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Conserved domains on  [gi|1777435726|pdb|6OJZ|B]
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Chain B, Twitching motility pilus retraction ATPase

Protein Classification

type IV pilus twitching motility protein PilT( domain architecture ID 10006640)

type IV pilus twitching motility protein PilT is a hexameric ATPase that drives pilus retraction, which provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility

CATH:  3.30.450.90
Gene Ontology:  GO:0005524|GO:0043107
PubMed:  12142488
SCOP:  4004005

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 20-362 0e+00

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


:

Pssm-ID: 442056  Cd Length: 342  Bit Score: 612.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       20 HMANMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGL 99
Cdd:COG2805   1 MAMDLDELLKLAVEQGASDLHLTVGSPPMLRIDGELVPLDDPPLTPEDLEALLKEILTEEQRERLEEEGELDFSYSLPGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      100 SRFRGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTV 179
Cdd:COG2805  81 GRFRVNIFRQRGGVAAVLRLIPSEIPTLEELGLPPVLKELAELPRGLVLVTGPTGSGKSTTLAAMIDYINETRAKHIITI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      180 EDPIEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTIN 259
Cdd:COG2805 161 EDPIEFVHKHKKSLINQREVGRDTPSFANALRAALREDPDVILVGEMRDLETIEAALTAAETGHLVFATLHTNSAAQTID 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      260 RIVDVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQeKFGMMTM 339
Cdd:COG2805 241 RIIDVFPPEEQAQIRSQLAESLRGVISQRLLPRADGGGRVAAREILVNTPAVRNLIREGKTHQIPSLIQTGK-KLGMQTM 319

                       330       340
                ....*....|....*....|...
6OJZ_B      340 NQCLYGLLQKRHITMDVGMGRSP 362
Cdd:COG2805 320 DQSLAELVKEGLITEETALAYAS 342
 
Name Accession Description Interval E-value
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 20-362 0e+00

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 612.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       20 HMANMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGL 99
Cdd:COG2805   1 MAMDLDELLKLAVEQGASDLHLTVGSPPMLRIDGELVPLDDPPLTPEDLEALLKEILTEEQRERLEEEGELDFSYSLPGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      100 SRFRGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTV 179
Cdd:COG2805  81 GRFRVNIFRQRGGVAAVLRLIPSEIPTLEELGLPPVLKELAELPRGLVLVTGPTGSGKSTTLAAMIDYINETRAKHIITI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      180 EDPIEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTIN 259
Cdd:COG2805 161 EDPIEFVHKHKKSLINQREVGRDTPSFANALRAALREDPDVILVGEMRDLETIEAALTAAETGHLVFATLHTNSAAQTID 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      260 RIVDVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQeKFGMMTM 339
Cdd:COG2805 241 RIIDVFPPEEQAQIRSQLAESLRGVISQRLLPRADGGGRVAAREILVNTPAVRNLIREGKTHQIPSLIQTGK-KLGMQTM 319

                       330       340
                ....*....|....*....|...
6OJZ_B      340 NQCLYGLLQKRHITMDVGMGRSP 362
Cdd:COG2805 320 DQSLAELVKEGLITEETALAYAS 342
pilT_fam TIGR01420
pilus retraction protein PilT; This model represents the PilT subfamily of proteins related to ...
 23-366 0e+00

pilus retraction protein PilT; This model represents the PilT subfamily of proteins related to GspE, a protein involved in type II secretion (also called the General Secretion Pathway). PilT is an apparent cytosolic ATPase associated with type IV pilus systems. It is not required for pilin biogenesis, but is required for twitching motility and social gliding behaviors, shown in some species, powered by pilus retraction. Members of this family may be found in some species that type IV pili but have related structures for DNA uptake and natural transformation. [Cell envelope, Surface structures, Cellular processes, Chemotaxis and motility]


Pssm-ID: 273613  Cd Length: 343  Bit Score: 541.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         23 NMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGLSRF 102
Cdd:TIGR01420   1 SLEEILREAVKLGASDIHLTAGAPPAMRIDGDLVRIEFEPLTPEDTQKLAREILSEKQREEFEENGELDFSFSLPGVGRF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        103 RGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDP 182
Cdd:TIGR01420  81 RVNAFYQRGGVALVLRLIPSKIPTFEELGLPPVLRELAERPRGLILVTGPTGSGKSTTLASMIDYINKNKAYHIITIEDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        183 IEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIV 262
Cdd:TIGR01420 161 IEYVHTNKRSLINQREVGEDTLSFANALRAALREDPDVILIGEMRDLETVELALTAAETGHLVFGTLHTNSAAQTIERII 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        263 DVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQeKFGMMTMNQC 342
Cdd:TIGR01420 241 DVFPAEEQEQIRTQLAESLVAIISQRLLPKADGGGRVLAVEILINTPAVRNLIREGKTHQIKSLIQTGQ-QLGMQTFDQH 319

