Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       54 TGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLS 132
Cdd:cd20433   1 TGPQLEKLMEKLRFEIASNPPLPGSYTPRKGDLCAAKFVeDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                ....
3OMC_A      133 PAFS 136
Cdd:cd20433  81 PAFS 84

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       54 TGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLS 132
Cdd:cd20433   1 TGPQLEKLMEKLRFEIASNPPLPGSYTPRKGDLCAAKFVeDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                ....
3OMC_A      133 PAFS 136
Cdd:cd20433  81 PAFS 84

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
3OMC_A          79 YAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAF 135
Cdd:smart00333   1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Staphylococcal nuclease homologues;

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
3OMC_A         195 FADSKGDVGLGLVKEGLVmvEVRKEKQFQKV-ITEYLNAQESAKSARLNLWRY 246
Cdd:smart00318  87 YLNGGNNIAEELVKEGLA--KVYRYADKDEYvYDELLEAEEAAKKARKGLWSD 137

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       54 TGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLS 132
Cdd:cd20433   1 TGPQLEKLMEKLRFEIASNPPLPGSYTPRKGDLCAAKFVeDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

                ....
3OMC_A      133 PAFS 136
Cdd:cd20433  81 PAFS 84

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       47 FYVQDVETG------TQLEKLmenmrnDIASHPPVEGSYAPRRGEFCIAKF-VDGEWYRARVekVESPA--------KIH 111
Cdd:cd20443   4 FYVQVVSDQrlssiqQQLEGL------SLKDKANPPGGFNPKKGELVLAQFsADNSWNRAMV--VNAPRqgtqspkdEYE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
3OMC_A      112 VFYIDYGNREVLPSTRLGTLSPAFSTrvLPAQATEYAFAFIQVP 155
Cdd:cd20443  76 VFYIDYGNQETVPLSALRPLDPSVSS--APGLAQLCSLAHIKVP 117

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
3OMC_A          79 YAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAF 135
Cdd:smart00333   1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       55 GTQLEKLMENMRNDiASHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSP 133
Cdd:cd20409   1 GRQLAELQESLSAY-CKVAPASSDFSPAVGEVCCAQFTeDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPP 79

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       38 VTEITDDLHFYVQDVETGTQLEKLMENMRnDIA---SHPPVEGSYAPRRGEFCIAKFV-DGEWYRARVEKVeSPAKIHVF 113
Cdd:cd20411   3 VLEVISPDLFYALPKTGQVNVEKLKALMT-ELAeycSKQSVPQQFRPRIGDACCARFTgDKNWYRAVVLET-SDSEVKVL 80

                        90       100
                ....*....|....*....|..
3OMC_A      114 YIDYGNREVLPSTRLGTLSPAF 135
Cdd:cd20411  81 YADYGNTETLPLSRILPITKSH 102

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3OMC_A       76 EGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFSTrvLPAQATEYAFAFIQ 153
Cdd:cd20415  20 LEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLS--LPEKARECRLAFIE 95

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       36 VFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYApRRGEFCIAKFV-DGEWYRARVEKVESPAKIHVFY 114
Cdd:cd20425   4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESL-QLGDLICAEYPeDGLWYRAVVKEKIPNNLVSVQF 82

                        90       100
                ....*....|....*....|.
3OMC_A      115 IDYGNREVLPSTRLGTLSPAF 135
Cdd:cd20425  83 IDYGNTSVVQPSKIHRLPKEL 103

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       47 FYVQDVETGTQLEKLMENM-----RNDIASHPPVEGSyaprrGEFCIAKFVDGEWYRARVEKVESPAKIHVFYIDYGNRE 121
Cdd:cd20437  18 FYCQLLSWEPELSKLTTQMtlhyeSVSKELNPSCENF-----GLLCAAKGKDGQWHRGFLQQLLPPSQVKVWFIDYGNSE 92

                        90
                ....*....|....*..
3OMC_A      122 VLPSTRLGTLSPAFSTR 138
Cdd:cd20437  93 AVSSHSVLKLPPDFFSL 109

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       37 FVTEITDDLHFYVQDVETGTQLEKLMENMrNDIASHPPVEGSY--APRRGEFCIAKFV-DGEWYRARVEKVESpAKIHVF 113
Cdd:cd20438  10 FVEYVLNPSNFWIRTDEYNNEFQALMKNI-ADIYNLCGNDEELlkKPEPGLLCCARYSkDRHYYRAVITEVLD-LKVSVY 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
3OMC_A      114 YIDYGNREVLPSTRLGTLSPAFStrVLPAQATEYAFAFIqVPQDD 158
Cdd:cd20438  88 FLDFGNTDTVPFYDVKTLLPEFS--ELPALAMCCSLAHV-FPVEE 129

