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Conserved domains on  [gi|1784428625|pdb|6RQL|O]
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Chain O, RNA polymerase I-specific transcription initiation factor RRN3

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 47-618 0e+00

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 615.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O         47 FSAAMYSRFVKSALDDLDKNDSTQIGIIANQVALPSKNPERINDKNLNILLDILSSNINRIESSRGTfLIQSIINFeKWW 126
Cdd:pfam05327   3 FSDKMYREFVRRALEEHEKGDSEQYDELKEQFSPDPESPDAPSTALLKQLLKALSSNVSRLDRSCSG-LVEAILSL-SWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        127 ELPPHTLSKYIYFIKILCSSIPKWWQDVSMILVSCFILPIKQTVC---------------HHDMLKYFLRMIPSSMGFID 191
Cdd:pfam05327  81 GRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRlpgyppvtrrevyerVHEALKYILRLIPTAPSVLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        192 TYLAKFFPNKNDTRRKLVNYTSNLLKLRGYCSELGFQIWSLLIEKIISIDVELQNELDELDDDVDDDDLEEVdleddddl 271
Cdd:pfam05327 161 PILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEIQVELEDLDDDEDEELLEQL-------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        272 dddsgddddencgnsneELRSGAADGSQSDSEDMDIIEGMDGTEEYN-VELTQGIKELSTKLDSILTLVSTHVEEQVT-- 348
Cdd:pfam05327 233 -----------------DEDDDDDDDDDSDDDSDSSDDGLDDDEEDDeVQRIKKIKELVEKLDAILDLLFEHLDSKFSsg 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        349 -PESLESGEGVGVFNTLTTLFKTHVLPTYYTRSIQYIMFHVSQQQLELMDSFLVTLIDISFAVNEAAEKKIKSLQYLGSY 427
Cdd:pfam05327 296 sPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASF 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        428 IARAKKLSRTQIIFVASYLTSWLNRYVIEREEEVdQRGGMERFKHFYAAFQALCYIFCFRHNIFRDT-------DGNWEC 500
Cdd:pfam05327 376 VARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC-RGPDLKRHGVFYAVCQALLYIFCFRWRDLTDAdddeeggDLEWLP 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        501 ELDKFFQRMVISKFNPLKFCNENVMLMFARIAQQESVAYCFSIIENNNNERLRGIigkadsdkkensaqanttssswslA 580
Cdd:pfam05327 455 GLDEFLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKREETAGT------------------------A 510

                         570       580       590
                  ....*....|....*....|....*....|....*...
6RQL_O        581 TRQQFIDLQSYFPYDPLFLKNYKILMKEYYIEWSEASG 618
Cdd:pfam05327 511 TGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 47-618 0e+00

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 615.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O         47 FSAAMYSRFVKSALDDLDKNDSTQIGIIANQVALPSKNPERINDKNLNILLDILSSNINRIESSRGTfLIQSIINFeKWW 126
Cdd:pfam05327   3 FSDKMYREFVRRALEEHEKGDSEQYDELKEQFSPDPESPDAPSTALLKQLLKALSSNVSRLDRSCSG-LVEAILSL-SWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        127 ELPPHTLSKYIYFIKILCSSIPKWWQDVSMILVSCFILPIKQTVC---------------HHDMLKYFLRMIPSSMGFID 191
Cdd:pfam05327  81 GRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRlpgyppvtrrevyerVHEALKYILRLIPTAPSVLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        192 TYLAKFFPNKNDTRRKLVNYTSNLLKLRGYCSELGFQIWSLLIEKIISIDVELQNELDELDDDVDDDDLEEVdleddddl 271
Cdd:pfam05327 161 PILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEIQVELEDLDDDEDEELLEQL-------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        272 dddsgddddencgnsneELRSGAADGSQSDSEDMDIIEGMDGTEEYN-VELTQGIKELSTKLDSILTLVSTHVEEQVT-- 348
Cdd:pfam05327 233 -----------------DEDDDDDDDDDSDDDSDSSDDGLDDDEEDDeVQRIKKIKELVEKLDAILDLLFEHLDSKFSsg 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        349 -PESLESGEGVGVFNTLTTLFKTHVLPTYYTRSIQYIMFHVSQQQLELMDSFLVTLIDISFAVNEAAEKKIKSLQYLGSY 427
Cdd:pfam05327 296 sPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASF 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        428 IARAKKLSRTQIIFVASYLTSWLNRYVIEREEEVdQRGGMERFKHFYAAFQALCYIFCFRHNIFRDT-------DGNWEC 500
Cdd:pfam05327 376 VARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC-RGPDLKRHGVFYAVCQALLYIFCFRWRDLTDAdddeeggDLEWLP 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        501 ELDKFFQRMVISKFNPLKFCNENVMLMFARIAQQESVAYCFSIIENNNNERLRGIigkadsdkkensaqanttssswslA 580
Cdd:pfam05327 455 GLDEFLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKREETAGT------------------------A 510