                         330       340
                  ....*....|....*....|....
6OJZ_B        343 LYGLLQKRHITMDVGMGRSPDPDE 366
Cdd:TIGR01420 320 LAQLYKKGLITLEDALEAAPSPHE 343
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 124-346 2.88e-143

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 405.77  E-value: 2.88e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      124 ILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDPIEYLHPHKSCVVNQREVGADT 203
Cdd:cd01131   1 IPTFEELGLPPVLKDLALKPRGLVLVTGPTGSGKSTTLAAMIDYINETRSKHIITIEDPIEFVHKHKKSLINQREVGRDT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      204 KSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSYQQPQVRAQLSFVLEG 283
Cdd:cd01131  81 ESFAAALRAALREDPDVILVGEMRDLETIELALTAAETGHLVFSTLHTNSAAQTIDRIIDVFPPEQQEQVRIQLASSLRG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
6OJZ_B      284 VLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQEkFGMMTMNQCLYGL 346
Cdd:cd01131 161 VISQRLLPKKDGGGRVAAFEILINTPAIRNLIREGKTHQIPSLIQTGAR-DGMQTMDQSLYEL 222
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 26-263 1.43e-46

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 160.14  E-value: 1.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         26 QLLTELVNRGGSDLHLttNSPPQI-----RIDGKLLPLDMPPLNAVdtKQLCYSILTEQQKHKFEENNELD----LSFGI 96
Cdd:pfam00437   2 LIPLEALDEGASDIHV--EPPERIvwirfRVDGVLREIPFPDADAL--ARLISRIKVMARLDISERRPPQDgrlpLRIGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         97 KGLsRFRGNVFVQRGAVAGVFRVIPYK--ILSFEELG----LPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINT 170
Cdd:pfam00437  78 KGV-RVRVSTLPTAGGEKLVIRLLDPSnvALSLDELGmtgaQDEALLEFLRQPRGNILVTGPTGSGKTTTLYAALGELNT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        171 dRHEHIVTVEDPIEYLHPHkscvVNQREVGADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATL 249
Cdd:pfam00437 157 -RDENIVTVEDPVEIQLEG----INQVQLNARAGvTFADLLRAILRQDPDRIMVGEIRDLETAEIALQAANTGHLVLSTL 231

                         250
                  ....*....|....
6OJZ_B        250 HTNSAVQTINRIVD 263
Cdd:pfam00437 232 HTNSAAGALTRLQD 245
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
136-291 5.04e-34

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 126.79  E-value: 5.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       136 VRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRheHIVTVEDPIEYLHPHksCV---VNQRevgADTkSFKNALKY 212
Cdd:NF041000 120 LKQLLQRRSGLILFSGPTGSGKTTTMYSLARKLALNK--QVITIEDPVEIKEPN--FLqlqVNEK---AGM-TYDTLLKA 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
6OJZ_B       213 ILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSyqqpqvRAQLSFVLEGVLSQTLLP 291
Cdd:NF041000 192 ALRHRPDILIIGEIRDAETAKAAIRAALTGHLVLSTVHAKSAAGVIYRLLELGIS------KEELEQTLIGISYQRLIP 264
PRK10436 PRK10436
hypothetical protein; Provisional
 125-260 7.52e-32

hypothetical protein; Provisional


Pssm-ID: 236694  Cd Length: 462  Bit Score: 125.04  E-value: 7.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       125 LSFEELGLPPV----VRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINT-DRHehIVTVEDPIEYlhPHKScvVNQREV 199
Cdd:PRK10436 195 LDLETLGMTPAqlaqFRQALQQPQGLILVTGPTGSGKTVTLYSALQTLNTaQIN--ICSVEDPVEI--PLAG--INQTQI 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
6OJZ_B       200 GADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINR 260
Cdd:PRK10436 269 HPKAGlTFQRVLRALLRQDPDVIMVGEIRDGETAEIAIKAAQTGHLVLSTLHTNSTSETLVR 330
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 143-226 5.24e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.13  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         143 PRGLVLVTGPTGSGKSTTLAAIIDKINTDRHE-HIVTVEDPIEYLHPHKSCVVNQREVGADT--KSFKNALKYILRQDPD 219
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGvIYIDGEDILEEVLDQLLLIIVGGKKASGSgeLRLRLALALARKLKPD 80


                   ....*..
6OJZ_B         220 VVLVGEL 226
Cdd:smart00382  81 VLILDEI 87
 
Name Accession Description Interval E-value
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 20-362 0e+00

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 612.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       20 HMANMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGL 99
Cdd:COG2805   1 MAMDLDELLKLAVEQGASDLHLTVGSPPMLRIDGELVPLDDPPLTPEDLEALLKEILTEEQRERLEEEGELDFSYSLPGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      100 SRFRGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTV 179
Cdd:COG2805  81 GRFRVNIFRQRGGVAAVLRLIPSEIPTLEELGLPPVLKELAELPRGLVLVTGPTGSGKSTTLAAMIDYINETRAKHIITI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      180 EDPIEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTIN 259
Cdd:COG2805 161 EDPIEFVHKHKKSLINQREVGRDTPSFANALRAALREDPDVILVGEMRDLETIEAALTAAETGHLVFATLHTNSAAQTID 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      260 RIVDVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQeKFGMMTM 339
Cdd:COG2805 241 RIIDVFPPEEQAQIRSQLAESLRGVISQRLLPRADGGGRVAAREILVNTPAVRNLIREGKTHQIPSLIQTGK-KLGMQTM 319

                       330       340
                ....*....|....*....|...
6OJZ_B      340 NQCLYGLLQKRHITMDVGMGRSP 362
Cdd:COG2805 320 DQSLAELVKEGLITEETALAYAS 342
pilT_fam TIGR01420
pilus retraction protein PilT; This model represents the PilT subfamily of proteins related to ...
 23-366 0e+00

pilus retraction protein PilT; This model represents the PilT subfamily of proteins related to GspE, a protein involved in type II secretion (also called the General Secretion Pathway). PilT is an apparent cytosolic ATPase associated with type IV pilus systems. It is not required for pilin biogenesis, but is required for twitching motility and social gliding behaviors, shown in some species, powered by pilus retraction. Members of this family may be found in some species that type IV pili but have related structures for DNA uptake and natural transformation. [Cell envelope, Surface structures, Cellular processes, Chemotaxis and motility]


Pssm-ID: 273613  Cd Length: 343  Bit Score: 541.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         23 NMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGLSRF 102
Cdd:TIGR01420   1 SLEEILREAVKLGASDIHLTAGAPPAMRIDGDLVRIEFEPLTPEDTQKLAREILSEKQREEFEENGELDFSFSLPGVGRF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        103 RGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDP 182
Cdd:TIGR01420  81 RVNAFYQRGGVALVLRLIPSKIPTFEELGLPPVLRELAERPRGLILVTGPTGSGKSTTLASMIDYINKNKAYHIITIEDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        183 IEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIV 262
Cdd:TIGR01420 161 IEYVHTNKRSLINQREVGEDTLSFANALRAALREDPDVILIGEMRDLETVELALTAAETGHLVFGTLHTNSAAQTIERII 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        263 DVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQeKFGMMTMNQC 342
Cdd:TIGR01420 241 DVFPAEEQEQIRTQLAESLVAIISQRLLPKADGGGRVLAVEILINTPAVRNLIREGKTHQIKSLIQTGQ-QLGMQTFDQH 319

                         330       340
                  ....*....|....*....|....
6OJZ_B        343 LYGLLQKRHITMDVGMGRSPDPDE 366
Cdd:TIGR01420 320 LAQLYKKGLITLEDALEAAPSPHE 343
PilU COG5008
Type IV pilus assembly protein, ATPase PilU [Cell motility, Extracellular structures];
23-358 2.26e-158

Type IV pilus assembly protein, ATPase PilU [Cell motility, Extracellular structures];


Pssm-ID: 444032  Cd Length: 370  Bit Score: 449.55  E-value: 2.26e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       23 NMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGLSRF 102
Cdd:COG5008   2 DLEDLLKLMVEKKASDLFITAGAPPSIKIDGKLTPLSQQPLTPEQVRELAYSIMNEEQREEFERTKECNFAISLPGVGRF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      103 RGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDP 182
Cdd:COG5008  82 RVNAFRQRGSVGMVLRRIETEIPTLDELGLPPVLKDLIMEKRGLVLFVGATGSGKSTTLAAMIDHRNENSSGHILTIEDP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      183 IEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIV 262
Cdd:COG5008 162 IEFVHKHKKSIVTQREVGVDTESYEVALKNALRQAPDVILIGEIRDRETMEHAIAFAETGHLCLATLHANNANQALDRII 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      263 DVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGtGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQEKfGMMTMNQC 342
Cdd:COG5008 242 NFFPEERRPQLLMDLSLNLRAIVSQRLVPTKDG-GRVAAVEVLLNTPLIADLIRKGEIHEIKEAMEKSREL-GMQTFDQA 319

                       330
                ....*....|....*.
6OJZ_B      343 LYGLLQKRHITMDVGM 358
Cdd:COG5008 320 LFRLYEAGKISYEEAL 335
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 124-346 2.88e-143

