NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|512125634|pdb|4JBW|M]
View 

Chain M, Glucose-specific phosphotransferase enzyme IIA component

Protein Classification

PTS glucose transporter subunit IIA( domain architecture ID 10013238)

PTS glucose transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming glucose substrates concomitantly with their translocation across the cell membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 4-172 3.49e-109

PTS system glucose-specific transporter subunit; Provisional


:

Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 308.44  E-value: 3.49e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         4 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 83
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M        84 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 163
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
4JBW_M       164 ETPVIRIKK 172
Cdd:PRK09439 161 ETPVIRVKK 169
 
Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 4-172 3.49e-109

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 308.44  E-value: 3.49e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         4 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 83
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M        84 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 163
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
4JBW_M       164 ETPVIRIKK 172
Cdd:PRK09439 161 ETPVIRVKK 169
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
19-172 1.70e-71

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 212.29  E-value: 1.70e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M       19 KDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGID 98
Cdd:COG2190   1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGID 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
4JBW_M       99 TVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKL-SGSVTVGEtPVIRIKK 172
Cdd:COG2190  81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTkSGQVKAGD-PLLTVKL 154
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 26-149 2.11e-62

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 188.27  E-value: 2.11e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M       26 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 105
Cdd:cd00210   1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
4JBW_M      106 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDE 149
Cdd:cd00210  81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 26-146 2.22e-61

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 185.53  E-value: 2.22e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         26 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 105
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
4JBW_M        106 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISN 146
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
24-144 9.06e-57

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 174.10  E-value: 9.06e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         24 IEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELK 103
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
4JBW_M        104 GEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVI 144
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
 
Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 4-172 3.49e-109

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 308.44  E-value: 3.49e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         4 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 83
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M        84 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 163
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
4JBW_M       164 ETPVIRIKK 172
Cdd:PRK09439 161 ETPVIRVKK 169
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
19-172 1.70e-71

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 212.29  E-value: 1.70e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M       19 KDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGID 98
Cdd:COG2190   1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGID 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
4JBW_M       99 TVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKL-SGSVTVGEtPVIRIKK 172
Cdd:COG2190  81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTkSGQVKAGD-PLLTVKL 154
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 26-149 2.11e-62

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 188.27  E-value: 2.11e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M       26 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 105
Cdd:cd00210   1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
4JBW_M      106 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDE 149
Cdd:cd00210  81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 26-146 2.22e-61

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 185.53  E-value: 2.22e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         26 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 105
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
4JBW_M        106 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISN 146
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
24-144 9.06e-57

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 174.10  E-value: 9.06e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M         24 IEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELK 103
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
4JBW_M        104 GEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVI 144
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 25-172 1.94e-49

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 168.51  E-value: 1.94e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M        25 EIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKG 104
Cdd:PRK10255 500 ELVSPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVALEG 579

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
4JBW_M       105 EGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKEL-IKLSGSVTVGETPVIRIKK 172
Cdd:PRK10255 580 KGFKRLVEEGAQVSAGQPILEMDLDYLNANARSMISPVVCSNIDDFSGLiIKAQGHVVAGQTPLYEIKK 648
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 15-170 1.93e-43

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 151.79  E-value: 1.93e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4JBW_M        15 SDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVH 94
Cdd:PRK09824 470 PEVITPPEQGGICSPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDGVEVLIH 549

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
4JBW_M        95 FGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRI 170
Cdd:PRK09824 550 VGIDTVKLDGKFFTAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDDYTDVLPHATAQVSAGEPLLSI 625
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH