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Conserved domains on  [gi|308388203|pdb|3P09|B]
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Chain B, Beta-lactamase

Protein Classification

class A beta-lactamase-related serine hydrolase( domain architecture ID 11457170)

class A beta-lactamase-related serine hydrolase, similar to beta lactamases which hydrolyze the amide bond of the beta-lactam ring via the formation of an acyl-enzyme covalent complex

CATH:  3.40.710.10
EC:  3.-.-.-
Gene Ontology:  GO:0016787
SCOP:  3001604

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
7-283 1.96e-66

Beta-lactamase class A [Defense mechanisms];


:

Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 208.60  E-value: 1.96e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        7 LVTTLSLIPSIILAAPQLDDSFKNLENKYDGKIGIYTLNTDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFLD 86
Cdd:COG2367   3 LLALLLLAAAAAAPASALEAELAALEAALGGRVGVYVLDLDTGETVGINADERFPAASTFKLPVLAAVLRQVDAGKLSLD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B       87 KKIPINQDDigKLGYAPITAKNV-GKTLTISQLNYAAI-LSDSPASNILVRELgGLQNLNKFIKKLGDNDTIITADEPEI 164
Cdd:COG2367  83 ERVTLTPED--LVGGSGILQKLPdGTGLTLRELAELMItVSDNTATNLLLRLL-GPDAVNAFLRSLGLTDTRLDRKEPDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B      165 NyTQPHSNINKTTPKAITKDIYKLAFGNILDKKHKDIFIKYLQdNNTGANRIAFS*PKDWIIGDKTGTCGqyAATNDVAI 244
Cdd:COG2367 160 N-ELPGDGRNTTTPRDMARLLAALYRGELLSPESRARLLDWLA-RQTGRDRLRAGLPEGWRVAHKTGTGG--GVRNDVGI 235
                       250       260       270
                ....*....|....*....|....*....|....*....
3P09_B      245 IWPKNQQPIALGILYTNPnDKNAPSNEEIIQQAAKLIAN 283
Cdd:COG2367 236 VWPPDGKPYVLAVFTKGP-DADAARAEALIAEIARAVYD 273
 
Name Accession Description Interval E-value
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
7-283 1.96e-66

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 208.60  E-value: 1.96e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        7 LVTTLSLIPSIILAAPQLDDSFKNLENKYDGKIGIYTLNTDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFLD 86
Cdd:COG2367   3 LLALLLLAAAAAAPASALEAELAALEAALGGRVGVYVLDLDTGETVGINADERFPAASTFKLPVLAAVLRQVDAGKLSLD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B       87 KKIPINQDDigKLGYAPITAKNV-GKTLTISQLNYAAI-LSDSPASNILVRELgGLQNLNKFIKKLGDNDTIITADEPEI 164
Cdd:COG2367  83 ERVTLTPED--LVGGSGILQKLPdGTGLTLRELAELMItVSDNTATNLLLRLL-GPDAVNAFLRSLGLTDTRLDRKEPDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B      165 NyTQPHSNINKTTPKAITKDIYKLAFGNILDKKHKDIFIKYLQdNNTGANRIAFS*PKDWIIGDKTGTCGqyAATNDVAI 244
Cdd:COG2367 160 N-ELPGDGRNTTTPRDMARLLAALYRGELLSPESRARLLDWLA-RQTGRDRLRAGLPEGWRVAHKTGTGG--GVRNDVGI 235
                       250       260       270
                ....*....|....*....|....*....|....*....
3P09_B      245 IWPKNQQPIALGILYTNPnDKNAPSNEEIIQQAAKLIAN 283
Cdd:COG2367 236 VWPPDGKPYVLAVFTKGP-DADAARAEALIAEIARAVYD 273
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
40-259 2.97e-51

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 167.45  E-value: 2.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B         40 GIYTLNTDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFLDKKIPINQDDigKLGYAPITAKN-VGKTLTISQL 118
Cdd:pfam13354   1 GIYVRDLDTGEELGINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAED--KVGGSGILQYLpDGSQLSLRDL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        119 NYAAI-LSDSPASNILVRELgGLQNLNKFIKKLGDNDTIITADEPEINYTqPHSNINKTTPKAITKDIYKLAFGNILDKK 197
Cdd:pfam13354  79 LTLMIaVSDNTATNLLIDRL-GLEAVNARLRALGLRDTRLRRKLPDLRAA-DKGGTNTTTARDMAKLLEALYRGELLSPE 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
3P09_B        198 HKDIFIKYLQDNNTgANRIAFS*PKDWIIGDKTGTCGQYaaTNDVAIIWPKNQQPIALGILY 259
Cdd:pfam13354 157 STDRLLDILSRQQF-RDRLPAGLPKGARVAHKTGDLGGV--RHDVGIVYAPDGRPYVLAVFT 215
PRK15442 PRK15442
beta-lactamase TEM; Provisional
7-283 1.60e-36

