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Conserved domains on  [gi|375332592|pdb|3V69|A]
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Chain A, Protein Filia

Protein Classification

KH domain-containing protein( domain architecture ID 10191018)

K homology (KH) domain-containing protein may bind single-stranded RNA or DNA; similar to Homo sapiens KH homology domain-containing protein 1 (KHDC1)

CATH:  3.30.1370.10
Gene Ontology:  GO:0003676
PubMed:  11160884|18422648
SCOP:  4001190

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 28-140 6.18e-42

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


:

Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 134.75  E-value: 6.18e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V69_A       28 PLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGP 107
Cdd:cd12795   1 QLREKVPMSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEAWDSSGLAEITVFGR 80

                        90       100       110
                ....*....|....*....|....*....|....
3V69_A      108 PPFRRDVDRMLTDLAHYCRMKLME-IEALEAGVE 140
Cdd:cd12795  81 PRARRRVKRMLLNLAAWHREHRARgREKLEELEE 114
 
Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 28-140 6.18e-42

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 134.75  E-value: 6.18e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V69_A       28 PLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGP 107
Cdd:cd12795   1 QLREKVPMSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEAWDSSGLAEITVFGR 80

                        90       100       110
                ....*....|....*....|....*....|....
3V69_A      108 PPFRRDVDRMLTDLAHYCRMKLME-IEALEAGVE 140
Cdd:cd12795  81 PRARRRVKRMLLNLAAWHREHRARgREKLEELEE 114
MOEP19 pfam16005
KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The ...
 44-128 1.21e-40

KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The family is expressed during early embryogenesis. It appears to effect an early form of molecular asymmetry within the murine oocyte cytoplasm. The family marks a defined cortical cytoplasmic domain in oocytes and provides evidence for mammalian oocyte polarity and a form of pre-patterning that persists in zygotes and early embryos through the morula stage.


Pssm-ID: 464969  Cd Length: 85  Bit Score: 130.45  E-value: 1.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V69_A         44 KLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAH 123
Cdd:pfam16005   1 KRPWWFPPEELKDPLVFYLEAWLLELIFGPDGERIPHIEWMSQTLLQVDVVDSEGLAEITIFGRPRYQKRVKKMLLSLAS 80


                  ....*
3V69_A        124 YCRMK 128
Cdd:pfam16005  81 WHRER 85
 
Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 28-140 6.18e-42

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 134.75  E-value: 6.18e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V69_A       28 PLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGP 107
Cdd:cd12795   1 QLREKVPMSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEAWDSSGLAEITVFGR 80

                        90       100       110
                ....*....|....*....|....*....|....
3V69_A      108 PPFRRDVDRMLTDLAHYCRMKLME-IEALEAGVE 140
Cdd:cd12795  81 PRARRRVKRMLLNLAAWHREHRARgREKLEELEE 114
MOEP19 pfam16005
KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The ...
 44-128 1.21e-40

KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The family is expressed during early embryogenesis. It appears to effect an early form of molecular asymmetry within the murine oocyte cytoplasm. The family marks a defined cortical cytoplasmic domain in oocytes and provides evidence for mammalian oocyte polarity and a form of pre-patterning that persists in zygotes and early embryos through the morula stage.


Pssm-ID: 464969  Cd Length: 85  Bit Score: 130.45  E-value: 1.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3V69_A         44 KLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAH 123
Cdd:pfam16005   1 KRPWWFPPEELKDPLVFYLEAWLLELIFGPDGERIPHIEWMSQTLLQVDVVDSEGLAEITIFGRPRYQKRVKKMLLSLAS 80


                  ....*
3V69_A        124 YCRMK 128
Cdd:pfam16005  81 WHRER 85
KH-I_KHDC1_like cd22440
type I K homology (KH) RNA-binding domain found in KHDC1-like family; The KHDC1-like family ...
 54-121 5.11e-30

type I K homology (KH) RNA-binding domain found in KHDC1-like family; The KHDC1-like family corresponds to a group of structurally related proteins characterized by an atypical RNA-binding KH domain. They are unique to eutherian mammals and specifically expressed in oocytes and/or embryonic stem cells. Family members include KH homology domain-containing protein 1 (KHDC1), KHDC1-like protein (KHDC1L), KHDC3-like protein (KHDC3L, also called ES cell-associated transcript 1 protein or ECAT1), developmental pluripotency-associated 5 protein (DPPA5, also called embryonal stem cell-specific gene 1 protein or ESG-1), Oocyte-expressed protein (OOEP, also called KH homology domain-containing protein 2 or KHDC2, or Oocyte- and embryo-specific protein 19 or OEP19). KHDC3L is essential for human oocyte maturation and pre-implantation development of the resulting embryos. DPPA5 is involved in the maintenance of embryonic stem (ES) cell pluripotency. OOEP plays an essential role for zygotes to progress beyond the first embryonic cell divisions.


Pssm-ID: 411868  Cd Length: 68  Bit Score: 103.15  E-value: 5.11e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
3V69_A       54 LEDPKRLYVEPRLLEIMFGKDGEHIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDL 121
Cdd:cd22440   1 LQDPSVFHVEARLLEKIFGPDGTLIPHLEQESHTLIHVDRWDPEGKAEITIFGPPRYRQRAKWMLQCL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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