                         570       580       590
                  ....*....|....*....|....*....|....*...
6RQL_O        581 TRQQFIDLQSYFPYDPLFLKNYKILMKEYYIEWSEASG 618
Cdd:pfam05327 511 TGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 47-618 0e+00

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 615.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O         47 FSAAMYSRFVKSALDDLDKNDSTQIGIIANQVALPSKNPERINDKNLNILLDILSSNINRIESSRGTfLIQSIINFeKWW 126
Cdd:pfam05327   3 FSDKMYREFVRRALEEHEKGDSEQYDELKEQFSPDPESPDAPSTALLKQLLKALSSNVSRLDRSCSG-LVEAILSL-SWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        127 ELPPHTLSKYIYFIKILCSSIPKWWQDVSMILVSCFILPIKQTVC---------------HHDMLKYFLRMIPSSMGFID 191
Cdd:pfam05327  81 GRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRlpgyppvtrrevyerVHEALKYILRLIPTAPSVLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        192 TYLAKFFPNKNDTRRKLVNYTSNLLKLRGYCSELGFQIWSLLIEKIISIDVELQNELDELDDDVDDDDLEEVdleddddl 271
Cdd:pfam05327 161 PILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEIQVELEDLDDDEDEELLEQL-------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        272 dddsgddddencgnsneELRSGAADGSQSDSEDMDIIEGMDGTEEYN-VELTQGIKELSTKLDSILTLVSTHVEEQVT-- 348
Cdd:pfam05327 233 -----------------DEDDDDDDDDDSDDDSDSSDDGLDDDEEDDeVQRIKKIKELVEKLDAILDLLFEHLDSKFSsg 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        349 -PESLESGEGVGVFNTLTTLFKTHVLPTYYTRSIQYIMFHVSQQQLELMDSFLVTLIDISFAVNEAAEKKIKSLQYLGSY 427
Cdd:pfam05327 296 sPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASF 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        428 IARAKKLSRTQIIFVASYLTSWLNRYVIEREEEVdQRGGMERFKHFYAAFQALCYIFCFRHNIFRDT-------DGNWEC 500
Cdd:pfam05327 376 VARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC-RGPDLKRHGVFYAVCQALLYIFCFRWRDLTDAdddeeggDLEWLP 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RQL_O        501 ELDKFFQRMVISKFNPLKFCNENVMLMFARIAQQESVAYCFSIIENNNNERLRGIigkadsdkkensaqanttssswslA 580
Cdd:pfam05327 455 GLDEFLQRAIYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKREETAGT------------------------A 510

                         570       580       590
                  ....*....|....*....|....*....|....*...
6RQL_O        581 TRQQFIDLQSYFPYDPLFLKNYKILMKEYYIEWSEASG 618
Cdd:pfam05327 511 TGQEFEQLDAYFPFDPYLLPRSKRWIEPDYVEWSEVAG 548
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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