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Conserved domains on  [gi|1562366204|pdb|6AGI|A]
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Chain A, Calcium uptake protein 3, mitochondrial

Protein Classification

EF-hand domain-containing protein; calcium-dependent protein kinase( domain architecture ID 13006737)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction| calcium-dependent protein kinase is a serine/threonine-protein kinase (STK) that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and is a multifunctional calcium and calmodulin (CaM) stimulated STK involved in cell cycle regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 106-373 3.80e-53

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


:

Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 172.31  E-value: 3.80e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      106 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 185
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      186 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 265
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      266 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 345
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
6AGI_A      346 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 373
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
PTZ00183 super family cl33171
centrin; Provisional
 108-236 1.09e-04

centrin; Provisional


The actual alignment was detected with superfamily member PTZ00183:

Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 42.37  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A       108 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 180
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
6AGI_A       181 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 236
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
 
Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 106-373 3.80e-53

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 172.31  E-value: 3.80e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      106 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 185
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      186 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 265
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      266 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 345
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
6AGI_A      346 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 373
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
PTZ00183 PTZ00183
centrin; Provisional
 108-236 1.09e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 42.37  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A       108 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 180
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
6AGI_A       181 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 236
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
EF-hand_7 pfam13499
EF-hand domain pair;
320-370 1.33e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.54  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
6AGI_A        320 SRSIGQDEFKRAVY-VATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 370
Cdd:pfam13499  16 DGYLDVEELKKLLRkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
291-371 8.43e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.39  E-value: 8.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      291 ITFDEFRSFFQFLNNLEDFAIALNMYNFA----SRSIGQDEFKRAVyvaTGLKFSPHLVNTVFKIFDVDKDDQLSYKEFI 366
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLdtdgDGKISADEFRRLL---TALGVSEEEADELFARLDTDGDGKISFEEFV 126


                ....*
6AGI_A      367 GIMKD 371
Cdd:COG5126 127 AAVRD 131
 
Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 106-373 3.80e-53

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 172.31  E-value: 3.80e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      106 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 185
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      186 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 265
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      266 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 345
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
6AGI_A      346 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 373
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
EFh_MICU cd15900
EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, ...
 106-373 3.39e-49

EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins; This family includes mitochondrial calcium uptake protein MICU1 and its two additional paralogs, MICU2 and MICU3. MICU1 localizes to the inner mitochondrial membrane (IMM). It functions as a gatekeeper of the mitochondrial calcium uniporter (MCU) and regulates MCU-mediated mitochondrial Ca2+ uptake, which is essential for maintaining mitochondrial homoeostasis. MICU1 and MICU2 are physically associated within the uniporter complex and are co-expressed across all tissues. They may play non-redundant roles in the regulation of the mitochondrial calcium uniporter. At present, the precise molecular function of MICU2 and MICU3 remain unclear. MICU2 may play possible roles in Ca2+ sensing and regulation of MCU, calcium buffering with a secondary impact on transport or assembly and stabilization of MCU. MICU3 likely has a role in mitochondrial calcium handling. All members in this family contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320080 [Multi-domain]  Cd Length: 152  Bit Score: 163.17  E-value: 3.39e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      106 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRAMLRLQlygyhsptnsvlktdaeelvsrsywdtlr 185
Cdd:cd15900   1 HFEIAFKMFDLDGDGELDKEEFNKVQSIIRSQTSVGQRHRDHTNGESTKLG----------------------------- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      186 rntsqalfsdlaeradditslvTDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 265
Cdd:cd15900  52 ----------------------MNSTLARYFFGKDGKQKLSIEKFLEFQENLQEEI------------------------ 85

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      266 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 345
Cdd:cd15900  86 -----------------------------------------DDVDTALTFYHLAGASIDRKTFKRAAKVVAGVELSDHVV 124

                       250       260
                ....*....|....*....|....*...
6AGI_A      346 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 373
Cdd:cd15900 125 DVVFTIFDEDGDGILSHKEFISVMKDRL 152
EFh_MICU2 cd16174
EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and ...
 106-373 1.25e-35

EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and similar proteins; MICU2, also termed EF-hand domain-containing family member A1 (EFHA1), is a mitochondrial-localized paralog of MICU1. MICU2 and its paralog, MICU1, are physically associated within the mitochondrial calcium uniporter (MCU) complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. At present, the precise molecular function of MICU2 remains unclear. It may play possible roles in Ca2+ sensing and regulation of MCU, calcium buffering with a secondary impact on transport or assembly and stabilization of MCU. MICU2 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320082 [Multi-domain]  Cd Length: 154  Bit Score: 127.68  E-value: 1.25e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      106 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRamlrlqlygyhsptnsvlktdaeelvsrsywdtlr 185
Cdd:cd16174   1 GFHIAFKMLDTDGNEQVEKREFFKLQKIIGKKDDLMTQGGTETYQ----------------------------------- 45

