVDEVVTVS 273
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
3HMK_B 264 EDEIKYATQLVWERMKLLIEPTAGVGLAAvLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVkqAER 330
Cdd:PRK12483 274 TDELCAAIKDIYDDTRSITEPAGALAVAG-IKKYAEREGIEGQTLVAIDSGANVNFDRLRHV--AER 337
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
1-330 |
2.87e-36 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 135.32 E-value: 2.87e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 1 MDAQYDISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTLEGKPKAVV 80
Cdd:PRK08639 1 MTVKMTVSAKDIDKAAKRLKDVVPETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAISQL---SDEELAAGVV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 81 THSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGAS----IVYSEPSDESrENVAQRIIQETEGILVHPNQE 156
Cdd:PRK08639 78 CASAGNHAQGVAYACRHLGIPGVIFMPVTTPQQKIDQVRFFGGEfveiVLVGDTFDDS-AAAAQEYAEETGATFIPPFDD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 157 PAVIAGQGTIALEVLNQV---PLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPP 233
Cdd:PRK08639 157 PDVIAGQGTVAVEILEQLekeGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPAGAASMKAALEAGKPVT-LEKI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 234 ETIADG--VKSsIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPtAGVGLAAVLSQHFQTVspEVKNICIV 311
Cdd:PRK08639 236 DKFVDGaaVAR-VGDLTFEILKDVVDDVVLVPEGAVCTTILELYNKEGIVAEP-AGALSIAALELYKDEI--KGKTVVCV 311
|
330
....*....|....*....
3HMK_B 312 LSGGNVDLTSLSWVKqaER 330
Cdd:PRK08639 312 ISGGNNDIERMPEIK--ER 328
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
7-333 |
7.09e-32 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 122.04 E-value: 7.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 7 ISFADVEKAHLNIQDSVHLTPVltssilnQIAGR-NLFFKCELFQKTGSFKIRGALNAirgLIPDTLEGKPKAVVTHSSG 85
Cdd:PRK08813 21 VSVADVLAAQARLRRYLSPTPL-------HYAERfGVWLKLENLQRTGSYKVRGALNA---LLAGLERGDERPVICASAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 86 NHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGT 165
Cdd:PRK08813 91 NHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAYAFARELADQNGYRFLSAFDDPDVIAGQGT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 166 IALEVLNQVPlvDALVVPVGGGGMVAGIAITIKTlkPSVKVYAAEPSNADDCYQSkLKGELTpNLHPPETIADGVKSSI- 244
Cdd:PRK08813 171 VGIELAAHAP--DVVIVPIGGGGLASGVALALKS--QGVRVVGAQVEGVDSMARA-IRGDLR-EIAPVATLADGVKVKIp 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 245 GLNTWPIIRDLVDDVFTVTEDEIKYA-TQLVWERmKLLIEPTAGVGLAAvlsqhFQTVSPEVKniCIVLSGGNVDLTSLS 323
Cdd:PRK08813 245 GFLTRRLCSSLLDDVVIVREAELRETlVRLALEE-HVIAEGAGALALAA-----GRRVSGKRK--CAVVSGGNIDATVLA 316
|
330
....*....|
3HMK_B 324 WVKQAERPAP 333
Cdd:PRK08813 317 TLLSEVRPRP 326
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
24-327 |
2.67e-30 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 120.80 E-value: 2.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 24 HLTPVLTSSI--------------LNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEgkpKAVVTHSSGNHGQ 89
Cdd:PLN02550 94 YLTNILSAKVydvaiesplqlakkLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKEQLD---KGVICSSAGNHAQ 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 90 ALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPS-DESRENVAQRIIQETEgILVHPNQEPAVIAGQGTIAL 168
Cdd:PLN02550 171 GVALSAQRLGCDAVIAMPVTTPEIKWQSVERLGATVVLVGDSyDEAQAYAKQRALEEGR-TFIPPFDHPDVIAGQGTVGM 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 169 EVLNQVP-LVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVK-SSIGL 246
Cdd:PLN02550 250 EIVRQHQgPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPSDANAMALSLHHGERV-MLDQVGGFADGVAvKEVGE 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVlSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVK 326
Cdd:PLN02550 329 ETFRLCRELVDGVVLVSRDAICASIKDMFEEKRSILEPAGALALAGA-EAYCKYYGLKDENVVAITSGANMNFDRLRIVT 407
|
.
