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Conserved domains on  [gi|320089843|pdb|3OMZ|A]
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Chain A, human Vdelta1 gamma delta T cell receptor delta1A/B-3

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 138-250 2.36e-65

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409503  Cd Length: 112  Bit Score: 198.90  E-value: 2.36e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      138 KVTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQ 217
Cdd:cd07706   1 KVTQAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQ 80

                        90       100       110
                ....*....|....*....|....*....|...
3OMZ_A      218 LEDSAKYFCALGESLTrADKLIFGKGTRVTVEP 250
Cdd:cd07706  81 LEDSAKYFCALSLPYD-TDKLIFGKGTRLTVEP 112
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 5-117 8.45e-35

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04982:

Pssm-ID: 472250  Cd Length: 117  Bit Score: 120.93  E-value: 8.45e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A        5 LEGRTKSVIRQTGSSAEITCDL--AEGSTGYIHWYLHQEGKAPQRLLYYDSyTSSVVLESGISPGKYDtygsTRKNLRM- 81
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVsgIDFSTTYIHWYRQKPGQALERLLYVSS-TSAVRKDSGKTKNKFE----ARKDVGKs 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
3OMZ_A       82 --ILR--NLIENDSGVYYCATWD--QNYYKKLFGSGTSLVVT 117
Cdd:cd04982  76 tsTLTitNLEKEDSATYYCAYWEsgSGYYIKVFGSGTKLIVT 117
 
Name Accession Description Interval E-value
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 138-250 2.36e-65

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 198.90  E-value: 2.36e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      138 KVTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQ 217
Cdd:cd07706   1 KVTQAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQ 80

                        90       100       110
                ....*....|....*....|....*....|...
3OMZ_A      218 LEDSAKYFCALGESLTrADKLIFGKGTRVTVEP 250
Cdd:cd07706  81 LEDSAKYFCALSLPYD-TDKLIFGKGTRLTVEP 112
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 5-117 8.45e-35

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 120.93  E-value: 8.45e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A        5 LEGRTKSVIRQTGSSAEITCDL--AEGSTGYIHWYLHQEGKAPQRLLYYDSyTSSVVLESGISPGKYDtygsTRKNLRM- 81
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVsgIDFSTTYIHWYRQKPGQALERLLYVSS-TSAVRKDSGKTKNKFE----ARKDVGKs 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
3OMZ_A       82 --ILR--NLIENDSGVYYCATWD--QNYYKKLFGSGTSLVVT 117
Cdd:cd04982  76 tsTLTitNLEKEDSATYYCAYWEsgSGYYIKVFGSGTKLIVT 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-248 1.08e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.56  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A        141 QAQSSVSMPVRKAVTLNCLYETSWW--SYYIFWYKRLPSK--EMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISAL 216
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKgpTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
3OMZ_A        217 QLEDSAKYFCALGESltraDKLIFGKGTRVTV 248
Cdd:pfam07686  81 TLSDSGTYTCAVIPS----GEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 10-117 2.44e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A         10 KSVIRQTGSSAEITC---DLAEGSTGYIHWYLHQEGKAPQRLLYYdsYTSSvvLESGISPGKYDTYGSTRK-NLRMILRN 85
Cdd:pfam07686   4 REVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGPTFLIAY--YSNG--SEEGVKKGRFSGRGDPSNgDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|..
3OMZ_A         86 LIENDSGVYYCATWDQNYYKklFGSGTSLVVT 117
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGV--FGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
154-227 6.84e-10

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 54.31  E-value: 6.84e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3OMZ_A         154 VTLNCLYETSWWS-YYIFWYKRLPSKEMIFLIRQGSDEQNAKS----GRYSVNFKKAAKSVALTISALQLEDSAKYFCA 227
Cdd:smart00406   2 VTLSCKFSGSTFSsYYVSWVRQPPGKGLEWLGYIGSNGSSYYQesykGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 10-116 1.95e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A          10 KSVIRQTGSSAEITCDLAEGSTGYIHWYLhqegKAPQRLLYYDSYTSSvvlesgispgkydtygSTRKNLRMILRNLIEN 89
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYK----QGGKLLAESGRFSVS----------------RSGSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....*..
3OMZ_A          90 DSGVYYCATWDQNYYKKlfgSGTSLVV 116
Cdd:smart00410  62 DSGTYTCAATNSSGSAS---SGTTLTV 85
 
