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Conserved domains on  [gi|281307114|pdb|3IWZ|C]
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Chain C, Catabolite activation-like protein

Protein Classification

Crp/Fnr family transcriptional regulator( domain architecture ID 11485491)

Crp/Fnr family transcriptional regulator such as Escherichia coli cAMP-activated global transcriptional regulator CRP, which complexes with cyclic AMP (cAMP) to allosterically activate DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') and to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome

Gene Ontology:  GO:0003677|GO:0006355
PubMed:  29146813|24914983

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
26-230 2.57e-129

cAMP-activated global transcriptional regulator CRP;


:

Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 363.53  E-value: 2.57e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C        26 TIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTR 105
Cdd:PRK11753  12 TLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       106 TQCELAEISYERLQQLFQtslspDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQ 185
Cdd:PRK11753  92 TACEVAEISYKKFRQLIQ-----VNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAMTHPDGMQ 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
3IWZ_C       186 LRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR 230
Cdd:PRK11753 167 IKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
 
Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
26-230 2.57e-129

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 363.53  E-value: 2.57e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C        26 TIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTR 105
Cdd:PRK11753  12 TLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       106 TQCELAEISYERLQQLFQtslspDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQ 185
Cdd:PRK11753  92 TACEVAEISYKKFRQLIQ-----VNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAMTHPDGMQ 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
3IWZ_C       186 LRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR 230
Cdd:PRK11753 167 IKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 22-226 1.96e-42

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 142.82  E-value: 1.96e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVI 101
Cdd:COG0664   4 LSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLL-GGEPSPAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C      102 LRTRTQCELAEISYERLQQLFQTSlspdaPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEpeamsHP 181
Cdd:COG0664  83 AEALEDSELLRIPREDLEELLERN-----PELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADR-----LD 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
3IWZ_C      182 QGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVL 226
Cdd:COG0664 153 GRIDLPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGRITI 197
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 22-125 7.50e-22

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 86.61  E-value: 7.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVI 101
Cdd:cd00038   5 LDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALL-GNGPRSAT 83

                        90       100
                ....*....|....*....|....
3IWZ_C      102 LRTRTQCELAEISYERLQQLFQTS 125
Cdd:cd00038  84 VRALTDSELLVLPRSDFRRLLQEY 107
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 36-125 4.88e-21

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 83.81  E-value: 4.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C         36 RRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVILRTRTQCELAEISY 115
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALL-GGEPRSATVVALTDSELLVIPR 79

                          90
                  ....*....|
3IWZ_C        116 ERLQQLFQTS 125
Cdd:pfam00027  80 EDFLELLERD 89
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 22-124 4.27e-18

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 77.06  E-value: 4.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C          22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVI 101
Cdd:smart00100   5 LDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALLTNSRRAASA 84

                           90       100
                   ....*....|....*....|....
3IWZ_C         102 -LRTRTQCELAEISYERLQQLFQT 124
Cdd:smart00100  85 aAVALELATLLRIDFRDFLQLLPE 108
 
Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
26-230 2.57e-129

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 363.53  E-value: 2.57e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C        26 TIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTR 105
Cdd:PRK11753  12 TLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       106 TQCELAEISYERLQQLFQtslspDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQ 185
Cdd:PRK11753  92 TACEVAEISYKKFRQLIQ-----VNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAMTHPDGMQ 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
3IWZ_C       186 LRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR 230
Cdd:PRK11753 167 IKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 22-226 1.96e-42

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 142.82  E-value: 1.96e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVI 101
Cdd:COG0664   4 LSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLL-GGEPSPAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C      102 LRTRTQCELAEISYERLQQLFQTSlspdaPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEpeamsHP 181
Cdd:COG0664  83 AEALEDSELLRIPREDLEELLERN-----PELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADR-----LD 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
3IWZ_C      182 QGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVL 226
Cdd:COG0664 153 GRIDLPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGRITI 197
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 22-125 7.50e-22

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 86.61  E-value: 7.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVI 101
Cdd:cd00038   5 LDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALL-GNGPRSAT 83