3HMK_B 327 Q 327
Cdd:PLN02550 408 E 408
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
8-325 |
2.12e-28 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 112.01 E-value: 2.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 8 SFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtlEGKPKAVVTHSSGNH 87
Cdd:PRK06110 4 TLAELEAAAAVVYAAMPPTPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARR--GPRVRGVISATRGNH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YSEPSDESRENvAQRIIQETEGILVhPNQEPAVIAGQGTI 166
Cdd:PRK06110 82 GQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAELIeHGEDFQAAREE-AARLAAERGLHMV-PSFHPDLVRGVATY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGEL--TPNlhpPETIADGVKSSI 244
Cdd:PRK06110 160 ALELFRAVPDLDVVYVPIGMGSGICGAIAARDALGLKTRIVGVVSAHAPAYALSFEAGRVvtTPV---ATTLADGMACRT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 245 GL-NTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTvspEVKNICIVLSGGNVDLTSLS 323
Cdd:PRK06110 237 PDpEALEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQERERL---AGKRVGLVLSGGNIDRAVFA 313
|
..
3HMK_B 324 WV 325
Cdd:PRK06110 314 RV 315
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
26-312 |
6.17e-26 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 104.90 E-value: 6.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDTlegkpkAVVTHSSGNHGQALTYAAKLEG 99
Cdd:cd01561 3 TPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIedaekRGLLkPGT------TIIEPTSGNTGIGLAMVAAAKG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSD----ESRENVAQRIIQETEGIlVHPNQ--EPA-VIAGQGTIALEVLN 172
Cdd:cd01561 77 YRFIIVMPETMSEEKRKLLRALGAEVILTPEAEadgmKGAIAKARELAAETPNA-FWLNQfeNPAnPEAHYETTAPEIWE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 173 QVP-LVDALvvpvggggmvagIA-------IT-----IKTLKPSVKVYAAEPSNADdcyqsklkgeLTPNLHPPETIADG 239
Cdd:cd01561 156 QLDgKVDAF------------VAgvgtggtITgvaryLKEKNPNVRIVGVDPVGSV----------LFSGGPPGPHKIEG 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
3HMK_B 240 vkssIGLNTWPII--RDLVDDVFTVTEDE-IKYATQLVwERMKLLIEPTAGVGLAAVLsqHFQTVSPEVKNICIVL 312
Cdd:cd01561 214 ----IGAGFIPENldRSLIDEVVRVSDEEaFAMARRLA-REEGLLVGGSSGAAVAAAL--KLAKRLGPGKTIVTIL 282
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
26-316 |
8.20e-23 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 96.60 E-value: 8.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPkAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:cd06448 2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLNECV-HVVCSSGGNAGLAAAYAARKLGVPCTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 106 VPQTAPNCKKLAIQAYGASIVYS-----EPSDESRENVAQRIIqetEGILVHPNQEPAVIAGQGTIALEVLNQVPL---V 177
Cdd:cd06448 81 VPESTKPRVVEKLRDEGATVVVHgkvwwEADNYLREELAENDP---GPVYVHPFDDPLIWEGHSSMVDEIAQQLQSqekV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 178 DALVVPVGGGGMVAGIaitIKTLK----PSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSS-IGLNTW--- 249
Cdd:cd06448 158 DAIVCSVGGGGLLNGI---VQGLErngwGDIPVVAVETEGAHSLNASLKAGKLVT-LPKITSVATSLGAKtVSSQALeya 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 250 ---PIIRDLVDD------VFTVTEDEikyatqlvwermKLLIEPTAGVGLAAVLSQHFQTVSPEVK-----NICIVLSGG 315
Cdd:cd06448 234 qehNIKSEVVSDrdavqaCLRFADDE------------RILVEPACGAALAVVYSGKILDLQLEVLltpldNVVVVVCGG 301
|
.