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 405.77  E-value: 2.88e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      124 ILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDPIEYLHPHKSCVVNQREVGADT 203
Cdd:cd01131   1 IPTFEELGLPPVLKDLALKPRGLVLVTGPTGSGKSTTLAAMIDYINETRSKHIITIEDPIEFVHKHKKSLINQREVGRDT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      204 KSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSYQQPQVRAQLSFVLEG 283
Cdd:cd01131  81 ESFAAALRAALREDPDVILVGEMRDLETIELALTAAETGHLVFSTLHTNSAAQTIDRIIDVFPPEQQEQVRIQLASSLRG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
6OJZ_B      284 VLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQEkFGMMTMNQCLYGL 346
Cdd:cd01131 161 VISQRLLPKKDGGGRVAAFEILINTPAIRNLIREGKTHQIPSLIQTGAR-DGMQTMDQSLYEL 222
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 137-308 4.16e-60

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 191.54  E-value: 4.16e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      137 RELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHeHIVTVEDPIEYLHPhkscVVNQREVGADTK-SFKNALKYILR 215
Cdd:cd01129   4 RRLIKRPHGLILVTGPTGSGKTTTLYAMLRELNGPER-NIITIEDPVEYQIP----GINQSQVNEKIGlTFADALRAILR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      216 QDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSyqqpqvRAQLSFVLEGVLSQTLLpkasg 295
Cdd:cd01129  79 QDPDIIMVGEIRDAETAEIAIRAALTGHLVLSTLHTNDALGAITRLLDMGIE------PFLLASALRGVIAQRLV----- 147

                       170
                ....*....|...
6OJZ_B      296 tGRVLAIEVMVPN 308
Cdd:cd01129 148 -GRTAIAEVLVLD 159
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 124-339 2.69e-57

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 195.80  E-value: 2.69e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      124 ILSFEELGLPP----VVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRhEHIVTVEDPIEYLHPHkscvVNQREV 199
Cdd:COG2804 289 LLDLEQLGFSPdqleRLRRLIRRPHGIILVTGPTGSGKTTTLYAALNELNTPE-RNIITVEDPVEYQLPG----INQVQV 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      200 GADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDV-FPSYqqpqvraQL 277
Cdd:COG2804 364 NPKIGlTFASALRSILRQDPDVIMVGEIRDLETAEIAVQAALTGHLVLSTLHTNDAPSAITRLLDMgVEPF-------LL 436

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      278 SFVLEGVLSQTLLPK---------------------------------ASG---------TGRVLAIEVMVPNPAIRNLI 315
Cdd:COG2804 437 ASSLLGVLAQRLVRRlcphckepyepdpeelerlglppeelapltfyrGVGcehcngtgyKGRTGIYELLVIDDELRELI 516

                       250       260
                ....*....|....*....|....*
6OJZ_B      316 REDK-IHQIYSQMQvgqeKFGMMTM 339
Cdd:COG2804 517 AEGAsAAELREAAR----KEGMRTL 537
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
 133-306 6.06e-48

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 160.62  E-value: 6.06e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      133 PPVVRELAekPR-GLVLVTGPTGSGKSTTLAAIIDKI--NTDRHEHIVTVEDPIEYLH--PH-KSCVVNQREVGADTKSF 206
Cdd:cd19516   1 PDLVEALF--PReGLVYVAGATGSGKSTLLAAIYRYIleNDPPDRKIITYEDPIEFVYdgIKsKHSIIVQSQIPRHFKSF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      207 KNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSYQQPQVRAQLSFVLEGVLS 286
Cdd:cd19516  79 AKAVREALRRKPSLIGVGELRDQETISAAVEASLTGHPVYSTVHTKSVAETIRRLISLFPPEERDAAAYDLLSTLRFIIV 158

                       170       180
                ....*....|....*....|
6OJZ_B      287 QTLLPKASGtGRVLAIEVMV 306
Cdd:cd19516 159 QRLVRTTDG-KRVAVREYLV 177
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 26-263 1.43e-46

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 160.14  E-value: 1.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         26 QLLTELVNRGGSDLHLttNSPPQI-----RIDGKLLPLDMPPLNAVdtKQLCYSILTEQQKHKFEENNELD----LSFGI 96
Cdd:pfam00437   2 LIPLEALDEGASDIHV--EPPERIvwirfRVDGVLREIPFPDADAL--ARLISRIKVMARLDISERRPPQDgrlpLRIGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         97 KGLsRFRGNVFVQRGAVAGVFRVIPYK--ILSFEELG----LPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINT 170
Cdd:pfam00437  78 KGV-RVRVSTLPTAGGEKLVIRLLDPSnvALSLDELGmtgaQDEALLEFLRQPRGNILVTGPTGSGKTTTLYAALGELNT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        171 dRHEHIVTVEDPIEYLHPHkscvVNQREVGADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATL 249
Cdd:pfam00437 157 -RDENIVTVEDPVEIQLEG----INQVQLNARAGvTFADLLRAILRQDPDRIMVGEIRDLETAEIALQAANTGHLVLSTL 231