Name Accession Description Interval E-value
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 138-250 2.36e-65

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 198.90  E-value: 2.36e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      138 KVTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQ 217
Cdd:cd07706   1 KVTQAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQ 80

                        90       100       110
                ....*....|....*....|....*....|...
3OMZ_A      218 LEDSAKYFCALGESLTrADKLIFGKGTRVTVEP 250
Cdd:cd07706  81 LEDSAKYFCALSLPYD-TDKLIFGKGTRLTVEP 112
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 139-249 5.92e-49

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 157.05  E-value: 5.92e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQAQSSVSMPVRKAVTLNCLYETSWwSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQL 218
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCNYSTST-FYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHISAAQL 79

                        90       100       110
                ....*....|....*....|....*....|.
3OMZ_A      219 EDSAKYFCALGESLtRADKLIFGKGTRVTVE 249
Cdd:cd04983  80 SDSAVYFCALSESG-GTGKLTFGKGTRLTVE 109
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 5-117 8.45e-35

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 120.93  E-value: 8.45e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A        5 LEGRTKSVIRQTGSSAEITCDL--AEGSTGYIHWYLHQEGKAPQRLLYYDSyTSSVVLESGISPGKYDtygsTRKNLRM- 81
Cdd:cd04982   1 LEQPQLSITREESKSVTISCKVsgIDFSTTYIHWYRQKPGQALERLLYVSS-TSAVRKDSGKTKNKFE----ARKDVGKs 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
3OMZ_A       82 --ILR--NLIENDSGVYYCATWD--QNYYKKLFGSGTSLVVT 117
Cdd:cd04982  76 tsTLTitNLEKEDSATYYCAYWEsgSGYYIKVFGSGTKLIVT 117
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 139-248 7.82e-32

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 113.20  E-value: 7.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAK---SGRYSVNFKKaAKSVALTISA 215
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKggvPGRFSGSRDG-TSSFSLTISN 79

                        90       100       110
                ....*....|....*....|....*....|...
3OMZ_A      216 LQLEDSAKYFCALGESLTrADKLIFGKGTRVTV 248
Cdd:cd00099  80 LQPEDSGTYYCAVSESGG-TDKLTFGSGTRLTV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 10-116 4.12e-22

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 87.77  E-value: 4.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       10 KSVIRQTGSSAEITCDL-AEGSTGYIHWYLHQEGKAPQRLLYYDSYTSSVvleSGISPGKYDTYGSTRKNLRMILRNLIE 88
Cdd:cd00099   6 RSLSVQEGESVTLSCEVsSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKT---KGGVPGRFSGSRDGTSSFSLTISNLQP 82

                        90       100
                ....*....|....*....|....*....
3OMZ_A       89 NDSGVYYCATWD-QNYYKKLFGSGTSLVV 116
Cdd:cd00099  83 EDSGTYYCAVSEsGGTDKLTFGSGTRLTV 111
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 139-248 2.07e-17

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 75.40  E-value: 2.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQAQSSVSMPVRKAVTLNCLYETSWwsYYIFWYKRLPSKEMIFLIRQGS----DEQNAKSGRYSVNFKKAAKSvALTIS 214
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSGH--DNMYWYRQDPGKGLQLLFYSYGgglnEEGDLPGDRFSASRPSLTRS-SLTIK 77

                        90       100       110
                ....*....|....*....|....*....|....*
3OMZ_A      215 ALQLEDSAKYFCAlgESLTR-ADKLIFGKGTRVTV 248
Cdd:cd05899  78 SAEPEDSAVYLCA--SSLGGgADEAYFGPGTRLTV 110
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 139-248 4.12e-16