                        90       100
                ....*....|....*....|....
3IWZ_C      102 LRTRTQCELAEISYERLQQLFQTS 125
Cdd:cd00038  84 VRALTDSELLVLPRSDFRRLLQEY 107
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 36-125 4.88e-21

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 83.81  E-value: 4.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C         36 RRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFiESDTREVILRTRTQCELAEISY 115
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALL-GGEPRSATVVALTDSELLVIPR 79

                          90
                  ....*....|
3IWZ_C        116 ERLQQLFQTS 125
Cdd:pfam00027  80 EDFLELLERD 89
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 22-124 4.27e-18

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 77.06  E-value: 4.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C          22 LDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVI 101
Cdd:smart00100   5 LDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALLTNSRRAASA 84

                           90       100
                   ....*....|....*....|....
3IWZ_C         102 -LRTRTQCELAEISYERLQQLFQT 124
Cdd:smart00100  85 aAVALELATLLRIDFRDFLQLLPE 108
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
180-227 2.94e-09

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 51.29  E-value: 2.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
3IWZ_C         180 HPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLY 227
Cdd:smart00419   1 EGIRVRLPLTRQEIAELLGLTRETVSRTLKRLEKEGLISREGGRIVIL 48
PRK13918 PRK13918
CRP/FNR family transcriptional regulator; Provisional
 43-219 6.44e-08

CRP/FNR family transcriptional regulator; Provisional


Pssm-ID: 237557 [Multi-domain]  Cd Length: 202  Bit Score: 50.97  E-value: 6.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C        43 TDVFRPGD---------PAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFieSDTREVILRTRTQCELAEI 113
Cdd:PRK13918   8 TVTYRPGAvilypgvpgPSDMLYRVRSGLVRLHTVDDEGNALTLRYVRPGEYFGEEALA--GAERAYFAEAVTDSRIDVL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C       114 SYERLqqlfqtslspdAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQG-TQLRVSRQE 192
Cdd:PRK13918  86 NPALM-----------SAEDNLVLTQHLVRTLARAYESIYRLVGQRLKNRIAAALLELSDTPLATQEDSGeTMIYATHDE 154

                        170       180
                 ....*....|....*....|....*..
3IWZ_C       193 LARLVGCSREMAGRVLKKLQADGLLHA 219
Cdd:PRK13918 155 LAAAVGSVRETVTKVIGELSREGYIRS 181
Crp pfam00325
Bacterial regulatory proteins, crp family;
186-217 4.91e-07

Bacterial regulatory proteins, crp family;


Pssm-ID: 425608  Cd Length: 32  Bit Score: 44.98  E-value: 4.91e-07
                          10        20        30
                  ....*....|....*....|....*....|..
3IWZ_C        186 LRVSRQELARLVGCSREMAGRVLKKLQADGLL 217
Cdd:pfam00325   1 LRMSRQDIANYLGLTRETVSRVLGKLQEKGLI 32
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 160-225 1.37e-06

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 44.58  E-value: 1.37e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3IWZ_C      160 VTDRIVRTLHDLSKEPEAmshPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVV 225
Cdd:cd00092   1 AKERLASFLLNLSLRYGA---GDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKY 63
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 163-226 3.60e-06

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 43.21  E-value: 3.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
3IWZ_C        163 RIVRTLHDLSKEPEAMShpqgTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHaRGKTVVL 226
Cdd:pfam13545   2 RLARFLLELAARDGGGR----IDLPLTQEDLADLLGTTRETVSRVLSELRREGLIE-RGRITIL 60
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-124 9.09e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 36.77  E-value: 9.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3IWZ_C        40 PTRTDVFRPGDPAGTLYYVISGSVSIIaEEDDDRELVLGYFGSGEFVGEMGLfIESDTREVILRTRTQCELAEISYERLQ 119
Cdd:PLN03192 403 PPREDVIMQNEAPDDVYIVVSGEVEII-DSEGEKERVVGTLGCGDIFGEVGA-LCCRPQSFTFRTKTLSQLLRLKTSTLI 480


                 ....*
3IWZ_C       120 QLFQT 124
Cdd:PLN03192 481 EAMQT 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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