3HMK_B 316 N 316
Cdd:cd06448 302 S 302
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
26-294 |
9.14e-23 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 97.58 E-value: 9.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKcELFQ-KTGSFKIRG---ALNAIRGLipdtleGKpKAVVTHSSGNHGQAL-TYAAKlEGI 100
Cdd:COG0498 67 TPLVKAPRLADELGKNLYVK-EEGHnPTGSFKDRAmqvAVSLALER------GA-KTIVCASSGNGSAALaAYAAR-AGI 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 101 PAYIVVPQT-APNCKKLAIQAYGASIV-----YSEpsdesRENVAQRIIQETEGILVHpNQEPAVIAGQGTIALEV---L 171
Cdd:COG0498 138 EVFVFVPEGkVSPGQLAQMLTYGAHVIavdgnFDD-----AQRLVKELAADEGLYAVN-SINPARLEGQKTYAFEIaeqL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 172 NQVP---------LVDALvvpvggggmvagiAI-----------TIKTLkPsvKVYAAEPSNADDCYQSKLKGELTPNLH 231
Cdd:COG0498 212 GRVPdwvvvptgnGGNIL-------------AGykafkelkelgLIDRL-P--RLIAVQATGCNPILTAFETGRDEYEPE 275
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
3HMK_B 232 PPETIADGVksSIG--LNTWPIIRDLVD---DVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVL 294
Cdd:COG0498 276 RPETIAPSM--DIGnpSNGERALFALREsggTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLR 341
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
26-294 |
1.10e-19 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 88.03 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRglipDTLEGKPKAVVTHSSGNHGQAL-TYAAKlEGIPAY 103
Cdd:cd01563 23 TPLVRAPRLGERLGgKNLYVKDEGLNPTGSFKDRGMTVAVS----KAKELGVKAVACASTGNTSASLaAYAAR-AGIKCV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 104 IVVPQTAPNCKKLAIQAYGASIVysePSDESRE---NVAQRIIQETEGILVHpNQEPAVIAGQGTIALEVLNQ------- 173
Cdd:cd01563 98 VFLPAGKALGKLAQALAYGATVL---AVEGNFDdalRLVRELAEENWIYLSN-SLNPYRLEGQKTIAFEIAEQlgwevpd 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 174 ---VPLVDALVVPVGGGGMVAGIAITIKTLKPsvKVYAAEPSNADDCYQSKLKG--ELTPNLHpPETIADGVKssIGlN- 247
Cdd:cd01563 174 yvvVPVGNGGNITAIWKGFKELKELGLIDRLP--RMVGVQAEGAAPIVRAFKEGkdDIEPVEN-PETIATAIR--IG-Np 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
3HMK_B 248 -TWPIIRDLVD----DVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVL 294
Cdd:cd01563 248 aSGPKALRAVResggTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLK 299
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
18-294 |
6.81e-18 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 82.40 E-value: 6.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 18 NIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDT--LEGkpkavvthSSGNHGQ 89
Cdd:COG0031 6 SILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIedaekRGLLkPGGtiVEA--------TSGNTGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 90 ALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSD--ESRENVAQRIIQETEGIlVHPNQ--EPA-VIAGQG 164
Cdd:COG0031 78 GLAMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEgmKGAIDKAEELAAETPGA-FWPNQfeNPAnPEAHYE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 165 TIALEVLNQVPL-VDALvvpvggggmvagIA-------IT-----IKTLKPSVKVYAAEPSNAddcyqSKLKGElTPNLH 231
Cdd:COG0031 157 TTGPEIWEQTDGkVDAF------------VAgvgtggtITgvgryLKERNPDIKIVAVEPEGS-----PLLSGG-EPGPH 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
3HMK_B 232 PPETIADGVKSSIglntwpIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVL 294
Cdd:COG0031 219 KIEGIGAGFVPKI------LDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAAL 275
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
33-318 |
