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Conserved domains on  [gi|1866605235|pdb|6KGE|C]
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Chain C, Probably cellulosomal scaffolding protein, secreted cellulose-binding and cohesin domain

Protein Classification

Reeler domain-containing protein( domain architecture ID 10171066)

Reeler N-terminal domain-containing protein similar to extracellular matrix protein F-spondin that mediates axon guidance during neuronal development, and to putative defense proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Type_I_cohesin_like cd08548
Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a ...
 7-143 4.26e-28

Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type I cohesins; their interactions with dockerin mediate assembly of a range of dockerin-borne enzymes to the complex.


:

Pssm-ID: 260085  Cd Length: 135  Bit Score: 100.81  E-value: 4.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C        7 VKLSVGTVSGNPGDTVKVPVTISQV-STPVGLICMDISYDASKFTVKDVLPnTDLVKDTdNYSFIVNTSTPGKISITFTD 85
Cdd:cd08548   1 VEVIIGNVSAKAGDTVTVPVTLSNVpSKGIGSCDFVLKYDSSVLEVVSVDA-GSIVKNP-TANFSSNVDEDGIIKFLFSD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6KGE_C       86 PTLANYPISVDGILAYLDFIINSNATAGDSALTVDPATlIVADENDKDIKDAASNGKI 143
Cdd:cd08548  79 STGGSYLIKTDGVFATLTFKVKSNAAGGTYAITLSSNG-AFSDADLKEISVTFINGKV 135
 
Name Accession Description Interval E-value
Type_I_cohesin_like cd08548
Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a ...
 7-143 4.26e-28

Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type I cohesins; their interactions with dockerin mediate assembly of a range of dockerin-borne enzymes to the complex.


Pssm-ID: 260085  Cd Length: 135  Bit Score: 100.81  E-value: 4.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C        7 VKLSVGTVSGNPGDTVKVPVTISQV-STPVGLICMDISYDASKFTVKDVLPnTDLVKDTdNYSFIVNTSTPGKISITFTD 85
Cdd:cd08548   1 VEVIIGNVSAKAGDTVTVPVTLSNVpSKGIGSCDFVLKYDSSVLEVVSVDA-GSIVKNP-TANFSSNVDEDGIIKFLFSD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6KGE_C       86 PTLANYPISVDGILAYLDFIINSNATAGDSALTVDPATlIVADENDKDIKDAASNGKI 143
Cdd:cd08548  79 STGGSYLIKTDGVFATLTFKVKSNAAGGTYAITLSSNG-AFSDADLKEISVTFINGKV 135
Cohesin pfam00963
Cohesin domain; Cohesin domains interact with a complementary domain, termed the dockerin ...
 7-145 6.12e-23

Cohesin domain; Cohesin domains interact with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.


Pssm-ID: 395769  Cd Length: 139  Bit Score: 87.84  E-value: 6.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C          7 VKLSVGTVSGNPGDTVKVPVTISQVSTP-VGLICMDISYDASKFTVKDVLPNTDLVKDTDNYSFIVNTsTPGKISITFTD 85
Cdd:pfam00963   1 VKVTIGKVSGKVGDTVTVPVTVSNVPKNgVAAADFTINYDPTVLEVVSVTPGSIVDNPNVNFGSNVLV-EPGKIKFLFLD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
6KGE_C         86 PT-LANYPISVDGILAYLDFIINSNATAGdSALTVDPATLIVADENDKDIKDAASNGKITV 145
Cdd:pfam00963  80 LTsLGSSGIAKDGVFATITFKVKSDAAAG-TTPIKISGTLSFGDGGLNEIKVTLTDGSINV 139
 
Name Accession Description Interval E-value
Type_I_cohesin_like cd08548
Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a ...
 7-143 4.26e-28

Type I cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type I cohesins; their interactions with dockerin mediate assembly of a range of dockerin-borne enzymes to the complex.


Pssm-ID: 260085  Cd Length: 135  Bit Score: 100.81  E-value: 4.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C        7 VKLSVGTVSGNPGDTVKVPVTISQV-STPVGLICMDISYDASKFTVKDVLPnTDLVKDTdNYSFIVNTSTPGKISITFTD 85
Cdd:cd08548   1 VEVIIGNVSAKAGDTVTVPVTLSNVpSKGIGSCDFVLKYDSSVLEVVSVDA-GSIVKNP-TANFSSNVDEDGIIKFLFSD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6KGE_C       86 PTLANYPISVDGILAYLDFIINSNATAGDSALTVDPATlIVADENDKDIKDAASNGKI 143
Cdd:cd08548  79 STGGSYLIKTDGVFATLTFKVKSNAAGGTYAITLSSNG-AFSDADLKEISVTFINGKV 135
Cohesin pfam00963
Cohesin domain; Cohesin domains interact with a complementary domain, termed the dockerin ...
 7-145 6.12e-23

Cohesin domain; Cohesin domains interact with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.


Pssm-ID: 395769  Cd Length: 139  Bit Score: 87.84  E-value: 6.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C          7 VKLSVGTVSGNPGDTVKVPVTISQVSTP-VGLICMDISYDASKFTVKDVLPNTDLVKDTDNYSFIVNTsTPGKISITFTD 85
Cdd:pfam00963   1 VKVTIGKVSGKVGDTVTVPVTVSNVPKNgVAAADFTINYDPTVLEVVSVTPGSIVDNPNVNFGSNVLV-EPGKIKFLFLD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
6KGE_C         86 PT-LANYPISVDGILAYLDFIINSNATAGdSALTVDPATLIVADENDKDIKDAASNGKITV 145
Cdd:pfam00963  80 LTsLGSSGIAKDGVFATITFKVKSDAAAG-TTPIKISGTLSFGDGGLNEIKVTLTDGSINV 139
Type_II_cohesin cd08547
Type II cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a ...
 6-141 2.31e-04

Type II cohesin domain, interaction partner of dockerin; Bacterial cohesin domains bind to a complementary protein domain named dockerin, and this interaction is required for the formation of the cellulosome, a cellulose-degrading complex. The cellulosome consists of scaffoldin, a noncatalytic scaffolding polypeptide, that comprises repeating cohesion modules and a single carbohydrate-binding module (CBM). Specific calcium-dependent interactions between cohesins and dockerins appear to be essential for cellulosome assembly. This subfamily represents type II cohesins; their interactions with dockerin mediate attachment of the cellulosome complex to the bacterial cell wall.


Pssm-ID: 260084  Cd Length: 136  Bit Score: 38.93  E-value: 2.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6KGE_C        6 TVKLSVGTVSGNPGDTVKVPVTISQVsTPVGLICMDISYDASKFTVKDVLPNTDLVKDTDNYSfivNTSTPGKISITFTD 85
Cdd:cd08547   2 SVSLSAPETDVKVGETFTVTVKVNNA-TNLAGYDFTLSYDPSVLEFVSVTTGSLSGGGGVIAN---EDAPPGTVRVAGSS 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
6KGE_C       86 PTLANyPISVDGILAYLDFIINSnatAGDSALTVDPATLIVADENDKDIKDAASNG 141
Cdd:cd08547  78 TGGAG-GVSGSGTLATLTFKAKA---AGTSTISLTDSNTTLSDADGSTIPTFVGGG 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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