beta-lactamase TEM; Provisional


Pssm-ID: 185339 [Multi-domain]  Cd Length: 284  Bit Score: 131.51  E-value: 1.60e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B         7 LVTTLSLIPSIILAAPQLDDSFKNLENKYDGKIGIYTLN-TDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFL 85
Cdd:PRK15442   8 LIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDlNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        86 DKKIPINQDDIGKlgYAPITAKNVGKTLTISQLNYAAI-LSDSPASNILVRELGGLQNLNKFIKKLGDNDTIITADEPEI 164
Cdd:PRK15442  88 GRRIHYSQNDLVE--YSPVTEKHLTDGMTVRELCSAAItMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPEL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B       165 NYTQPHSNINKTTPKAITKDIYKLAFGNILDKKHKDIFIKYLQDNNTGANRIAFS*PKDWIIGDKTGTcGQYAATNDVAI 244
Cdd:PRK15442 166 NEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGA-GERGSRGIIAA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
3P09_B       245 IWPKNqQPIALGILYTNPNDKN-APSNEEIIQQAAKLIAN 283
Cdd:PRK15442 245 LGPDG-KPSRIVVIYTTGSQATmDERNRQIAEIGASLIKH 283
 
Name Accession Description Interval E-value
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
7-283 1.96e-66

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 208.60  E-value: 1.96e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        7 LVTTLSLIPSIILAAPQLDDSFKNLENKYDGKIGIYTLNTDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFLD 86
Cdd:COG2367   3 LLALLLLAAAAAAPASALEAELAALEAALGGRVGVYVLDLDTGETVGINADERFPAASTFKLPVLAAVLRQVDAGKLSLD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B       87 KKIPINQDDigKLGYAPITAKNV-GKTLTISQLNYAAI-LSDSPASNILVRELgGLQNLNKFIKKLGDNDTIITADEPEI 164
Cdd:COG2367  83 ERVTLTPED--LVGGSGILQKLPdGTGLTLRELAELMItVSDNTATNLLLRLL-GPDAVNAFLRSLGLTDTRLDRKEPDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B      165 NyTQPHSNINKTTPKAITKDIYKLAFGNILDKKHKDIFIKYLQdNNTGANRIAFS*PKDWIIGDKTGTCGqyAATNDVAI 244
Cdd:COG2367 160 N-ELPGDGRNTTTPRDMARLLAALYRGELLSPESRARLLDWLA-RQTGRDRLRAGLPEGWRVAHKTGTGG--GVRNDVGI 235
                       250       260       270
                ....*....|....*....|....*....|....*....
3P09_B      245 IWPKNQQPIALGILYTNPnDKNAPSNEEIIQQAAKLIAN 283
Cdd:COG2367 236 VWPPDGKPYVLAVFTKGP-DADAARAEALIAEIARAVYD 273
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
40-259 2.97e-51

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 167.45  E-value: 2.97e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B         40 GIYTLNTDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFLDKKIPINQDDigKLGYAPITAKN-VGKTLTISQL 118
Cdd:pfam13354   1 GIYVRDLDTGEELGINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAED--KVGGSGILQYLpDGSQLSLRDL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        119 NYAAI-LSDSPASNILVRELgGLQNLNKFIKKLGDNDTIITADEPEINYTqPHSNINKTTPKAITKDIYKLAFGNILDKK 197
Cdd:pfam13354  79 LTLMIaVSDNTATNLLIDRL-GLEAVNARLRALGLRDTRLRRKLPDLRAA-DKGGTNTTTARDMAKLLEALYRGELLSPE 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
3P09_B        198 HKDIFIKYLQDNNTgANRIAFS*PKDWIIGDKTGTCGQYaaTNDVAIIWPKNQQPIALGILY 259
Cdd:pfam13354 157 STDRLLDILSRQQF-RDRLPAGLPKGARVAHKTGDLGGV--RHDVGIVYAPDGRPYVLAVFT 215
PRK15442 PRK15442
beta-lactamase TEM; Provisional
7-283 1.60e-36

beta-lactamase TEM; Provisional


Pssm-ID: 185339 [Multi-domain]  Cd Length: 284  Bit Score: 131.51  E-value: 1.60e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B         7 LVTTLSLIPSIILAAPQLDDSFKNLENKYDGKIGIYTLN-TDDKTNIKYNESYHFPICSVFKFLLVGAILDYD*HNQGFL 85
Cdd:PRK15442   8 LIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDlNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B        86 DKKIPINQDDIGKlgYAPITAKNVGKTLTISQLNYAAI-LSDSPASNILVRELGGLQNLNKFIKKLGDNDTIITADEPEI 164
Cdd:PRK15442  88 GRRIHYSQNDLVE--YSPVTEKHLTDGMTVRELCSAAItMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPEL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3P09_B       165 NYTQPHSNINKTTPKAITKDIYKLAFGNILDKKHKDIFIKYLQDNNTGANRIAFS*PKDWIIGDKTGTcGQYAATNDVAI 244
Cdd:PRK15442 166 NEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGA-GERGSRGIIAA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
3P09_B       245 IWPKNqQPIALGILYTNPNDKN-APSNEEIIQQAAKLIAN 283
Cdd:PRK15442 245 LGPDG-KPSRIVVIYTTGSQATmDERNRQIAEIGASLIKH 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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