3.14e-14 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 72.41 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 33 ILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdtLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPN 112
Cdd:TIGR00260 31 LAANVGIKNLYVKELGHNPTLSFKDRGMAVALTKA----LELGNDTVLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKIS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 113 CKKLAIQ-AYGASIV-YSEPSDESRENVAQrIIQETEGILVHP-NQEPAVIAGQGTIALEVLNQVP------LVDALVVP 183
Cdd:TIGR00260 107 LGKLAQAlGYNAEVVaIDGNFDDAQRLVKQ-LFEDKPALGLNSaNSIPYRLEGQKTYAFEAVEQLGweapdkVVVPVPNS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 184 VGGGGMVAGIAITIKTLKPSVKVY-AAEPSNADDCYQSKLK-GELTPNLHPpETIA---DGVKSSIGLNTWPIIRDLVDD 258
Cdd:TIGR00260 186 GNFGAIWKGFKEKKMLGLDSLPVKrGIQAEGAADIVRAFLEgGQWEPIETP-ETLStamDIGNPANWPRALEAFRRSNGY 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
3HMK_B 259 VFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQ-TVSPEVKNICIVLSGGNVD 318
Cdd:TIGR00260 265 AEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKgTADPAERVVCALTGNGLKD 325
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
26-314 |
1.12e-13 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 71.38 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIaGRNLFFKCELFQKTGSFKIRGALNAIRglipDTLEGKPKAVVTHSSGNHGQALT-YAAKlEGIPAYI 104
Cdd:PRK05638 67 TPLIRARISEKL-GENVYIKDETRNPTGSFRDRLATVAVS----YGLPYAANGFIVASDGNAAASVAaYSAR-AGKEAFV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 105 VVPQTAPNCKKLAIQAYGAS-IVYSEPSDESRENVAQRiiQETEGIL-VHPNQEPAVIAGQGTIALEVLNQ-------VP 175
Cdd:PRK05638 141 VVPRKVDKGKLIQMIAFGAKiIRYGESVDEAIEYAEEL--ARLNGLYnVTPEYNIIGLEGQKTIAFELWEEinpthviVP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 176 LVDALVVPVGGGGMVAGIAITIKTLKPsvKVYAAEPSNADDCYQSKL--KGELTPNLHPPETIADGVKSSIGLNtwpIIR 253
Cdd:PRK05638 219 TGSGSYLYSIYKGFKELLEIGVIEEIP--KLIAVQTERCNPIASEILgnKTKCNETKALGLYVKNPVMKEYVSE---AIK 293
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
3HMK_B 254 DLVDDVFTVTEDEIKYATQLVWERmKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSG 314
Cdd:PRK05638 294 ESGGTAVVVNEEEIMAGEKLLAKE-GIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTG 353
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
24-319 |
4.13e-12 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 66.39 E-value: 4.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 24 HLTPVLTSSILNqiaGRNLFFKCELFQKTGSFKIRGALNAIRGLipdtLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAY 103
Cdd:PRK08329 59 HLTPPITPTVKR---SIKVYFKLDYLQPTGSFKDRGTYVTVAKL----KEEGINEVVIDSSGNAALSLALYSLSEGIKVH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 104 IVVPQTAPNCKKLAIQAYGASIVYSepsDESRENVAQRIIQ--ETEGIL-VHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180
Cdd:PRK08329 132 VFVSYNASKEKISLLSRLGAELHFV---EGDRMEVHEEAVKfsKRNNIPyVSHWLNPYFLEGTKTIAYEIYEQIGVPDYA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 181 VVPVGGGGMVAGIAITIKTLK--------PSVKVYAAEPSNAdDCYQSKLKGELT-----PNlhPP--ETIADGVKSSIG 245
Cdd:PRK08329 209 FVPVGSGTLFLGIWKGFKELHemgeiskmPKLVAVQAEGYES-LCKRSKSENKLAdgiaiPE--PPrkEEMLRALEESNG 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3HMK_B 246 LntwpiirdlvddVFTVTEDEIKYAtqLVW-ERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDL 319
Cdd:PRK08329 286 F------------CISVGEEETRAA--LHWlRRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLKN 346
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