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 71.72  E-value: 4.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQaQSSVSMPVRKAVTLNCLYETSWWS-YYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNfkKAAKSVALTISALQ 217
Cdd:cd04984   2 LTQ-PSSLSVSPGETVTITCTGSSGNISgNYVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSGS--KSGNTASLTISGAQ 78

                        90       100       110
                ....*....|....*....|....*....|.
3OMZ_A      218 LEDSAKYFCALGESLTradkLIFGKGTRVTV 248
Cdd:cd04984  79 TEDEADYYCQVWDSNS----YVFGGGTKLTV 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-248 1.08e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.56  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A        141 QAQSSVSMPVRKAVTLNCLYETSWW--SYYIFWYKRLPSK--EMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISAL 216
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKgpTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
3OMZ_A        217 QLEDSAKYFCALGESltraDKLIFGKGTRVTV 248
Cdd:pfam07686  81 TLSDSGTYTCAVIPS----GEGVFGKGTRLTV 108
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 17-116 5.26e-13

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 63.63  E-value: 5.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       17 GSSAEITCDLAEGSTG--YIHWYLHQEGKAPQRLLYYDSYTSsvvleSGIsPGKYDtyGSTRKNLR-MILRNLIENDSGV 93
Cdd:cd04984  13 GETVTITCTGSSGNISgnYVNWYQQKPGSAPRYLIYEDKHRP-----SGI-PDRFS--GSKSGNTAsLTISGAQTEDEAD 84

                        90       100
                ....*....|....*....|...
3OMZ_A       94 YYCATWDQNYYkkLFGSGTSLVV 116
Cdd:cd04984  85 YYCQVWDSNSY--VFGGGTKLTV 105
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 10-116 1.10e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 62.68  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       10 KSVIRQTGSSAEITCDLAEGSTgYIHWYLHQEGKAPQrLLYYdSYTSSVVLESGISPGKYDTYGSTRKNLRMILRNLIEN 89
Cdd:cd05899   6 RYLIKRRGQSVTLRCSQKSGHD-NMYWYRQDPGKGLQ-LLFY-SYGGGLNEEGDLPGDRFSASRPSLTRSSLTIKSAEPE 82

                        90       100
                ....*....|....*....|....*...
3OMZ_A       90 DSGVYYCA-TWDQNYYKKLFGSGTSLVV 116
Cdd:cd05899  83 DSAVYLCAsSLGGGADEAYFGPGTRLTV 110
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 145-249 5.20e-12

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 61.03  E-value: 5.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      145 SVSMPVRKAVTLNCLYE-TSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQLEDSAK 223
Cdd:cd20988   7 TVTVSVGKPVTLKCSMKgEAISNYYINWYRKTQGNTMTFIYREGGIYGPGFKDNFRGDIDSSNNLAVLKILEASERDEGS 86

                        90       100
                ....*....|....*....|....*...
3OMZ_A      224 YFCALGESL--TRADKLIFGKGTRVTVE 249
Cdd:cd20988  87 YYCASDTPGggREYDPLIFGKGTYLTVE 114
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 139-248 9.02e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 60.45  E-value: 9.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQAQSSVSMPVRKAVTLNC-LYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAK-----SGRYSVNFKKAAKSVALT 212
Cdd:cd04982   1 LEQPQLSITREESKSVTISCkVSGIDFSTTYIHWYRQKPGQALERLLYVSSTSAVRKdsgktKNKFEARKDVGKSTSTLT 80

                        90       100       110
                ....*....|....*....|....*....|....*.
3OMZ_A      213 ISALQLEDSAKYFCALGESLTRADKLIFGKGTRVTV 248
Cdd:cd04982  81 ITNLEKEDSATYYCAYWESGSGYYIKVFGSGTKLIV 116
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 10-117 2.44e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A         10 KSVIRQTGSSAEITC---DLAEGSTGYIHWYLHQEGKAPQRLLYYdsYTSSvvLESGISPGKYDTYGSTRK-NLRMILRN 85
Cdd:pfam07686   4 REVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGPTFLIAY--YSNG--SEEGVKKGRFSGRGDPSNgDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|..
3OMZ_A         86 LIENDSGVYYCATWDQNYYKklFGSGTSLVVT 117
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGV--FGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
154-227 6.84e-10

