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Conserved domains on  [gi|1540347141|pdb|6DO3|B]
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Chain B, Kelch domain-containing protein 2

Protein Classification

Kelch repeat-containing protein( domain architecture ID 14144492)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Kelch domain-containing protein 2, a substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-338 3.24e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       79 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 158
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      159 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 238
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      239 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 318
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                       250       260
                ....*....|....*....|
6DO3_B      319 PRLWHTACASDeGEVIVFGG 338
Cdd:COG3055 196 ARAGHAAAVLG-GKILVFGG 214
Kelch_4 pfam13418
Galactose oxidase, central domain;
33-90 1.75e-03

Galactose oxidase, central domain;


:

Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
6DO3_B         33 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 90
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-338 3.24e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       79 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 158
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      159 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 238
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      239 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 318
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                       250       260
                ....*....|....*....|
6DO3_B      319 PRLWHTACASDeGEVIVFGG 338
Cdd:COG3055 196 ARAGHAAAVLG-GKILVFGG 214
PLN02193 PLN02193
nitrile-specifier protein
 30-297 1.36e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B        30 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 106
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       107 FGGHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 186
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       187 SHP----------------------RGWN----DHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGryrD 240
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6DO3_B       241 ARMNDLHY------------LNLDTWEWNELIPQGI---CPVGRSWHSLTPVSSD---HLFLFGGfttdKQPLSD 297
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
Kelch_4 pfam13418
Galactose oxidase, central domain;
268-308 1.16e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
6DO3_B        268 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 308
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 49-158 1.09e-04

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.12  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B         49 GGYKsnqVRGLYDFYLPR--EELWIYNMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYMLDS-- 124
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIVSfd 124

                          90       100       110
                  ....*....|....*....|....*....|....
6DO3_B        125 RSTDRVLQWERIDCqgIPPSSKDKLGVWVYKNKL 158
Cdd:TIGR01640 125 VSSERFKEFIPLPC--GNSDSVDYLSLINYKGKL 156
Kelch_4 pfam13418
Galactose oxidase, central domain;
33-90 1.75e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
6DO3_B         33 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 90
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
79-338 3.24e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       79 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 158
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      159 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 238
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      239 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 318
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                       250       260
                ....*....|....*....|
6DO3_B      319 PRLWHTACASDeGEVIVFGG 338
Cdd:COG3055 196 ARAGHAAAVLG-GKILVFGG 214
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
205-346 1.83e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.58  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      205 TWSqpiTTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFL 284
Cdd:COG3055   2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYV 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
6DO3_B      285 FGGFTTDK---QPLSDAWTYCISKNEWIQfnHPYTEKPRLWHTAcASDEGEVIVFGGCANNLLVH 346
Cdd:COG3055  76 FGGFTGANpssTPLNDVYVYDPATNTWTK--LAPMPTPRGGATA-LLLDGKIYVVGGWDDGGNVA 137
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
31-299 3.68e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       31 AERSGHVAVSDGRHMFVWGGYksnqvRGLYDFYLPREELWIYNMETGRWKKInteGDVPPSMSGSCAVCVDRVLYLFGGH 110
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGF-----TGANPSSTPLNDVYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      111 HSRGNTNKFYMLDsRSTDrvlQWERIdcqGIPPSSKDKL-GVWVYKNKLIFFGGYgylpedkvlgtfefDETSFWNsshp 189
Cdd:COG3055 131 DDGGNVAWVEVYD-PATG---TWTQL---APLPTPRDHLaAAVLPDGKILVIGGR--------------NGSGFSN---- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B      190 rgwndhvhildtetfTWSqpiTTGKAPSPRAAHACATVGNRGFVFGGRYrdARMNDLHYLNLDTWEWNELipqGICPVGR 269
Cdd:COG3055 186 ---------------TWT---TLAPLPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL---GELPTPR 242

                       250       260       270
                ....*....|....*....|....*....|.
6DO3_B      270 swHSLTPVS-SDHLFLFGGFTTDKQPLSDAW 299
Cdd:COG3055 243 --HGHAAVLtDGKVYVIGGETKPGVRTPLVT 271
PLN02193 PLN02193
nitrile-specifier protein
 30-297 1.36e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B        30 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 106
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       107 FGGHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 186
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       187 SHP----------------------RGWN----DHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGryrD 240
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6DO3_B       241 ARMNDLHY------------LNLDTWEWNELIPQGI---CPVGRSWHSLTPVSSD---HLFLFGGfttdKQPLSD 297
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
PLN02193 PLN02193
nitrile-specifier protein
 132-314 1.10e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.67  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       132 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYgYLPEDKVlgtfefdetsfwnsshprgwNDHVHILDTETFTWSQPIT 211
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE-FTPNQPI--------------------DKHLYVFDLETRTWSISPA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       212 TGKAPSPRAAHAC-ATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTpVSSDHLFLFGGFT- 289
Cdd:PLN02193 211 TGDVPHLSCLGVRmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSa 289