37-173 |
1.09e-10 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 62.06 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 37 IAGRNLFFKCELFQKTGSFKIRGAlnaiRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKL 116
Cdd:PRK06450 62 IKKGNIWFKLDFLNPTGSYKDRGS----VTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPETASGGKLK 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
3HMK_B 117 AIQAYGASIVYSEpsdESRENVaQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PRK06450 138 QIESYGAEVVRVR---GSREDV-AKAAENSGYYYASHVLQPQFRDGIRTLAYEIAKD 190
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
26-174 |
2.69e-10 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 60.49 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRglipDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYI 104
Cdd:PRK06381 16 TPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVR----RAMRLGYSGITVGTCGNYGASIAYFARLYGLKAVI 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
3HMK_B 105 VVPQTAPNCKKLAIQAYGASIVYSEPSDEsrENVAQ-RIIQETEGIL-VHPNQEPAVIA--GQGTIALEVLNQV 174
Cdd:PRK06381 92 FIPRSYSNSRVKEMEKYGAEIIYVDGKYE--EAVERsRKFAKENGIYdANPGSVNSVVDieAYSAIAYEIYEAL 163
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
25-173 |
4.96e-09 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 56.93 E-value: 4.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 25 LTPVLTSSIL-NQIAGRNLFFKCELFQKTGSFKIRGALNAI-RGLipdtlEGKPKAVVTHSSGNHGQAL-TYAAKLeGIP 101
Cdd:PRK08197 79 MTPLLPLPRLgKALGIGRLWVKDEGLNPTGSFKARGLAVGVsRAK-----ELGVKHLAMPTNGNAGAAWaAYAARA-GIR 152
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3HMK_B 102 AYIVVPQTAPNCKKLAIQAYGASIVYSEP--SDESREnVAQRIiqETEGIL-VHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PRK08197 153 ATIFMPADAPEITRLECALAGAELYLVDGliSDAGKI-VAEAV--AEYGWFdVSTLKEPYRIEGKKTMGLELAEQ 224
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
53-295 |
6.60e-09 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 56.81 E-value: 6.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 53 GSFKIRGALNA------------IRGLIPDTL---EGKPKA----VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNC 113
Cdd:PRK08206 74 NAFKALGGAYAvarllaeklgldISELSFEELtsgEVREKLgditFATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 114 KKLAIQAYGASIVYSEPS-DES-REnvAQRIIQETEGILVhpnQEPA----------VIAGQGTIALEVLNQVPlvdalv 181
Cdd:PRK08206 154 RVDAIRALGAECIITDGNyDDSvRL--AAQEAQENGWVVV---QDTAwegyeeiptwIMQGYGTMADEAVEQLK------ 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 182 vpvggggmvagiaitIKTLKPS-------------------VKVYAA--------EPSNADDCYQSKLKGELTPNLHPPE 234
Cdd:PRK08206 223 ---------------EMGVPPThvflqagvgslagavlgyfAEVYGEqrphfvvvEPDQADCLYQSAVDGKPVAVTGDMD 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
3HMK_B 235 TI----ADGVKSSIGlntWPIIRDLVDDVFTVTEDEIKYAtqlvwerMKLLIEPTAG-----------VGLAAVLS 295
Cdd:PRK08206 288 TImaglACGEPNPLA---WEILRNCADAFISCPDEVAALG-------MRILANPLGGdppivsgesgaVGLGALAA 353
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
19-150 |
4.27e-06 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 47.56 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 19 IQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-P-DTLegkpkavVTHSSGNHGQAL 91
Cdd:PRK11761 6 LEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIvqaekRGEIkPgDTL-------IEATSGNTGIAL 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
3HMK_B 92 TYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSePSDESRE---NVAQRIIQETEGIL 150