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      186 rntsqalfsDLAERADDItslvtDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 265
Cdd:cd16174  46 ---------EASDNSDEV-----NTTLQVHFFGKDGNEKLQYKEFCRFMENLQTEV------------------------ 87

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      266 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 345
Cdd:cd16174  88 -----------------------------------------EDFAIAMKMFSEANRPIKLAEFKRAVKVATGQELSDNVL 126

                       250       260
                ....*....|....*....|....*...
6AGI_A      346 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 373
Cdd:cd16174 127 DTVFKIFDLDGDDCLSHGEFLGVLKNRV 154
EFh_MICU1 cd16173
EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and ...
 292-373 1.36e-06

EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins; MICU1, also termed atopy-related autoantigen CALC (ara CALC), or calcium-binding atopy-related autoantigen 1 (CBARA1), or Hom s 4, or EFHA3, localizes to the inner mitochondrial membrane (IMM). It functions as a gatekeeper of the mitochondrial calcium uniporter (MCU) and regulates MCU-mediated mitochondrial Ca2+ uptake, which is essential for maintaining mitochondrial homoeostasis. MICU1 and its paralog, MICU2, are physically associated within the uniporter complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. The mutations in MICU1 are associated with neuromuscular abnormalities in children. MICU1 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320081 [Multi-domain]  Cd Length: 153  Bit Score: 47.71  E-value: 1.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      292 TFDEFRSFFQflNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKD 371
Cdd:cd16173  74 NFLEFQRKLQ--HDVNDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVAIMKQ 151


                ..
6AGI_A      372 RL 373
Cdd:cd16173 152 RL 153
PTZ00183 PTZ00183
centrin; Provisional
 108-236 1.09e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 42.37  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A       108 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 180
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
6AGI_A       181 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 236
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
EF-hand_7 pfam13499
EF-hand domain pair;
320-370 1.33e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.54  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
6AGI_A        320 SRSIGQDEFKRAVY-VATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 370
Cdd:pfam13499  16 DGYLDVEELKKLLRkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EF-hand_8 pfam13833
EF-hand domain pair;
320-372 4.96e-04

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 37.68  E-value: 4.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
6AGI_A        320 SRSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDR 372
Cdd:pfam13833   2 KGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
291-371 8.43e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.39  E-value: 8.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      291 ITFDEFRSFFQFLNNLEDFAIALNMYNFA----SRSIGQDEFKRAVyvaTGLKFSPHLVNTVFKIFDVDKDDQLSYKEFI 366
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLdtdgDGKISADEFRRLL---TALGVSEEEADELFARLDTDGDGKISFEEFV 126


                ....*
6AGI_A      367 GIMKD 371
Cdd:COG5126 127 AAVRD 131
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 320-370 1.36e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.76  E-value: 1.36e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
6AGI_A      320 SRSIGQDEFKRAVyVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 370
Cdd:cd00051  14 DGTISADELKAAL-KSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EFh_PEF_ALG-2_like cd16185
EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein ...
 291-368 1.42e-03

EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein (ALG-2); The family includes some homologs of mammalian apoptosis-linked gene 2 protein (ALG-2) mainly found in lower eukaryotes, such as a parasitic protist Leishmarua major and a cellular slime mold Dictyostelium discoideum. These homologs contains five EF-hand motifs. Due to the presence of unfavorable residues at the Ca2+-coordinating positions, their non-canonical EF4 and EF5 hands may not bind Ca2+. Two Dictyostelium PEF proteins are the prototypes of this family. They may bind to cytoskeletal proteins and/or signal-transducing proteins localized to detergent-resistant membranes named lipid rafts, and occur as monomers or weak homo- or heterodimers like ALG-2. They can serve as a mediator for Ca2+ signaling-related Dictyostehum programmed cell death (PCD).


Pssm-ID: 320060 [Multi-domain]  Cd Length: 163  Bit Score: 39.12  E-value: 1.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6AGI_A      291 ITFDEFRSFFQFLNNLEDfaiALNMYNfASRS--IGQDEFKRAVyVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGI 368
Cdd:cd16185  53 IDFEEFAALHQFLSNMQN---GFEQRD-TSRSgrLDANEVHEAL-AASGFQLDPPAFQALFRKFDPDRGGSLGFDDYIEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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