                         250
                  ....*....|....
6OJZ_B        250 HTNSAVQTINRIVD 263
Cdd:pfam00437 232 HTNSAAGALTRLQD 245
plasmid_TraJ TIGR02525
plasmid transfer ATPase TraJ; Members of this protein family are predicted ATPases associated ...
 37-313 3.23e-40

plasmid transfer ATPase TraJ; Members of this protein family are predicted ATPases associated with plasmid transfer loci in bacteria. This family is most similar to the DotB ATPase of a type-IV secretion-like system of obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii (TIGR02524). [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 131577 [Multi-domain]  Cd Length: 372  Bit Score: 146.10  E-value: 3.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         37 SDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKG------------LSRFRG 104
Cdd:TIGR02525  25 SDIHLQGGSPIVVERHGRQVPASSFPLDNLELERLVDEVFGPEIKPTVKSGAPVDRAIQLRGdengryglgrgeRVRFRC 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        105 NvFVQ------RGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKI-NTDRHEHIV 177
Cdd:TIGR02525 105 N-FIQatigklETAISLTLRVIPSDIPDLKQMGIEPDLFNSLLPAAGLGLICGETGSGKSTLAASIYQHCgETYPDRKIV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        178 TVEDPIEYLHPHKSCVV--NQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAV 255
Cdd:TIGR02525 184 TYEDPIEYILGSPDDLLppAQSQIGRDVDSFANGIRLALRRAPKIIGVGEIRDLETFQAAVLAGQSGHFCLGTLHVKSPG 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
6OJZ_B        256 QTINRIVDVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGtGRVLAIEVMVPNPAIRN 313
Cdd:TIGR02525 264 EAISRCLQMYPPEMREAAAFDLLSILQYIIVQRLLRTTDG-KRQAVREYIVFDDSLRR 320
type_II_gspE TIGR02533
type II secretion system protein E; This family describes GspE, the E protein of the type II ...
 125-263 1.74e-39

type II secretion system protein E; This family describes GspE, the E protein of the type II secretion system, also called the main terminal branch of the general secretion pathway. This model separates GspE from the PilB protein of type IV pilin biosynthesis. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 131585 [Multi-domain]  Cd Length: 486  Bit Score: 146.75  E-value: 1.74e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        125 LSFEELGLPPVV----RELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINT-DRHehIVTVEDPIEY-LHPHKSCVVNQRe 198
Cdd:TIGR02533 219 LDLETLGMSPELlsrfERLIRRPHGIILVTGPTGSGKTTTLYAALSRLNTpERN--ILTVEDPVEYqIEGIGQIQVNPK- 295

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
6OJZ_B        199 VGADtksFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVD 263
Cdd:TIGR02533 296 IGLT---FAAGLRAILRQDPDIIMVGEIRDLETAQIAIQASLTGHLVLSTLHTNDAAGAVTRLID 357
type_IV_pilB TIGR02538
type IV-A pilus assembly ATPase PilB; This model describes a protein of type IV pilus ...
 125-263 4.35e-38

type IV-A pilus assembly ATPase PilB; This model describes a protein of type IV pilus biogenesis designated PilB in Pseudomonas aeruginosa but PilF in Neisseria gonorrhoeae; the more common usage, reflected here, is PilB. This protein is an ATPase involved in protein export for pilin assembly and is closely related to GspE (TIGR02533) of type II secretion, also called the main terminal branch of the general secretion pathway. Note that type IV pilus systems are often divided into type IV-A and IV-B, with the latter group including bundle-forming pilus, mannose-sensitive hemagglutinin, etc. Members of this family are found in type IV-A systems. [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274186 [Multi-domain]  Cd Length: 564  Bit Score: 144.00  E-value: 4.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        125 LSFEELGLPPVVREL----AEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDrHEHIVTVEDPIEYLHPHkscvVNQREVG 200
Cdd:TIGR02538 293 LDIDKLGFEPDQKALfleaIHKPQGMVLVTGPTGSGKTVSLYTALNILNTE-EVNISTAEDPVEINLPG----INQVNVN 367

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
6OJZ_B        201 ADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVD 263
Cdd:TIGR02538 368 PKIGlTFAAALRSFLRQDPDIIMVGEIRDLETAEIAIKAAQTGHLVLSTLHTNDAPETLARLVN 431
ATPase_ComGA NF041000
competence type IV pilus ATPase ComGA;
136-291 5.04e-34

competence type IV pilus ATPase ComGA;