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
3OMC_A       87 CIAKF-VDGEWYRARVEKVESPAK-IHVFYIDYGNREVLPSTRLGTLSPAFSTrvLPAQATE 146
Cdd:cd20423   9 CLAKYsEDGKWCRALIDNVYEPVEmVEVTYVDYGNKELVSLKNLRSISEEFLK--LKAQAFR 68

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       46 HFYVQDVETGTQLEKLMENMRN--DIASHPPVEGSYAprrgefCIAKFV-DGEWYRARVEKVESPAKIHVFYIDYGNREV 122
Cdd:cd20439  24 DFWCQLQTKSSELKSLMKQIQSyyLIHNDPYKHGQIA------CVAKYSkDGKWYRAAVLKQVSAKEVDVIFVDYGNQER 97

                        90       100
                ....*....|....*....|..
3OMC_A      123 LPSTRLGTLSPAFSTrvLPAQA 144
Cdd:cd20439  98 VLISDLRAIKPQFLL--LEGQA 117

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       57 QLEKLMENMRNDIASHPPVEgsyAPRRGEFCIAKFVDGEWYRARVEKVESpAKIHVFYIDYGNREVLPSTRLGTLSPAFS 136
Cdd:cd20427   2 QMEDEMKEFYSKSSTAMCLR---SPSVGQLVAVKAEEDAWLRAQVIEVEE-DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                        90       100
                ....*....|....*....|..
3OMC_A      137 TrvLPAQATEYAFAFIQVPQDD 158
Cdd:cd20427  78 S--LPFQATKCKLAGLEPFSDD 97

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       81 PRRGEFCIAKFVDGEWYRARVEKVE------SPAKIHVFYIDYGNREVLPSTRLGTLSPAFstRVLPAQATEYAFAFIQv 154
Cdd:cd20435  50 VKVGDLCAVEDENNLYHRVKVLEITekddktKPREVLVKFIDEGRVETVVVSQLLELPEEL--KSLPPQAVEVFLCNVK- 126

                ....*
3OMC_A      155 PQDDD 159
Cdd:cd20435 127 PVDND 131

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       37 FVTEITDDLHFYVQDV--ETGTQLEKLMENMRNdIASHPPVEGSY-AP----RRGEFCIAKF-VDGEWYRARVEKVESPA 108
Cdd:cd20419   1 FVEYIESPSQFYVRFYskDTSEMLEDMMIEMRR-CYSNEHVSERYvMPeafiQPGQVCCVRIpEDVWWYRVIIHQVLNKQ 79

                        90       100       110
                ....*....|....*....|....*....|....*.
3OMC_A      109 KIHVFYIDYGNREVLPSTRLGTLSPAFSTrvLPAQA 144
Cdd:cd20419  80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSK--LPAQA 113

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
3OMC_A       85 EFCIAKFVDgEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFST 137
Cdd:cd20445   3 ELCIAKYMD-KWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFAT 54

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMC_A       57 QLEKLMENMRndIASHPPVEGSYAPRRGEFCIAKfVDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFs 136
Cdd:cd20429   8 KLEVLMEEMI--LYYNKTEERPVAIEKNKVYAAK-IENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKF- 83

                ....*...
3OMC_A      137 tRVLPAQA 144
Cdd:cd20429  84 -RQLPFQA 90

Staphylococcal nuclease homologues;

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
3OMC_A         195 FADSKGDVGLGLVKEGLVmvEVRKEKQFQKV-ITEYLNAQESAKSARLNLWRY 246
Cdd:smart00318  87 YLNGGNNIAEELVKEGLA--KVYRYADKDEYvYDELLEAEEAAKKARKGLWSD 137

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
3OMC_A       82 RRGEFCIAKF-VDGEWYRARVEKVESPAKIH-VFYIDYGNRE 121
Cdd:cd20413   2 KPGDECLAKYwEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYE 43

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
3OMC_A       84 GEFCIAKF-VDGEWYRARVEKVESPAKIHVFYiDYGNREVLPSTRL 128
Cdd:cd04508   1 GDRVEAKWsDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDI 45

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
3OMC_A       82 RRGEFCIAKFVDGEWYRARVEKVESPAkIHVFYIDYGNREVLP 124
Cdd:cd20417   2 KKGEGCVVRGSDTLWYRGKVLEVIGGM-VRVQYVDQGYIEKIP 43