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Conserved domains on  [gi|262118710|pdb|3JRP|A]
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Chain A, FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
23-283 1.87e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       23 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 102
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      103 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 182
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      183 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 262
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
3JRP_A      263 SWSLSGNVLALSGGDNKVTLW 283
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
23-283 1.87e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       23 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 102
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      103 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 182
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      183 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 262
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
3JRP_A      263 SWSLSGNVLALSGGDNKVTLW 283
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-284 8.78e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 8.78e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEthKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENG 89
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       90 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKengTTSPI-IIDAHAIGVNSASWAPatieedgehng 168
Cdd:cd00200 126 K--CLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLR---TGKCVaTLTGHTGEVNSVAFSP----------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      169 tkESRKFVTGGADNLVKIWKYNSDAQTYvlesTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQGpwKKT 248
Cdd:cd00200 188 --DGEKLLSSSSDGTIKLWDLSTGKCLG----TLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVWDLRTGEC--VQT 256

                       250       260       270
                ....*....|....*....|....*....|....*.
3JRP_A      249 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLWK 284
Cdd:cd00200 257 LSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 44-85 7.89e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.89e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
3JRP_A          44 THKLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWK 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
198-236 1.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
3JRP_A        198 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 236
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-187 6.56e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        21 YYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDW--AHPkfgTILASCSYDGKVLIWKEENGrwsqIAVHA 98
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLWSINQG----VSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        99 VHS-ASVNSVQWaPHEYGPLLLVASSDGKVSVVEFKeNGTTSPIIIDAHAIGVNSASWApatieedgehngtkESRKFVT 177
Cdd:PLN00181 614 IKTkANICCVQF-PSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHSKTVSYVRFV--------------DSSTLVS 677

                        170
                 ....*....|
3JRP_A       178 GGADNLVKIW 187
Cdd:PLN00181 678 SSTDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
23-283 1.87e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.87e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       23 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 102
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      103 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 182
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      183 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 262
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
3JRP_A      263 SWSLSGNVLALSGGDNKVTLW 283
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
23-294 1.89e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 1.89e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       23 GKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 102
Cdd:COG2319 132 GKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      103 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 182
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSP-----DG--------RLLASGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      183 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 262
Cdd:COG2319 269 TVRLW----DLATGELLRTLTGHSGGVNSVAFSPD---GKLLASGSDDGTVRLW--DLATGKLLRTL---TGHTGAVRSV 336

                       250       260       270
                ....*....|....*....|....*....|..
3JRP_A      263 SWSLSGNVLALSGGDNKVTLWkeNLEGKWEPA 294
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW--DLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
10-283 1.60e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.66  E-value: 1.60e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENG 89
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       90 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKENGTTSpiIIDAHAIGVNSASWAPatieeDGehngt 169
Cdd:COG2319 153 K--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGAVRSVAFSP-----DG----- 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      170 kesRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTL 249
Cdd:COG2319 217 ---KLLASGSADGTVRLW----DLATGKLLRTLTGHSGSVRSVAFSPD---GRLLASGSADGTVRLW--DLATGELLRTL 284

                       250       260       270
                ....*....|....*....|....*....|....
3JRP_A      250 lkeEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283
Cdd:COG2319 285 ---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-284 8.78e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 8.78e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEthKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENG 89
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       90 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKengTTSPI-IIDAHAIGVNSASWAPatieedgehng 168
Cdd:cd00200 126 K--CLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLR---TGKCVaTLTGHTGEVNSVAFSP----------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      169 tkESRKFVTGGADNLVKIWKYNSDAQTYvlesTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQGpwKKT 248
Cdd:cd00200 188 --DGEKLLSSSSDGTIKLWDLSTGKCLG----TLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVWDLRTGEC--VQT 256

                       250       260       270
                ....*....|....*....|....*....|....*.
3JRP_A      249 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLWK 284
Cdd:cd00200 257 LSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-283 1.25e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 1.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEThkLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWKEENG 89
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       90 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKENGTTspIIIDAHAIGVNSASWAPatieedgehngt 169
Cdd:cd00200  84 E--CVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSP------------ 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      170 keSRKFVTGG-ADNLVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKT 248
Cdd:cd00200 146 --DGTFVASSsQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSPD---GEKLLSSSSDGTIKLW--DLSTGKCLGT 214