Pssm-ID: 468930 [Multi-domain]  Cd Length: 265  Bit Score: 126.79  E-value: 5.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       136 VRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRheHIVTVEDPIEYLHPHksCV---VNQRevgADTkSFKNALKY 212
Cdd:NF041000 120 LKQLLQRRSGLILFSGPTGSGKTTTMYSLARKLALNK--QVITIEDPVEIKEPN--FLqlqVNEK---AGM-TYDTLLKA 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
6OJZ_B       213 ILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSyqqpqvRAQLSFVLEGVLSQTLLP 291
Cdd:NF041000 192 ALRHRPDILIIGEIRDAETAKAAIRAALTGHLVLSTVHAKSAAGVIYRLLELGIS------KEELEQTLIGISYQRLIP 264
PRK10436 PRK10436
hypothetical protein; Provisional
 125-260 7.52e-32

hypothetical protein; Provisional


Pssm-ID: 236694  Cd Length: 462  Bit Score: 125.04  E-value: 7.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       125 LSFEELGLPPV----VRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINT-DRHehIVTVEDPIEYlhPHKScvVNQREV 199
Cdd:PRK10436 195 LDLETLGMTPAqlaqFRQALQQPQGLILVTGPTGSGKTVTLYSALQTLNTaQIN--ICSVEDPVEI--PLAG--INQTQI 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
6OJZ_B       200 GADTK-SFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINR 260
Cdd:PRK10436 269 HPKAGlTFQRVLRALLRQDPDVIMVGEIRDGETAEIAIKAAQTGHLVLSTLHTNSTSETLVR 330
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
 136-263 8.42e-26

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 102.09  E-value: 8.42e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      136 VRELAEKPrGLVLVTGPTGSGKSTTLAAIIDKINTDRHehIVTVEDPIEYLHPHKSCVvNQREVGADTkSFKNALKYILR 215
Cdd:cd19477   3 IKDGIAIG-KNVIVCGGTGSGKTTYIKSILEFIPKEER--IISIEDTEEIVFKHHKNY-TQLFFGGNI-TSADCLKSCLR 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
6OJZ_B      216 QDPDVVLVGELRDlETIEAALTLAETGH-LCFATLHTNSAVQTINRIVD 263
Cdd:cd19477  78 QRPDRIILGELRS-SEAYDFYNVLCSGHkGTLTTLHAGSSEEAFIRLAN 125
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 147-262 1.46e-19

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 85.28  E-value: 1.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      147 VLVTGPTGSGKSTTLAAIIDKIntDRHEHIVTVEDPIEYLHPHKSCV---VNQREVGADTKSFKNALKYILRQDPDVVLV 223
Cdd:cd01130  15 ILISGGTGSGKTTLLNALLSFI--PPDERIVTIEDTRELQLPHPNVVhllTRPGGGEKGEVTMADLLKAALRMRPDRIIV 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
6OJZ_B      224 GELRDLETIEaALTLAETGHL-CFATLHTNSAVQTINRIV 262
Cdd:cd01130  93 GEVRGGEAYD-MLQAMNTGHPgSITTIHANSAEDAIDRLA 131
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 147-262 4.25e-16

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 79.05  E-value: 4.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      147 VLVTGPTGSGKSTTLAAIIDKIntDRHEHIVTVEDPIEyLHPHKSCVV-------NQREVGADTKS--FKNALkyilRQD 217
Cdd:COG4962 185 ILVSGGTGSGKTTLLNALSGFI--PPDERIVTIEDAAE-LQLQHPHVVrletrppNVEGAGEVTLRdlVRNAL----RMR 257

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
6OJZ_B      218 PDVVLVGELRDLETIEAaLTLAETGHL-CFATLHTNSAVQTINRIV 262
Cdd:COG4962 258 PDRIIVGEVRGAEALDM-LQAMNTGHDgSMSTLHANSARDALARLE 302
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 144-263 4.23e-15

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 76.27  E-value: 4.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      144 RGLVLVTGPTGSGKSTTLAAIIDKIN-TDRhehIVTVEDPIEYLHPHKSCV--VNQREVGADTKSFK--NALKYILRQDP 218
Cdd:COG0630 290 GKSVLVAGGTASGKTTLLNALLSFIPpDAK---IVTIEDTRELNLPHENWIslVTRESFGGEEGDVTmfDLLKAALRQRP 366

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
6OJZ_B      219 DVVLVGELRDletiEAALTLAE---TGHLCFATLHTNSAVQTINRIVD 263
Cdd:COG0630 367 DYIVVGEVRG----EEAYTLFQamaTGHGVLSTFHADSVESAINRLTS 410
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 147-261 1.23e-10

