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Conserved domains on  [gi|1530732632|pdb|6IRX|A]
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Chain A, PDX1 C-terminal-inhibiting factor 1

Protein Classification

phosphorylated CTD interacting factor 1 WW domain-domain-containing( domain architecture ID 10573743)

phosphorylated CTD interacting factor 1 (PCIF1) WW domain-domain-containing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCIF1_WW pfam12237
Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and ...
 274-444 8.27e-102

Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.


:

Pssm-ID: 463502  Cd Length: 172  Bit Score: 302.27  E-value: 8.27e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        274 KLELLYR-YSCIDDPRFEKFLSRVWCLIKRYQV*FGSGVNEGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFC 352
Cdd:pfam12237   1 KLEQLYRsYSCFDDKKFEIFLPRLFCLLLRYQTLLGGQSNEGGGTQAALPESVFDCLHRFFGVSFECFASPLNCYFRQYC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        353 SAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEEL*DA*VTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTR*EASRF 432
Cdd:pfam12237  81 SAFPDTDGYFGSRGSFFDFKPVSGSFEANPPFCEELMDAMADHIERLLEASSEPLSFVVFVPEWRDPPTPALLKLEESRF 160

                         170
                  ....*....|..
6IRX_A        433 RRHQ*TVPAFEH 444
Cdd:pfam12237 161 KRKQVVIPANEH 172
 
Name Accession Description Interval E-value
PCIF1_WW pfam12237
Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and ...
 274-444 8.27e-102

Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.


Pssm-ID: 463502  Cd Length: 172  Bit Score: 302.27  E-value: 8.27e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        274 KLELLYR-YSCIDDPRFEKFLSRVWCLIKRYQV*FGSGVNEGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFC 352
Cdd:pfam12237   1 KLEQLYRsYSCFDDKKFEIFLPRLFCLLLRYQTLLGGQSNEGGGTQAALPESVFDCLHRFFGVSFECFASPLNCYFRQYC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        353 SAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEEL*DA*VTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTR*EASRF 432
Cdd:pfam12237  81 SAFPDTDGYFGSRGSFFDFKPVSGSFEANPPFCEELMDAMADHIERLLEASSEPLSFVVFVPEWRDPPTPALLKLEESRF 160

                         170
                  ....*....|..
6IRX_A        433 RRHQ*TVPAFEH 444
Cdd:pfam12237 161 KRKQVVIPANEH 172
 
Name Accession Description Interval E-value
PCIF1_WW pfam12237
Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and ...
 274-444 8.27e-102

Phosphorylated CTD interacting factor 1 WW domain; This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.


Pssm-ID: 463502  Cd Length: 172  Bit Score: 302.27  E-value: 8.27e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        274 KLELLYR-YSCIDDPRFEKFLSRVWCLIKRYQV*FGSGVNEGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFC 352
Cdd:pfam12237   1 KLEQLYRsYSCFDDKKFEIFLPRLFCLLLRYQTLLGGQSNEGGGTQAALPESVFDCLHRFFGVSFECFASPLNCYFRQYC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IRX_A        353 SAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEEL*DA*VTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTR*EASRF 432
Cdd:pfam12237  81 SAFPDTDGYFGSRGSFFDFKPVSGSFEANPPFCEELMDAMADHIERLLEASSEPLSFVVFVPEWRDPPTPALLKLEESRF 160

                         170
                  ....*....|..
6IRX_A        433 RRHQ*TVPAFEH 444
Cdd:pfam12237 161 KRKQVVIPANEH 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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