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 54.31  E-value: 6.84e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3OMZ_A         154 VTLNCLYETSWWS-YYIFWYKRLPSKEMIFLIRQGSDEQNAKS----GRYSVNFKKAAKSVALTISALQLEDSAKYFCA 227
Cdd:smart00406   2 VTLSCKFSGSTFSsYYVSWVRQPPGKGLEWLGYIGSNGSSYYQesykGRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 17-114 1.36e-09

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 54.32  E-value: 1.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       17 GSSAEITCDLAEG-STGYIHWYLHQEGKAPQRLLYYDSYtssvvLESGIsPGKYDTYGStRKNLRMILRNLIENDSGVYY 95
Cdd:cd04980  15 GERVTISCKASQSiSSNYLAWYQQKPGQAPKLLIYYAST-----LHSGV-PSRFSGSGS-GTDFTLTISSVEPEDAAVYY 87

                        90
                ....*....|....*....
3OMZ_A       96 CATWDQNYYKklFGSGTSL 114
Cdd:cd04980  88 CQQGYTFPYT--FGGGTKL 104
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 139-248 4.57e-09

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 52.78  E-value: 4.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      139 VTQAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNfkKAAKSVALTISALQL 218
Cdd:cd04980   3 MTQSPASLSVSPGERVTISCKASQSISSNYLAWYQQKPGQAPKLLIYYASTLHSGVPSRFSGS--GSGTDFTLTISSVEP 80

                        90       100       110
                ....*....|....*....|....*....|
3OMZ_A      219 EDSAKYFCALGESLTradkLIFGKGTRVTV 248
Cdd:cd04980  81 EDAAVYYCQQGYTFP----YTFGGGTKLEI 106
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 166-248 2.43e-08

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 51.16  E-value: 2.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      166 SYYIFWYKRLPSK--EMIFLIRQGSDEQNAKS---GRYSVNFKKAAKSVALTISALQLEDSAKYFCALGESLTRADKL-I 239
Cdd:cd04981  29 SYGMGWVRQAPGKglEWIGLIYPGGGDTYYADsfkGRFTITRDTSKSTAYLQLNSLTSEDTAVYYCARGLGGYGYSYFdY 108


                ....*....
3OMZ_A      240 FGKGTRVTV 248
Cdd:cd04981 109 WGQGTTVTV 117
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 147-249 3.55e-06

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 44.86  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      147 SMPVRKAVTLNC-----LYETSWWSyyifWYKRLPSKEMIFLIRQGSDEQNAKSGRYSVNFKKAAKSVALTISALQLEDS 221
Cdd:cd16095  11 SHPAGKTLSLKCqtsgfQFNTSQLS----WYLWVPGHAPLWLTSLDHISTKVSEDRITSSREDTNSQIFLQIKGLGLRDS 86

                        90       100       110
                ....*....|....*....|....*....|
3OMZ_A      222 AKYFCA--LGESlTRADKLIFGKGTRVTVE 249
Cdd:cd16095  87 GQYHCArrVGYG-DDTDKLIFGPGTDVIVE 115
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 141-248 1.51e-05

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 43.21  E-value: 1.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      141 QAQSSVSMPVRKAVTLNCLYETSWWSYYIFWYK--RLPSKEMIFLIRQGSDE-------QNAKSGRYSVNFKKAAKSVAL 211
Cdd:cd07700   3 QTPGSLLVQTNQTVKMSCEAKTSPKNTRIYWLRqrQAPSKDSHFEFLASWDPskgivygEGVDQEKLIILSDSDSSRYIL 82