                       250       260       270
                ....*....|....*....|....*....|....*
3JRP_A      249 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLW 283
Cdd:cd00200 215 LRGHENG---VNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-283 1.44e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 1.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       47 LIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGK 126
Cdd:cd00200   1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASAD--GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      127 VSVveFKENGTTSPIIIDAHAIGVNSASWAPatieedgehngtkESRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHS 206
Cdd:cd00200  75 IRL--WDLETGECVRTLTGHTSYVSSVAFSP-------------DGRILSSSSRDKTIKVW----DVETGKCLTTLRGHT 135

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3JRP_A      207 DWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLLKEEkfpDVLWRASWSLSGNVLALSGGDNKVTLW 283
Cdd:cd00200 136 DWVNSVAFSPD---GTFVASSSQDGTIKLW--DLRTGKCVATLTGHT---GEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
47-283 1.30e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 1.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       47 LIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGK 126
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPD--GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      127 VSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHS 206
Cdd:COG2319 102 VRLWDL--ATGLLLRTLTGHTGAVRSVAFSP-----DG--------KTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3JRP_A      207 DWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283
Cdd:COG2319 163 GAVTSVAFSPD---GKLLASGSDDGTVRLW--DLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-188 1.52e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 1.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        8 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEE 87
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWDLS 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A       88 NGRWsqIAVHAVHSASVNSVQWAPHEYgpLLLVASSDGKV---SVVEFKENGTtspiiIDAHAIGVNSASWAPatieedg 164
Cdd:cd00200 208 TGKC--LGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIrvwDLRTGECVQT-----LSGHTNSVTSLAWSP------- 271

                       170       180
                ....*....|....*....|....
3JRP_A      165 ehngtkESRKFVTGGADNLVKIWK 188
Cdd:cd00200 272 ------DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1-127 1.28e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 1.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGK 80
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAF-SPD-GKTLASGSDDGT 353

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
3JRP_A       81 VLIWKEENGRwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKV 127
Cdd:COG2319 354 VRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
1-84 1.54e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGK 80
Cdd:COG2319 320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGT 395


                ....
3JRP_A       81 VLIW 84
Cdd:COG2319 396 VRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 198-284 3.91e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 3.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A      198 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQgpwKKTLLKEEKFPdvLWRASWSLSGNVLALSGGD 277
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGP--VRDVAASADGTYLASGSSD 72


                ....*..
3JRP_A      278 NKVTLWK 284
Cdd:cd00200  73 KTIRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 44-85 7.89e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.89e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
3JRP_A          44 THKLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWK 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-236 1.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.75e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
3JRP_A         195 TYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 236
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
198-236 1.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
3JRP_A        198 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 236
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
46-84 1.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
3JRP_A         46 KLIDTLTGHEGPVWRVDWahPKFGTILASCSYDGKVLIW 84
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 21-187 6.56e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        21 YYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDW--AHPkfgTILASCSYDGKVLIWKEENGrwsqIAVHA 98
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLWSINQG----VSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        99 VHS-ASVNSVQWaPHEYGPLLLVASSDGKVSVVEFKeNGTTSPIIIDAHAIGVNSASWApatieedgehngtkESRKFVT 177
Cdd:PLN00181 614 IKTkANICCVQF-PSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHSKTVSYVRFV--------------DSSTLVS 677

                        170
                 ....*....|
3JRP_A       178 GGADNLVKIW 187
Cdd:PLN00181 678 SSTDNTLKLW 687
PTZ00420 PTZ00420
coronin; Provisional
 22-109 1.07e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3JRP_A        22 YGKRLATCSSDKTIKIFEV--EGETHKLID----TLTGHEGPVWRVDWaHPKFGTILASCSYDGKVLIWKEENgrwSQIA 95
Cdd:PTZ00420  86 FSEILASGSEDLTIRVWEIphNDESVKEIKdpqcILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVNIWDIEN---EKRA 161

                         90
                 ....*....|....
3JRP_A        96 VHAVHSASVNSVQW 109
Cdd:PTZ00420 162 FQINMPKKLSSLKW 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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