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Conserved domains on  [gi|1258500314|pdb|5NRP|A]
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Chain A, Transcobalamin-2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4430 super family cl20531
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ...
 33-107 5.62e-08

Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.


The actual alignment was detected with superfamily member pfam14478:

Pssm-ID: 433979  Cd Length: 72  Bit Score: 46.14  E-value: 5.62e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
5NRP_A         33 GSTVEDVLKKAHELggftYETQASLSGPYLTSVMGKAA--GEREFWQLLRDpNTPLLQGIADYRPKDGETIELRLVS 107
Cdd:pfam14478   1 GDTVLDVLKANLKV----KEIKGSYDGGFITSINGLEQdtGKNSYWMYSVN-GKMPNVGAGDYKLKNGDKIVWYYTK 72
 
Name Accession Description Interval E-value
DUF4430 pfam14478
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ...
 33-107 5.62e-08

Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.


Pssm-ID: 433979  Cd Length: 72  Bit Score: 46.14  E-value: 5.62e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
5NRP_A         33 GSTVEDVLKKAHELggftYETQASLSGPYLTSVMGKAA--GEREFWQLLRDpNTPLLQGIADYRPKDGETIELRLVS 107
Cdd:pfam14478   1 GDTVLDVLKANLKV----KEIKGSYDGGFITSINGLEQdtGKNSYWMYSVN-GKMPNVGAGDYKLKNGDKIVWYYTK 72
 
Name Accession Description Interval E-value
DUF4430 pfam14478
Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the ...
 33-107 5.62e-08

Domain of unknown function (DUF4430); Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.


Pssm-ID: 433979  Cd Length: 72  Bit Score: 46.14  E-value: 5.62e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
5NRP_A         33 GSTVEDVLKKAHELggftYETQASLSGPYLTSVMGKAA--GEREFWQLLRDpNTPLLQGIADYRPKDGETIELRLVS 107
Cdd:pfam14478   1 GDTVLDVLKANLKV----KEIKGSYDGGFITSINGLEQdtGKNSYWMYSVN-GKMPNVGAGDYKLKNGDKIVWYYTK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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