Cdd:PRK11761 79 AMIAAIKGYRMKLIMPENMSQERRAAMRAYGAELILV-PKEQGMEgarDLALQMQAEGEGKV 139
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
26-276 |
6.58e-06 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 47.16 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtlegKP-KAVVTHSSGNHGQALTYAAKLEG 99
Cdd:PRK10717 14 TPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIwdaekRGLL------KPgGTIVEGTAGNTGIGLALVAAARG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESREN----VAQRIIQEtegiLVHPNQEPAVIAGQ-----------G 164
Cdd:PRK10717 88 YKTVIVMPETQSQEKKDLLRALGAELVLVPAAPYANPNnyvkGAGRLAEE----LVASEPNGAIWANQfdnpanreahyE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 165 TIALEVLNQVP-LVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNAdDCYQSKLKGELTPnlhPPETIADGvkss 243
Cdd:PRK10717 164 TTGPEIWEQTDgKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGS-ALYSYYKTGELKA---EGSSITEG---- 235
|
250 260 270
....*....|....*....|....*....|....*.
3HMK_B 244 IGLN--TWPIIRDLVDDVFTVTEDE-IKYATQLVWE 276
Cdd:PRK10717 236 IGQGriTANLEGAPIDDAIRIPDEEaLSTAYRLLEE 271
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
17-294 |
8.97e-05 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 43.80 E-value: 8.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 17 LNIQDSVHL----TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtLEGKpKAVVTHSSGNH 87
Cdd:PLN02556 47 TKIKTDASQligkTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIedaekKNLI---TPGK-TTLIEPTSGNM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENV--AQRIIQET-EGILVHPNQEPA-VIAGQ 163
Cdd:PLN02556 123 GISLAFMAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVkkAYELLESTpDAFMLQQFSNPAnTQVHF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 164 GTIALEVL-NQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKlkgeltPNLHPPETIADGVKS 242
Cdd:PLN02556 203 ETTGPEIWeDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGK------PGPHHITGNGVGFKP 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
3HMK_B 243 SIglntwpIIRDLVDDVFTVT-EDEIKYATQLVWERmKLLIEPTAGVGLAAVL 294
Cdd:PLN02556 277 DI------LDMDVMEKVLEVSsEDAVNMARELALKE-GLMVGISSGANTVAAL 322
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
21-141 |
3.15e-04 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 42.29 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 21 DSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNairgLIPDTLE-GK--PKAVVTH-SSGNHGQALTYAAK 96
Cdd:PLN02356 49 DAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVK----IIEEALEsGQlfPGGVVTEgSAGSTAISLATVAP 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
3HMK_B 97 LEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRE----NVAQR 141
Cdd:PLN02356 125 AYGCKCHVVIPDDVAIEKSQILEALGATVERVRPVSITHKdhyvNIARR 173
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
36-173 |
1.12e-03 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 40.57 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HMK_B 36 QIAGRN-LFFKCELFQKTGSFKIRG------ALNAIRGLipdtleGKP-KAVVTHSSGNHGQALTYAAKLEGIPAYIVVP 107
Cdd:PLN02569 145 EFLGMNdLWVKHCGISHTGSFKDLGmtvlvsQVNRLRKM------AKPvVGVGCASTGDTSAALSAYCAAAGIPSIVFLP 218
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HMK_B 108 QTAPNCKKLAIQAYGASIVYSEPSDesrENVAQRIIQETEG---ILVHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PLN02569 219 ADKISIAQLVQPIANGALVLSIDTD---FDGCMRLIREVTAelpIYLANSLNSLRLEGQKTAAIEILQQ 284
|
|
| |