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 62.06  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       147 VLVTGPTGSGKSTTLAAIIDK-INTDRHEHIVTVEDPIEYLHPHKSCVvnQREVGADTkSFKNALKYILRQDPDVVLVGE 225
Cdd:PRK13894 151 ILVIGGTGSGKTTLVNAIINEmVIQDPTERVFIIEDTGEIQCAAENYV--QYHTSIDV-NMTALLKTTLRMRPDRILVGE 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
6OJZ_B       226 LRDLEtieaALTLAE---TGHL-CFATLHTNSAVQTINRI 261
Cdd:PRK13894 228 VRGPE----ALDLLMawnTGHEgGAATLHANNAKAGLDRL 263
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
 144-270 1.31e-09

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 59.14  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       144 RGLVLVTGPTGSGKSTTLAAIIDKIntDRHEHIVTVEDPIEYLHPHKSCV---VNQREVGADTKSFKNALKYILRQDPDV 220
Cdd:PRK13851 162 RLTMLLCGPTGSGKTTMSKTLISAI--PPQERLITIEDTLELVIPHENHVrllYSKNGAGLGAVTAEHLLQASLRMRPDR 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
6OJZ_B       221 VLVGELRDlETIEAALTLAETGHL-CFATLHTNSAVQTINRIVDVFPSYQQ 270
Cdd:PRK13851 240 ILLGEMRD-DAAWAYLSEVVSGHPgSISTIHGANPVQGFKKLFSLVKSSAQ 289
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
 147-261 9.99e-09

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 56.34  E-value: 9.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       147 VLVTGPTGSGKSTTLAAIIDKINTDRHEH-IVTVEDPIEYLHPHKSCVVNQRevgADTKSFKNALKYILRQDPDVVLVGE 225
Cdd:PRK13833 147 IVISGGTGSGKTTLANAVIAEIVASAPEDrLVILEDTAEIQCAAENAVALHT---SDTVDMARLLKSTMRLRPDRIIVGE 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
6OJZ_B       226 LRDletiEAALTLAE---TGHL-CFATLHTNSAVQTINRI 261
Cdd:PRK13833 224 VRD----GAALTLLKawnTGHPgGVTTIHSNTAMSALRRL 259
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 143-226 5.24e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.13  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B         143 PRGLVLVTGPTGSGKSTTLAAIIDKINTDRHE-HIVTVEDPIEYLHPHKSCVVNQREVGADT--KSFKNALKYILRQDPD 219
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGvIYIDGEDILEEVLDQLLLIIVGGKKASGSgeLRLRLALALARKLKPD 80


                   ....*..
6OJZ_B         220 VVLVGEL 226
Cdd:smart00382  81 VLILDEI 87
AAA_29 pfam13555
P-loop containing region of AAA domain;
142-170 2.54e-04

P-loop containing region of AAA domain;


Pssm-ID: 433304 [Multi-domain]  Cd Length: 61  Bit Score: 38.74  E-value: 2.54e-04
                          10        20
                  ....*....|....*....|....*....
6OJZ_B        142 KPRGLVLVTGPTGSGKSTtlaaIIDKINT 170
Cdd:pfam13555  20 DPRGNTLLTGPSGSGKST----LLDAIQT 44
AAA_30 pfam13604
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 136-164 8.23e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.


Pssm-ID: 433343 [Multi-domain]  Cd Length: 191  Bit Score: 40.24  E-value: 8.23e-04
                          10        20
                  ....*....|....*....|....*....
6OJZ_B        136 VRELAEKPRGLVLVTGPTGSGKSTTLAAI 164
Cdd:pfam13604  10 VRALLTSGDRVAVLVGPAGTGKTTALKAL 38
FlhF TIGR03499
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]
 128-162 8.37e-04

flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]


Pssm-ID: 274609 [Multi-domain]  Cd Length: 282  Bit Score: 40.78  E-value: 8.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
6OJZ_B        128 EELGLPPVVRELAEKPRGLVLVtGPTGSGKSTTLA 162
Cdd:TIGR03499 179 GMLPVKPEEDPILEQGGVIALV-GPTGVGKTTTLA 212
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 138-261 1.31e-03

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 40.51  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B       138 ELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDrhEHIVTVEDPIEYL---HPHKSCVV----NQREVGADTKSFKNAl 210
Cdd:PRK13900 154 EHAVISKKNIIISGGTSTGKTTFTNAALREIPAI--ERLITVEDAREIVlsnHPNRVHLLaskgGQGRAKVTTQDLIEA- 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
6OJZ_B       211 kyILRQDPDVVLVGELRDLETIeAALTLAETGHL-CFATLHTNSAVQTINRI 261
Cdd:PRK13900 231 --CLRLRPDRIIVGELRGAEAF-SFLRAINTGHPgSISTLHADSPAMAIEQL 279
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 143-165 1.49e-03

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 39.37  E-value: 1.49e-03
                        10        20
                ....*....|....*....|....
6OJZ_B      143 PRG-LVLVTGPTGSGKSTTLAAII 165
Cdd:cd03250  29 PKGeLVAIVGPVGSGKSSLLSALL 52
FlhF COG1419
Flagellar biosynthesis GTPase FlhF [Cell motility];
132-162 2.18e-03

