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Conserved domains on  [gi|1704664901|pdb|6OS9|B]
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Chain B, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-344 4.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 268.82  E-value: 4.41e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       52 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 126
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      127 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 205
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      206 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 284
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      285 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-344 4.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 268.82  E-value: 4.41e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       52 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 126
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      127 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 205
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      206 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 284
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      285 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-344 4.62e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.22  E-value: 4.62e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       50 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 129
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      130 LKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 208
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      209 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIicGITSVSFSKSGRL 288
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
6OS9_B      289 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-258 5.37e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 5.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
6OS9_B         220 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 258
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 44-175 7.48e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B        44 VGRIQMRTRrtLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSwvMTCAYAPS--GNYVACGG 120
Cdd:PLN00181 562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
6OS9_B       121 LDNICSIYNLKtregNVRVSR-ELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 175
Cdd:PLN00181 638 ADHKVYYYDLR----NPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
220-258 2.83e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 2.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
6OS9_B        220 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-344 4.41e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 268.82  E-value: 4.41e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       52 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRssWVMTCAYapsGNYVACGGLDNICS 126
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPVR--DVAASAD---GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      127 IYNLKTREgnvrVSRELAGHTGYLSCCRFLDDNQIVTSSG-DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS 205
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      206 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICgitSVSFSK 284
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---SVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      285 SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-344 4.62e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.22  E-value: 4.62e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       50 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 129
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      130 LKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 208
Cdd:COG2319 191 LATG----KLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      209 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIicGITSVSFSKSGRL 288
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
6OS9_B      289 LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
30-344 7.51e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 7.51e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       30 ADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 109
Cdd:COG2319   7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      110 APSGNYVACGGLDNICSIYNLKTRegnvRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHT 188
Cdd:COG2319  87 SPDGRLLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPDGKtLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      189 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY 268
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
6OS9_B      269 SHDNIicGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:COG2319 243 TGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
50-260 7.18e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 7.18e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       50 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 129
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      130 LKTREgnvrVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC 208
Cdd:COG2319 275 LATGE----LLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
6OS9_B      209 DASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 260
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
154-344 3.39e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 3.39e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      154 RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 233
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      234 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNiicGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL 312
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190
                ....*....|....*....|....*....|..
6OS9_B      313 AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-344 2.07e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 2.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B      222 CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HDNiicGITSVSFSKSGRLLLAGYDDFNCNV 300
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTG---PVRDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
6OS9_B      301 WDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-174 3.45e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 3.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       49 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIY 128
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
6OS9_B      129 NLKTREgnvrVSRELAGHTGYLSCCRFLDD-NQIVTSSGDTTCALWD 174
Cdd:cd00200 247 DLRTGE----CVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-132 1.69e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       50 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN 129
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ...
6OS9_B      130 LKT 132
Cdd:COG2319 401 LAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-258 5.37e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 5.37e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
6OS9_B         220 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 258
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 44-175 7.48e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B        44 VGRIQMRTRrtLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSwvMTCAYAPS--GNYVACGG 120
Cdd:PLN00181 562 VARSQLVTE--MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSesGRSLAFGS 637

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
6OS9_B       121 LDNICSIYNLKtregNVRVSR-ELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDI 175
Cdd:PLN00181 638 ADHKVYYYDLR----NPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 101-335 7.68e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 7.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       101 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-----REGNVRVSrELAGHTGYLSCC-RFLDDNQIVTSSGDTTCALWD 174
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESiikdgRDIHYPVV-ELASRSKLSGICwNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       175 IETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFtghESDINAICF-FPN--GNAFATGSD 250
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI---KTKANICCVqFPSesGRSLAFGSA 638

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       251 DATCRLFDLRADQ-ELMTY-SHDNIicgITSVSFSKSGRLLLAGYDDfNCNVWDaLKADRAGV-------LAGHDNRVSC 321
Cdd:PLN00181 639 DHKVYYYDLRNPKlPLCTMiGHSKT---VSYVRFVDSSTLVSSSTDN-TLKLWD-LSMSISGInetplhsFMGHTNVKNF 713

                        250
                 ....*....|....
6OS9_B       322 LGVTDDGMAVATGS 335
Cdd:PLN00181 714 VGLSVSDGYIATGS 727
WD40 pfam00400
WD domain, G-beta repeat;
220-258 2.83e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 2.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
6OS9_B        220 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-87 5.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
6OS9_B          53 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-87 2.03e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
6OS9_B         53 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD 87
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
310-344 1.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
6OS9_B        310 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-344 2.52e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....
6OS9_B         311 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 344
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
187-216 9.10e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 9.10e-04
                          10        20        30
                  ....*....|....*....|....*....|
6OS9_B        187 HTGDVMSLSLAPDTRLFVSGACDASAKLWD 216
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-216 2.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
6OS9_B         187 HTGDVMSLSLAPDTRLFVSGACDASAKLWD 216
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 315-343 3.40e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 3.40e-03
                          10        20
                  ....*....|....*....|....*....
6OS9_B        315 HDNRVSCLGVTDDGMAVATGSWDSFLKIW 343
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW 151
PTZ00421 PTZ00421
coronin; Provisional
 157-305 4.87e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       157 DDNQIVTSSGDTTCALWDIETGQQTTTFTG-------HTGDVMSLSLAPDTR-LFVSGACDASAKLWDVREGMCRQTFTG 228
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivhlqgHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6OS9_B       229 HESDINAICFFPNGNAFATGSDDATCRLFDLRadqelmtysHDNIICGITSVSFSKSGRLLLAGYDD----FNCN----- 299
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR---------DGTIVSSVEAHASAKSQRCLWAKRKDliitLGCSksqqr 237


                 ....*....
6OS9_B       300 ---VWDALK 305
Cdd:PTZ00421 238 qimLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-174 4.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
6OS9_B         138 RVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTTCALWD 174
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-174 9.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
6OS9_B        141 RELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWD 174
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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