                        90       100       110
                ....*....|....*....|....*....|....*..
3OMZ_A      212 TISALQLEDSAKYFCALGESltraDKLIFGKGTRVTV 248
Cdd:cd07700  83 SLMSVKPEDSGTYFCMTVGS----PELIFGTGTKLSV 115
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 10-116 1.95e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A          10 KSVIRQTGSSAEITCDLAEGSTGYIHWYLhqegKAPQRLLYYDSYTSSvvlesgispgkydtygSTRKNLRMILRNLIEN 89
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYK----QGGKLLAESGRFSVS----------------RSGSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....*..
3OMZ_A          90 DSGVYYCATWDQNYYKKlfgSGTSLVV 116
Cdd:smart00410  62 DSGTYTCAATNSSGSAS---SGTTLTV 85
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 10-116 2.91e-05

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 42.44  E-value: 2.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       10 KSVIRQTGSSAEITCDL-AEGSTGYIHWYLHQEGKAPQR----LLYYDSyTSSVVLESGISPGKYDTYG-STRKNLRMIL 83
Cdd:cd07700   6 GSLLVQTNQTVKMSCEAkTSPKNTRIYWLRQRQAPSKDShfefLASWDP-SKGIVYGEGVDQEKLIILSdSDSSRYILSL 84

                        90       100       110
                ....*....|....*....|....*....|...
3OMZ_A       84 RNLIENDSGVYYCATWDQNyyKKLFGSGTSLVV 116
Cdd:cd07700  85 MSVKPEDSGTYFCMTVGSP--ELIFGTGTKLSV 115
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 143-248 3.19e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 3.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A         143 QSSVSMPVRKAVTLNCLYETSWwSYYIFWYKrlPSKEMIflirqgsdeqnAKSGRYSVNFKKaaKSVALTISALQLEDSA 222
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP-PPEVTWYK--QGGKLL-----------AESGRFSVSRSG--STSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|....*.
3OMZ_A         223 KYFCALGESLtradKLIFGkGTRVTV 248
Cdd:smart00410  65 TYTCAATNSS----GSASS-GTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
19-98 4.67e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 40.83  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A          19 SAEITCDLA--EGSTGYIHWYLHQEGKAPQRLLYYDSYTSSVVLESgiSPGKYDTYGSTRKN-LRMILRNLIENDSGVYY 95
Cdd:smart00406   1 SVTLSCKFSgsTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQES--YKGRFTISKDTSKNdVSLTISNLRVEDTGTYY 78


                   ...
3OMZ_A          96 CAT 98
Cdd:smart00406  79 CAV 81
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 146-249 2.83e-04

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 39.30  E-value: 2.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A      146 VSMPVRKAVTLNCLYETSWWSYYIFWYKrLPSKEMIFLIRQGSDEQNaksGRYSVNFKKAAKSVALTISALQLEDSAKYF 225
Cdd:cd05716   7 VTGVEGGSVTIQCPYPPKYASSRKYWCK-WGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKEDAGWYW 82

                        90       100
                ....*....|....*....|....
3OMZ_A      226 CALGESLTRadklifGKGTRVTVE 249
Cdd:cd05716  83 CGVGDDGDR------GLTVQVKLV 100
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 10-96 2.83e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 35.62  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A         10 KSVIRQTGSSAEITCDLAEGSTGYIHWYLHQEGKAPQRLLYYDSYTSSVVLesgispgkydtygstrknlrmILRNLIEN 89
Cdd:pfam13927   9 SSVTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTL---------------------TISNVTRS 67


                  ....*..
3OMZ_A         90 DSGVYYC 96
Cdd:pfam13927  68 DAGTYTC 74
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 15-116 7.30e-03

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 35.62  E-value: 7.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3OMZ_A       15 QTGSSAEITCDLA--EGSTGYIHWYLHQEGKAPQRLLYYDSyTSSVVLESGISPGKYDtygsTRKNLRMILRNLIENDSG 92
Cdd:cd16095  13 PAGKTLSLKCQTSgfQFNTSQLSWYLWVPGHAPLWLTSLDH-ISTKVSEDRITSSRED----TNSQIFLQIKGLGLRDSG 87

                        90       100
                ....*....|....*....|....*..
3OMZ_A       93 VYYCAT---WDQNYYKKLFGSGTSLVV 116
Cdd:cd16095  88 QYHCARrvgYGDDTDKLIFGPGTDVIV 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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