Flagellar biosynthesis GTPase FlhF [Cell motility];


Pssm-ID: 441029 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 2.18e-03
                        10        20        30
                ....*....|....*....|....*....|.
6OJZ_B      132 LPPVVRELAEKPRGLVLVtGPTGSGKSTTLA 162
Cdd:COG1419 153 LPVAEDPLLDEGGVIALV-GPTGVGKTTTIA 182
PRK13764 PRK13764
ATPase; Provisional
 119-182 3.10e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 39.44  E-value: 3.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
6OJZ_B       119 VIPYKILSFEELGLPPVVRE-LAEKPRGlVLVTGPTGSGKSTTLAAIIDKINtdRHEHIV-TVEDP 182
Cdd:PRK13764 232 VRPVVKLSLEDYNLSEKLKErLEERAEG-ILIAGAPGAGKSTFAQALAEFYA--DMGKIVkTMESP 294
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 141-243 3.85e-03

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 38.11  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B        141 EKPRgLVLVTGPTGSGKSTTLAAIIDKIntDRHEHIVTVeDPIEY--LHPHKSCVVNQR------EVGADTKSF-KNALK 211
Cdd:pfam06414   9 ERPK-AILLGGQPGAGKTELARALLDEL--GRQGNVVRI-DPDDFreLHPHYRELQAADpktaseYTQPDASRWvEKLLQ 84

                          90       100       110
                  ....*....|....*....|....*....|...
6OJZ_B        212 YILRQDPDVVLVGELRDLETIEAALT-LAETGH 243
Cdd:pfam06414  85 HAIENGYNIILEGTLRSPDVAKKIARaLKAAGY 117
AAA_23 pfam13476
AAA domain;
144-164 4.03e-03

AAA domain;


Pssm-ID: 463890 [Multi-domain]  Cd Length: 190  Bit Score: 38.25  E-value: 4.03e-03
                          10        20
                  ....*....|....*....|.
6OJZ_B        144 RGLVLVTGPTGSGKSTTLAAI 164
Cdd:pfam13476  18 KGLTLITGPNGSGKTTILDAI 38
AAA_22 pfam13401
AAA domain;
144-182 5.37e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.94  E-value: 5.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
6OJZ_B        144 RGLVLVTGPTGSGKSTTLAAIIDKINTdRHEHIVTVEDP 182
Cdd:pfam13401   5 AGILVLTGESGTGKTTLLRRLLEQLPE-VRDSVVFVDLP 42
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
144-240 7.91e-03

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 440188 [Multi-domain]  Cd Length: 204  Bit Score: 37.30  E-value: 7.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OJZ_B      144 RGLVLVTGPTGSGKSTTLAAI-------IDKINTDRHEHIVTVEDP----IEYLHPHKSCVVN------QREVGADTKSF 206
Cdd:COG0419  23 DGLNLIVGPNGAGKSTILEAIryalygkARSRSKLRSDLINVGSEEasveLEFEHGGKRYRIErrqgefAEFLEAKPSER 102

                        90       100       110
                ....*....|....*....|....*....|....*
6OJZ_B      207 KNALKYILRQDPDVVLVGELRDL-ETIEAALTLAE 240
Cdd:COG0419 103 KEALKRLLGLEIYEELKERLKELeEALESALEELA 137
CydD TIGR02857
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ...
 109-164 8.09e-03

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD


Pssm-ID: 274323 [Multi-domain]  Cd Length: 529  Bit Score: 38.04  E-value: 8.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
6OJZ_B        109 QRGAVAGVFRVIPYKILSFEELGLPPVVRE--LAEKPRGLVLVTGPTGSGKSTTLAAI 164
Cdd:TIGR02857 311 KAPVTAAPASSLEFSGVSVAYPGRRPALRPvsFTVPPGERVALVGPSGAGKSTLLNLL 368
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 138-166 8.39e-03

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 38.03  E-value: 8.39e-03
                        10        20
                ....*....|....*....|....*....
6OJZ_B      138 ELAEKPRGLVLVTGPTGSGKSTTLAAIID 166
Cdd:COG0507 134 ALALTTRRVSVLTGGAGTGKTTTLRALLA 162
Cas3 COG1203
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ...
 135-165 9.74e-03

CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440816 [Multi-domain]  Cd Length: 535  Bit Score: 38.14  E-value: 9.74e-03
                        10        20        30
                ....*....|....*....|....*....|.
6OJZ_B      135 VVRELAEKPRGLVLVTGPTGSGKstTLAAII 165
Cdd:COG1203 138 LALEAAEEEPGLFILTAPTGGGK--TEAALL 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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