                        170       180
                 ....*....|....*....|....*
6DO3_B       290 TDKQPLSDAwtYCISKNEWIQFNHP 314
Cdd:PLN02193 290 TARLKTLDS--YNIVDKKWFHCSTP 312
PLN02153 PLN02153
epithiospecifier protein
 30-304 3.56e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B        30 PAERSGHVAVSDGRHMFVWGG-YKSNQVRGlydfylprEELWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYLF 107
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGeLKPNEHID--------KDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       108 GGHHSRGNTNKFYMLDSRSTdrvlQWE---RIDCQGIPPS------SKDKLGVWVY----KNKL--------------IF 160
Cdd:PLN02153  92 GGRDEKREFSDFYSYDTVKN----EWTfltKLDEEGGPEArtfhsmASDENHVYVFggvsKGGLmktperfrtieaynIA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       161 FGGYGYLP------EDKVLGTFEFDETSFW------NSSHPRGWNDH----VHILDTETFTWSQPITTGKAPSPRAAHAC 224
Cdd:PLN02153 168 DGKWVQLPdpgenfEKRGGAGFAVVQGKIWvvygfaTSILPGGKSDYesnaVQFFDPASGKWTEVETTGAKPSARSVFAH 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       225 ATVGNRGFVFGGR-YRDAR--------MNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSD---HLFLFGGFTTDK 292
Cdd:PLN02153 248 AVVGKYIIIFGGEvWPDLKghlgpgtlSNEGYALDTETLVWEKLGECGEPAMPRGWTAYTTATVYgknGLLMHGGKLPTN 327

                        330
                 ....*....|..
6DO3_B       293 QPLSDAWTYCIS 304
Cdd:PLN02153 328 ERTDDLYFYAVN 339
PLN02153 PLN02153
epithiospecifier protein
 213-338 1.83e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.46  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       213 GKAPSPRAAHACATVGNRGFVFGGRYRDARM--NDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGfTT 290
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG-RD 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
6DO3_B       291 DKQPLSDAWTYCISKNEW---IQFNHPYTEKPRLWHTAcASDEGEVIVFGG 338
Cdd:PLN02153  96 EKREFSDFYSYDTVKNEWtflTKLDEEGGPEARTFHSM-ASDENHVYVFGG 145
Kelch_4 pfam13418
Galactose oxidase, central domain;
268-308 1.16e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
6DO3_B        268 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 308
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
PLN02193 PLN02193
nitrile-specifier protein
 206-338 1.37e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.04  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       206 WSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMND--LHYLNLDTWEWNELIPQGICPvGRSWHSLTPVS-SDHL 282
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDkhLYVFDLETRTWSISPATGDVP-HLSCLGVRMVSiGSTL 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
6DO3_B       283 FLFGGFTTDKQpLSDAWTYCISKNEWiQFNHPYTE--KPRLWHTAcASDEGEVIVFGG 338
Cdd:PLN02193 232 YVFGGRDASRQ-YNGFYSFDTTTNEW-KLLTPVEEgpTPRSFHSM-AADEENVYVFGG 286
PLN02153 PLN02153
epithiospecifier protein
 26-248 5.41e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.59  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B        26 ELACPAERSGHVAVSDGRHMFVWGGYKSNqvrGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGS-CAVCVDRVL 104
Cdd:PLN02153 121 EEGGPEARTFHSMASDENHVYVFGGVSKG---GLMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAgFAVVQGKIW 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B       105 YLFG-------GHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGtfe 177
Cdd:PLN02153 198 VVYGfatsilpGGKSDYESNAVQFFDPASG----KWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEVWPDLKGHLG--- 270

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
6DO3_B       178 fdetsfwnsshPRGWNDHVHILDTETFTWSQPITTGKAPSPRA--AHACATV-GNRGFVF-GGRY-RDARMNDLHY 248
Cdd:PLN02153 271 -----------PGTLSNEGYALDTETLVWEKLGECGEPAMPRGwtAYTTATVyGKNGLLMhGGKLpTNERTDDLYF 335
Kelch_3 pfam13415
Galactose oxidase, central domain;
280-327 9.83e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 9.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
6DO3_B        280 DHLFLFGGFTTDKQP-LSDAWTYCISKNEWIQFNHPYTekPRLWHTACA 327
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPP--PRSGHSATY 48
PHA03098 PHA03098
kelch-like protein; Provisional
 58-205 1.08e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B        58 GLYDFYLPREELWIYNMETGRWKKINTegdVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTdRVLQWERID 137
Cdd:PHA03098 397 GISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVESYNP-VTNKWTELS 472

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
6DO3_B       138 CQGIPpssKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEfDETSFWNSSHprGWNDHVHILDTETFT 205
Cdd:PHA03098 473 SLNFP---RINASLCIFNNKIYVVGGDKYEYYINEIEVYD-DKTNTWTLFC--KFPKVIGSLEKNIFT 534
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 49-158 1.09e-04

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.12  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6DO3_B         49 GGYKsnqVRGLYDFYLPR--EELWIYNMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYMLDS-- 124
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIVSfd 124

                          90       100       110
                  ....*....|....*....|....*....|....
6DO3_B        125 RSTDRVLQWERIDCqgIPPSSKDKLGVWVYKNKL 158
Cdd:TIGR01640 125 VSSERFKEFIPLPC--GNSDSVDYLSLINYKGKL 156
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 218-259 2.13e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 2.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
6DO3_B        218 PRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNEL 259
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_3 pfam13415
Galactose oxidase, central domain;
228-275 1.39e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
6DO3_B        228 GNRGFVFGGRYRDA--RMNDLHYLNLDTWEWNELipqGICPVGRSWHSLT 275
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
33-90 1.75e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
6DO3_B         33 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 90
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 30-77 5.43e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.46  E-value: 5.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
6DO3_B         30 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFylpreelWIYNMETG 77
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDV-------YVLSLPTF 41
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 89-123 9.07e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 9.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
6DO3_B         89 PPSMSGSCAVCVDRVLYLFGGHHSRGN--TNKFYMLD 123
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGqpSDDVYVLS 37
Kelch_6 pfam13964
Kelch motif;
218-259 9.91e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.85  E-value: 9.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
6DO3_B        218 PRAAHACATVGNRGFVFGGRYRDA-RMNDLHYLNLDTWEWNEL 259
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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